Data for (Study ST003904)
(Analysis AN006409)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|
| Ha_ADALT | 1.0683 | 0.8229 | 1.0031 | NA | NA | 1.0182 | NA |
| Ha_AEALER | 1.2882 | 0.8471 | 0.9759 | NA | NA | 0.7953 | NA |
| Ha_AE;EA | 1.1091 | 1.1653 | 0.9931 | NA | NA | 0.7325 | NA |
| Ha_AGEY;EYGA;YGAE | 1.0713 | 0.9878 | 1.0586 | NA | NA | 0.8689 | NA |
| Ha_AGEYG;GEYGA | 1.0474 | 0.7276 | 0.9937 | NA | NA | 1.1007 | NA |
| Ha_AHAGEYGA | 0.8649 | 1.1058 | 1.2989 | NA | NA | 0.7657 | NA |
| Ha_AHKLR | 0.7630 | 0.8987 | 0.8747 | NA | NA | 1.4373 | NA |
| Ha_ALSDLH;LSDLHA | 1.0673 | 0.9706 | 1.0568 | NA | NA | 0.8842 | NA |
| Ha_AVAHVDDM | 1.0983 | 0.8510 | 1.1508 | NA | NA | 0.8152 | NA |
| Ha_DALT | 1.1820 | 0.9256 | 1.0291 | NA | NA | 0.8158 | NA |
| Ha_DALTN | 1.0345 | 1.1150 | 1.0029 | NA | NA | 0.9242 | NA |
| Ha_DDM | 1.2728 | 1.0634 | 0.8429 | NA | NA | 0.8392 | NA |
| Ha_DLH | 2.6163 | 2.6985 | 2.9615 | 0.0607 | 0.0708 | 2.5793 | 0.0623 |
| Ha_DLHA | 1.1022 | 0.5591 | 1.2193 | NA | NA | 1.1194 | NA |
| Ha_DLS;LSD;SDL;SLD | 1.1279 | 0.8573 | 1.0790 | NA | NA | 0.8565 | NA |
| Ha_DP | 1.1044 | 1.6776 | 1.8110 | 0.1745 | 0.1448 | 1.6961 | 0.1391 |
| Ha_DPVNF | 1.0824 | 0.7225 | 1.0431 | NA | NA | 1.0141 | NA |
| Ha_EALERMF | 0.9480 | 0.6209 | 0.9905 | NA | NA | 1.1878 | NA |
| Ha_FLSF | 1.0493 | 0.9759 | 1.0011 | NA | NA | 0.9594 | NA |
| Ha_FLSFP | 0.8877 | 0.8592 | 0.9712 | NA | NA | 1.2115 | NA |
| Ha_FLSFPTT | 1.0689 | 1.0297 | 1.2238 | NA | NA | 0.6925 | NA |
| Ha_FTPAVH | 1.2829 | 0.7109 | 1.0427 | NA | NA | 0.7750 | NA |
| Ha_GA;AG | 0.9294 | 1.0457 | 0.9896 | NA | NA | 1.0616 | NA |
| Ha_GEYG | 1.0698 | 0.9087 | 1.0620 | NA | NA | 0.9175 | NA |
| Ha_GKVGAH;QVKGH | 0.7752 | 0.7834 | 0.9412 | NA | NA | 1.4149 | NA |
| Ha_HAGEYG | 1.1283 | 0.8711 | 1.1912 | NA | NA | 0.7664 | NA |
| Ha_HGKKV | 0.9485 | 0.6766 | 0.9996 | NA | NA | 1.2261 | NA |
| Ha_HGKKVA | 1.1019 | NA | 0.7608 | NA | NA | 1.2059 | NA |
| Ha_HKLRV | 0.6905 | 0.8031 | 0.8784 | NA | NA | 1.5606 | NA |
| Ha_HLPAEFT | 0.9667 | 1.2073 | 1.0446 | NA | NA | 0.8991 | NA |
| Ha_HVDD | 1.0346 | 1.2998 | 1.2241 | NA | NA | 0.4415 | NA |
| Ha_KGHGK;GHGKK | 0.8767 | 0.7026 | 0.7431 | NA | NA | 1.5348 | NA |
| Ha_KGHGKK | 0.8918 | 0.8077 | 0.9114 | NA | NA | 1.3103 | NA |
| Ha_KTNV;TNVK | 0.7716 | NA | 1.2679 | NA | NA | 0.9604 | NA |
| Ha_KTYFP | 1.0673 | 0.9706 | 1.0568 | NA | NA | 0.8842 | NA |
| Ha_KVGAH | 1.0035 | 1.2977 | 0.8919 | NA | NA | 0.9845 | NA |
| Ha_LASVST | NA | NA | NA | 1.0147 | 1.0899 | NA | 0.7645 |
| Ha_LE | 1.0111 | 1.0300 | 0.9684 | NA | NA | 1.0058 | NA |
| Ha_LERM | 0.8152 | 1.1433 | 0.7694 | NA | NA | 1.3837 | NA |
| Ha_LHAH | 1.3311 | 0.3723 | 1.1980 | NA | NA | 0.7848 | NA |
| Ha_LRVD | 1.2609 | 0.5861 | 1.0149 | NA | NA | 1.0002 | NA |
| Ha_NAVA | 1.3369 | 0.3101 | 0.9428 | NA | NA | 0.9442 | NA |
| Ha_NAVAHV | 1.1435 | 0.7737 | 1.0309 | NA | NA | 0.9351 | NA |
| Ha_NVKAA;AQVKG | 1.2609 | 0.5861 | 1.0149 | NA | NA | 1.0002 | NA |
| Ha_PA | NA | NA | NA | 1.0724 | 0.9878 | NA | 0.8646 |
| Ha_PADKT | 1.0721 | 1.0687 | 1.0160 | NA | NA | 0.8762 | NA |
| Ha_PAVH | 0.7081 | 1.3794 | 0.4730 | NA | NA | 1.7550 | NA |
| Ha_PHFD | 1.0176 | 0.7025 | 1.4537 | NA | NA | 0.8261 | NA |
| Ha_PHFDLS | 1.2790 | 0.9016 | 1.0457 | NA | NA | 0.7737 | NA |
| Ha_PNAL | 1.0463 | 1.0196 | 0.9738 | NA | NA | 0.9683 | NA |
| Ha_PNALS | 1.3687 | 0.8725 | 1.0052 | NA | NA | 0.6716 | NA |
| Ha_PT;TP | NA | NA | NA | 1.0913 | 0.9125 | NA | 0.9914 |
| Ha_PVNF | 1.1531 | 0.8427 | 1.1029 | NA | NA | 0.8123 | NA |
| Ha_SHCLLV | 1.2829 | 0.7109 | 1.0427 | NA | NA | 0.7750 | NA |
| Ha_SVST | 0.8277 | NA | 1.1243 | NA | NA | 1.0719 | NA |
| Ha_TPAVH | 1.1631 | 0.6223 | 1.1653 | NA | NA | 0.9508 | NA |
| Ha_TVLT | 1.0905 | 0.8116 | 1.1834 | NA | NA | 0.8203 | NA |
| Ha_TY | 1.0072 | 1.0351 | 0.9041 | NA | NA | 1.0777 | NA |
| Ha_TYFP | 1.3322 | 1.4422 | 1.2762 | 0.0933 | 0.0673 | 1.3105 | 0.0860 |
| Ha_VADA | 1.1903 | 1.3608 | 0.9513 | NA | NA | 0.7472 | NA |
| Ha_VD | 2.8037 | NA | 2.7780 | 0.3750 | 0.3274 | 2.0878 | 0.4174 |
| Ha_VDD | 1.2466 | 1.0882 | 1.8215 | 0.1003 | 0.1088 | 1.5260 | 0.1150 |
| Ha_VDPVNF | 1.0080 | 0.8794 | 1.1719 | NA | NA | 0.8733 | NA |
| Ha_VHASL | 0.8565 | NA | 1.7291 | NA | NA | 0.4144 | NA |
| Ha_VLSP | 1.0292 | 1.0130 | 0.9863 | NA | NA | 0.9767 | NA |
| Ha_VLSPAD | 1.1171 | 0.8238 | 1.0412 | NA | NA | 0.9474 | NA |
| Ha_YG | 0.9684 | 1.0491 | 0.9650 | NA | NA | 1.0445 | NA |
| Ha_YGA | 1.0769 | 1.0065 | 1.0224 | NA | NA | 0.8913 | NA |
| Hb_AHLD | 1.1022 | 0.5591 | 1.2193 | NA | NA | 1.1194 | NA |
| Hb_ATLS | 1.1635 | 0.6565 | 1.0325 | NA | NA | 0.9372 | NA |
| Hb_DE | 1.1782 | 0.8154 | 0.9004 | NA | NA | 0.9948 | NA |
| Hb_DEVGG | 0.8594 | 0.0156 | 1.8310 | NA | NA | 1.2941 | NA |
| Hb_DEVGGEA | 1.1959 | 1.0286 | 1.0161 | NA | NA | 0.7595 | NA |
| Hb_DEVGGEALG | 1.1735 | 0.9767 | 1.0689 | NA | NA | 0.7751 | NA |
| Hb_DEVG;STPD | 0.9869 | 0.9409 | 1.0803 | NA | NA | 0.9660 | NA |
| Hb_DGLA | 1.1903 | 1.3608 | 0.9513 | NA | NA | 0.7472 | NA |
| Hb_DGLAH | 1.1928 | 1.6263 | 1.2740 | 0.2633 | 0.3844 | 1.0495 | 0.3225 |
| Hb_DLS | 1.1279 | 0.8573 | 1.0790 | NA | NA | 0.8565 | NA |
| Hb_DLSTPDA | 1.1630 | 0.7968 | 0.9134 | NA | NA | 1.0488 | NA |
| Hb_DNLKG | 1.1079 | 0.7614 | 0.8246 | NA | NA | 1.2266 | NA |
| Hb_DPE | 1.1450 | NA | 0.7972 | NA | NA | 1.0578 | NA |
| Hb_DPEN | 0.7573 | 1.8892 | 0.8855 | NA | NA | 0.8951 | NA |
| Hb_DPENF | 0.9791 | 1.1025 | 1.0368 | NA | NA | 0.9170 | NA |
| Hb_EA | 1.1091 | 1.1653 | 0.9931 | NA | NA | 0.7325 | NA |
| Hb_EE | 1.0847 | 0.8377 | 0.9329 | NA | NA | 1.1041 | NA |
| Hb_EL | 1.0111 | 1.0300 | 0.9684 | NA | NA | 1.0058 | NA |
| Hb_ESFG;AFSD | 1.0713 | 0.9878 | 1.0586 | NA | NA | 0.8689 | NA |
| Hb_EVGGEA | 0.8723 | 1.9282 | 0.5057 | NA | NA | 1.1895 | NA |
| Hb_EVGG;VGGE;LDN;DNL | 1.1136 | 0.8100 | 0.8987 | NA | NA | 1.0827 | NA |
| Hb_FATLSE | 1.1088 | 0.9200 | 1.0448 | NA | NA | 0.8697 | NA |
| Hb_FESFG | 1.1602 | 1.1776 | 0.9869 | NA | NA | 0.7640 | NA |
| Hb_FTPPVQ | 1.2882 | 0.8471 | 0.9759 | NA | NA | 0.7953 | NA |
| Hb_GA;AG | 0.9294 | 1.0457 | 0.9896 | NA | NA | 1.0616 | NA |
| Hb_GAFSD;AFSDG | 1.0474 | 0.7276 | 0.9937 | NA | NA | 1.1007 | NA |
| Hb_GDLS;SDGL | 0.9521 | NA | 1.1659 | NA | NA | 0.8672 | NA |
| Hb_GGEALG | 1.3360 | NA | 1.0701 | NA | NA | 0.5939 | NA |
| Hb_GGEAL;GEALG | 1.0803 | 0.9999 | 1.1177 | NA | NA | 0.7905 | NA |
| Hb_GTFAT | 1.0939 | 1.0288 | 0.8789 | NA | NA | 1.0140 | NA |
| Hb_HGKKV | 0.9485 | 0.6766 | 0.9996 | NA | NA | 1.2261 | NA |
| Hb_HLD | 2.6163 | 2.6985 | 2.9615 | 0.0607 | 0.0708 | 2.5793 | 0.0623 |
| Hb_HVDPEN | 1.6297 | NA | 0.4635 | NA | NA | 0.9068 | NA |
| Hb_HVDPENF | 1.0983 | 0.8510 | 1.1508 | NA | NA | 0.8152 | NA |
| Hb_KAHG;AHGK | 0.9826 | 1.1607 | 0.7307 | NA | NA | 1.2185 | NA |
| Hb_KAHGKK | 1.0375 | 0.8449 | 0.9895 | NA | NA | 1.0535 | NA |
| Hb_KVKAHG;VKAHGK;AHGKKV | 1.1019 | NA | 0.7608 | NA | NA | 1.2059 | NA |
| Hb_LAHH | 1.3311 | 0.3723 | 1.1980 | NA | NA | 0.7848 | NA |
| Hb_LWGK | 0.8303 | NA | 1.7818 | NA | NA | 0.3878 | NA |
| Hb_NVDE | 0.8594 | 0.0156 | 1.8310 | NA | NA | 1.2941 | NA |
| Hb_NVDEVG | 1.1108 | 1.0032 | 1.0477 | NA | NA | 0.8304 | NA |
| Hb_NVDEVGGEA | 1.1476 | 1.0172 | 1.0525 | NA | NA | 0.7790 | NA |
| Hb_PD;DP | 1.1044 | 1.6776 | 1.8110 | 0.1745 | 0.1448 | 1.6961 | 0.1391 |
| Hb_PE | 0.9028 | NA | 1.3014 | NA | NA | 0.7958 | NA |
| Hb_PEE | 1.9935 | 1.5851 | 1.8207 | 0.2992 | 0.2403 | 1.5918 | 0.2384 |
| Hb_PENF | 1.0695 | 0.9215 | 1.0951 | NA | NA | 0.8673 | NA |
| Hb_PPVQ | 1.1694 | 0.8807 | 1.0689 | NA | NA | 0.8108 | NA |
| Hb_PVQ | 1.8338 | NA | 2.6756 | 0.0811 | 0.0839 | 1.8605 | 0.0737 |
| Hb_PVQA | 1.0463 | 1.0196 | 0.9738 | NA | NA | 0.9683 | NA |
| Hb_PW | 1.2088 | 0.5992 | 1.0715 | NA | NA | 0.8715 | NA |
| Hb_SELHC | 1.0432 | 1.0579 | 0.7079 | NA | NA | 1.2104 | NA |
| Hb_SFG | 1.0769 | 1.0065 | 1.0224 | NA | NA | 0.8913 | NA |
| Hb_SFGD;FSDG | 1.0698 | 0.9087 | 1.0620 | NA | NA | 0.9175 | NA |
| Hb_SFGDL;FGDLS;FSDGL | 1.2704 | 0.7957 | 0.9940 | NA | NA | 0.8042 | NA |
| Hb_SFGDLS | 1.2107 | 0.8054 | 1.1039 | NA | NA | 0.8021 | NA |
| Hb_STPDAVM | 0.9786 | 0.9444 | 1.1893 | NA | NA | 0.8516 | NA |
| Hb_STPDAVMGNP;ATLSELHCD | 1.4467 | 0.0049 | 1.1469 | NA | NA | 0.9040 | NA |
| Hb_TP | NA | NA | NA | 1.0913 | 0.9125 | NA | 0.9914 |
| Hb_VAGVANAL | 0.7858 | 0.7491 | 0.9598 | NA | NA | 1.4022 | NA |
| Hb_VANA | 1.3369 | 0.3101 | 0.9428 | NA | NA | 0.9442 | NA |
| Hb_VC;CV | 1.0525 | 0.6838 | 1.1178 | NA | NA | 1.0456 | NA |
| Hb_VCVLAH | 0.6406 | 1.1054 | 0.8550 | NA | NA | 1.4726 | NA |
| Hb_VD | 2.8037 | NA | 2.7780 | 0.3750 | 0.3274 | 2.0878 | 0.4174 |
| Hb_VDE;DEV | 0.7389 | 1.2945 | 1.2629 | NA | NA | 0.8019 | NA |
| Hb_VDEVG | 0.9193 | 1.1658 | 1.1022 | NA | NA | 0.8894 | NA |
| Hb_VDEVGG | 1.2267 | 0.9463 | 0.9371 | NA | NA | 0.8358 | NA |
| Hb_VDEVGGEA;GDLSTPDA | 0.8649 | 1.1058 | 1.2989 | NA | NA | 0.7657 | NA |
| Hb_VDEVGGEALG | 0.9569 | 1.3580 | 1.2221 | NA | NA | 0.6420 | NA |
| Hb_VDPEN | 0.8491 | 1.0152 | 1.0458 | NA | NA | 1.1105 | NA |
| Hb_VDPENF | 0.9786 | 0.9444 | 1.1893 | NA | NA | 0.8516 | NA |
| Hb_VGGEALG | 0.8276 | 1.0531 | 1.3061 | NA | NA | 0.8486 | NA |
| Hb_VHL;LHV | 1.0510 | 0.9384 | 0.9517 | NA | NA | 1.0298 | NA |
| Hb_VHLTP | 0.9402 | 0.8742 | 0.8749 | NA | NA | 1.2624 | NA |
| Hb_VHLTPEE | 0.9386 | 0.8402 | 0.8859 | NA | NA | 1.2705 | NA |
| Hb_VKAHG | 1.0035 | 1.2977 | 0.8919 | NA | NA | 0.9845 | NA |
| Hb_VLGAFSDG | 1.1321 | 0.8557 | 1.0704 | NA | NA | 0.8619 | NA |
| Hb_VNVD | 1.0803 | 0.9999 | 1.1177 | NA | NA | 0.7905 | NA |
| Hb_VNVDE;NVDEV | 1.2267 | 0.9463 | 0.9371 | NA | NA | 0.8358 | NA |
| Hb_VNVDEVG;EVGGEALG | 0.9463 | 1.1450 | 1.1080 | NA | NA | 0.8657 | NA |
| Hb_VNVDEVGGEA | 1.4467 | 0.0049 | 1.1469 | NA | NA | 0.9040 | NA |
| Hb_WTQ | NA | NA | NA | 0.6363 | 0.7831 | NA | 2.3065 |
| Hb_YPW | 0.8652 | 0.9019 | 0.8382 | NA | NA | 1.3660 | NA |
| Hb_YPWT | 1.1319 | 0.7405 | 1.0414 | NA | NA | 0.9564 | NA |
| Hb_YQ | 1.0769 | 1.0065 | 1.0224 | NA | NA | 0.8913 | NA |
Factors:
| F1 | Sample source:Cultured Plasmodium falciparum 3D7 | Genotype:WT | Treatment:10 nM Atovaquone |
| F2 | Sample source:Cultured Plasmodium falciparum 3D7 | Genotype:WT | Treatment:140 nM Piperaquine |
| F3 | Sample source:Cultured Plasmodium falciparum 3D7 | Genotype:WT | Treatment:None |
| F4 | Sample source:Cultured Plasmodium falciparum RF7_B9 | Genotype:1 copy plasmepsin II/III | Treatment:None |
| F5 | Sample source:Cultured Plasmodium falciparum RF7_D4 | Genotype:3 copies plasmepsin II/III | Treatment:None |
| F6 | Sample source:Pooled Cultured Plasmodium falciparum 3D7 | Genotype:WT | Treatment:NA |
| F7 | Sample source:Pooled Cultured Plasmodium falciparum RF7_B9 and RF7_D4 | Genotype:NA | Treatment:NA |
