Summary of study ST001750

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001122. The data can be accessed directly via it's Project DOI: 10.21228/M8P686 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001750
Study TitleGut microbiome influence on metabolic 1 disease in HIV and high-risk populations
Study SummaryPoor metabolic health, characterized by insulin resistance and dyslipidemia, is higher in people living with HIV (PLWH) and has been linked with inflammation, anti-retroviral therapy (ART) drugs, and ART-associated lipodystrophy (LD). Metabolic disease is associated with gut microbiome composition outside the context of HIV but has not been deeply explored in HIV infection nor in high-risk men who have sex with men (HR-MSM), who have a highly altered gut microbiome composition. Furthermore, the contribution of increased bacterial translocation and associated systemic inflammation that has been described in HIV-positive and HR-MSM individuals has not been explored. We used a multi-omic approach to explore relationships between gut microbes, immune phenotypes, diet, and metabolic health across ART-treated PLWH with and without LD; untreated PLWH; and HR-MSM. For PLWH on ART, we further explored associations with the plasma metabolome.
Institute
University of Colorado Anschutz Medical Campus
Last NameReisdorph
First NameNichole
Address12850 East Montview Blvd, Aurora, CO, 80045, USA
Emailnichole.reisdorph@cuanschutz.edu
Phone303-724-9234
Submit Date2021-04-24
Raw Data AvailableYes
Raw Data File Type(s).xml
Analysis Type DetailLC-MS
Release Date2021-05-04
Release Version1
Nichole Reisdorph Nichole Reisdorph
https://dx.doi.org/10.21228/M8P686
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR001122
Project DOI:doi: 10.21228/M8P686
Project Title:Gut microbiome influence on metabolic 1 disease in HIV and high-risk populations
Project Summary:Poor metabolic health, characterized by insulin resistance and dyslipidemia, is higher in people living with HIV (PLWH) and has been linked with inflammation, anti-retroviral therapy (ART) drugs, and ART-associated lipodystrophy (LD). Metabolic disease is associated with gut microbiome composition outside the context of HIV but has not been deeply explored in HIV infection nor in high-risk men who have sex with men (HR-MSM), who have a highly altered gut microbiome composition. Furthermore, the contribution of increased bacterial translocation and associated systemic inflammation that has been described in HIV-positive and HR-MSM individuals has not been explored. We used a multi-omic approach to explore relationships between gut microbes, immune phenotypes, diet, and metabolic health across ART-treated PLWH with and without LD; untreated PLWH; and HR-MSM. For PLWH on ART, we further explored associations with the plasma metabolome.
Institute:University of Colorado Anschutz Medical Campus
Last Name:Reisdorph
First Name:Nichole
Address:12850 East Montview Blvd, Aurora, CO, 80045, USA
Email:nichole.reisdorph@cuanschutz.edu
Phone:303-724-9234
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