Data for (Study ST003458)
(Analysis AN005681)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|
| 2,6-Dimethylpyrazine | 2.1222 | 1.9584 | 0.5636 | NA | 0.3316 | 0.3169 | 0.4642 |
| 2-Amino-3-methoxybenzoic acid | 0.8996 | 0.8903 | 0.9057 | NA | 1.1834 | 0.9601 | 1.1831 |
| 2-Amino-4-methylpyrimidine | 1.0643 | 1.1070 | 1.3346 | NA | 0.8064 | 0.8352 | 0.9148 |
| 2-Picolinic acid | 0.8196 | 1.3443 | 1.6576 | NA | 0.7141 | 0.7855 | 0.7910 |
| 3-(3-pyridinyl)propanoic acid | 0.6943 | 0.8711 | 0.8344 | NA | 1.3607 | 1.0088 | 1.2525 |
| 3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6-diol | 1.0044 | 0.9733 | 1.0078 | NA | 1.1994 | 0.7873 | 1.0397 |
| 3-Aminoisobutanoic acid | 0.9484 | 1.1127 | 1.2405 | NA | 0.6374 | 1.0991 | 1.0293 |
| 3-Hydroxyhippuric acid | 0.4584 | 0.3689 | 1.0547 | NA | 1.8195 | 1.3124 | 0.9998 |
| 3-Methylhistidine | 0.6332 | 0.9096 | 1.0218 | NA | 0.8988 | 1.3190 | 1.2974 |
| 3-Ureidopropionic acid | 0.4909 | 0.8928 | 0.6497 | NA | 1.7131 | 0.8587 | 1.4097 |
| 4-[2-(1H-indol-3-yl)ethyl]morpholine-3,5-dione | 1.4262 | 1.8169 | 1.7138 | NA | 0.2426 | 0.2440 | 0.6466 |
| 4-Amino-3-hydroxybenzoic acid_1 | 2.6990 | 2.5946 | 0.1356 | NA | 0.0499 | 0.0341 | 0.0276 |
| 4-Amino-3-hydroxybenzoic acid_2 | 2.2096 | 1.0696 | 1.3696 | NA | 0.7036 | 0.2807 | 0.2789 |
| 4-Amino-3-hydroxybenzoic acid_3 | 2.1020 | 1.3388 | 0.7300 | NA | 0.4611 | 0.3777 | 0.8973 |
| 4-Guanidinobutyric acid | 0.6752 | 0.5758 | 1.3143 | NA | 2.1111 | 0.5331 | 0.8253 |
| 4-Hydroxyproline | 0.7819 | 0.9640 | 1.0677 | NA | 1.1056 | 1.0352 | 1.0833 |
| 5-Hydroxylysine | 0.3186 | 1.0925 | 1.2221 | NA | 1.3759 | 0.8453 | 1.2682 |
| 5-Methoxytryptamine | 1.1655 | 1.0399 | 1.4120 | NA | 0.8378 | 0.7373 | 0.8807 |
| 5-Methyltryptophan | 1.2899 | 0.7745 | 1.3034 | NA | 0.6129 | 1.2547 | 0.7874 |
| 6-Aminocaproic acid | 3.4552 | 0.9527 | 0.4725 | NA | 0.3090 | 0.1630 | 0.3543 |
| 6-Methylnicotinamide | 2.6682 | 1.8159 | 0.4722 | NA | 0.2785 | 0.1933 | 0.2533 |
| 7-Methylguanine | 1.4082 | 1.1740 | 1.5516 | NA | 0.8047 | 0.5096 | 0.5863 |
| 7-Methylguanosine | 1.2975 | 1.1012 | 1.3026 | NA | 0.8289 | 0.6667 | 0.8383 |
| Acadesine | 1.2086 | 1.3320 | 1.2894 | NA | 0.7705 | 0.6544 | 0.7566 |
| Acetohydroxamic acid | 2.6175 | 1.4052 | 0.8055 | NA | 0.3070 | 0.3044 | 0.3489 |
| Acetylcarnitine | 0.5147 | 0.8413 | 0.8367 | NA | 1.7234 | 0.8890 | 1.2053 |
| Acetylcarnosine | 1.5020 | 1.2980 | 1.4264 | NA | 0.8051 | 0.4663 | 0.4783 |
| Acetyl-β-methylcholine | 1.3685 | 0.9196 | 1.8087 | NA | 0.4210 | 0.8835 | 0.7345 |
| Adenine | 0.7114 | 0.6839 | 0.7488 | NA | 1.4158 | 0.9646 | 1.5503 |
| Adenosine | 0.8614 | 0.7570 | 0.8338 | NA | 1.4919 | 0.8339 | 1.2406 |
| Alanine | 0.9053 | 0.9795 | 1.1750 | NA | 0.9475 | 0.9473 | 1.1189 |
| Alanyltyrosine | 1.9626 | 1.1991 | 1.0419 | NA | 0.6223 | 0.5157 | 0.5584 |
| ALK_1 | 1.3918 | 1.7940 | 2.2845 | NA | 0.2108 | 0.2395 | 0.2005 |
| ALK_2 | 1.4377 | 2.3462 | 2.0942 | NA | 0.0156 | 0.0689 | 0.0813 |
| ALK_3 | 1.2694 | 1.8920 | 1.4862 | NA | 0.2124 | 0.4219 | 0.7863 |
| Allopurinol | 1.4435 | 0.7971 | 0.8772 | NA | 1.1037 | 0.8158 | 0.9094 |
| AMP | 1.0478 | 1.0313 | 1.4011 | NA | 0.9211 | 0.7865 | 0.8832 |
| Anserine/ Homocarnosine | 0.8860 | 0.6863 | 0.4369 | NA | 2.1132 | 0.8817 | 0.8069 |
| Argininosuccinic acid | 1.3242 | 0.7744 | 0.9121 | NA | 1.1445 | 0.6653 | 1.2101 |
| Asparagine | 1.3432 | 0.9832 | 1.2232 | NA | 0.8591 | 0.7896 | 0.8100 |
| Aspartame | 1.1644 | 1.6492 | 1.4032 | NA | 0.7888 | 0.3443 | 0.6677 |
| Aspartic acid | 1.3522 | 0.9773 | 1.2084 | NA | 0.8614 | 0.8044 | 0.7979 |
| Betaine | 0.8789 | 1.1704 | 1.1153 | NA | 0.8672 | 0.9088 | 1.1176 |
| Butyrylcarnitine | 0.5212 | 0.8144 | 0.7034 | NA | 1.3214 | 1.2175 | 1.4639 |
| Carnitine | 0.8101 | 0.8332 | 0.9861 | NA | 1.1060 | 1.1209 | 1.1870 |
| Carnosine | 1.5019 | 1.0591 | 1.4311 | NA | 0.6868 | 0.7252 | 0.6050 |
| Choline | 0.8938 | 0.9557 | 1.0624 | NA | 1.0378 | 0.9913 | 1.0994 |
| CMP | 1.2330 | 1.2578 | 1.4680 | NA | 0.8205 | 0.5304 | 0.7432 |
| Creatine | 1.2522 | 1.0550 | 1.1669 | NA | 0.7746 | 0.8794 | 0.8848 |
| Cystine | 0.8393 | 0.8482 | 1.0014 | NA | 1.5440 | 0.6874 | 1.1068 |
| Cytidine | 1.1861 | 1.5429 | 1.6083 | NA | 0.6491 | 0.4021 | 0.6847 |
| Deoxycytidine | 1.2467 | 1.2517 | 1.1440 | NA | 0.7886 | 0.6217 | 0.9778 |
| Ecgonine | 0.8161 | 0.9676 | 1.0608 | NA | 0.6710 | 1.2820 | 1.2904 |
| FLK_1 | 0.9911 | 2.1818 | 1.2232 | NA | 0.2918 | 0.1327 | 1.3136 |
| FLK_2 | 1.4151 | 1.5185 | 1.7193 | NA | 0.5841 | 0.3998 | 0.3907 |
| GLK | 1.3193 | 1.8510 | 2.3226 | NA | 0.2102 | 0.2530 | 0.1661 |
| Glucosamine/ Galactosamine | 1.2753 | 0.6873 | 0.5814 | NA | 1.2502 | 0.9064 | 1.2596 |
| Glutamic acid/ N-Methylaspartic acid | 1.0366 | 0.9435 | 1.0731 | NA | 1.1496 | 0.7879 | 1.0368 |
| Glutamine | 1.0590 | 1.0969 | 1.2968 | NA | 0.8560 | 0.8059 | 0.9462 |
| Glycerol 3-phosphate | 0.8409 | 0.8230 | 0.9900 | NA | 1.4759 | 0.7635 | 1.1389 |
| Glycine | 0.9969 | 0.8889 | 1.1538 | NA | 1.0812 | 0.8701 | 1.0634 |
| Glycylproline | 1.4826 | 1.2403 | 1.3005 | NA | 0.6945 | 0.6887 | 0.5582 |
| Guanidoacetic acid | 0.8516 | 0.7733 | 0.9551 | NA | 1.2625 | 0.9809 | 1.2204 |
| Guanosine | 0.9742 | 1.0217 | 1.1302 | NA | 1.0559 | 0.9738 | 0.8358 |
| Guanosine monophosphate (GMP) | 1.1476 | 1.0345 | 1.2464 | NA | 1.0006 | 0.6907 | 0.9225 |
| Histidine | 1.7627 | 0.9774 | 1.1155 | NA | 0.6948 | 0.6761 | 0.7364 |
| Homoarginine | 1.2458 | 1.0990 | 1.8177 | NA | 0.3704 | 0.9294 | 0.6563 |
| Hypoxanthine | 0.8513 | 0.9013 | 1.0193 | NA | 1.0932 | 1.0330 | 1.1423 |
| Indole-3-carboxyaldehyde | 0.9428 | 0.9574 | 0.9523 | NA | 0.9863 | 0.8257 | 1.4315 |
| Indole-3-lactic acid | 1.6298 | 0.8927 | 0.1159 | NA | 1.2602 | 0.6667 | 1.2848 |
| Inosine | 1.5339 | 0.7698 | 0.8763 | NA | 1.0944 | 0.7722 | 0.8966 |
| Isoleucine | 1.2177 | 1.2176 | 1.5063 | NA | 0.6923 | 0.6780 | 0.7529 |
| Isovalerylcarnitine/ 2-Methylbutyroylcarnitine | 0.5072 | 0.9109 | 0.8012 | NA | 1.3308 | 1.0702 | 1.4400 |
| Ketamine | 1.7527 | 0.8597 | 1.0226 | NA | 0.7830 | 0.7848 | 0.7371 |
| L-Ergothioneine | 1.5477 | 0.5768 | 0.7255 | NA | 1.6427 | 0.8549 | 0.4450 |
| Leucine | 1.1694 | 1.1383 | 1.3979 | NA | 0.7269 | 0.7576 | 0.8793 |
| Leucylalanine | 1.4411 | 1.4828 | 1.5754 | NA | 0.4835 | 0.4256 | 0.6473 |
| Leucylproline_1 | 1.3600 | 1.0790 | 1.7069 | NA | 0.6494 | 0.6955 | 0.5813 |
| Leucylproline_2 | 1.5465 | 1.0972 | 1.8704 | NA | 0.5012 | 0.5196 | 0.5769 |
| LLK_1 | 0.6280 | 1.3822 | 0.9144 | NA | 0.5345 | 0.3013 | 2.6241 |
| LLK_2 | 1.3786 | 1.3669 | 1.5779 | NA | 0.6265 | 0.5173 | 0.5698 |
| LNK | 0.9034 | 2.0652 | 1.3494 | NA | 0.2481 | 0.2994 | 1.2956 |
| Lysine | 1.2433 | 1.2006 | 1.6021 | NA | 0.6770 | 0.6375 | 0.7200 |
| Methionine | 1.2140 | 1.1227 | 1.4116 | NA | 0.7227 | 0.7547 | 0.8363 |
| Methylimidazoleacetic acid | 2.5779 | 1.6192 | 1.1662 | NA | 0.2013 | 0.1506 | 0.1018 |
| N1-[3-(1H-Imidazol-1-yl)propyl]-2,6-dimethoxy-3-nitrobenzamide | 1.0348 | 0.7623 | 1.1288 | NA | 1.0400 | 1.1403 | 0.9012 |
| N1-Methyl-2-pyridone-5-carboxamide | 1.6820 | 1.2090 | 0.7506 | NA | 0.6711 | 0.5527 | 1.0962 |
| N1-Methyl-Adenosine | 2.2856 | 1.3253 | 0.8100 | NA | 0.4352 | 0.4669 | 0.5058 |
| N2-Acetyllysine | 0.8741 | 0.8014 | 0.8961 | NA | 1.2384 | 0.8741 | 1.3866 |
| N-(2-morpholinophenyl)-2-furamide | 1.2143 | 1.5150 | 1.3817 | NA | 0.7796 | 0.5440 | 0.5479 |
| N3,N4-Dimethyl-L-arginine | 1.3697 | 1.3542 | 1.6876 | NA | 0.5235 | 0.5871 | 0.5330 |
| N6,N6,N6-Trimethyl-L-lysine | 1.0213 | 1.1633 | 1.6754 | NA | 0.6176 | 0.7646 | 0.9023 |
| N8-Acetylspermidine | 1.7643 | 2.4400 | 0.9656 | NA | 0.1079 | 0.2751 | 0.2514 |
| N-Acetylalanine | 1.2444 | 1.1510 | 1.3635 | NA | 0.7982 | 0.7453 | 0.7180 |
| N-Acetylglutamine | 0.9390 | 1.1187 | 0.6100 | NA | 1.6875 | 0.5620 | 0.9804 |
| N-Acetylhistamine | 2.3448 | 2.7614 | 0.4786 | NA | 0.0141 | 0.0140 | 0.0089 |
| N-Acetylhistidine | 1.6738 | 1.9562 | 1.0773 | NA | 0.3842 | 0.2814 | 0.5286 |
| N-acetylmannosamine | 1.0268 | 1.0457 | 1.0434 | NA | 1.0647 | 0.8558 | 0.9659 |
| N-Acetylornithine | 0.5023 | 0.7239 | 1.1998 | NA | 1.4264 | 0.6560 | 1.7221 |
| Nicotinamide N-oxide | 0.2014 | 0.3552 | 0.4754 | NA | 2.0030 | 1.0074 | 2.1019 |
| Nicotinamide riboside | 1.1644 | 1.0241 | 1.1130 | NA | 0.9428 | 0.7654 | 1.0247 |
| Nicotine amide | 0.9443 | 0.8999 | 0.9911 | NA | 1.1007 | 0.9826 | 1.1056 |
| Nicotinic acid | 0.9802 | 2.4374 | 2.0669 | NA | 0.1779 | 0.1944 | 0.2132 |
| Nα-({1,3,4-trihydroxy-5-[(N-methylvalyl)amino]cyclohexyl}carbonyl)phenylalaninamide | 1.5320 | 1.5748 | 1.7480 | NA | 0.4737 | 0.2812 | 0.4363 |
| O-Acetylserine | 1.1517 | 1.0274 | 1.3743 | NA | 0.7359 | 0.8497 | 0.9395 |
| Phenylalanine | 1.1286 | 1.1130 | 1.3530 | NA | 0.7389 | 0.7934 | 0.9486 |
| Phosphocholine | 3.0602 | 0.6956 | 0.6817 | NA | 0.5384 | 0.3991 | 0.3941 |
| Pipecolinic acid | 1.0347 | 0.7237 | 1.0118 | NA | 1.2653 | 0.7981 | 1.2258 |
| PLK | 0.5731 | 1.5143 | 1.4216 | NA | 0.9088 | 0.8654 | 0.7631 |
| Proline | 1.1313 | 1.1053 | 1.2889 | NA | 0.8209 | 0.8229 | 0.8706 |
| Prolylglycine | 1.3926 | 1.0748 | 1.3006 | NA | 0.7836 | 0.6997 | 0.7650 |
| Prolylleucine | 2.0433 | 1.1209 | 0.8363 | NA | 0.7733 | 0.5207 | 0.5527 |
| Propionylcarnitine | 1.0918 | 0.8681 | 0.9684 | NA | 1.0250 | 0.8495 | 1.2526 |
| Purine | 0.7464 | 0.9859 | 1.2339 | NA | 0.7685 | 1.1727 | 1.2014 |
| Pyridoxamine | 0.6784 | 0.8552 | 0.9011 | NA | 1.3804 | 0.9470 | 1.2843 |
| Riboflavin | 0.9001 | 0.8294 | 0.9936 | NA | 1.2754 | 0.8452 | 1.2063 |
| RLK | 1.2288 | 2.0273 | 2.3578 | NA | 0.1681 | 0.1867 | 0.1611 |
| S-Adenosylmethionine | 1.4929 | 0.6536 | 0.9285 | NA | 1.3943 | 0.6481 | 0.8198 |
| SLH | 0.4703 | 1.3369 | 0.7828 | NA | 0.3884 | 0.3761 | 3.1216 |
| Spermine | 1.1816 | 1.0897 | 1.2061 | NA | 0.9840 | 0.8270 | 0.6841 |
| tert-Butyl N-[1-(aminocarbonyl)-3-methylbutyl]carbamate | 1.2414 | 1.2976 | 1.5577 | NA | 0.6455 | 0.5857 | 0.7486 |
| Thiamine | 1.2694 | 1.1569 | 0.8320 | NA | 0.8960 | 0.7746 | 1.0387 |
| Threonine/ Homoserine | 1.1836 | 1.1717 | 1.3076 | NA | 0.7443 | 0.7257 | 0.9253 |
| Tiglylcarnitine | 0.6892 | 0.7863 | 0.8123 | NA | 1.3199 | 1.0710 | 1.3659 |
| TLK | 1.2912 | 2.0624 | 1.8354 | NA | 0.3200 | 0.2208 | 0.3054 |
| Trigonelline | 0.2116 | 0.6028 | 1.1759 | NA | 1.5888 | 0.6834 | 2.0420 |
| Trimethylamine N-Oxide | 1.5539 | 0.8576 | 0.2406 | NA | 1.5556 | 0.5967 | 1.0076 |
| Tryptophan | 1.1351 | 1.1313 | 1.4025 | NA | 0.7185 | 0.7358 | 0.9699 |
| Tyrosylalanine_1 | 1.4324 | 1.3593 | 1.7274 | NA | 0.4576 | 0.5407 | 0.5527 |
| Tyrosylalanine_2 | 1.3925 | 1.2466 | 1.6465 | NA | 0.6391 | 0.5547 | 0.5764 |
| Valine | 1.3856 | 1.1234 | 1.3170 | NA | 0.7431 | 0.6496 | 0.8142 |
| VLK | 1.3161 | 1.7637 | 1.7341 | NA | 0.4772 | 0.2673 | 0.5003 |
| VNK | 0.8379 | 2.0678 | 1.1954 | NA | 0.2946 | 0.2049 | 1.5978 |
| γ-Aminobutyric acid | 0.9823 | 0.9464 | 0.9996 | NA | 1.0133 | 1.0324 | 1.0347 |
Factors:
| F1 | Sample source:Kidney | Group:CLP (24h) / 12C-Serin |
| F2 | Sample source:Kidney | Group:CLP (24h) / 13C-Serin |
| F3 | Sample source:Kidney | Group:CLP (24h) / Vehicle |
| F4 | Sample source:Kidney | Group:QC |
| F5 | Sample source:Kidney | Group:Sham / 12C-Serin |
| F6 | Sample source:Kidney | Group:Sham / 13C-Serin |
| F7 | Sample source:Kidney | Group:Sham / Vehicle |
