Data for (Study ST003845)
(Analysis AN006319)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
|---|---|---|---|---|---|---|---|---|
| 1-Methylnicotinamide | 1.3343 | 1.9456 | 0.9456 | 1.8813 | 0.3927 | 0.8437 | 0.1513 | 0.5054 |
| 2-Hydroxyisovalerate | 0.9220 | 1.3423 | 0.9159 | 0.8218 | 1.0416 | 0.7678 | 1.2472 | 0.9414 |
| 2-Hydroxyvalerate | 1.2612 | 1.2380 | 1.2429 | 1.1253 | 0.5945 | 1.1223 | 0.4004 | 1.0155 |
| 3-Aminoisobutyrate | 0.5547 | 1.0716 | 0.7188 | 1.4663 | 1.0377 | 0.9919 | 0.9224 | 1.2366 |
| 3-Hydroxybutyric acid | 1.2200 | 1.5703 | 0.9788 | 1.0982 | 0.5778 | 1.0152 | 0.6518 | 0.8880 |
| 3-Hydroxyisovalerate | 0.6143 | 1.2317 | 1.3656 | 0.5425 | 0.9969 | 1.0096 | 1.5750 | 0.6644 |
| 3-Indoxylsulfate | 0.6574 | 1.0739 | 1.0950 | 1.5620 | 0.6984 | 1.1345 | 0.9454 | 0.8332 |
| 3-Methylhistidine | 0.9290 | 1.2457 | 1.2523 | 1.5370 | 0.9533 | 0.7624 | 0.6461 | 0.6268 |
| 4-Aminobutyrate | 0.8314 | 1.6400 | 1.0815 | 1.0748 | 0.6873 | 1.0797 | 0.5103 | 1.0951 |
| 5-Aminopentanoate | 1.1252 | 1.4780 | 1.0707 | 1.0632 | 0.6641 | 1.0079 | 0.6133 | 0.9777 |
| Acetamide | 0.8130 | 1.6625 | 1.1936 | 0.9607 | 0.5866 | 1.0876 | 0.7461 | 0.9499 |
| Acetate | 0.9164 | 1.5584 | 1.0348 | 0.9359 | 0.8145 | 0.8737 | 0.6957 | 1.1706 |
| Acetoacetate | 0.8520 | 2.1771 | 1.0514 | 0.9963 | 0.6111 | 0.8375 | 0.7232 | 0.7515 |
| Acetone | 1.0925 | 1.2513 | 1.0615 | 1.0888 | 0.7822 | 0.9072 | 0.9606 | 0.8559 |
| Adenine | 1.2965 | 2.3477 | 0.8676 | 0.8549 | 0.3769 | 0.8535 | 0.6312 | 0.7717 |
| Adenosine | 1.1269 | 1.3070 | 0.7591 | 1.0233 | 0.9326 | 0.7720 | 1.2293 | 0.8497 |
| Adipate | 0.9665 | 1.3967 | 1.0635 | 1.3060 | 0.7202 | 0.5555 | 1.0082 | 0.9834 |
| ADP | 1.1295 | 1.6871 | 1.0118 | 1.2406 | 1.1469 | 0.5391 | 0.5784 | 0.6666 |
| AMP | 0.9865 | 1.6911 | 1.1766 | 0.8751 | 0.6653 | 0.8718 | 0.6948 | 1.0389 |
| Anserine | 0.8611 | 1.8775 | 1.1587 | 1.1025 | 0.9567 | 0.8905 | 0.3816 | 0.7714 |
| Aspartate | 0.7644 | 3.1525 | 0.8267 | 0.8769 | 0.4707 | 0.7817 | 0.5340 | 0.5931 |
| ATP | 0.8209 | 1.9195 | 0.8386 | 1.0931 | 0.6937 | 0.7446 | 0.8895 | 1.0001 |
| Butyrate | 0.9167 | 1.2995 | 0.9403 | 0.9449 | 0.9470 | 0.8445 | 1.1918 | 0.9154 |
| Cadaverine | 1.3529 | 1.3802 | 1.1584 | 1.0067 | 0.8534 | 0.7025 | 0.5620 | 0.9838 |
| Caffeine | 1.5680 | 1.2834 | 1.0579 | 1.0702 | 0.9125 | 0.9608 | 0.4799 | 0.6674 |
| Carnitine | 0.9766 | 1.3943 | 1.1209 | 0.9422 | 1.1142 | 1.1111 | 0.3453 | 0.9953 |
| Choline | 1.1200 | 1.7349 | 1.0698 | 1.2442 | 0.5207 | 1.2953 | 0.3386 | 0.6765 |
| cis-Aconitate | 1.0146 | 1.3932 | 0.9604 | 0.9645 | 0.8137 | 0.9709 | 0.9763 | 0.9064 |
| Citrate | 0.8271 | 1.2101 | 2.0647 | 1.0079 | 0.6815 | 0.6321 | 0.7802 | 0.7964 |
| Creatine | 0.9805 | 1.6025 | 1.2820 | 1.1557 | 0.6752 | 0.8405 | 0.6416 | 0.8220 |
| Creatinine | 0.8922 | 1.7598 | 0.9867 | 1.3700 | 0.9435 | 0.6293 | 0.7077 | 0.7109 |
| Cytosine | 1.1270 | 1.0326 | 1.4574 | 0.9094 | 0.8692 | 0.8681 | 0.8888 | 0.8475 |
| D-Galactose | 1.0813 | 1.9147 | 1.1186 | 0.9084 | 0.7326 | 0.9867 | 0.4931 | 0.7647 |
| D-Glucose | 1.0064 | 1.6778 | 0.8689 | 0.8422 | 0.7844 | 0.9773 | 0.8027 | 1.0403 |
| Dimethylamine | 1.0423 | 1.7754 | 1.2385 | 0.9351 | 0.3713 | 0.9111 | 1.0636 | 0.6627 |
| Dimethyl sulfone | 0.9773 | 1.5828 | 0.9847 | 1.3369 | 0.5572 | 0.8614 | 0.7051 | 0.9946 |
| Ethanol | 0.3261 | 0.7601 | 0.3581 | 0.9101 | 0.5923 | 1.4301 | 2.9135 | 0.7096 |
| Ethanolamine | 0.8764 | 1.6109 | 1.0298 | 1.1461 | 1.1644 | 0.6919 | 0.5968 | 0.8836 |
| Formate | 0.8031 | 1.7666 | 0.9080 | 0.8385 | 0.8177 | 0.7566 | 1.2776 | 0.8318 |
| Fumaric acid | 0.9143 | 1.0133 | 0.9395 | 1.2126 | 0.8184 | 1.5687 | 0.6217 | 0.9116 |
| Gluconic acid | 1.0033 | 1.7617 | 1.1394 | 1.0308 | 0.6900 | 0.9743 | 0.6216 | 0.7790 |
| Glucose | 0.7293 | 1.9223 | 1.2391 | 0.8629 | 0.6170 | 0.7971 | 1.0674 | 0.7649 |
| Glucuronate | 0.9041 | 1.8783 | 0.9889 | 0.9248 | 0.5594 | 0.8171 | 0.9705 | 0.9569 |
| Glutarate | 1.0101 | 1.5123 | 1.1899 | 0.8527 | 0.6684 | 0.8914 | 0.8330 | 1.0423 |
| Glycerol | 0.7071 | 1.8478 | 1.0379 | 1.0890 | 0.8549 | 0.6394 | 0.9422 | 0.8817 |
| Glycine | 1.0428 | 1.1666 | 1.0139 | 1.0688 | 0.9767 | 1.0934 | 0.7783 | 0.8594 |
| Glycolate | 0.4543 | 1.3741 | 0.4162 | 0.9162 | 1.5202 | 0.4437 | 2.3097 | 0.5656 |
| Guanidoacetate | 0.8997 | 1.5695 | 0.9572 | 1.0986 | 0.8072 | 1.0811 | 0.6861 | 0.9007 |
| Guanosine | 0.6364 | 1.1809 | 1.3666 | 0.7104 | 1.2894 | 0.6632 | 1.2619 | 0.8911 |
| Hippuric acid | 1.0358 | 1.7265 | 1.0409 | 1.1625 | 0.5623 | 0.9838 | 0.6433 | 0.8449 |
| Histamine | 0.9264 | 1.5725 | 0.9383 | 1.0087 | 0.5458 | 1.0028 | 0.8099 | 1.1956 |
| Hypoxanthine | 0.1396 | 6.8222 | 0.1876 | 0.1963 | 0.1527 | 0.0960 | 0.3141 | 0.0916 |
| Imidazole | 0.9962 | 0.9760 | 0.9428 | 0.9968 | 1.0602 | 1.0235 | 1.0431 | 0.9614 |
| Indole-3-lactate | 0.8568 | 1.0697 | 0.9106 | 0.8367 | 0.9755 | 1.2467 | 1.0766 | 1.0275 |
| Inosine | 1.0299 | 1.6483 | 0.8264 | 0.8920 | 0.7506 | 0.6943 | 1.4161 | 0.7425 |
| Isobutyrate | 0.9261 | 1.3099 | 0.9238 | 0.9726 | 0.9402 | 0.8499 | 1.1487 | 0.9288 |
| Isocitrate | 0.7268 | 1.8237 | 0.6537 | 1.2779 | 1.2893 | 0.6571 | 0.8778 | 0.6937 |
| Isoleucine | 1.0163 | 2.2415 | 0.9790 | 1.1561 | 0.5336 | 0.7161 | 0.6703 | 0.6871 |
| Isovaleric acid | 1.2668 | 1.1725 | 1.2411 | 1.0097 | 0.5984 | 1.0732 | 0.6810 | 0.9573 |
| L-Alanine | 0.9784 | 1.5912 | 1.0737 | 1.3357 | 0.7171 | 0.8851 | 0.6270 | 0.7918 |
| L-Arginine | 0.9120 | 1.9748 | 0.9260 | 1.0519 | 0.8752 | 0.7365 | 0.7504 | 0.7204 |
| L-Asparagine | 0.9954 | 1.8104 | 0.9071 | 1.1210 | 0.7320 | 0.9179 | 0.7051 | 0.8111 |
| L-Cysteine | 1.1302 | 1.3856 | 0.9510 | 1.3261 | 0.8571 | 0.9255 | 0.6436 | 0.8462 |
| L-Cystine | 0.9911 | 1.5248 | 0.9719 | 0.9049 | 0.7123 | 0.9424 | 0.9460 | 1.0066 |
| L-Fucose | 1.0420 | 1.7518 | 0.8302 | 1.0348 | 0.7233 | 0.8999 | 0.8826 | 0.8354 |
| L-Glutamic acid | 1.0235 | 1.3959 | 0.9632 | 1.0625 | 0.7532 | 0.8619 | 1.2080 | 0.7317 |
| L-Glutamine | 1.3468 | 1.8037 | 0.7613 | 1.6545 | 0.6393 | 0.7380 | 0.5232 | 0.4919 |
| L-Histidine | 1.1680 | 0.9795 | 0.9834 | 1.0254 | 0.8522 | 1.2570 | 0.4069 | 1.3276 |
| L-Lactic acid | 1.4413 | 1.1047 | 0.9269 | 0.7667 | 0.5683 | 0.7728 | 0.6846 | 1.7346 |
| L-Leucine | 0.8361 | 1.6756 | 1.0086 | 1.0629 | 0.8506 | 0.8586 | 0.6820 | 1.0255 |
| L-Lysine | 1.1328 | 1.5532 | 1.1240 | 1.0056 | 0.6700 | 0.9965 | 0.4083 | 1.1096 |
| L-Phenylalanine | 0.7095 | 3.0239 | 0.8472 | 0.8589 | 0.5783 | 0.6682 | 0.6429 | 0.6711 |
| L-Serine | 0.7495 | 1.4263 | 0.6772 | 0.8260 | 1.1119 | 1.0809 | 1.1842 | 0.9440 |
| L-Threonine | 1.0974 | 1.3575 | 1.2681 | 1.1133 | 0.6937 | 0.8886 | 0.6757 | 0.9057 |
| Malonate | 0.6058 | 1.9858 | 0.7514 | 1.1152 | 1.2988 | 0.0609 | 2.0348 | 0.1166 |
| Mandelate | 0.6204 | 1.2244 | 1.2291 | 1.4779 | 0.9051 | 0.8442 | 0.7596 | 0.9394 |
| Mannitol | 0.5835 | 1.9822 | 1.0613 | 0.9947 | 0.9113 | 0.7080 | 1.0476 | 0.7115 |
| Methanol | 0.9519 | 0.9815 | 1.0646 | 0.8017 | 1.1474 | 0.7449 | 1.0468 | 1.2612 |
| Methionine | 1.3056 | 1.4098 | 1.0604 | 1.5857 | 0.8793 | 0.4760 | 0.3964 | 0.6454 |
| Methylamine | 1.0790 | 1.7700 | 1.1960 | 1.0796 | 0.5985 | 0.9734 | 0.4484 | 0.8550 |
| Methylguanidine | 0.9284 | 1.6341 | 1.0848 | 1.0110 | 0.6909 | 0.9458 | 0.6948 | 1.0101 |
| Methylmalonate | 0.9225 | 1.4156 | 1.0748 | 1.0856 | 0.7443 | 0.8275 | 1.0038 | 0.9259 |
| Methylmalonic acid | 1.2824 | 1.0418 | 0.8259 | 1.0819 | 0.5723 | 1.1264 | 0.6699 | 1.3333 |
| Methylsuccinate | 1.1589 | 1.0324 | 0.6599 | 0.7686 | 0.8570 | 0.6387 | 1.9961 | 0.8885 |
| Myo-inositol | 0.7287 | 2.4641 | 0.9293 | 0.9951 | 0.7770 | 0.8517 | 0.6970 | 0.5571 |
| N,N-Dimethylglycine | 1.2595 | 2.0208 | 1.2090 | 1.1678 | 0.5591 | 0.7833 | 0.3586 | 0.6418 |
| O-Acetylcarnitine | 0.9401 | 1.9593 | 1.1754 | 0.8578 | 0.7423 | 0.8739 | 0.6166 | 0.8346 |
| p-Cresol sulfate | 0.9974 | 1.4293 | 1.1146 | 0.8730 | 0.9159 | 0.9701 | 0.8541 | 0.8457 |
| Phenylacetate | 0.7550 | 2.6966 | 0.7862 | 0.8369 | 0.7043 | 0.9406 | 0.8298 | 0.7901 |
| Phosphorylcholine | 1.4137 | 0.8630 | 1.0710 | 1.5262 | 0.7526 | 1.0027 | 0.3736 | 0.9619 |
| Propylene glycol | 1.0116 | 1.2061 | 1.1151 | 1.1151 | 0.8482 | 0.8710 | 0.9082 | 0.9247 |
| Pyridoxine | 0.6465 | 2.2984 | 0.8566 | 1.4870 | 0.4849 | 0.8010 | 0.5185 | 0.9071 |
| Pyroglutamic acid | 0.9550 | 1.6640 | 0.9626 | 0.9980 | 0.6796 | 0.8742 | 1.0096 | 0.8570 |
| Pyruvate | 0.8192 | 0.8579 | 0.9008 | 0.7697 | 0.9080 | 0.6239 | 2.5434 | 0.5771 |
| Pyruvic acid | 0.8674 | 1.0430 | 0.9045 | 0.6416 | 0.9320 | 0.6321 | 2.4541 | 0.5253 |
| Sarcosine | 0.9989 | 1.9106 | 1.0671 | 0.8804 | 0.7320 | 0.9117 | 0.7863 | 0.7130 |
| Sorbitol | 0.8570 | 2.2119 | 1.1188 | 0.9698 | 0.5309 | 0.8753 | 0.6364 | 0.7998 |
| Succinate | 0.9833 | 1.5652 | 1.1832 | 0.9815 | 0.6758 | 1.1373 | 0.3437 | 1.1301 |
| Taurine | 0.7354 | 2.1245 | 0.7940 | 1.1686 | 1.4728 | 0.3830 | 1.0290 | 0.2928 |
| Thymine | 1.1286 | 1.1568 | 1.0631 | 1.2498 | 0.7354 | 0.9971 | 0.5919 | 1.0772 |
| trans-Aconitate | 0.9268 | 2.1355 | 1.1066 | 1.1320 | 0.7720 | 0.6568 | 0.4671 | 0.8033 |
| Trigonelline | 0.9433 | 1.9760 | 1.1006 | 1.0530 | 0.7570 | 0.8666 | 0.4349 | 0.8686 |
| Trimethylamine | 1.0234 | 2.4834 | 0.9727 | 1.8220 | 0.2622 | 0.8373 | 0.1899 | 0.4091 |
| Trimethylamine N-oxide | 0.5479 | 0.9930 | 0.7238 | 0.5536 | 1.2667 | 0.9662 | 0.7461 | 2.2027 |
| Tryptophan | 1.1689 | 1.4844 | 1.0280 | 0.9845 | 0.6293 | 1.2017 | 0.6099 | 0.8934 |
| Tyramine | 0.8139 | 1.1968 | 0.8641 | 0.9059 | 1.3984 | 0.7557 | 1.3293 | 0.7359 |
| Tyrosine | 1.0051 | 1.3252 | 1.0747 | 0.9121 | 0.9510 | 0.9083 | 1.0503 | 0.7733 |
| Uracil | 1.1426 | 1.5107 | 1.1201 | 1.0872 | 0.3007 | 0.7371 | 1.1642 | 0.8261 |
| Urea | 0.8010 | 2.1257 | 1.0612 | 1.0646 | 0.9529 | 0.5760 | 0.7994 | 0.6191 |
| Urocanate | 0.6461 | 1.3035 | 0.7354 | 0.8045 | 1.3438 | 0.8253 | 1.6035 | 0.7379 |
| Valine | 1.3632 | 1.2812 | 1.0332 | 1.2443 | 0.6229 | 1.0584 | 0.5206 | 0.9155 |
Factors:
| F1 | Dose:0.03 µg/kg TCDD |
| F2 | Dose:0.1 µg/kg TCDD |
| F3 | Dose:0.3 µg/kg TCDD |
| F4 | Dose:0 µg/kg TCDD |
| F5 | Dose:10 µg/kg TCDD |
| F6 | Dose:1 µg/kg TCDD |
| F7 | Dose:30 µg/kg TCDD |
| F8 | Dose:3 µg/kg TCDD |