Clustering data with hclust algorithm for (Study ST003904)
(Analysis AN006409)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|---|
| Ha_DLH | ME1033784 | 2.62 | 2.70 | 2.96 | 0.06 | 0.07 | 2.58 | 0.06 |
| Hb_HLD | ME1033871 | 2.62 | 2.70 | 2.96 | 0.06 | 0.07 | 2.58 | 0.06 |
| Hb_PVQ | ME1033887 | 1.83 | NA | 2.68 | 0.08 | 0.08 | 1.86 | 0.07 |
| Ha_VD | ME1033832 | 2.80 | NA | 2.78 | 0.38 | 0.33 | 2.09 | 0.42 |
| Hb_VD | ME1033902 | 2.80 | NA | 2.78 | 0.38 | 0.33 | 2.09 | 0.42 |
| Hb_DEVGG | ME1033844 | 0.86 | 0.02 | 1.83 | NA | NA | 1.29 | NA |
| Hb_NVDE | ME1033879 | 0.86 | 0.02 | 1.83 | NA | NA | 1.29 | NA |
| Hb_PEE | ME1033884 | 1.99 | 1.59 | 1.82 | 0.30 | 0.24 | 1.59 | 0.24 |
| Ha_TYFP | ME1033830 | 1.33 | 1.44 | 1.28 | 0.09 | 0.07 | 1.31 | 0.09 |
| Hb_DGLAH | ME1033848 | 1.19 | 1.63 | 1.27 | 0.26 | 0.38 | 1.05 | 0.32 |
| Ha_VDD | ME1033833 | 1.25 | 1.09 | 1.82 | 0.10 | 0.11 | 1.53 | 0.12 |
| Ha_DP | ME1033787 | 1.10 | 1.68 | 1.81 | 0.17 | 0.14 | 1.70 | 0.14 |
| Hb_PD;DP | ME1033882 | 1.10 | 1.68 | 1.81 | 0.17 | 0.14 | 1.70 | 0.14 |
| Hb_STPDAVMGNP;ATLSELHCD | ME1033896 | 1.45 | 0.00 | 1.15 | NA | NA | 0.90 | NA |
| Hb_VNVDEVGGEA | ME1033919 | 1.45 | 0.00 | 1.15 | NA | NA | 0.90 | NA |
| Ha_LHAH | ME1033811 | 1.33 | 0.37 | 1.20 | NA | NA | 0.78 | NA |
| Hb_LAHH | ME1033877 | 1.33 | 0.37 | 1.20 | NA | NA | 0.78 | NA |
| Ha_NAVA | ME1033813 | 1.34 | 0.31 | 0.94 | NA | NA | 0.94 | NA |
| Hb_VANA | ME1033899 | 1.34 | 0.31 | 0.94 | NA | NA | 0.94 | NA |
| Ha_HKLRV | ME1033800 | 0.69 | 0.80 | 0.88 | NA | NA | 1.56 | NA |
| Ha_KGHGK;GHGKK | ME1033803 | 0.88 | 0.70 | 0.74 | NA | NA | 1.53 | NA |
| Ha_FLSFP | ME1033791 | 0.89 | 0.86 | 0.97 | NA | NA | 1.21 | NA |
| Ha_KGHGKK | ME1033804 | 0.89 | 0.81 | 0.91 | NA | NA | 1.31 | NA |
| Hb_VHLTP | ME1033912 | 0.94 | 0.87 | 0.87 | NA | NA | 1.26 | NA |
| Hb_VHLTPEE | ME1033913 | 0.94 | 0.84 | 0.89 | NA | NA | 1.27 | NA |
| Ha_GKVGAH;QVKGH | ME1033796 | 0.78 | 0.78 | 0.94 | NA | NA | 1.41 | NA |
| Hb_VAGVANAL | ME1033898 | 0.79 | 0.75 | 0.96 | NA | NA | 1.40 | NA |
| Ha_AHKLR | ME1033778 | 0.76 | 0.90 | 0.87 | NA | NA | 1.44 | NA |
| Hb_YPW | ME1033921 | 0.87 | 0.90 | 0.84 | NA | NA | 1.37 | NA |
| Hb_DNLKG | ME1033851 | 1.11 | 0.76 | 0.82 | NA | NA | 1.23 | NA |
| Ha_EALERMF | ME1033789 | 0.95 | 0.62 | 0.99 | NA | NA | 1.19 | NA |
| Ha_HGKKV | ME1033798 | 0.95 | 0.68 | 1.00 | NA | NA | 1.23 | NA |
| Hb_HGKKV | ME1033870 | 0.95 | 0.68 | 1.00 | NA | NA | 1.23 | NA |
| Hb_KAHG;AHGK | ME1033874 | 0.98 | 1.16 | 0.73 | NA | NA | 1.22 | NA |
| Hb_SELHC | ME1033890 | 1.04 | 1.06 | 0.71 | NA | NA | 1.21 | NA |
| Ha_LERM | ME1033810 | 0.82 | 1.14 | 0.77 | NA | NA | 1.38 | NA |
| Hb_VCVLAH | ME1033901 | 0.64 | 1.11 | 0.86 | NA | NA | 1.47 | NA |
| Ha_HVDD | ME1033802 | 1.03 | 1.30 | 1.22 | NA | NA | 0.44 | NA |
| Hb_VDEVGGEALG | ME1033907 | 0.96 | 1.36 | 1.22 | NA | NA | 0.64 | NA |
| Hb_VDE;DEV | ME1033903 | 0.74 | 1.29 | 1.26 | NA | NA | 0.80 | NA |
| Hb_VGGEALG | ME1033910 | 0.83 | 1.05 | 1.31 | NA | NA | 0.85 | NA |
| Ha_AHAGEYGA | ME1033777 | 0.86 | 1.11 | 1.30 | NA | NA | 0.77 | NA |
| Hb_VDEVGGEA;GDLSTPDA | ME1033906 | 0.86 | 1.11 | 1.30 | NA | NA | 0.77 | NA |
| Ha_PHFD | ME1033819 | 1.02 | 0.70 | 1.45 | NA | NA | 0.83 | NA |
| Ha_KVGAH | ME1033807 | 1.00 | 1.30 | 0.89 | NA | NA | 0.98 | NA |
| Hb_VKAHG | ME1033914 | 1.00 | 1.30 | 0.89 | NA | NA | 0.98 | NA |
| Ha_DDM | ME1033783 | 1.27 | 1.06 | 0.84 | NA | NA | 0.84 | NA |
| Ha_VADA | ME1033831 | 1.19 | 1.36 | 0.95 | NA | NA | 0.75 | NA |
| Hb_DGLA | ME1033847 | 1.19 | 1.36 | 0.95 | NA | NA | 0.75 | NA |
| Hb_FESFG | ME1033862 | 1.16 | 1.18 | 0.99 | NA | NA | 0.76 | NA |
| Ha_AE;EA | ME1033773 | 1.11 | 1.17 | 0.99 | NA | NA | 0.73 | NA |
| Hb_EA | ME1033855 | 1.11 | 1.17 | 0.99 | NA | NA | 0.73 | NA |
| Ha_DLHA | ME1033785 | 1.10 | 0.56 | 1.22 | NA | NA | 1.12 | NA |
| Hb_AHLD | ME1033840 | 1.10 | 0.56 | 1.22 | NA | NA | 1.12 | NA |
| Ha_LRVD | ME1033812 | 1.26 | 0.59 | 1.01 | NA | NA | 1.00 | NA |
| Ha_NVKAA;AQVKG | ME1033815 | 1.26 | 0.59 | 1.01 | NA | NA | 1.00 | NA |
| Ha_TPAVH | ME1033827 | 1.16 | 0.62 | 1.17 | NA | NA | 0.95 | NA |
| Hb_ATLS | ME1033841 | 1.16 | 0.66 | 1.03 | NA | NA | 0.94 | NA |
| Hb_PW | ME1033889 | 1.21 | 0.60 | 1.07 | NA | NA | 0.87 | NA |
| Hb_EE | ME1033856 | 1.08 | 0.84 | 0.93 | NA | NA | 1.10 | NA |
| Hb_EVGG;VGGE;LDN;DNL | ME1033859 | 1.11 | 0.81 | 0.90 | NA | NA | 1.08 | NA |
| Hb_DE | ME1033842 | 1.18 | 0.82 | 0.90 | NA | NA | 0.99 | NA |
| Hb_DLSTPDA | ME1033850 | 1.16 | 0.80 | 0.91 | NA | NA | 1.05 | NA |
| Ha_AGEYG;GEYGA | ME1033776 | 1.05 | 0.73 | 0.99 | NA | NA | 1.10 | NA |
| Hb_GAFSD;AFSDG | ME1033865 | 1.05 | 0.73 | 0.99 | NA | NA | 1.10 | NA |
| Ha_ADALT | ME1033772 | 1.07 | 0.82 | 1.00 | NA | NA | 1.02 | NA |
| Hb_KAHGKK | ME1033875 | 1.04 | 0.84 | 0.99 | NA | NA | 1.05 | NA |
| Hb_VC;CV | ME1033900 | 1.05 | 0.68 | 1.12 | NA | NA | 1.05 | NA |
| Ha_DPVNF | ME1033788 | 1.08 | 0.72 | 1.04 | NA | NA | 1.01 | NA |
| Ha_VLSPAD | ME1033837 | 1.12 | 0.82 | 1.04 | NA | NA | 0.95 | NA |
| Ha_NAVAHV | ME1033814 | 1.14 | 0.77 | 1.03 | NA | NA | 0.94 | NA |
| Hb_YPWT | ME1033922 | 1.13 | 0.74 | 1.04 | NA | NA | 0.96 | NA |
| Ha_PNALS | ME1033822 | 1.37 | 0.87 | 1.01 | NA | NA | 0.67 | NA |
| Ha_FTPAVH | ME1033793 | 1.28 | 0.71 | 1.04 | NA | NA | 0.78 | NA |
| Ha_SHCLLV | ME1033825 | 1.28 | 0.71 | 1.04 | NA | NA | 0.78 | NA |
| Ha_PHFDLS | ME1033820 | 1.28 | 0.90 | 1.05 | NA | NA | 0.77 | NA |
| Hb_SFGDL;FGDLS;FSDGL | ME1033893 | 1.27 | 0.80 | 0.99 | NA | NA | 0.80 | NA |
| Ha_AEALER | ME1033774 | 1.29 | 0.85 | 0.98 | NA | NA | 0.80 | NA |
| Hb_FTPPVQ | ME1033863 | 1.29 | 0.85 | 0.98 | NA | NA | 0.80 | NA |
| Ha_DALTN | ME1033782 | 1.03 | 1.11 | 1.00 | NA | NA | 0.92 | NA |
| Hb_DPENF | ME1033854 | 0.98 | 1.10 | 1.04 | NA | NA | 0.92 | NA |
| Ha_HLPAEFT | ME1033801 | 0.97 | 1.21 | 1.04 | NA | NA | 0.90 | NA |
| Hb_VDEVG | ME1033904 | 0.92 | 1.17 | 1.10 | NA | NA | 0.89 | NA |
| Hb_VNVDEVG;EVGGEALG | ME1033918 | 0.95 | 1.15 | 1.11 | NA | NA | 0.87 | NA |
| Hb_VHL;LHV | ME1033911 | 1.05 | 0.94 | 0.95 | NA | NA | 1.03 | NA |
| Ha_LE | ME1033809 | 1.01 | 1.03 | 0.97 | NA | NA | 1.01 | NA |
| Hb_EL | ME1033857 | 1.01 | 1.03 | 0.97 | NA | NA | 1.01 | NA |
| Ha_FLSF | ME1033790 | 1.05 | 0.98 | 1.00 | NA | NA | 0.96 | NA |
| Ha_VLSP | ME1033836 | 1.03 | 1.01 | 0.99 | NA | NA | 0.98 | NA |
| Ha_PNAL | ME1033821 | 1.05 | 1.02 | 0.97 | NA | NA | 0.97 | NA |
| Hb_PVQA | ME1033888 | 1.05 | 1.02 | 0.97 | NA | NA | 0.97 | NA |
| Ha_TY | ME1033829 | 1.01 | 1.04 | 0.90 | NA | NA | 1.08 | NA |
| Hb_GTFAT | ME1033869 | 1.09 | 1.03 | 0.88 | NA | NA | 1.01 | NA |
| Hb_VDPEN | ME1033908 | 0.85 | 1.02 | 1.05 | NA | NA | 1.11 | NA |
| Ha_YG | ME1033838 | 0.97 | 1.05 | 0.97 | NA | NA | 1.04 | NA |
| Ha_GA;AG | ME1033794 | 0.93 | 1.05 | 0.99 | NA | NA | 1.06 | NA |
| Hb_GA;AG | ME1033864 | 0.93 | 1.05 | 0.99 | NA | NA | 1.06 | NA |
| Ha_FLSFPTT | ME1033792 | 1.07 | 1.03 | 1.22 | NA | NA | 0.69 | NA |
| Ha_VDPVNF | ME1033834 | 1.01 | 0.88 | 1.17 | NA | NA | 0.87 | NA |
| Hb_STPDAVM | ME1033895 | 0.98 | 0.94 | 1.19 | NA | NA | 0.85 | NA |
| Hb_VDPENF | ME1033909 | 0.98 | 0.94 | 1.19 | NA | NA | 0.85 | NA |
| Ha_HAGEYG | ME1033797 | 1.13 | 0.87 | 1.19 | NA | NA | 0.77 | NA |
| Ha_TVLT | ME1033828 | 1.09 | 0.81 | 1.18 | NA | NA | 0.82 | NA |
| Ha_AVAHVDDM | ME1033780 | 1.10 | 0.85 | 1.15 | NA | NA | 0.82 | NA |
| Hb_HVDPENF | ME1033873 | 1.10 | 0.85 | 1.15 | NA | NA | 0.82 | NA |
| Hb_SFGDLS | ME1033894 | 1.21 | 0.81 | 1.10 | NA | NA | 0.80 | NA |
| Hb_VLGAFSDG | ME1033915 | 1.13 | 0.86 | 1.07 | NA | NA | 0.86 | NA |
| Ha_DLS;LSD;SDL;SLD | ME1033786 | 1.13 | 0.86 | 1.08 | NA | NA | 0.86 | NA |
| Hb_DLS | ME1033849 | 1.13 | 0.86 | 1.08 | NA | NA | 0.86 | NA |
| Ha_PVNF | ME1033824 | 1.15 | 0.84 | 1.10 | NA | NA | 0.81 | NA |
| Hb_PPVQ | ME1033886 | 1.17 | 0.88 | 1.07 | NA | NA | 0.81 | NA |
| Hb_VDEVGG | ME1033905 | 1.23 | 0.95 | 0.94 | NA | NA | 0.84 | NA |
| Hb_VNVDE;NVDEV | ME1033917 | 1.23 | 0.95 | 0.94 | NA | NA | 0.84 | NA |
| Ha_DALT | ME1033781 | 1.18 | 0.93 | 1.03 | NA | NA | 0.82 | NA |
| Hb_DEVGGEA | ME1033845 | 1.20 | 1.03 | 1.02 | NA | NA | 0.76 | NA |
| Hb_DEVGGEALG | ME1033846 | 1.17 | 0.98 | 1.07 | NA | NA | 0.78 | NA |
| Hb_NVDEVGGEA | ME1033881 | 1.15 | 1.02 | 1.05 | NA | NA | 0.78 | NA |
| Hb_DEVG;STPD | ME1033843 | 0.99 | 0.94 | 1.08 | NA | NA | 0.97 | NA |
| Hb_GGEAL;GEALG | ME1033867 | 1.08 | 1.00 | 1.12 | NA | NA | 0.79 | NA |
| Hb_VNVD | ME1033916 | 1.08 | 1.00 | 1.12 | NA | NA | 0.79 | NA |
| Hb_FATLSE | ME1033861 | 1.11 | 0.92 | 1.04 | NA | NA | 0.87 | NA |
| Hb_PENF | ME1033885 | 1.07 | 0.92 | 1.10 | NA | NA | 0.87 | NA |
| Ha_GEYG | ME1033795 | 1.07 | 0.91 | 1.06 | NA | NA | 0.92 | NA |
| Hb_SFGD;FSDG | ME1033892 | 1.07 | 0.91 | 1.06 | NA | NA | 0.92 | NA |
| Ha_PADKT | ME1033817 | 1.07 | 1.07 | 1.02 | NA | NA | 0.88 | NA |
| Hb_NVDEVG | ME1033880 | 1.11 | 1.00 | 1.05 | NA | NA | 0.83 | NA |
| Hb_YQ | ME1033923 | 1.08 | 1.01 | 1.02 | NA | NA | 0.89 | NA |
| Ha_YGA | ME1033839 | 1.08 | 1.01 | 1.02 | NA | NA | 0.89 | NA |
| Hb_SFG | ME1033891 | 1.08 | 1.01 | 1.02 | NA | NA | 0.89 | NA |
| Ha_AGEY;EYGA;YGAE | ME1033775 | 1.07 | 0.99 | 1.06 | NA | NA | 0.87 | NA |
| Hb_ESFG;AFSD | ME1033858 | 1.07 | 0.99 | 1.06 | NA | NA | 0.87 | NA |
| Ha_ALSDLH;LSDLHA | ME1033779 | 1.07 | 0.97 | 1.06 | NA | NA | 0.88 | NA |
| Ha_KTYFP | ME1033806 | 1.07 | 0.97 | 1.06 | NA | NA | 0.88 | NA |
| Ha_PAVH | ME1033818 | 0.71 | 1.38 | 0.47 | NA | NA | 1.76 | NA |
| Hb_DPEN | ME1033853 | 0.76 | 1.89 | 0.89 | NA | NA | 0.90 | NA |
| Hb_EVGGEA | ME1033860 | 0.87 | 1.93 | 0.51 | NA | NA | 1.19 | NA |
Factors:
| F1 | Sample source:Cultured Plasmodium falciparum 3D7 | Genotype:WT | Treatment:10 nM Atovaquone |
| F2 | Sample source:Cultured Plasmodium falciparum 3D7 | Genotype:WT | Treatment:140 nM Piperaquine |
| F3 | Sample source:Cultured Plasmodium falciparum 3D7 | Genotype:WT | Treatment:None |
| F4 | Sample source:Cultured Plasmodium falciparum RF7_B9 | Genotype:1 copy plasmepsin II/III | Treatment:None |
| F5 | Sample source:Cultured Plasmodium falciparum RF7_D4 | Genotype:3 copies plasmepsin II/III | Treatment:None |
| F6 | Sample source:Pooled Cultured Plasmodium falciparum 3D7 | Genotype:WT | Treatment:NA |
| F7 | Sample source:Pooled Cultured Plasmodium falciparum RF7_B9 and RF7_D4 | Genotype:NA | Treatment:NA |
