Summary of study ST001745

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001118. The data can be accessed directly via it's Project DOI: 10.21228/M86404 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001745
Study TitleMetabolomic profiling of the rat hippocampus across developmental ages and after learning
Study TypeDevelopmental study
Study SummaryLittle is known about how the hippocampal metabolomic profile changes across development and in response to learning at different ages. To fill this knowledge gap, we employed an untargeted metabolomic analyses in rats to determine how the hippocampal metabolome changes over the course of post-natal development under basal conditions and following inhibitory avoidance (IA) training, an aversive episodic event. We found that unique metabolomic profiles accompany learning at different ages. Subsequent biochemical and behavioral studies based on unique metabolomic regulations in the infant hippocampus established that infantile learning selectively recruits the glutathione-mediated antioxidant defenses for the formation of infantile memory.
Institute
New York University
DepartmentCenter for Neural Science (NYU)
LaboratoryCristina Alberini
Last NameBessieres
First NameBenjamin
Address4 Washington Place, Room 623
Emailbjb11@nyu.edu
Phone6315684274
Submit Date2021-03-26
Num Groups8
Total Subjects52
Num Males35
Num Females17
Raw Data AvailableYes
Raw Data File Type(s).xls
Analysis Type DetailLC-MS
Release Date2021-05-01
Release Version1
Benjamin Bessieres Benjamin Bessieres
https://dx.doi.org/10.21228/M86404
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR001118
Project DOI:doi: 10.21228/M86404
Project Title:Metabolomic profiling of the rat hippocampus across developmental ages and after learning.
Project Type:Neuroscience
Project Summary:The metabolic mechanisms underlying the formation of early-life episodic memories remain poorly characterized. To fill this knowledge gap, we employed an untargeted metabolomic analysis in rats to determine how the hippocampal metabolome changes over the course of post-natal development under basal conditions and following inhibitory avoidance (IA) training, an aversive episodic event. We found that unique metabolomic profiles accompany learning at different ages. Subsequent biochemical and behavioral studies based on unique metabolomic regulations in the infant hippocampus established that infantile learning selectively recruits the glutathione-mediated antioxidant defenses for the formation of infantile memory.
Institute:New York University
Department:Center for Neural Science (NYU)
Laboratory:Cristina Alberini
Last Name:Bessieres
First Name:Benjamin
Address:4 Washington Place, Room 623
Email:bjb11@nyu.edu
Phone:6315684274
Funding Source:NIH
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