Data for (Study ST003224)
(Analysis AN005286)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 1_3-Bisphosphoglyceric acid | 1.1511 | 1.3917 | 0.6030 | 1.2512 |
| 2-dehydro-D-gluconate | 0.9403 | 1.4895 | 0.5306 | 1.5089 |
| 2-Hydroxy-2-methylbutanedioic acid | 1.1237 | 1.4307 | 0.6353 | 1.1751 |
| 2-oxo-4-methylthiobutanoate | 0.8957 | 1.3424 | 0.9062 | 0.8557 |
| 3-phosphoglycerate | 1.2111 | 0.9702 | 0.6831 | 1.4526 |
| 3-phospho-serine | 1.1638 | 1.2664 | 0.5674 | 1.2909 |
| 4-aminobutyrate | 1.3127 | 1.1265 | 0.6188 | 1.3232 |
| 4-phosphopantothenate | 0.9391 | 1.0946 | 0.7569 | 1.2906 |
| 4-Pyridoxic acid | 1.2188 | 1.2196 | 0.6260 | 1.3095 |
| 6-phospho-D-gluconate | 1.2501 | 1.1950 | 0.6022 | 1.3504 |
| acetyl-aspartate | 1.1909 | 1.2184 | 0.6381 | 1.3145 |
| acetyl-CoA | 0.7297 | 1.3206 | 0.8964 | 1.0532 |
| Acetyl-glycine | 1.0282 | 1.0842 | 0.8967 | 1.0942 |
| Acetyllysine | 1.4010 | 0.7327 | 0.4965 | 1.8732 |
| aconitate | 1.0756 | 1.0996 | 0.6195 | 1.5858 |
| adenine | 1.1871 | 1.1442 | 0.7310 | 1.2068 |
| ADP-D-glucose | 0.9784 | 1.0041 | 0.9298 | 1.0877 |
| a-ketoglutarate | 1.2603 | 0.9451 | 0.5944 | 1.6058 |
| alanine/sarcosine | 1.2205 | 1.0131 | 0.6675 | 1.4313 |
| allantoin | 1.0319 | 1.1855 | 0.7670 | 1.2487 |
| Aminoadipic acid | 1.0424 | 1.2636 | 0.6728 | 1.3484 |
| anthranilate | 1.0806 | 0.6807 | 1.0386 | 1.1615 |
| arginine | 1.4664 | 0.8592 | 0.7938 | 1.0869 |
| Ascorbic acid | 0.7287 | 1.6019 | 0.7432 | 1.1830 |
| asparagine | 1.2304 | 1.1601 | 0.6231 | 1.3633 |
| aspartate | 1.0035 | 1.1563 | 0.6280 | 1.5842 |
| aspartate (standard) | 1.0128 | 1.0028 | 1.0088 | 0.9668 |
| Asp-Leu-His (DLH) | 1.4642 | 0.6227 | 0.5169 | 1.8793 |
| Asp-Leu-Ser (DLS) | 1.3265 | 0.6197 | 0.6160 | 1.6938 |
| Benzoyl-CoA | 1.2965 | 0.7208 | 0.9808 | 1.0083 |
| Carbamoyl phosphate | 0.4671 | 1.5960 | 1.1403 | 0.7967 |
| carnitine | 1.2763 | 1.0104 | 0.7109 | 1.2914 |
| cCMP | 0.8455 | 1.1556 | 1.1319 | 0.8669 |
| CDP | 0.6549 | 1.2924 | 1.0978 | 0.9549 |
| CDP-choline | 0.7205 | 1.1247 | 0.8059 | 1.3489 |
| CDP-ethanolamine | 1.0066 | 1.4148 | 0.6536 | 1.2715 |
| cGMP | 1.0986 | 1.2355 | 0.6799 | 1.3060 |
| chlorpropamide | 1.0274 | 1.0096 | 0.9778 | 1.0074 |
| Citraconic acid | 1.1150 | 1.4396 | 0.6106 | 1.2243 |
| citrate/isocitrate | 0.9512 | 1.2293 | 0.6603 | 1.4988 |
| CMP | 0.7470 | 1.2670 | 0.9556 | 1.0304 |
| coenzyme A | 1.0076 | 0.9783 | 0.6657 | 1.4599 |
| creatine | 0.8987 | 1.3479 | 0.6432 | 1.3481 |
| CTP | 0.5821 | 1.2563 | 0.9837 | 1.1833 |
| cystathionine | 1.3047 | 0.8591 | 0.6746 | 1.3786 |
| Cystine | 0.4317 | 1.0655 | 1.5389 | 0.4249 |
| cytidine | 1.3618 | 1.0765 | 0.6402 | 1.2814 |
| dAMP | 1.3196 | 1.2267 | 0.6364 | 0.9384 |
| dATP | 1.3081 | 0.9943 | 0.6410 | 1.1763 |
| dCDP | 0.8700 | 1.3129 | 0.9378 | 0.8793 |
| dCMP | 0.9538 | 1.3503 | 0.7258 | 1.0616 |
| dCTP | 0.7499 | 1.1148 | 1.0204 | 1.1150 |
| Decanoyl-CoA | 0.9138 | 1.7370 | 0.5860 | 1.0391 |
| deoxyadenosine | 1.1676 | 1.3270 | 0.5652 | 1.3750 |
| deoxyguanosine (1) | 1.1719 | 0.9449 | 0.7142 | 1.2643 |
| deoxyinosine | 1.4864 | 0.8717 | 0.6560 | 1.1006 |
| deoxyribose-phosphate | 0.7296 | 2.0188 | 0.5997 | 1.0522 |
| deoxyuridine | 1.3711 | 1.2149 | 0.6552 | 1.1037 |
| D-erythrose-4-phosphate | 1.0352 | 1.2958 | 0.6421 | 1.3849 |
| dGDP/ADP | 1.3652 | 1.2513 | 0.5513 | 1.2809 |
| D-gluconate | 1.2815 | 1.1948 | 0.5895 | 1.3446 |
| D-glucosamine-1/6-phosphate | 1.2240 | 1.2881 | 0.5049 | 1.3132 |
| dGMP/AMP | 1.4134 | 1.2706 | 0.5594 | 1.1973 |
| dGTP/ATP | 1.2160 | 1.0838 | 0.6534 | 1.2780 |
| dihydroorotate | 3.5385 | 0.1758 | 0.5030 | 0.2797 |
| dihydroxy-acetone-phosphate | 1.0855 | 1.0608 | 0.7363 | 1.3811 |
| DL-Pipecolic Acid | 1.9384 | 0.4242 | 0.4952 | 1.6471 |
| D-sedoheptulose-1/7-phosphate | 1.2289 | 1.2802 | 0.6688 | 1.1532 |
| dTDP | 0.6098 | 1.4401 | 0.7520 | 1.2807 |
| dTMP | 0.9928 | 1.4332 | 0.6471 | 1.1622 |
| dTTP | 0.6571 | 1.3915 | 0.6406 | 1.5505 |
| dUMP | 1.2238 | 1.1634 | 0.6398 | 1.3333 |
| FAD | 1.1052 | 1.1367 | 0.7340 | 1.1128 |
| FMN | 0.8250 | 0.9970 | 0.9015 | 1.2765 |
| folate | 0.9797 | 1.0476 | 0.9112 | 1.0615 |
| fructose-1-6-bisphosphate | 0.9649 | 1.0024 | 0.8929 | 1.2113 |
| fumarate | 1.3169 | 0.7775 | 0.5883 | 1.7290 |
| GDP | 1.3081 | 1.2149 | 0.6356 | 1.0844 |
| glucono-lactone | 1.1034 | 1.2813 | 0.6167 | 1.3820 |
| glucose-1-phosphate | 1.2699 | 1.1867 | 0.5831 | 1.3772 |
| glutamate | 1.3840 | 1.1147 | 0.5764 | 1.3486 |
| glutamine | 1.3134 | 1.1461 | 0.6196 | 1.3014 |
| glutathione | 1.2654 | 1.2192 | 0.4996 | 1.5162 |
| glutathione disulfide | 1.3032 | 1.1688 | 0.5863 | 1.3553 |
| glycerate | 1.2492 | 1.1856 | 0.6750 | 1.2152 |
| GMP | 1.6291 | 1.0688 | 0.4861 | 1.3300 |
| GTP | 1.2456 | 1.0918 | 0.6805 | 1.1951 |
| Guanidoacetic acid | 1.0654 | 0.8951 | 0.9380 | 1.1015 |
| guanine | 1.5552 | 1.2940 | 0.5397 | 1.0714 |
| guanosine | 1.5828 | 1.4245 | 0.5054 | 0.9820 |
| Hexose | 1.2765 | 1.1863 | 0.6335 | 1.2701 |
| hexose-phosphate | 1.0704 | 1.2431 | 0.6310 | 1.4246 |
| histidine | 1.2927 | 0.9753 | 0.6424 | 1.4473 |
| His-Val-Asp-Asp (HVDD) | 1.1880 | 0.4141 | 0.7865 | 1.6115 |
| homocysteine | 1.1486 | 1.0984 | 0.7256 | 1.0273 |
| Hydroxyphenylacetic acid | 0.9250 | 1.1662 | 1.0313 | 0.8461 |
| hydroxyproline/Aminolevulinate | 1.2652 | 1.1972 | 0.6094 | 1.3188 |
| hypoxanthine | 1.3201 | 1.1956 | 0.5935 | 1.2973 |
| IDP | 0.9838 | 1.4701 | 0.5183 | 1.3488 |
| IMP | 1.2720 | 1.3842 | 0.5343 | 1.2752 |
| indole | 0.9899 | 0.9223 | 1.0668 | 1.0210 |
| Indoleacrylic acid | 0.8556 | 1.1064 | 1.0023 | 1.0357 |
| inosine | 1.2661 | 1.1783 | 0.5926 | 1.3706 |
| isoleucine | 1.3526 | 1.1585 | 0.6126 | 1.2637 |
| Kynurenine | 1.3174 | 1.0471 | 0.7059 | 1.2238 |
| lactate | 1.1325 | 0.9330 | 0.8405 | 1.2534 |
| L-arginino-succinate | 1.1439 | 0.8040 | 0.7920 | 1.3293 |
| Leu-Asp (LD) | 1.2968 | 1.0176 | 0.5751 | 1.5354 |
| leucine | 1.3655 | 1.1075 | 0.6107 | 1.3056 |
| lysine | 1.6915 | 0.4295 | 0.7149 | 1.4493 |
| malate | 1.3763 | 0.8698 | 0.5767 | 1.6005 |
| maleic acid | 1.5920 | 0.7927 | 0.5815 | 1.4525 |
| mefloquine | 0.9948 | 1.0556 | 0.8952 | 1.0544 |
| methionine | 1.3842 | 1.0933 | 0.6109 | 1.3007 |
| myo-inositol | 1.0651 | 1.1709 | 0.7079 | 1.3482 |
| N-acetyl-glucosamine | 1.6375 | 1.1375 | 0.5034 | 1.2182 |
| N-acetyl-glucosamine-1/6-phosphate | 1.0391 | 0.8567 | 0.9333 | 1.1709 |
| N-acetyl-glutamate | 1.3027 | 1.2008 | 0.5656 | 1.3654 |
| N-acetyl-glutamine | 1.6919 | 0.7931 | 0.5505 | 1.4141 |
| N-Acetyl-L-alanine | 1.5290 | 1.0167 | 0.5605 | 1.3332 |
| N-acetyl-L-ornithine | 1.3655 | 0.7227 | 0.5351 | 1.8417 |
| NAD+ | 1.1057 | 1.1294 | 0.6716 | 1.4218 |
| NADH | 0.9377 | 1.4529 | 0.7731 | 0.9119 |
| NADP+ | 1.0470 | 1.1034 | 0.7361 | 1.2015 |
| NADPH | 0.9182 | 1.2686 | 0.8168 | 1.0575 |
| N-carbamoyl-L-aspartate | 3.2377 | 0.2431 | 0.5653 | 0.3885 |
| nicotinamide mononucleotide | 1.1604 | 1.3313 | 0.5737 | 1.3609 |
| nicotinate | 1.2565 | 1.3446 | 0.5865 | 1.2259 |
| Nicotinic acid mononucleotide | 1.1065 | 1.2987 | 0.5633 | 1.4682 |
| Octulose 8/1P | 1.1335 | 1.2552 | 0.6283 | 1.3547 |
| Octulose Bisphosphate | 0.9658 | 0.7157 | 1.2845 | 1.0339 |
| ornithine | 1.3489 | 1.1372 | 0.6185 | 1.2769 |
| orotate | 0.9413 | 1.3118 | 0.5704 | 1.6060 |
| orotidine-5^-phosphate | 0.9462 | 0.9269 | 0.7654 | 1.3615 |
| oxaloacetate | 1.0476 | 1.1982 | 0.6503 | 1.4536 |
| p-aminobenzoate | 1.3213 | 1.2166 | 0.6598 | 1.1425 |
| pantothenate | 1.2260 | 1.0595 | 0.7282 | 1.2583 |
| Phenol Red | 1.3125 | 1.1648 | 0.6104 | 1.3020 |
| phenylalanine | 1.3798 | 1.0947 | 0.5927 | 1.3402 |
| phosphoenolpyruvate | 1.1380 | 0.9441 | 0.7379 | 1.3547 |
| p-hydroxybenzoate | 1.1557 | 1.1942 | 0.6238 | 1.4024 |
| prephenate | 1.1835 | 0.7814 | 0.7857 | 1.4637 |
| Pro-Asp (PD) | 1.7292 | 0.4106 | 0.5019 | 1.8563 |
| Pro-Glu-Glu-Lys (PEEK) | 1.0312 | 0.8849 | 0.7547 | 1.4110 |
| Pro-Glu-Glu (PEE) | 1.5323 | 0.5371 | 0.5757 | 1.7791 |
| Pro-Glu (PE) | 1.6275 | 0.4712 | 0.6157 | 1.6699 |
| proline | 1.3227 | 1.1076 | 0.6312 | 1.3073 |
| propionyl-CoA | 1.0220 | 0.5768 | 1.1990 | 1.2022 |
| Pro-Val-Asn-Phe (PVNF) | 1.2851 | 0.4150 | 0.7881 | 1.5117 |
| pyridoxine | 1.3513 | 1.2135 | 0.6146 | 1.2058 |
| Pyroglutamic acid | 1.0401 | 1.1349 | 0.8400 | 1.1450 |
| Pyrophosphate | 1.5419 | 1.1935 | 0.5292 | 1.2061 |
| pyruvate | 1.0392 | 1.1363 | 0.8079 | 1.2088 |
| quinolinate | 1.1042 | 1.3330 | 0.7095 | 1.1438 |
| riboflavin | 1.1414 | 0.8641 | 0.9251 | 1.0695 |
| ribose | 1.3254 | 1.1481 | 0.6361 | 1.2543 |
| Ribose-5-phosphate | 1.2782 | 0.9359 | 0.6602 | 1.4656 |
| Ribose-5-S-homocysteine | 0.6368 | 0.9435 | 0.7739 | 1.7211 |
| ribose-phosphate | 1.2770 | 0.9754 | 0.6318 | 1.4840 |
| ribulose-5-phosphate | 1.5057 | 1.1111 | 0.5594 | 1.2643 |
| S-adenosyl-L-homocysteine | 1.2769 | 1.2628 | 0.5587 | 1.3429 |
| S-adenosyl-L-methionine | 1.0803 | 0.9028 | 0.9453 | 1.0716 |
| Sedoheptulose bisphosphate | 0.8407 | 0.8315 | 1.3848 | 0.9430 |
| Ser-Asp-Leu (SDL) | 1.2564 | 0.4674 | 0.7644 | 1.5117 |
| Ser-Asp (SD) | 1.3973 | 0.7925 | 0.6043 | 1.6016 |
| Ser-Ile-Asp (SID) | 1.0836 | 1.3721 | 0.5863 | 1.0958 |
| serine | 1.1492 | 1.0468 | 0.7988 | 1.2064 |
| shikimate-3-phosphate | 1.0370 | 0.9920 | 0.6743 | 1.6225 |
| S-methyl-5^-thioadenosine | 1.1345 | 1.1252 | 0.8357 | 1.0688 |
| sn-glycerol-3-phosphate | 1.2627 | 0.9680 | 0.6284 | 1.5125 |
| succinate/Methylmalonic acid | 1.1309 | 1.4802 | 0.6628 | 1.0634 |
| succinyl-CoA/methylmalonyl-CoA | 0.6005 | 1.3330 | 0.8711 | 1.1954 |
| taurine | 0.8896 | 1.0848 | 0.9276 | 1.1705 |
| Tetrahydrobiopterin | 1.3131 | 0.9476 | 0.6800 | 1.2726 |
| thiamine | 1.0633 | 0.8561 | 0.8789 | 1.2018 |
| thiamine-phosphate | 1.0010 | 1.0657 | 0.8839 | 1.0494 |
| Thiamine pyrophosphate | 1.0371 | 1.0361 | 0.6851 | 1.3467 |
| threonine/homoserine | 1.2911 | 1.0284 | 0.6807 | 1.3191 |
| thymidine | 0.8375 | 1.4200 | 0.7045 | 1.3334 |
| trehalose-6-Phosphate | 1.0159 | 1.0869 | 0.7951 | 1.3069 |
| tryptophan | 1.2476 | 1.1648 | 0.6518 | 1.2840 |
| tyrosine | 1.3322 | 1.1734 | 0.6035 | 1.2875 |
| UDP | 0.6002 | 1.6926 | 0.6490 | 1.4092 |
| UDP-D-glucose | 1.1655 | 1.3005 | 0.6202 | 1.2936 |
| UDP-D-glucuronate | 0.9502 | 1.0216 | 0.9432 | 1.0851 |
| UDP-N-acetyl-glucosamine | 0.9161 | 1.2580 | 0.7449 | 1.1660 |
| UMP | 0.7750 | 1.4930 | 0.5707 | 1.5906 |
| uridine | 0.6151 | 2.5847 | 0.4697 | 0.8606 |
| UTP | 0.5377 | 1.3820 | 0.7606 | 1.4793 |
| Val-Asp (VD) | 1.3057 | 0.5185 | 0.7138 | 1.7483 |
| valine | 1.3760 | 1.0495 | 0.6034 | 1.3678 |
| xanthine | 1.0440 | 0.9605 | 0.8812 | 1.1143 |
| xanthosine | 1.5617 | 0.5299 | 0.7981 | 1.1102 |
| xanthosine-5-phosphate | 1.0130 | 1.0693 | 0.7404 | 1.2638 |
| Xanthurenic acid | 1.0832 | 1.1043 | 0.7627 | 1.1289 |
Factors:
| F1 | Treatment:ATQ |
| F2 | Treatment:AZD0156 |
| F3 | Treatment:N/A |
| F4 | Treatment:ND |
