Data for (Study ST004240)
(Analysis AN007057)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 |
|---|---|---|---|---|---|
| 1-methyladenosine | NA | NA | NA | NA | NA |
| 1-methylhistamine | 1.4769 | 0.8794 | NA | NA | 0.9406 |
| 1-methylnicotinamide | 0.1049 | 0.1912 | 0.1901 | 0.1459 | 3.5082 |
| 1-pyrroline-5-carboxylase[15]N | NA | NA | NA | NA | NA |
| 1-pyrroline-5-carboxylate | NA | NA | NA | NA | NA |
| 1-pyrroline-5-carboxylate[13]C1[15]N1 | NA | NA | NA | NA | NA |
| 1-pyrroline-5-carboxylate[13]C5 | NA | NA | NA | NA | NA |
| 2-deoxycytidine | 1.1145 | 1.0482 | 1.0287 | 0.8086 | NA |
| 5-adenosylhomocysteine | 0.9860 | 1.1032 | 0.9932 | 0.9176 | NA |
| 5-aminolevulinic acid | NA | NA | NA | 1.0000 | NA |
| 5-hydroxytryptophan | 0.4817 | 0.9251 | 0.8087 | 0.8900 | 1.6045 |
| acetylcholine | 0.7294 | 0.7894 | 0.8405 | 0.8527 | 1.7880 |
| adenosine | 1.2846 | 1.1343 | 1.3091 | 1.0438 | 0.2282 |
| ADMA | 1.4789 | 1.1707 | 1.1596 | 1.0616 | 0.1292 |
| alanine | 0.6639 | 0.7965 | 0.7898 | 0.7536 | 1.9962 |
| allantoin | NA | NA | NA | NA | 1.0000 |
| alpha-glycerophosphocholine | 1.1081 | 1.1322 | 1.0909 | 0.9524 | 0.7164 |
| anserine | NA | NA | NA | NA | NA |
| anthranilic acid | 0.7943 | 1.1527 | 1.1370 | 1.0408 | 0.8502 |
| arginine | 1.5111 | 1.1368 | 1.1239 | 1.0139 | 0.2143 |
| arginine[13]C1[15]N1 | 1.4439 | 1.0607 | 1.0429 | 0.8640 | 0.1769 |
| arginine [13]C5 | NA | NA | NA | NA | NA |
| arginine[15]N | 1.4998 | 1.1350 | 1.1558 | 1.0069 | 0.2025 |
| argininosuccinate | NA | NA | NA | NA | NA |
| asparagine | 0.9118 | 1.1162 | 1.1187 | 1.0593 | 0.7940 |
| aspartate | 1.2781 | 1.2408 | 1.1792 | 1.1118 | 0.1900 |
| beta-alanine | 0.3989 | 0.3770 | 0.4400 | 0.3951 | 1.8822 |
| betaine | 0.4962 | 0.6668 | 0.6989 | 0.6135 | 2.5245 |
| butyrobetaine | NA | NA | NA | NA | NA |
| C10:2 carnitine | NA | NA | NA | NA | NA |
| C10 carnitine | 0.2345 | 0.2481 | 0.2776 | NA | 1.3733 |
| C12:1 carnitine | NA | NA | NA | NA | NA |
| C12 carnitine | 0.3523 | 0.3075 | 0.3441 | 0.2981 | 1.7837 |
| C14:1 carnitine | 0.2999 | 0.3683 | 0.3761 | 0.3389 | 2.3018 |
| C14:2 carnitine | NA | NA | NA | NA | 1.0000 |
| C14 carnitine | 0.3709 | 0.4952 | 0.5163 | 0.4189 | 3.1986 |
| C16 carnitine | 0.3386 | 0.4604 | 0.5000 | 0.4253 | 3.2757 |
| C18:1 carnitine | 0.3152 | 0.4121 | 0.4371 | 0.3528 | 3.4828 |
| C18:2 carnitine | 0.0790 | 0.0993 | 0.1129 | 0.0927 | 4.4626 |
| C18 carnitine | 0.7829 | 0.9317 | 1.0087 | 0.8358 | 1.4408 |
| C20:4 carnitine | 0.1337 | 0.2063 | 0.1824 | 0.1126 | 3.5275 |
| C20 carnitine | 0.5432 | 0.7061 | 0.7325 | 0.5172 | 2.5010 |
| C26 carnitine | 0.2998 | 0.5136 | 0.3488 | 0.3140 | 2.2456 |
| C2 carnitine | 0.3105 | 0.5127 | 0.5684 | 0.4103 | 3.1982 |
| C3 carnitine | 0.1589 | 0.3139 | 0.3320 | 0.2295 | 3.9657 |
| C3-DC-CH3 carnitine | 0.5055 | 0.6901 | 0.7347 | 0.6082 | 2.4614 |
| C4 carnitine | 0.2903 | 0.4259 | 0.4695 | 0.3464 | 3.4679 |
| C4-OH carnitine | 0.5700 | 0.8373 | 0.9388 | 0.6640 | 1.9899 |
| C5:1 carnitine | 0.4130 | 0.6647 | 0.6120 | 0.4455 | 2.5574 |
| C5 carnitine | 0.3491 | 0.6245 | 0.6993 | 0.4853 | 2.8418 |
| C6 carnitine | 0.8161 | 0.9046 | 1.3727 | 0.6690 | 1.3132 |
| C7 carnitine | NA | NA | NA | NA | NA |
| C8 carnitine | NA | NA | NA | NA | NA |
| cAMP | 1.2395 | 1.0203 | 0.8871 | 0.8237 | NA |
| carnitine | 0.2626 | 0.3903 | 0.4341 | 0.2938 | 3.6192 |
| carnosine | 0.9026 | 1.2785 | 1.1135 | 1.1895 | 0.0319 |
| choline | 1.1727 | 0.9312 | 1.0893 | 1.0352 | 0.7715 |
| citrulline | 0.1060 | 0.2169 | 0.2179 | 0.1915 | 4.2676 |
| citrulline[13]C1[15]N1 | NA | NA | NA | NA | NA |
| citrulline[13]C5 | NA | NA | NA | NA | 1.0000 |
| citrulline[15]N | NA | NA | NA | NA | NA |
| cotinine | 0.7220 | 0.6516 | 1.4533 | 1.3556 | 0.8175 |
| creatine | 0.2680 | 0.4714 | 0.4887 | 0.3963 | 3.3755 |
| creatinine | 0.0190 | 0.0225 | 0.0290 | 0.0232 | 4.9063 |
| cytosine | 1.4942 | 1.2399 | 1.2230 | 1.0334 | 0.0094 |
| dimethylglycine | 0.8267 | 0.7466 | 0.7470 | 0.7214 | 1.9583 |
| GABA | 1.6669 | 0.9841 | 0.9922 | 0.8517 | 0.0103 |
| glucose | NA | NA | NA | NA | NA |
| glutamate | 1.6955 | 1.1168 | 1.1134 | 1.0140 | 0.0603 |
| glutamate[13]C3[15]N1 | 0.9788 | 1.1994 | 1.0284 | 0.9522 | 0.8709 |
| glutamate[13]C5 | 1.1183 | 0.9500 | 0.9356 | 0.9954 | NA |
| glutamate[15]N | 1.4180 | 0.7887 | 0.8188 | 0.7561 | NA |
| glutamine | 0.6078 | 0.9532 | 1.0284 | 0.9442 | 1.4665 |
| glutamine[13]C1[15]N1 | NA | NA | NA | NA | NA |
| glutamine[13]C5 | NA | NA | NA | NA | NA |
| glutamine[15]N | 0.5757 | 0.9352 | 0.9756 | 0.8743 | 1.6391 |
| glycine | 0.6260 | 0.7756 | 0.7562 | 0.7462 | 2.0960 |
| histamine | 1.3427 | 0.9504 | 1.0371 | 0.9705 | 0.6393 |
| histidine | 1.1847 | 1.0673 | 1.1537 | 1.1437 | 0.4506 |
| homocysteine | 1.0425 | 1.0264 | 1.0807 | 0.8094 | NA |
| isoleucine | 0.4557 | 0.7854 | 0.8055 | 0.7919 | 2.1614 |
| kynurenic acid | NA | NA | NA | NA | NA |
| leucine | 0.5796 | 1.1213 | 1.0889 | 1.0614 | 1.1488 |
| lysine | 1.3282 | 1.2597 | 1.2182 | 0.9884 | 0.2055 |
| methionine | 0.5080 | 0.6612 | 0.7024 | 0.6729 | 2.4555 |
| methionine sulfoxide | 0.6159 | 0.9657 | 1.0046 | 0.9735 | 1.4403 |
| methylthioadenosine | 1.0610 | 1.1748 | 1.0882 | 1.2860 | 0.3900 |
| N-carbamoyl-beta-alanine | NA | NA | NA | 0.7330 | 1.0890 |
| niacinamide | 0.8513 | 1.2902 | 1.4584 | 0.9428 | 0.4573 |
| NMMA | 1.4152 | 1.2456 | 1.2549 | 0.9894 | 0.0949 |
| ornithine | 0.8063 | 0.8864 | 0.9506 | 0.7947 | 1.5621 |
| ornithine[13]C1[15]N1 | NA | NA | NA | NA | NA |
| ornithine [13]C5 | NA | NA | NA | NA | NA |
| ornithine[15]N | NA | NA | NA | NA | NA |
| phenylalanine | 0.7712 | 0.9729 | 0.9614 | 0.9099 | 1.3846 |
| phenylalanine-d8 | 1.0142 | 1.0056 | 1.0418 | 1.0292 | 0.9093 |
| phosphocholine | 1.5112 | 1.1455 | 1.1731 | 1.1622 | 0.0081 |
| phosphoethanolamine | 1.1918 | 1.0723 | 0.9399 | 0.7959 | NA |
| pipecholic acid[13]C1[15]N1 | NA | 1.0013 | NA | 0.9992 | NA |
| pipecolic acid | 0.3475 | 1.6010 | 1.5810 | 1.4368 | 0.0336 |
| pipecolic acid [13]C5 | NA | NA | NA | NA | NA |
| pipecolic acid[15]N | 0.3155 | 1.2377 | 1.2639 | 1.1009 | 0.1229 |
| proline | 0.0703 | 1.5922 | 1.5865 | 1.5059 | 0.2451 |
| proline[13]C1[15]N1 | 0.1756 | 1.5222 | 1.3543 | 2.0606 | 0.3809 |
| proline [13]C5 | NA | NA | NA | NA | NA |
| proline[15]N | 0.0579 | 1.5854 | 1.5865 | 1.5337 | 0.2366 |
| putrescine | 1.3031 | 1.2515 | 1.2663 | 1.1568 | 0.0222 |
| pyroglutamic acid | 0.5706 | 0.9527 | 1.0430 | 0.9438 | 1.4898 |
| s-adenosylmethionine | 1.4761 | 1.2715 | 0.9424 | 1.1260 | 0.1840 |
| sarcosine | 0.2512 | 0.4397 | 0.4612 | 0.3772 | 3.4707 |
| SDMA | 1.3973 | 1.0293 | 1.0876 | 0.9837 | 0.5021 |
| serine | 0.8278 | 1.0686 | 1.0297 | 0.9721 | 1.1018 |
| spermidine | 1.2472 | 1.1598 | 1.1902 | 1.1488 | 0.2540 |
| taurine | 0.0936 | 0.1438 | 0.1530 | 0.1279 | 4.4817 |
| thiamine | 1.4189 | 1.2390 | 1.2523 | 1.0837 | 0.0061 |
| threonine | 0.7661 | 1.0925 | 1.0655 | 1.0289 | 1.0469 |
| thymidine | NA | NA | NA | NA | NA |
| trans-hydroxyproline | NA | NA | NA | NA | NA |
| trans-hydroxyproline[13]C1[15]N1 | 0.8767 | 1.1924 | 1.0224 | 1.0898 | 0.8658 |
| trans-hydroxyproline [13]C5 | NA | NA | NA | NA | NA |
| trans-hydroxyproline[15]N | 0.9104 | 1.1184 | 1.1210 | 1.0580 | 0.7922 |
| trimethylamine-N-oxide | 0.1068 | 0.0691 | 0.0731 | 0.0672 | 4.0642 |
| tryptophan | 0.5428 | 0.7376 | 0.7845 | 0.7364 | 2.1986 |
| tyrosine | 0.6454 | 0.9227 | 0.9420 | 0.8572 | 1.6328 |
| valine | 0.7475 | 1.0123 | 0.9909 | 0.9755 | 1.2738 |
| valine-d8 | 0.9978 | 1.0038 | 1.0274 | 1.0209 | 0.9502 |
| xanthosine | 1.1301 | 0.6231 | 1.3706 | 0.9378 | NA |
Factors:
| F1 | Sample source:infected RBC (iRBC) | Parasite_type:PF Dd2 iRBC | Parasite_line:Dd2 |
| F2 | Sample source:infected RBC (iRBC) | Parasite_type:PF MFR-4 KO iRBC Clone 1 | Parasite_line:Dd2ΔApiAT2 Clone 1 |
| F3 | Sample source:infected RBC (iRBC) | Parasite_type:PF MFR-4 KO iRBC Clone 2 | Parasite_line:Dd2ΔApiAT2 Clone 2 |
| F4 | Sample source:infected RBC (iRBC) | Parasite_type:PF MFR-4 KO iRBC Clone 3 | Parasite_line:Dd2ΔApiAT2 Clone 3 |
| F5 | Sample source:uninfected RBC (uRBC) | Parasite_type:uRBC | Parasite_line:Control RBCs |
