Summary of study ST001982

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001258. The data can be accessed directly via it's Project DOI: 10.21228/M83M69 This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001982
Study TitleLipidomic characterization of Candida albicans in response to Aureobasidin treatment in vitro.
Study SummaryCandida albicans is an opportunistic yeast pathogen that causes a wide range of infections especially amongst immunocompromised patients. Aureobasidin A (AbA) has been shown to inhibit inositolphosphoryl ceramide synthase (IPCS), a key enzyme responsible for sphingolipid biosynthesis. There are limited studies exploring IPCS as a target molecule for antifungal treatment. It is hypothesized that the mechanism of AbA inhibition involves alteration of C. albicans phospholipid and sphingolipid profiles. The profiling of C. albicans phospholipid and sphingolipid upon exposure to 0.5-4 µg/ml of AbA were determined using Liquid chromatography-mass spectrometry (LC-MS).
Institute
University of Malaya
Last NameHamdan
First NameNur Wahida
AddressJalan Profesor Diraja Ungku Aziz, 50603 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Emailnurwahidahamdan@siswa.um.edu.my
Phone0193354272
Submit Date2021-09-16
Num Groups5
Total SubjectsDuplicates
Num MalesNA
Num FemalesNA
Analysis Type DetailLC-MS
Release Date2021-11-22
Release Version1
Nur Wahida Hamdan Nur Wahida Hamdan
https://dx.doi.org/10.21228/M83M69
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR001258
Project DOI:doi: 10.21228/M83M69
Project Title:Lipidomic characterization of Candida albicans in response to Aureobasidin treatment in vitro.
Project Summary:Candida albicans is an opportunistic yeast pathogen that causes a wide range of infections especially amongst immunocompromised patients. Aureobasidin A (AbA) has been shown to inhibit inositolphosphoryl ceramide synthase (IPCS), a key enzyme responsible for sphingolipid biosynthesis. There are limited studies exploring IPCS as a target molecule for antifungal treatment. It is hypothesized that the mechanism of AbA inhibition involves alteration of C. albicans phospholipid and sphingolipid profiles. The profiling of C. albicans phospholipid and sphingolipid upon exposure to 0.5-4 µg/ml of AbA were determined using Liquid chromatography-mass spectrometry (LC-MS).
Institute:University of Malaya
Department:Medical Microbiology Department
Laboratory:Lab 3
Last Name:Hamdan
First Name:Nur Wahida
Address:Jalan Profesor Diraja Ungku Aziz, 50603 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Email:nurwahidahamdan@siswa.um.edu.my
Phone:0193354272
Funding Source:FRGS(FP035-2014A), UM PPP(PG178-2015B)
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