Data for (Study ST003461)
(Analysis AN005687)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|
| 10-(Hydroxymethyl)-4-methyl-8,11-dioxa-2,6-diazatricyclo[7.2.1.02,7]dodeca-3,6-dien-5-one | 0.8253 | 1.0003 | 0.9209 | NA | 1.5031 | 0.8970 | 0.7783 |
| 1-Methyladenosine | 0.9980 | 1.0324 | 1.1173 | NA | 0.8854 | 1.0226 | 0.9648 |
| 2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acid | 0.9214 | 1.3521 | 1.1134 | NA | 0.7965 | 0.9307 | 0.8858 |
| 2-Amino-3-methoxybenzoic acid | 0.8939 | 1.0383 | 1.0290 | NA | 0.8383 | 1.4050 | 0.7369 |
| 2-Amino-4-methylpyrimidine | 0.9259 | 1.1434 | 1.0986 | NA | 0.9203 | 1.0694 | 0.8228 |
| 2^-Deoxyadenosine | 0.9125 | 1.1626 | 1.1313 | NA | 0.8764 | 1.1171 | 0.7772 |
| 3-Methylhistidine | 1.0114 | 1.0924 | 1.1066 | NA | 0.8720 | 1.1929 | 0.6684 |
| 4-[2-(1H-indol-3-yl)ethyl]morpholine-3,5-dione | 0.8931 | 1.2036 | 0.9194 | NA | 1.0764 | 0.9107 | 0.9688 |
| 5-Methoxytryptamine | 0.9483 | 1.1917 | 1.0860 | NA | 0.8966 | 0.9692 | 0.9063 |
| 5-Methylcytosine | 0.8712 | 0.9567 | 0.9827 | NA | 0.9467 | 1.3461 | 0.8564 |
| 5-Methyltryptophan | 0.9768 | 1.0730 | 1.0905 | NA | 1.0065 | 1.0048 | 0.8280 |
| 6beta-Naltrexol-d3 | 1.3228 | 0.9647 | 1.0831 | NA | 0.7603 | 1.0578 | 0.7760 |
| 6-Methoxyquinoline | 1.1426 | 1.0710 | 1.0090 | NA | 0.9821 | 0.6209 | 1.2356 |
| Acetylcarnitine | 1.5249 | 0.9175 | 0.6646 | NA | 0.8947 | 0.8745 | 1.0533 |
| Adenine | 0.9261 | 0.9160 | 1.3036 | NA | 0.9813 | 1.1067 | 0.7896 |
| Alanine | 0.8997 | 1.1154 | 1.0454 | NA | 0.9625 | 1.0599 | 0.9046 |
| ALK_1 | 1.3083 | 0.8307 | 1.0322 | NA | 1.0305 | 0.9663 | 0.7867 |
| ALK_2 | 1.0527 | 0.9242 | 1.0273 | NA | 1.1523 | 1.0324 | 0.7572 |
| Allopurinol | 1.1400 | 0.8523 | 0.8346 | NA | 1.1675 | 0.8598 | 1.1393 |
| Anserine/ Homocarnosine | 1.4005 | 0.8957 | 0.8416 | NA | 1.4669 | 0.7269 | 0.5050 |
| APH | 0.9763 | 1.0071 | 1.2083 | NA | 1.0525 | 1.0986 | 0.6124 |
| APK | 1.1862 | 1.0105 | 1.2800 | NA | 0.7213 | 1.1566 | 0.6205 |
| Arginine | 0.9007 | 1.1921 | 1.1625 | NA | 0.8587 | 1.1041 | 0.7635 |
| Aspartame_3 | 0.9466 | 0.9814 | 1.0370 | NA | 1.3205 | 0.7234 | 1.0006 |
| Betaine | 0.6208 | 1.2702 | 0.9034 | NA | 1.0895 | 0.8081 | 1.3784 |
| Butyrylcarnitine | 0.8674 | 0.8868 | 0.9539 | NA | 0.9182 | 1.5079 | 0.8057 |
| Carnitine | 0.7121 | 1.0297 | 0.9699 | NA | 1.2281 | 0.9935 | 1.0788 |
| Carnosine | 0.9989 | 0.9549 | 1.1224 | NA | 0.9862 | 1.1694 | 0.7318 |
| Choline | 0.8550 | 1.0759 | 1.0762 | NA | 0.9565 | 1.0729 | 0.9768 |
| Creatine | 1.0442 | 1.0487 | 1.0736 | NA | 0.9468 | 0.8761 | 1.0387 |
| Cysteine | 1.1271 | 0.9104 | 0.8328 | NA | 1.0562 | 0.9182 | 1.1513 |
| Cytidine | 1.1034 | 0.9312 | 1.1021 | NA | 0.9364 | 1.1444 | 0.7439 |
| DLK_1 | 1.2937 | 1.0125 | 1.0958 | NA | 0.9094 | 1.0261 | 0.5818 |
| DLK_2 | 0.9983 | 1.0003 | 1.2323 | NA | 0.7873 | 1.3417 | 0.5976 |
| DPK | 0.8406 | 1.1455 | 1.3134 | NA | 0.9154 | 1.0517 | 0.7492 |
| Ecgonine | 0.7462 | 1.1419 | 1.1674 | NA | 0.6620 | 1.2330 | 1.1219 |
| EKK | 1.2149 | 0.7787 | 0.8513 | NA | 1.0086 | 1.2719 | 0.7832 |
| FLK_1 | 0.8089 | 1.2608 | 1.0689 | NA | 1.1089 | 0.7611 | 1.0115 |
| FLK_2 | 0.9206 | 1.3872 | 1.0734 | NA | 0.8387 | 0.8677 | 0.9077 |
| FPH | 1.1649 | 0.9253 | 1.2271 | NA | 1.0169 | 1.0435 | 0.5721 |
| GLK | 1.0143 | 0.9805 | 1.1031 | NA | 1.1394 | 1.0144 | 0.6989 |
| Glucosamine/ Galactosamine | 0.9091 | 1.1186 | 1.1055 | NA | 0.9244 | 1.1126 | 0.8081 |
| Glycylproline_1 | 1.1524 | 0.8883 | 1.3338 | NA | 0.9120 | 0.9365 | 0.8140 |
| Glycylproline_2 | 1.2543 | 0.8422 | 0.9723 | NA | 0.9621 | 1.0656 | 0.8620 |
| GNK | 1.2830 | 0.9059 | 1.2965 | NA | 0.5992 | 1.1517 | 0.7838 |
| Guanidoacetic acid | 1.3946 | 1.3251 | 1.3286 | NA | 0.7127 | 0.6082 | 0.6173 |
| Histidine | 0.9345 | 1.1533 | 1.1074 | NA | 0.8871 | 1.0793 | 0.8203 |
| Homoarginine | 1.1034 | 0.9312 | 1.1021 | NA | 0.9364 | 1.1444 | 0.7439 |
| Hypoxanthine | 0.9596 | 1.0186 | 1.0531 | NA | 1.0159 | 0.9834 | 0.9769 |
| IKK | 0.7777 | 1.0471 | 1.1053 | NA | 0.9591 | 1.4413 | 0.5945 |
| INH | 0.8186 | 1.2465 | 1.1958 | NA | 0.8965 | 1.1438 | 0.6637 |
| Inosine | 1.0480 | 0.9525 | 0.9814 | NA | 1.0748 | 0.9232 | 1.0207 |
| IPH | 1.3235 | 0.8366 | 1.0679 | NA | 0.8539 | 1.1727 | 0.6831 |
| IPK | 1.0183 | 0.7237 | 1.1146 | NA | 0.8727 | 1.5266 | 0.6970 |
| Isoleucine | 0.8663 | 1.0071 | 1.0738 | NA | 1.1353 | 1.0119 | 0.8986 |
| Isovalerylcarnitine/ 2-Methylbutyroylcarnitine | 0.6269 | 1.3021 | 1.1323 | NA | 0.7562 | 1.2649 | 0.9343 |
| Ketamine | 0.9606 | 1.0794 | 1.0901 | NA | 0.9431 | 1.1030 | 0.7950 |
| KLK | 1.1590 | 1.0910 | 1.2148 | NA | 0.8432 | 1.0397 | 0.6080 |
| KMK | 0.9585 | 1.1604 | 1.1429 | NA | 0.8695 | 1.0848 | 0.7595 |
| L-Alanine methyl ester | 1.0779 | 1.0351 | 1.0360 | NA | 0.9293 | 1.0459 | 0.8464 |
| Leucine | 0.9688 | 1.0684 | 1.0314 | NA | 1.0038 | 1.0412 | 0.8591 |
| Leucylproline_1 | 0.6099 | 1.1763 | 0.9391 | NA | 1.0615 | 1.3281 | 0.8265 |
| Leucylproline_2 | 0.8963 | 1.0950 | 1.0964 | NA | 1.0430 | 1.0764 | 0.7561 |
| LLK_1 | 0.8005 | 1.3258 | 1.1655 | NA | 0.8615 | 1.0050 | 0.8440 |
| LLK_2 | 0.7725 | 1.4036 | 1.1524 | NA | 0.9922 | 0.8257 | 0.8555 |
| LLK_3 | 1.3172 | 0.7356 | 1.1743 | NA | 0.9072 | 1.2381 | 0.5615 |
| LLK_4 | 1.2426 | 1.0310 | 0.9447 | NA | 0.9272 | 1.0418 | 0.7319 |
| LNK_1 | 1.0025 | 1.1208 | 1.1714 | NA | 0.8275 | 1.0984 | 0.7630 |
| LNK_2 | 0.8694 | 1.0665 | 1.0338 | NA | 1.0814 | 0.9979 | 0.9458 |
| Lysine | 0.9125 | 1.1626 | 1.1313 | NA | 0.8764 | 1.1171 | 0.7772 |
| Methionine | 0.9606 | 1.0794 | 1.0901 | NA | 0.9431 | 1.1030 | 0.7950 |
| Methyl isonicotinate | 1.3652 | 1.3119 | 1.0612 | NA | 0.7161 | 0.7941 | 0.6890 |
| N1-(2-{2-[2-(acetylamino)phenoxy]ethoxy}phenyl)acetamide | 0.9105 | 1.2314 | 0.9779 | NA | 0.9741 | 0.9466 | 0.9385 |
| N1-Methyl-2-pyridone-5-carboxamide | 2.3467 | 1.5739 | 0.5322 | NA | 0.4864 | 0.3062 | 0.5169 |
| N2-neopentyl-5-methyl-1,3,4-thiadiazol-2-amine | 1.1533 | 1.1228 | 0.7546 | NA | 1.1898 | 1.0044 | 0.6183 |
| N3,N4-Dimethyl-L-arginine | 0.9367 | 1.0920 | 1.0749 | NA | 0.9825 | 1.0614 | 0.8284 |
| N8-Acetylspermidine | 1.1838 | 1.0457 | 0.7954 | NA | 0.7144 | 1.3203 | 0.8523 |
| N-Acetylarginine | 1.1923 | 1.0424 | 0.9851 | NA | 1.0355 | 0.8429 | 0.8642 |
| N-Acetylglucosamine | 1.1438 | 1.1184 | 1.0120 | NA | 0.8821 | 0.8551 | 0.9889 |
| N-Acetylglutamic acid | 1.1547 | 1.0288 | 0.8951 | NA | 0.9556 | 1.0563 | 0.8444 |
| N-Acetylmannosamine | 0.9835 | 1.2024 | 1.0752 | NA | 0.8618 | 0.9437 | 0.9361 |
| N-Acetylornithine | 0.7355 | 0.8810 | 1.0622 | NA | 1.2054 | 0.8695 | 1.3493 |
| Nicotine amide | 1.0180 | 1.0915 | 1.0991 | NA | 0.9051 | 1.0884 | 0.7635 |
| O-Acetylserine | 1.0953 | 1.0028 | 1.0156 | NA | 1.0522 | 0.9863 | 0.8025 |
| O-Phosphorylethanolamine | 1.0535 | 1.0303 | 1.0243 | NA | 1.0388 | 0.8879 | 0.9616 |
| Ornithine | 0.9100 | 0.8448 | 1.9415 | NA | 1.1432 | 0.6840 | 0.6157 |
| Phenylalanine | 0.9367 | 1.0920 | 1.0749 | NA | 0.9825 | 1.0614 | 0.8284 |
| Phosphocholine | 0.9670 | 0.9553 | 0.9779 | NA | 1.1975 | 0.8594 | 1.0498 |
| Proline | 0.9927 | 0.9939 | 1.0527 | NA | 0.9393 | 1.1803 | 0.8058 |
| Prolylleucine | 1.1086 | 1.1396 | 1.0479 | NA | 0.9019 | 0.9062 | 0.8770 |
| Propionylcarnitine | 0.8132 | 0.8134 | 0.5478 | NA | 1.6626 | 0.9898 | 1.0802 |
| Pyroglutamic acid | 0.8227 | 1.0372 | 1.1574 | NA | 1.0215 | 0.9742 | 1.0351 |
| QLK | 1.5190 | 1.0262 | 1.3414 | NA | 0.6022 | 0.9689 | 0.5035 |
| Riboflavin | 0.9167 | 1.2430 | 0.8647 | NA | 0.9950 | 0.9318 | 1.0201 |
| RLK_1 | 1.1680 | 0.9374 | 1.1386 | NA | 0.8863 | 1.0057 | 0.8649 |
| RLK_2 | 1.3353 | 0.8438 | 1.2343 | NA | 0.6887 | 1.3137 | 0.5236 |
| S-Adenosylmethionine | 1.4821 | 0.8208 | 0.9847 | NA | 1.2933 | 0.6978 | 0.6233 |
| Serine | 0.9498 | 1.1015 | 1.1111 | NA | 0.9419 | 1.0478 | 0.8342 |
| Serotonin | 1.1252 | 1.1337 | 1.0217 | NA | 0.9934 | 0.5892 | 1.1896 |
| SLK_1 | 0.8341 | 1.2193 | 1.2746 | NA | 0.9115 | 0.9869 | 0.7897 |
| SLK_2 | 1.0135 | 1.2617 | 1.0023 | NA | 0.9814 | 0.9217 | 0.7600 |
| SLK_3 | 0.8801 | 1.3531 | 0.9720 | NA | 1.0229 | 0.8203 | 0.9260 |
| SLK_4 | 1.2396 | 0.8835 | 1.0000 | NA | 1.0933 | 0.9138 | 0.8264 |
| Spermine | 0.8550 | 1.0759 | 1.0762 | NA | 0.9565 | 1.0729 | 0.9768 |
| Thiamine | 1.2112 | 1.0453 | 0.8527 | NA | 1.0911 | 0.7776 | 0.9803 |
| Thymine | 0.8934 | 1.0409 | 1.0424 | NA | 0.8454 | 1.2073 | 0.9751 |
| Tiglic acid | 0.7792 | 1.0980 | 1.0934 | NA | 0.9302 | 1.0467 | 1.1010 |
| TLK | 0.9317 | 0.9845 | 1.0125 | NA | 1.1018 | 1.3410 | 0.5088 |
| Trigonelline | 0.9037 | 1.1458 | 1.1100 | NA | 1.0566 | 0.6670 | 1.1924 |
| Trimethylamine N-Oxide | 1.8323 | 0.7093 | 0.3073 | NA | 1.2572 | 0.6848 | 1.0479 |
| Tryptophan | 0.8956 | 1.1678 | 1.0802 | NA | 0.9787 | 1.0060 | 0.8557 |
| Valine | 1.1133 | 1.2004 | 1.1927 | NA | 0.9007 | 0.8165 | 0.7660 |
| VLK_1 | 1.2309 | 0.9253 | 1.1351 | NA | 0.8274 | 1.2104 | 0.6062 |
| VLK_2 | 0.8277 | 1.3433 | 1.4618 | NA | 0.7812 | 0.8722 | 0.7724 |
| VNK_1 | 1.4007 | 0.8956 | 0.8415 | NA | 1.4668 | 0.7269 | 0.5051 |
| VNK_2 | 1.0570 | 1.0569 | 1.1750 | NA | 0.8257 | 1.0970 | 0.7762 |
| WLH | 1.1338 | 1.1962 | 1.0044 | NA | 0.8542 | 1.0793 | 0.6444 |
| α-Aspartylphenylalanine | 0.9382 | 1.0417 | 1.1155 | NA | 1.0067 | 1.1162 | 0.7475 |
| γ-Aminobutyric acid | 1.1593 | 0.9107 | 0.9165 | NA | 0.9801 | 1.0647 | 0.9305 |
| Υ-Glutamylcysteine | 1.3358 | 0.9743 | 0.8314 | NA | 1.1363 | 0.7318 | 0.9311 |
| Υ-L-Glutamyl-L-glutamic acid | 0.9823 | 0.9965 | 1.1298 | NA | 1.0841 | 1.0442 | 0.7274 |
Factors:
| F1 | Sample source:Spleen | Group:CLP (24h) / 12C-Serin |
| F2 | Sample source:Spleen | Group:CLP (24h) / 13C-Serin |
| F3 | Sample source:Spleen | Group:CLP (24h) / Vehicle |
| F4 | Sample source:Spleen | Group:QC |
| F5 | Sample source:Spleen | Group:Sham / 12C-Serin |
| F6 | Sample source:Spleen | Group:Sham / 13C-Serin |
| F7 | Sample source:Spleen | Group:Sham / Vehicle |
