Summary of study ST001643

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001051. The data can be accessed directly via it's Project DOI: 10.21228/M8V702 This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001643
Study TitleDeletion of the diabetes candidate gene Slc16a13 in mice
Study SummaryThe metabolome of plasma and liver lysates of Slc16a13 knockout mice was analyzed. Genome-wide association studies identified SLC16A13 as novel target gene in type 2 diabetes. The SLC16A13 gene encodes for SLC16A13/MCT13, a member of the solute carrier 16 family of monocarboxylate transporters. So far, biology and physiological function of SLC16A13 is unknown. Deletion of Slc16a13 is hypothezised to affect intrahepatocellular monocarboxylate availability, that drives increased oxidative phosphorylation, while reducing hepatic lipid content, thereby attenuating hepatic insulin resistance.
Institute
University of California, Davis
DepartmentWest Coast Metabolomics Center
LaboratoryInstitut für Diabetesforschung und Metabolische Erkrankungen (IDM)
Last NameBirkenfeld
First NameAndreas
AddressOttfried-Müller Str. 10 72076 Tübingen
EmailAndreas.Birkenfeld@med.uni-tuebingen.de
Phone+49(0)7071 84 20257
Submit Date2021-01-06
Raw Data AvailableYes
Raw Data File Type(s).cdf
Analysis Type DetailGC-MS
Release Date2021-04-01
Release Version1
Andreas Birkenfeld Andreas Birkenfeld
https://dx.doi.org/10.21228/M8V702
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR001051
Project DOI:doi: 10.21228/M8V702
Project Title:Deletion of the diabetes candidate gene Slc16a13 in mice
Project Summary:The metabolome of plasma and liver lysates of Slc16a13 knockout mice was analyzed. Genome-wide association studies identified SLC16A13 as novel target gene in type 2 diabetes. The SLC16A13 gene encodes for SLC16A13/MCT13, a member of the solute carrier 16 family of monocarboxylate transporters. So far, biology and physiological function of SLC16A13 is unknown. Deletion of Slc16a13 is hypothezised to affect intrahepatocellular monocarboxylate availability, that drives increased oxidative phosphorylation, while reducing hepatic lipid content, thereby attenuating hepatic insulin resistance.
Institute:University of California, Davis
Department:West Coast Metabolomics Center
Last Name:Birkenfeld
First Name:Andreas
Address:Ottfried-Müller Str. 10 72076 Tübingen
Email:Andreas.Birkenfeld@med.uni-tuebingen.de
Phone:+49(0)7071 84 20257
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