Summary of study ST001523

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001005. The data can be accessed directly via it's Project DOI: 10.21228/M8SH6G This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001523
Study TitleThe effect of fasting and sirtuin overexpression on serum metabolome.
Study Typeuntargeted metabolomics
Study SummaryThe levels of the sirtuins SIRT1 and SIRT6 are regulated by nutrient availability in several mammalian tissues. In addition, overexpressing SIRT1 in mice improves healthspan, while SIRT6 overexpression increases both healthspan and lifespan. However, little is known about the impact of these sirtuins at the in vivo metabolomics level. Thus, we performed metabolomics on serum taken from 15 months old male mice overexpressing SIRT1, SIRT6 and SIRT1+SIRT6 as well as WT controls. Sera were obtained from mice at three nutritional time points - at fed state, after 4h morning fast and after 16h fast.
Institute
Bar Ilan University
DepartmentThe Mina & Everard Goodman Faculty of Life Sciences
LaboratoryLaboratory of Prof. Haim Cohen
Last NameCohen
First NameHaim
AddressBar Ilan University, Ramat Gan, Israel, 5290002
EmailHaim.Cohen@biu.ac.il
Phone+97235318383
Submit Date2020-09-10
Raw Data AvailableYes
Raw Data File Type(s).cdf
Analysis Type DetailGC-MS
Release Date2021-03-11
Release Version1
Haim Cohen Haim Cohen
https://dx.doi.org/10.21228/M8SH6G
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR001005
Project DOI:doi: 10.21228/M8SH6G
Project Title:The effect of fasting and sirtuin overexpression on serum metabolome.
Project Type:metabolomics
Project Summary:The levels of the sirtuins SIRT1 and SIRT6 are regulated by nutrient availability in several mammalian tissues. In addition, overexpressing SIRT1 in mice improves healthspan, while SIRT6 overexpression increases both healthspan and lifespan. However, little is known about the impact of these sirtuins at the in vivo metabolomics level. Thus, we performed metabolomics on serum taken from 15 months old male mice overexpressing SIRT1, SIRT6 and SIRT1+SIRT6 as well as WT controls. Sera were obtained from mice at three nutritional time points - at fed state, after 4h morning fast and after 16h fast.
Institute:Bar Ilan University
Department:The Mina & Everard Goodman Faculty of Life Sciences
Laboratory:Laboratory of Prof. Haim Cohen
Last Name:Haim
First Name:Cohen
Address:Bar Ilan University, Ramat Gan, Israel, 5290002
Email:Haim.Cohen@biu.ac.il
Phone:+97235318383
Funding Source:Intramural Research Program of the National Institute on Aging, NIH
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