Summary of Study ST003200

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001994. The data can be accessed directly via it's Project DOI: 10.21228/M8014R This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003200
Study TitleA study of 9 common breath VOCs in 504 healthy subjects using PTR-TOF-MS
Study SummaryThis study utilized Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) to analyze the exhaled breath profiles of 504 healthy adults, focusing on nine common breath volatile organic compounds (VOCs): acetone, acetaldehyde, acetonitrile, ethanol, isoprene, methanol, propanol, phenol, and toluene. The concentrations of these VOCs exhibited log normal distributions, with distinct differences observed based on different gender, age, and smoking history groups. Male group showed higher average VOC concentrations of acetaldehyde, acetonitrile, isoprene, and toluene. Age-related effects were evident, particularly in propanol and methanol, whose concentrations increased significantly with age. Smoking history also influenced VOC concentrations, with significant differences among non-smokers, current smokers, and ex-smokers. Ex-smokers demonstrated lower VOC levels than current smokers, indicating a normalization post-smoking cessation. Positive correlations were identified between breath VOC concentrations and years of smoking. The study enhances understanding of demographic influences on exhaled VOC profiles, contributing valuable insights for potential applications in health monitoring and clinical diagnosis. The use of PTR-MS was crucial for real-time VOC measurement, offering advantages over conventional methods. The research lays a foundation for future developments in non-invasive disease detection. The results highlight the potential of breath analysis as a valuable tool for health assessment.
Institute
Breathonix Pte Ltd
Last NameZihao
First NameXing
Address83 Science Park, #02-01A, The Curie, Singapore, Singapore, Singapore, 118258, Singapore
Emailzihao@breathonix.com
Phone87805084
Submit Date2024-05-08
Raw Data AvailableYes
Raw Data File Type(s)h5
Analysis Type DetailAPCI-MS
Release Date2025-05-08
Release Version1
Xing Zihao Xing Zihao
https://dx.doi.org/10.21228/M8014R
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR001994
Project DOI:doi: 10.21228/M8014R
Project Title:A study of 9 common breath VOCs in 504 healthy subjects using PTR-TOF-MS
Project Summary:This study utilized Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) to analyze the exhaled breath profiles of 504 healthy adults, focusing on nine common breath volatile organic compounds (VOCs): acetone, acetaldehyde, acetonitrile, ethanol, isoprene, methanol, propanol, phenol, and toluene. The concentrations of these VOCs exhibited log normal distributions, with distinct differences observed based on different gender, age, and smoking history groups. Male group showed higher average VOC concentrations of acetaldehyde, acetonitrile, isoprene, and toluene. Age-related effects were evident, particularly in propanol and methanol, whose concentrations increased significantly with age. Smoking history also influenced VOC concentrations, with significant differences among non-smokers, current smokers, and ex-smokers. Ex-smokers demonstrated lower VOC levels than current smokers, indicating a normalization post-smoking cessation. Positive correlations were identified between breath VOC concentrations and years of smoking. The study enhances understanding of demographic influences on exhaled VOC profiles, contributing valuable insights for potential applications in health monitoring and clinical diagnosis. The use of PTR-MS was crucial for real-time VOC measurement, offering advantages over conventional methods. The research lays a foundation for future developments in non-invasive disease detection. The results highlight the potential of breath analysis as a valuable tool for health assessment.
Institute:Breathonix Pte Ltd
Last Name:Xing
First Name:Zihao
Address:83 Science Park, #02-01A, The Curie, Singapore, Singapore, Singapore, 118258, Singapore
Email:zihao@breathonix.com
Phone:87805084

Subject:

Subject ID:SU003319
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Mammals

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sample source Sex Smoking Status
SA348129L3390180430Breath Female -
SA348130L3390185443Breath Female Current smoker
SA348131L3390229574Breath Female Current smoker
SA348132L3390169529Breath Female Current smoker
SA348133L3390271039Breath Female Current smoker
SA348134L3390274640Breath Female Current smoker
SA348135L3390117365Breath Female Current smoker
SA348136L3390190940Breath Female Current smoker
SA348137L3390233441Breath Female Current smoker
SA348138L3390010319Breath Female Current smoker
SA348139L3390149019Breath Female Current smoker
SA348140L3390295837Breath Female Current smoker
SA348141L3390014376Breath Female Current smoker
SA348632L3390287771Breath female Non smoker
SA348142L3390271293Breath Female Non smoker
SA348143L3390162532Breath Female Non smoker
SA348144L3390162434Breath Female Non smoker
SA348145L3390167099Breath Female Non smoker
SA348146L3390166992Breath Female Non smoker
SA348147L3390167239Breath Female Non smoker
SA348148L3390163095Breath Female Non smoker
SA348149L3390163046Breath Female Non smoker
SA348150L3390162923Breath Female Non smoker
SA348151L3390163245Breath Female Non smoker
SA348152L3390167060Breath Female Non smoker
SA348153L3390168773Breath Female Non smoker
SA348154L3390269577Breath Female Non smoker
SA348155L3390174673Breath Female Non smoker
SA348156L3380087213Breath Female Non smoker
SA348157L3390176618Breath Female Non smoker
SA348158L3390178611Breath Female Non smoker
SA348159L3390269698Breath Female Non smoker
SA348160L3390172425Breath Female Non smoker
SA348161L3390171612Breath Female Non smoker
SA348162L3390271076Breath Female Non smoker
SA348163L3390167447Breath Female Non smoker
SA348164L3390162355Breath Female Non smoker
SA348165L3390170091Breath Female Non smoker
SA348166L3390270301Breath Female Non smoker
SA348167L3390271108Breath Female Non smoker
SA348168L3390271949Breath Female Non smoker
SA348169L3390276627Breath Female Non smoker
SA348170L3390148423Breath Female Non smoker
SA348171L3390147661Breath Female Non smoker
SA348172L3390151003Breath Female Non smoker
SA348173L3390155956Breath Female Non smoker
SA348174L3390158544Breath Female Non smoker
SA348175L3390276075Breath Female Non smoker
SA348176L3390147438Breath Female Non smoker
SA348177L3390146198Breath Female Non smoker
SA348178L3390136047Breath Female Non smoker
SA348179L3390134528Breath Female Non smoker
SA348180L3390137810Breath Female Non smoker
SA348181L3390138445Breath Female Non smoker
SA348182L3390145748Breath Female Non smoker
SA348183L3390277923Breath Female Non smoker
SA348184L3390158561Breath Female Non smoker
SA348185L3390158570Breath Female Non smoker
SA348186L3390272628Breath Female Non smoker
SA348187L3390272638Breath Female Non smoker
SA348188L3390161085Breath Female Non smoker
SA348189L3390179504Breath Female Non smoker
SA348190L3390271791Breath Female Non smoker
SA348191L3390161417Breath Female Non smoker
SA348192L3390160303Breath Female Non smoker
SA348193L3390272793Breath Female Non smoker
SA348194L3390158822Breath Female Non smoker
SA348195L3390158580Breath Female Non smoker
SA348196L3390274468Breath Female Non smoker
SA348197L3390159181Breath Female Non smoker
SA348198L3390159894Breath Female Non smoker
SA348199L3390273320Breath Female Non smoker
SA348200L3390162225Breath Female Non smoker
SA348201L3390267965Breath Female Non smoker
SA348202L3390205999Breath Female Non smoker
SA348203L3390204980Breath Female Non smoker
SA348204L3390203710Breath Female Non smoker
SA348205L3390206358Breath Female Non smoker
SA348206L3390207726Breath Female Non smoker
SA348207L3390232430Breath Female Non smoker
SA348208L3390207739Breath Female Non smoker
SA348209L3390233975Breath Female Non smoker
SA348210L3390202334Breath Female Non smoker
SA348211L3390198376Breath Female Non smoker
SA348212L3390198301Breath Female Non smoker
SA348213L3390199175Breath Female Non smoker
SA348214L3390199705Breath Female Non smoker
SA348215L3390202251Breath Female Non smoker
SA348216L3390201577Breath Female Non smoker
SA348217L3390232371Breath Female Non smoker
SA348218L3390210818Breath Female Non smoker
SA348219L3390226227Breath Female Non smoker
SA348220L3390220174Breath Female Non smoker
SA348221L3390226219Breath Female Non smoker
SA348222L3390225257Breath Female Non smoker
SA348223L3390223515Breath Female Non smoker
SA348224L3390225225Breath Female Non smoker
SA348225L3390219848Breath Female Non smoker
SA348226L3390219803Breath Female Non smoker
SA348227L3390215621Breath Female Non smoker
Showing page 1 of 6     Results:    1  2  3  4  5  Next  Last     Showing results 1 to 100 of 504

Collection:

Collection ID:CO003312
Collection Summary:Participants were instructed to breathe naturally through a mouthpiece, allowing sufficient time for VOC levels to equilibrate with the background concentration before advancing to the subsequent sample. This procedure was iterated three times per participant.
Collection Protocol Filename:Breathonix_Clinical_Trial_Protocol.pdf
Sample Type:Breath

Treatment:

Treatment ID:TR003328
Treatment Summary:NA

Sample Preparation:

Sampleprep ID:SP003326
Sampleprep Summary:NA
Sampleprep Protocol ID:Breathonix_Clinical_Trial_Protocol.pdf

Combined analysis:

Analysis ID AN005250
Analysis type MS
Chromatography type None (Direct infusion)
Chromatography system none
Column none
MS Type APCI
MS instrument type PTR-TOF
MS instrument name Ionicon PTR-MS 1000
Ion Mode POSITIVE
Units parts per billion by volume

Chromatography:

Chromatography ID:CH003975
Instrument Name:none
Column Name:none
Column Temperature:none
Flow Gradient:none
Flow Rate:none
Solvent A:none
Solvent B:none
Chromatography Type:None (Direct infusion)

MS:

MS ID:MS004983
Analysis ID:AN005250
Instrument Name:Ionicon PTR-MS 1000
Instrument Type:PTR-TOF
MS Type:APCI
MS Comments:-
Ion Mode:POSITIVE
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