Data for (Study ST004233)
(Analysis AN007048)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|
| 1-methyladenosine | 1.1641 | 1.3487 | 0.6705 | 0.7541 | NA | 0.3860 | NA |
| 1-methylhistamine | NA | NA | NA | NA | NA | NA | NA |
| 1-methylnicotinamide | 0.2555 | 0.1752 | 0.1622 | 0.1621 | 1.5952 | 1.2174 | 1.1135 |
| 1-pyrroline-5-carboxylase[15]N | NA | NA | NA | NA | NA | NA | NA |
| 1-pyrroline-5-carboxylate | 0.7816 | 0.8232 | 0.5820 | NA | 1.0714 | 1.0692 | 0.8954 |
| 1-pyrroline-5-carboxylate[13]C1[15]N1 | NA | NA | NA | NA | NA | NA | NA |
| 1-pyrroline-5-carboxylate[13]C5 | NA | NA | NA | NA | NA | NA | NA |
| 2-deoxycytidine | 1.6272 | 0.7009 | 0.3392 | 1.3943 | NA | 0.6440 | NA |
| 5-adenosylhomocysteine | 1.3230 | 1.2548 | 0.4102 | 1.3827 | 0.0154 | 1.3030 | NA |
| 5-aminolevulinic acid | NA | NA | NA | NA | NA | NA | NA |
| 5-hydroxytryptophan | NA | NA | 0.1978 | NA | 1.0303 | 1.6263 | 0.4283 |
| acetylcholine | NA | NA | NA | NA | NA | NA | NA |
| adenosine | 1.7759 | 1.2813 | 0.8637 | 1.4892 | 0.8479 | 0.8083 | 0.4515 |
| ADMA | 4.4443 | 2.3660 | 1.0108 | 2.1769 | 0.0492 | 0.1894 | 0.0168 |
| alanine | 2.3097 | 0.9602 | 0.8100 | 1.3884 | 0.7255 | 0.8669 | 0.2693 |
| allantoin | NA | NA | NA | NA | 1.0000 | NA | NA |
| alpha-glycerophosphocholine | 1.3588 | 0.8820 | 0.5687 | 1.1738 | 0.9901 | 1.1156 | 0.1181 |
| anserine | NA | NA | NA | NA | 1.0000 | NA | NA |
| anthranilic acid | 0.8635 | 0.6763 | 0.9663 | 0.8232 | 1.2207 | 0.8998 | 1.1369 |
| arginine | 1.4249 | 0.4318 | 0.1244 | 0.2185 | 2.2294 | 0.0706 | 0.0648 |
| arginine[13]C1[15]N1 | 1.8003 | 2.3198 | 1.1201 | 1.4618 | 0.0152 | 1.2704 | 1.2436 |
| arginine [13]C5 | NA | NA | NA | NA | NA | NA | NA |
| arginine[15]N | 1.5691 | 1.0917 | 0.4751 | 0.6583 | 1.4626 | 0.4767 | 0.4634 |
| argininosuccinate | 1.0000 | NA | NA | NA | NA | NA | NA |
| asparagine | 0.9785 | 0.6437 | 0.6344 | 0.7155 | 1.2327 | 1.0158 | 0.8201 |
| aspartate | 1.6934 | 1.1235 | 0.7696 | 1.0188 | 0.9123 | 0.9198 | 0.3776 |
| beta-alanine | NA | NA | NA | 0.4092 | 1.0966 | 1.0927 | 0.3580 |
| betaine | 0.4340 | 0.3339 | 0.3541 | 0.2955 | 1.4257 | 1.2820 | 0.6471 |
| butyrobetaine | NA | NA | NA | NA | NA | NA | NA |
| C10:2 carnitine | NA | NA | NA | NA | NA | NA | NA |
| C10 carnitine | NA | NA | NA | NA | 0.9730 | 1.1281 | 0.4471 |
| C12:1 carnitine | NA | NA | NA | NA | 1.0333 | 1.0035 | 0.7122 |
| C12 carnitine | 0.0584 | 0.0783 | NA | 0.0407 | 1.3859 | 1.1162 | 0.8635 |
| C14:1 carnitine | 0.1176 | 0.1088 | 0.0881 | 0.1301 | 1.6689 | 1.1364 | 0.9054 |
| C14:2 carnitine | NA | NA | NA | NA | 1.0626 | 0.9811 | 0.6122 |
| C14 carnitine | 0.0655 | 0.0610 | 0.0295 | 0.0327 | 1.8210 | 1.0294 | 0.8768 |
| C16 carnitine | 0.0298 | 0.0308 | 0.0311 | 0.0089 | 1.6095 | 1.1120 | 1.1798 |
| C18:1 carnitine | 0.0675 | 0.0468 | 0.0406 | 0.0296 | 1.6707 | 1.2859 | 1.2265 |
| C18:2 carnitine | 0.0284 | NA | 0.0160 | NA | 1.2110 | 1.0774 | 0.8028 |
| C18 carnitine | 0.1629 | 0.1028 | 0.0935 | 0.0720 | 1.6132 | 1.2635 | 1.2962 |
| C20:4 carnitine | 0.0156 | NA | NA | NA | 1.1449 | 0.9566 | 1.0860 |
| C20 carnitine | 0.4298 | 0.3104 | 0.2804 | 0.2919 | 1.4378 | 1.1985 | 0.6256 |
| C26 carnitine | 0.3126 | 0.2677 | 0.1825 | 0.1903 | 1.4847 | 1.2459 | 0.5551 |
| C2 carnitine | 0.1725 | 0.1206 | 0.0555 | 0.0830 | 1.6875 | 1.1626 | 1.4088 |
| C3 carnitine | 0.1084 | 0.0740 | 0.0362 | 0.0330 | 1.6382 | 1.3508 | 0.8608 |
| C3-DC-CH3 carnitine | 0.4930 | 0.2064 | 0.1590 | 0.1678 | 1.4996 | 1.3146 | 0.4232 |
| C4 carnitine | 0.1102 | 0.1123 | 0.0372 | 0.0856 | 1.5735 | 1.4517 | 0.5347 |
| C4-OH carnitine | 0.3435 | 0.2468 | 0.1070 | 0.2375 | 1.5328 | 1.0999 | 1.1696 |
| C5:1 carnitine | NA | NA | NA | NA | NA | NA | NA |
| C5 carnitine | 0.1605 | 0.1298 | 0.0750 | 0.0814 | 1.5690 | 1.4124 | 0.5886 |
| C6 carnitine | 0.0388 | 0.0572 | 0.0241 | NA | 1.2540 | 1.5250 | 0.6202 |
| C7 carnitine | NA | NA | NA | NA | NA | NA | NA |
| C8 carnitine | NA | NA | NA | NA | 0.9796 | 1.0238 | NA |
| cAMP | 0.9401 | 0.9837 | 0.7515 | 1.2028 | NA | 1.2581 | NA |
| carnitine | 0.1290 | 0.0727 | 0.0527 | 0.0435 | 1.7131 | 1.1372 | 1.6538 |
| carnosine | NA | NA | NA | NA | 1.0267 | 0.9555 | NA |
| choline | 1.3734 | 0.8180 | 0.7848 | 1.2367 | 0.9748 | 1.0187 | 0.5083 |
| citrulline | 0.1819 | 0.1320 | 0.0839 | NA | 1.5164 | 1.3408 | 0.5062 |
| citrulline[13]C1[15]N1 | NA | NA | NA | NA | NA | NA | NA |
| citrulline[13]C5 | NA | NA | NA | NA | NA | NA | NA |
| citrulline[15]N | NA | NA | NA | NA | NA | NA | NA |
| cotinine | 0.6255 | 1.3604 | 0.8418 | NA | 1.2035 | 0.9554 | 0.4028 |
| creatine | 0.2009 | 0.0861 | 0.0906 | 0.0354 | 1.6019 | 1.3188 | 0.9621 |
| creatinine | 0.0799 | 0.0997 | 0.0649 | 0.0600 | 1.5711 | 1.3889 | 1.0802 |
| cytosine | 3.4197 | 1.9601 | 1.3629 | 3.8831 | 0.0331 | 0.4165 | 0.0313 |
| dimethylglycine | 1.0230 | 0.9839 | 0.9504 | 0.9703 | 1.0151 | 0.9917 | 1.0294 |
| GABA | 4.7844 | 2.5366 | 0.7873 | 1.8905 | 0.0270 | 0.1243 | 0.0221 |
| glucose | 0.8209 | 0.5305 | 0.8659 | 0.4246 | 1.2332 | 0.9654 | 1.5172 |
| glutamate | 1.3081 | 1.1640 | 0.8975 | 0.8942 | 1.2376 | 0.6809 | 0.3913 |
| glutamate[13]C3[15]N1 | NA | NA | NA | NA | NA | NA | NA |
| glutamate[13]C5 | 1.6227 | 1.6943 | 0.8323 | 1.4677 | 0.0016 | 0.7606 | 0.2851 |
| glutamate[15]N | 1.1765 | 0.8361 | 1.2209 | 0.7792 | 1.3443 | 0.6113 | 0.3316 |
| glutamine | 0.1899 | 0.1211 | 0.0966 | 0.0709 | 2.6983 | 0.1693 | 0.1530 |
| glutamine[13]C1[15]N1 | NA | NA | NA | NA | NA | NA | NA |
| glutamine[13]C5 | 1.1630 | 0.8639 | 1.4499 | 0.7159 | 0.0048 | 1.6570 | 2.5345 |
| glutamine[15]N | NA | NA | NA | NA | 1.1177 | 0.0580 | NA |
| glycine | 0.7331 | 0.3420 | 0.3367 | 0.4621 | 1.3920 | 1.1683 | 0.6666 |
| histamine | NA | NA | NA | NA | NA | NA | NA |
| histidine | 1.7328 | 1.0605 | 0.6418 | 1.2676 | 0.9339 | 0.8697 | 0.5707 |
| homocysteine | 1.3487 | NA | 0.2451 | 0.7952 | NA | 0.9135 | NA |
| isoleucine | 0.6826 | 0.4524 | 0.6605 | 0.4213 | 1.3940 | 1.0222 | 0.9980 |
| kynurenic acid | 2.1457 | NA | 1.0119 | NA | 0.9041 | 0.8263 | 0.5733 |
| leucine | 0.9463 | 0.6547 | 0.7677 | 0.6335 | 1.2421 | 0.9763 | 0.9118 |
| lysine | 1.2995 | 6.3941 | 0.6356 | 0.8996 | 0.3588 | 0.2910 | 0.2353 |
| methionine | 0.5541 | 0.3024 | 0.5604 | 0.2937 | 1.4982 | 1.0558 | 0.9427 |
| methionine sulfoxide | 0.6461 | 0.4160 | 0.5297 | 0.3562 | 1.5051 | 0.9432 | 1.1707 |
| methylthioadenosine | 1.7664 | 2.8776 | 0.8327 | 3.9123 | 0.2573 | 0.7336 | 0.1739 |
| N-carbamoyl-beta-alanine | NA | NA | NA | NA | NA | NA | NA |
| niacinamide | 0.8617 | 0.5669 | 0.7576 | 0.6379 | 1.3685 | 0.8477 | 1.2464 |
| NMMA | 4.8953 | 1.9264 | 0.8985 | 1.8129 | 0.0831 | 0.1658 | 0.0261 |
| ornithine | 0.1177 | 3.6568 | 0.0444 | 0.0798 | 1.9257 | 0.1055 | 0.0205 |
| ornithine[13]C1[15]N1 | 0.3179 | 4.1990 | 0.1823 | 0.3318 | 0.0100 | 1.2251 | 0.3460 |
| ornithine [13]C5 | NA | NA | NA | NA | NA | NA | NA |
| ornithine[15]N | 0.2502 | 3.4496 | NA | NA | 0.8116 | 0.5596 | NA |
| phenylalanine | 0.9771 | 0.7412 | 0.7326 | 0.7453 | 1.2951 | 0.8846 | 0.8226 |
| phenylalanine-d8 | 1.0213 | 1.1244 | 0.9695 | 1.0859 | 0.9875 | 0.9662 | 0.9987 |
| phosphocholine | 3.5912 | 2.1358 | 1.2406 | 3.0704 | 0.0209 | 0.4596 | 0.0189 |
| phosphoethanolamine | 1.5980 | 1.3357 | 0.4288 | 1.6028 | NA | 0.3580 | NA |
| pipecholic acid[13]C1[15]N1 | NA | NA | NA | NA | NA | NA | NA |
| pipecolic acid | 3.9315 | 0.0258 | 1.0527 | 1.9288 | 0.0117 | 0.1808 | NA |
| pipecolic acid [13]C5 | NA | NA | NA | NA | NA | NA | NA |
| pipecolic acid[15]N | 1.3199 | NA | 0.5383 | 0.5021 | NA | NA | NA |
| proline | 0.6285 | 0.8580 | 0.2821 | 0.4815 | 2.1686 | 0.2702 | 0.1124 |
| proline[13]C1[15]N1 | 1.6321 | 0.1837 | 1.1014 | 2.6901 | 0.0034 | 0.8885 | 0.6206 |
| proline [13]C5 | NA | NA | NA | NA | NA | NA | NA |
| proline[15]N | 1.1220 | 0.6955 | 1.0860 | 0.6705 | 0.0121 | 1.9970 | 2.3242 |
| putrescine | 1.9524 | 4.8919 | 1.6293 | 2.1990 | 0.0640 | 0.3360 | 0.0379 |
| pyroglutamic acid | NA | NA | NA | NA | NA | NA | NA |
| s-adenosylmethionine | 2.1659 | 2.5514 | 1.1208 | 2.9324 | 0.1193 | 0.8857 | 0.0711 |
| sarcosine | NA | NA | NA | NA | NA | NA | NA |
| SDMA | 4.4343 | 2.3949 | 0.9761 | 1.9803 | 0.0875 | 0.1800 | 0.0147 |
| serine | 0.8870 | 0.6407 | 0.9055 | 0.5763 | 1.1539 | 1.0432 | 1.1362 |
| spermidine | 2.1250 | 2.3091 | 1.5373 | 2.3710 | 0.3311 | 0.6708 | 0.2169 |
| taurine | 0.1117 | 0.0608 | 0.0509 | 0.0392 | 1.6534 | 1.3621 | 0.6406 |
| thiamine | 2.0400 | 1.4206 | 1.0505 | 1.8823 | 0.6684 | 0.7277 | 0.6142 |
| threonine | 1.2115 | 0.7864 | 0.8909 | 0.7378 | 1.1082 | 0.9169 | 0.9891 |
| thymidine | NA | NA | NA | NA | NA | NA | NA |
| trans-hydroxyproline | 0.6597 | 0.4915 | 0.6056 | 0.4026 | 1.3861 | 1.0634 | 0.8913 |
| trans-hydroxyproline[13]C1[15]N1 | NA | NA | NA | NA | NA | NA | NA |
| trans-hydroxyproline [13]C5 | NA | NA | NA | NA | NA | NA | NA |
| trans-hydroxyproline[15]N | NA | NA | NA | NA | NA | NA | NA |
| trimethylamine-N-oxide | 0.1011 | 0.1649 | 0.0938 | 0.1380 | 1.6662 | 1.2285 | 1.1122 |
| tryptophan | 0.8662 | 0.6250 | 0.5658 | 0.6780 | 1.3706 | 0.9641 | 0.6277 |
| tyrosine | 0.9029 | 0.5525 | 0.4678 | 0.6916 | 1.7013 | 0.6467 | 0.4219 |
| valine | 1.1763 | 0.7847 | 0.8946 | 0.8523 | 1.1228 | 0.9176 | 0.8548 |
| valine-d8 | 1.0366 | 1.0664 | 1.0398 | 1.0517 | 0.9720 | 0.9748 | 1.0260 |
| xanthosine | 1.7531 | 0.3739 | 0.2493 | 1.0650 | NA | 0.6786 | NA |
Factors:
| F1 | Sample source:infected RBC (iRBC) | Parasite_type:Dd2 AD7 | Parasite_line:Dd2∆ARG C1 | Timepoint:10 h |
| F2 | Sample source:infected RBC (iRBC) | Parasite_type:Dd2 OD12 | Parasite_line:Dd2∆OAT C1 | Timepoint:10 h |
| F3 | Sample source:infected RBC (iRBC) | Parasite_type:Dd2 WT | Parasite_line:Dd2 | Timepoint:10 h |
| F4 | Sample source:infected RBC (iRBC) | Parasite_type:Dd2 WT | Parasite_line:Dd2 | Timepoint:10h |
| F5 | Sample source:uninfected RBC (uRBC) | Parasite_type:Control | Parasite_line:Control RBCs | Timepoint:0 h |
| F6 | Sample source:uninfected RBC (uRBC) | Parasite_type:Control | Parasite_line:Control RBCs | Timepoint:10 h |
| F7 | Sample source:uninfected RBC (uRBC) | Parasite_type:Control | Parasite_line:Control RBCs | Timepoint:10h |
