Summary of Study ST000946

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000651. The data can be accessed directly via it's Project DOI: 10.21228/M8HX17 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000946
Study TitleUntargeted Metabolomics of T1 Participants
Study TypeMS analysis
Study SummarySpecific Aims: (a) Identify sex differences in serum untargeted metabolomics profiles during late adolescence, (b) examine changes in metabolomics profiles between early and late adolescence in the same children, and (c) evaluate associations of exposure to prenatal and concurrent exposure to PAHs, metals, and EDCs with serum metabolite profiles among boys and girls, separately, during late adolescence.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2018-03-14
Num Groups2
Total Subjects207
Study CommentsThe overall objective of this project is to expand upon available data from Early Life Exposure in Mexico to ENvironental Toxicants (ELEMENT) Project to examine effects of toxicant exposures during three sensitive developmental timeframes – the prenatal period, early adolescence, and late adolescence – on adiposity and metabolic risk in adolescence with an emphasis on sex differences and the related molecular underpinnings. In addition to existing exposure data on BPA, metals and phthalates, we propose to add measures of polycyclic aromatic hydrocarbon (PAH) metabolites in archived urine samples from mothers and children. We also propose to assess the epigenome at three developmental periods (prenatal aka in utero, early and late adolescence) and the circulating metabolome during late adolescence. We will incorporate data on toxicant exposures and ‘omics, including untargeted metabolomics of 404 teenagers from the ELEMENT cohorts, to addressing several specific aims.
Raw Data AvailableYes
Raw Data File Type(s)d
Chear StudyYes
Analysis Type DetailLC-MS
Release Date2021-08-31
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8HX17
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000651
Project DOI:doi: 10.21228/M8HX17
Project Title:UM CEHC Sexual Maturation Study
Project Type:MS analysis
Project Summary:Study of in utero EDC exposure and sexual maturation in adolescents
Institute:University of Michigan
Department:Nutritional Sciences
Laboratory:Meeker Lab
Last Name:Meeker
First Name:John
Address:Ann Arbor, MI
Email:meekerj@umich.edu
Phone:734-764-7184

Subject:

Subject ID:SU000985
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sex
SA056291C-XBWC1-S-00female
SA056292C-XCB50-S-00female
SA056293C-WEG02-S-00female
SA056294C-V80G5-S-00female
SA056295C-YX746-S-00female
SA056296C-Y7E60-S-00female
SA056297C-VMKU1-S-00female
SA056298C-Y4YL9-S-00female
SA056299C-XP1E3-S-00female
SA056300C-XCNS2-S-00female
SA056301C-XDP12-S-00female
SA056302C-WBKE9-S-00female
SA056303C-VL1Q8-S-00female
SA056304C-Y7NG4-S-00female
SA056305C-V8H01-S-00female
SA056306C-VNNU5-S-00female
SA056307C-WY159-S-00female
SA056308C-WPZ09-S-00female
SA056309C-Z22U1-S-00female
SA056310C-V2AP1-S-00female
SA056311C-WPVU2-S-00female
SA056312C-VZEY9-S-00female
SA056313C-Z3JA9-S-00female
SA056314C-VCSH4-S-00female
SA056315C-W2D07-S-00female
SA056316C-Y0XQ7-S-00female
SA056317C-Y7Y45-S-00female
SA056318C-XN7L6-S-00female
SA056319C-Y68S1-S-00female
SA056320C-WTQ74-S-00female
SA056321C-X1131-S-00female
SA056322C-Y2V31-S-00female
SA056323C-Z8VM0-S-00female
SA056324C-WMKX3-S-00female
SA056325C-VLHF9-S-00female
SA056326C-XPEC8-S-00female
SA056327C-WJ2G2-S-00female
SA056328C-YZTU0-S-00female
SA056329C-VBUV3-S-00female
SA056330C-YSL12-S-00female
SA056331C-VPFM7-S-00female
SA056332C-V66R9-S-00female
SA056333C-YFRQ5-S-00female
SA056334C-Z10U5-S-00female
SA056335C-WM6D8-S-00female
SA056336C-VMFJ0-S-00female
SA056337C-V4A31-S-00female
SA056338C-Y75Y9-S-00female
SA056339C-WE9F8-S-00female
SA056340C-Z95J7-S-00female
SA056341C-YFV60-S-00female
SA056342C-X2UX1-S-00female
SA056343C-XEBK7-S-00female
SA056344C-XYUV0-S-00female
SA056345C-WXK97-S-00female
SA056346C-WHPF9-S-00female
SA056347C-Y8DH0-S-00female
SA056348C-VJSE4-S-00female
SA056349C-XB563-S-00female
SA056350C-XAR25-S-00female
SA056351C-W6GB6-S-00female
SA056352C-XJYY2-S-00female
SA056353C-YAMS6-S-00female
SA056354C-WBTM3-S-00female
SA056355C-X1GF7-S-00female
SA056356C-Z9HA8-S-00female
SA056357C-VNZ87-S-00female
SA056358C-Z0QQ3-S-00female
SA056359C-YVCC6-S-00female
SA056360C-WSE52-S-00female
SA056361C-VF6N2-S-00female
SA056362C-VGPU9-S-00female
SA056363C-WMW58-S-00female
SA056364C-VY1L0-S-00female
SA056365C-X8KV3-S-00female
SA056366C-YC8A3-S-00female
SA056367C-Y9CY1-S-00female
SA056368C-Z57A3-S-00female
SA056369C-V7TJ4-S-00female
SA056370C-WRZR1-S-00female
SA056371C-W0C10-S-00female
SA056372C-VDWM6-S-00female
SA056373C-W7SL0-S-00female
SA056374C-X8X86-S-00female
SA056375C-YB323-S-00female
SA056376C-YFGV5-S-00female
SA056377C-Y1AL9-S-00female
SA056378C-XPQ98-S-00female
SA056379C-XY372-S-00female
SA056380C-V8YE8-S-00female
SA056381C-VM1A1-S-00female
SA056382C-Y6KY9-S-00female
SA056383C-YPGB7-S-00female
SA056384C-WRP21-S-00female
SA056385C-X6LL8-S-00female
SA056386C-WESM7-S-00female
SA056387C-VNV08-S-00female
SA056388C-VPYV8-S-00female
SA056389C-WUUR9-S-00female
SA056390C-X1HL3-S-00female
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Collection:

Collection ID:CO000979
Collection Summary:None
Sample Type:Blood (serum)

Treatment:

Treatment ID:TR000999
Treatment Summary:None

Sample Preparation:

Sampleprep ID:SP000992
Sampleprep Summary:None
Sampleprep Protocol Filename:Untargeted_metabolomics_analysis.doc

Combined analysis:

Analysis ID AN001552 AN001553
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Agilent 6530 Agilent 6530
Column Waters Acquity HSS T3 (100 x 2.1mm,1.8um) Waters Acquity HSS T3 (100 x 2.1mm,1.8um)
MS Type ESI ESI
MS instrument type QTOF QTOF
MS instrument name Agilent 6530 QTOF Agilent 6530 QTOF
Ion Mode NEGATIVE POSITIVE
Units Counts Counts

Chromatography:

Chromatography ID:CH001089
Methods Filename:Neg_Untargeted_20171016_460ulmin_Agilent_AS_0mm.m.zip
Pos_Untargeted_20171016_Agillent_460_ulmin_AS+0mm-5ul.m.zip
Chromatography Comments:C18
Instrument Name:Agilent 6530
Column Name:Waters Acquity HSS T3 (100 x 2.1mm,1.8um)
Chromatography Type:Reversed phase

MS:

MS ID:MS001430
Analysis ID:AN001552
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:NEGATIVE
  
MS ID:MS001431
Analysis ID:AN001553
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:POSITIVE
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