Clustering data with hclust algorithm for (Study ST004206)
(Analysis AN006995)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DG(18:0_22:6) | ME1136687 | 0.01 | 2.71 | NA | 0.04 | 0.02 | NA | 0.12 | 0.02 | NA | 7.47 | 0.01 | 2.21 | NA | 0.65 | 0.03 | NA | 0.24 |
| TG(18:1_34:3) | ME1136778 | NA | 0.06 | NA | 1.19 | 0.06 | NA | 1.22 | NA | NA | 1.40 | 0.06 | 0.04 | NA | 1.37 | 0.00 | NA | 1.24 |
| DG(16:0_18:1) | ME1136683 | 0.54 | 0.48 | NA | 1.61 | 0.57 | NA | 1.61 | 0.54 | NA | 1.72 | 0.51 | 0.30 | NA | 1.61 | 0.55 | NA | 1.72 |
| DG(18:0_18:1) | ME1136685 | 0.63 | 0.36 | NA | 1.60 | 0.66 | NA | 1.63 | 0.59 | NA | 1.46 | 0.60 | 0.22 | NA | 1.53 | 0.67 | NA | 1.85 |
| TG(18:0_36:2) | ME1136776 | 0.20 | 0.48 | NA | 1.68 | 0.23 | NA | 1.71 | 0.17 | NA | 2.33 | 0.23 | 0.58 | NA | 1.91 | 0.20 | NA | 1.59 |
| DG(18:1/18:1) | ME1136688 | 0.09 | 0.06 | NA | 2.10 | 0.10 | NA | 2.05 | 0.09 | NA | 2.40 | 0.08 | 0.06 | NA | 2.23 | 0.08 | NA | 2.01 |
| TG(18:1_34:2) | ME1136777 | 0.10 | 0.19 | NA | 1.81 | 0.11 | NA | 2.02 | 0.10 | NA | 2.51 | 0.12 | 0.20 | NA | 2.26 | 0.07 | NA | 1.91 |
| TG(22:6_36:2) | ME1136785 | 0.94 | NA | NA | 1.16 | 0.72 | NA | 1.12 | 1.27 | NA | NA | 1.11 | NA | NA | 0.98 | 0.96 | NA | 1.03 |
| PC(16:0/5:0(CHO)) | ME1136731 | 0.23 | 3.05 | NA | 0.30 | 0.36 | NA | 0.25 | 0.23 | NA | 0.38 | 0.27 | 2.71 | NA | 0.39 | 0.23 | NA | 0.48 |
| PC(O-16:0/0:0) | ME1136744 | 0.24 | 3.62 | NA | 0.29 | 0.24 | NA | 0.32 | 0.24 | NA | 0.24 | 0.24 | 2.46 | NA | 0.32 | 0.24 | NA | 0.32 |
| DG(16:0_20:4) | ME1136684 | 0.30 | 3.44 | NA | 0.51 | 0.16 | NA | 0.29 | 0.23 | NA | 0.36 | 0.30 | 2.26 | NA | 0.55 | 0.21 | NA | 0.33 |
| LPC(16:0) | ME1136705 | 0.40 | 3.17 | NA | 0.41 | 0.33 | NA | 0.34 | 0.40 | NA | 0.36 | 0.44 | 2.31 | NA | 0.47 | 0.25 | NA | 0.40 |
| CE(20:4) | ME1136666 | 1.94 | 2.05 | NA | 0.47 | 0.16 | NA | 0.21 | 1.01 | NA | 0.40 | 1.89 | 2.08 | NA | 0.48 | 0.18 | NA | 0.25 |
| LacCer(d18:1/24:0) | ME1136719 | NA | 1.00 | NA | 1.00 | 1.00 | NA | 1.00 | NA | NA | 1.00 | NA | 1.00 | NA | 1.00 | 1.00 | NA | 1.00 |
| HexCer(d18:1/18:0) | ME1136700 | 1.06 | 2.69 | NA | 0.36 | 0.60 | NA | 0.30 | 0.86 | NA | 0.33 | 0.92 | 1.98 | NA | 0.39 | 0.69 | NA | 0.34 |
| HexCer(d18:1/24:0) | ME1136702 | 1.06 | 2.42 | NA | 0.41 | 0.77 | NA | 0.43 | 0.85 | NA | 0.41 | 0.93 | 1.71 | NA | 0.45 | 0.94 | NA | 0.49 |
| HexCer(d18:1/24:1) | ME1136703 | 1.12 | 2.49 | NA | 0.30 | 0.73 | NA | 0.34 | 0.93 | NA | 0.39 | 0.90 | 1.96 | NA | 0.35 | 0.92 | NA | 0.37 |
| HexCer(d18:1/22:0) | ME1136701 | 1.10 | 2.06 | NA | 0.50 | 0.90 | NA | 0.48 | 0.93 | NA | 0.49 | 1.00 | 1.67 | NA | 0.55 | 0.95 | NA | 0.53 |
| HexCer(d18:1/16:0) | ME1136699 | 1.04 | 2.05 | NA | 0.51 | 0.73 | NA | 0.36 | 0.99 | NA | 0.43 | 1.23 | 1.91 | NA | 0.55 | 0.78 | NA | 0.44 |
| LacCer(d18:1/18:0) | ME1136718 | 1.10 | 2.29 | NA | 0.55 | 0.49 | NA | 0.37 | 0.98 | NA | 0.37 | 1.16 | 1.80 | NA | 0.62 | 0.67 | NA | 0.37 |
| DG(18:0_20:4) | ME1136686 | 0.50 | 2.60 | NA | 0.61 | 0.41 | NA | 0.61 | 0.52 | NA | 0.66 | 0.47 | 1.78 | NA | 0.68 | 0.54 | NA | 0.67 |
| LPC(20:4) | ME1136710 | 0.30 | 2.87 | NA | 0.42 | 0.33 | NA | 0.48 | 0.40 | NA | 0.40 | 0.47 | 2.07 | NA | 0.58 | 0.43 | NA | 0.72 |
| LPC(18:0) | ME1136707 | 0.52 | 2.66 | NA | 0.56 | 0.31 | NA | 0.47 | 0.42 | NA | 0.52 | 0.47 | 2.15 | NA | 0.69 | 0.37 | NA | 0.50 |
| PC(16:0/9:0(CHO)) | ME1136732 | 0.36 | 2.58 | NA | 0.49 | 0.43 | NA | 0.43 | 0.59 | NA | 0.59 | 0.40 | 2.26 | NA | 0.59 | 0.33 | NA | 0.67 |
| PE(34:1) | ME1136750 | 0.72 | 2.29 | NA | 0.73 | 0.30 | NA | 0.46 | 0.49 | NA | 0.59 | 0.69 | 2.09 | NA | 0.77 | 0.35 | NA | 0.51 |
| PE(36:4) | ME1136753 | 0.79 | 1.91 | NA | 0.84 | 0.32 | NA | 0.51 | 0.60 | NA | 0.76 | 0.87 | 1.90 | NA | 0.94 | 0.40 | NA | 0.62 |
| Cer(d18:1/16:0) | ME1136674 | 0.77 | 2.10 | NA | 0.72 | 0.43 | NA | 0.46 | 0.67 | NA | 0.62 | 0.94 | 1.95 | NA | 0.84 | 0.40 | NA | 0.51 |
| Cer(d18:1/18:0) | ME1136675 | 0.96 | 2.13 | NA | 0.77 | 0.36 | NA | 0.42 | 0.68 | NA | 0.59 | 0.89 | 1.92 | NA | 0.85 | 0.42 | NA | 0.45 |
| PC(16:0/9:0(COOH)) | ME1136733 | 0.52 | 1.86 | NA | 0.62 | 0.52 | NA | 0.61 | 0.52 | NA | 0.52 | 0.52 | 1.64 | NA | 0.59 | 0.52 | NA | 0.59 |
| Cholesterol | ME1136678 | 0.52 | 2.01 | NA | 0.74 | 0.44 | NA | 0.64 | 0.67 | NA | 0.69 | 0.60 | 1.97 | NA | 0.78 | 0.47 | NA | 0.73 |
| SM(d18:1/16:0) | ME1136763 | 0.80 | 1.79 | NA | 0.77 | 0.56 | NA | 0.66 | 0.68 | NA | 0.68 | 0.84 | 1.73 | NA | 0.82 | 0.60 | NA | 0.76 |
| PE(36:1) | ME1136751 | 0.73 | 1.95 | NA | 0.71 | 0.54 | NA | 0.72 | 0.58 | NA | 0.71 | 0.63 | 1.69 | NA | 0.79 | 0.63 | NA | 0.84 |
| SM(d18:1/18:0) | ME1136764 | 0.71 | 1.91 | NA | 0.73 | 0.41 | NA | 0.70 | 0.50 | NA | 0.63 | 0.64 | 1.82 | NA | 0.85 | 0.51 | NA | 0.86 |
| CE(16:1) | ME1136662 | 1.65 | 1.65 | NA | 0.81 | 0.45 | NA | 0.85 | 0.75 | NA | 0.75 | 1.28 | 1.25 | NA | 0.63 | 0.45 | NA | 0.68 |
| LPC(22:6) | ME1136711 | NA | 1.73 | NA | 0.65 | 0.65 | NA | 0.72 | 0.65 | NA | 0.65 | 0.65 | 1.50 | NA | 0.79 | 0.65 | NA | 0.91 |
| CE(22:6) | ME1136668 | 1.03 | 1.04 | NA | 0.83 | 0.39 | NA | 0.98 | 0.77 | NA | 1.00 | 0.99 | 1.09 | NA | 1.07 | 0.57 | NA | 1.64 |
| PE(40:7) | ME1136760 | 0.82 | 1.17 | NA | 1.19 | 0.43 | NA | 0.83 | 0.66 | NA | 1.30 | 0.83 | 1.23 | NA | 1.35 | 0.54 | NA | 0.96 |
| Cer(d18:1/24:0) | ME1136676 | 0.73 | 1.37 | NA | 1.00 | 0.57 | NA | 0.91 | 0.62 | NA | 0.97 | 0.79 | 1.18 | NA | 1.14 | 0.67 | NA | 1.13 |
| SM(d18:1/24:0) | ME1136765 | 0.71 | 1.50 | NA | 0.95 | 0.57 | NA | 0.95 | 0.50 | NA | 0.91 | 0.66 | 1.26 | NA | 1.02 | 0.66 | NA | 1.17 |
| PE(38:5) | ME1136755 | 0.70 | 1.41 | NA | 0.97 | 0.41 | NA | 0.82 | 0.60 | NA | 1.14 | 0.74 | 1.46 | NA | 1.16 | 0.53 | NA | 1.00 |
| PE(40:6) | ME1136759 | 0.60 | 1.39 | NA | 0.95 | 0.51 | NA | 0.95 | 0.55 | NA | 1.03 | 0.59 | 1.43 | NA | 1.15 | 0.61 | NA | 1.07 |
| PC(40:6) | ME1136743 | 0.75 | 0.96 | NA | 0.97 | 0.70 | NA | 1.06 | 0.78 | NA | 1.02 | 0.75 | 0.97 | NA | 1.21 | 0.90 | NA | 1.45 |
| PC(38:6) | ME1136741 | 0.85 | 1.19 | NA | 0.98 | 0.57 | NA | 0.89 | 0.80 | NA | 0.92 | 0.88 | 1.18 | NA | 1.19 | 0.72 | NA | 1.14 |
| PC(36:1) | ME1136737 | 0.78 | 1.27 | NA | 0.89 | 0.65 | NA | 1.03 | 0.71 | NA | 0.91 | 0.70 | 1.16 | NA | 1.05 | 0.81 | NA | 1.26 |
| PC(38:4) | ME1136740 | 0.66 | 1.15 | NA | 0.87 | 0.71 | NA | 0.99 | 0.75 | NA | 0.94 | 0.70 | 1.18 | NA | 1.10 | 0.91 | NA | 1.33 |
| TG(20:4_36:2) | ME1136783 | 0.72 | 1.73 | NA | 0.72 | NA | NA | 0.72 | 0.72 | NA | 0.72 | 0.72 | 1.49 | NA | 0.72 | 0.72 | NA | 0.72 |
| DG(18:1_20:4) | ME1136689 | 0.46 | 1.89 | NA | 0.90 | 0.39 | NA | 0.78 | 0.48 | NA | 0.95 | 0.44 | 1.56 | NA | 1.05 | 0.59 | NA | 0.91 |
| MG(16:0) | ME1136722 | 0.87 | 1.33 | NA | 0.91 | 0.81 | NA | 0.90 | 0.95 | NA | 0.79 | 0.85 | 1.38 | NA | 0.85 | 0.87 | NA | 0.89 |
| PC(36:2) | ME1136738 | 0.86 | 1.42 | NA | 0.91 | 0.64 | NA | 0.82 | 0.81 | NA | 0.88 | 0.85 | 1.32 | NA | 1.04 | 0.72 | NA | 0.97 |
| PC(36:4) | ME1136739 | 0.91 | 1.44 | NA | 0.81 | 0.66 | NA | 0.73 | 0.89 | NA | 0.79 | 0.97 | 1.46 | NA | 0.91 | 0.80 | NA | 0.91 |
| PE(36:2) | ME1136752 | 0.77 | 1.74 | NA | 0.93 | 0.37 | NA | 0.71 | 0.62 | NA | 0.90 | 0.74 | 1.61 | NA | 1.03 | 0.47 | NA | 0.78 |
| Cer(d18:1/24:1) | ME1136677 | 0.89 | 1.65 | NA | 0.98 | 0.49 | NA | 0.68 | 0.69 | NA | 0.91 | 0.86 | 1.42 | NA | 1.06 | 0.53 | NA | 0.81 |
| PE(38:6) | ME1136756 | 0.87 | 1.60 | NA | 1.06 | 0.37 | NA | 0.64 | 0.65 | NA | 0.93 | 0.86 | 1.59 | NA | 1.11 | 0.43 | NA | 0.72 |
| LPC(18:1) | ME1136709 | 0.70 | 1.80 | NA | 0.81 | 0.69 | NA | 0.81 | 0.69 | NA | 0.84 | 0.70 | 1.49 | NA | 0.83 | 0.69 | NA | 0.82 |
| SM(d18:1/24:1) | ME1136766 | 0.70 | 1.74 | NA | 0.82 | 0.52 | NA | 0.82 | 0.61 | NA | 0.73 | 0.68 | 1.58 | NA | 0.86 | 0.62 | NA | 0.94 |
| PE(38:4) | ME1136754 | 0.67 | 1.49 | NA | 0.87 | 0.52 | NA | 0.82 | 0.62 | NA | 0.90 | 0.71 | 1.54 | NA | 1.05 | 0.65 | NA | 0.99 |
| PC(34:1) | ME1136736 | 0.86 | 1.58 | NA | 0.85 | 0.57 | NA | 0.76 | 0.74 | NA | 0.77 | 0.85 | 1.49 | NA | 0.96 | 0.67 | NA | 0.88 |
| PE(40:4) | ME1136757 | 0.79 | 1.63 | NA | 0.83 | 0.55 | NA | 0.73 | 0.64 | NA | 0.85 | 0.79 | 1.63 | NA | 0.96 | 0.59 | NA | 0.83 |
| CE(18:2) | ME1136665 | 1.09 | 1.04 | NA | 1.48 | 0.51 | NA | 1.20 | 0.63 | NA | 1.25 | 1.29 | 0.88 | NA | 0.89 | 0.35 | NA | 1.03 |
| MG(18:1) | ME1136726 | 0.92 | 0.63 | NA | 1.26 | 0.88 | NA | 1.30 | 1.03 | NA | 1.05 | 0.91 | 0.67 | NA | 1.16 | 0.97 | NA | 1.32 |
| LacCer(d18:1/16:0) | ME1136716 | 0.94 | 0.94 | NA | 0.94 | 1.41 | NA | 0.94 | 1.25 | NA | 0.94 | 0.94 | 0.94 | NA | 0.94 | 1.25 | NA | 0.94 |
| CE(18:1) | ME1136664 | 0.99 | 1.09 | NA | 1.01 | 0.90 | NA | 0.95 | 0.99 | NA | 1.05 | 0.96 | 1.11 | NA | 0.96 | 0.92 | NA | 0.96 |
| MG(18:0) | ME1136724 | 0.89 | 0.95 | NA | 1.10 | 0.87 | NA | 1.10 | 0.93 | NA | 0.99 | 0.91 | 0.99 | NA | 1.06 | 0.92 | NA | 1.09 |
| PC(O-16:0/2:0) | ME1136745 | 0.97 | 0.97 | NA | 0.97 | 0.97 | NA | 0.97 | 0.97 | NA | 0.97 | 0.97 | 0.97 | NA | 1.13 | 0.97 | NA | 1.11 |
Factors:
| F1 | Genotype:GPR34-KO | Disease_State:APP-KI | Age_months:16 months | Sample source:Microglia |
| F2 | Genotype:GPR34-KO | Disease_State:APP-KI | Age_months:24 months | Sample source:Microglia |
| F3 | Genotype:GPR34-KO | Disease_State:APP-KI | Age_months:4 months | Sample source:Microglia |
| F4 | Genotype:GPR34-KO | Disease_State:APP-KI | Age_months:8 months | Sample source:Microglia |
| F5 | Genotype:GPR34-KO | Disease_State:WT | Age_months:16 months | Sample source:Microglia |
| F6 | Genotype:GPR34-KO | Disease_State:WT | Age_months:4 months | Sample source:Microglia |
| F7 | Genotype:GPR34-KO | Disease_State:WT | Age_months:8 months | Sample source:Microglia |
| F8 | Genotype:NA | Disease_State:NA | Age_months:16 months | Sample source:Microglia |
| F9 | Genotype:NA | Disease_State:NA | Age_months:4 months | Sample source:Microglia |
| F10 | Genotype:NA | Disease_State:NA | Age_months:8 months | Sample source:Microglia |
| F11 | Genotype:WT | Disease_State:APP-KI | Age_months:16 months | Sample source:Microglia |
| F12 | Genotype:WT | Disease_State:APP-KI | Age_months:24 months | Sample source:Microglia |
| F13 | Genotype:WT | Disease_State:APP-KI | Age_months:4 months | Sample source:Microglia |
| F14 | Genotype:WT | Disease_State:APP-KI | Age_months:8 months | Sample source:Microglia |
| F15 | Genotype:WT | Disease_State:WT | Age_months:16 months | Sample source:Microglia |
| F16 | Genotype:WT | Disease_State:WT | Age_months:4 months | Sample source:Microglia |
| F17 | Genotype:WT | Disease_State:WT | Age_months:8 months | Sample source:Microglia |
