Data for (Study ST004244)
(Analysis AN007065)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| 1-methyladenosine | NA | NA | NA | NA | NA | NA |
| 1-methylhistamine | NA | NA | NA | NA | NA | NA |
| 1-methylnicotinamide | 0.4911 | 0.7969 | 0.4214 | 0.4014 | 0.4948 | 3.3943 |
| 1-pyrroline-5-carboxylase[15]N | NA | NA | NA | NA | NA | NA |
| 1-pyrroline-5-carboxylate | NA | NA | NA | NA | NA | NA |
| 1-pyrroline-5-carboxylate[13]C1[15]N1 | NA | NA | NA | NA | NA | NA |
| 1-pyrroline-5-carboxylate[13]C5 | NA | NA | NA | NA | NA | NA |
| 2-deoxycytidine | 1.0283 | 1.0441 | 0.9941 | 0.8086 | 1.1249 | NA |
| 5-adenosylhomocysteine | 0.9725 | 1.1858 | 1.0008 | 0.8606 | 1.1369 | 0.0605 |
| 5-aminolevulinic acid | NA | NA | NA | NA | NA | NA |
| 5-hydroxytryptophan | 0.0317 | 0.0582 | NA | 0.0230 | NA | 1.4812 |
| acetylcholine | 1.3581 | 1.7957 | 0.7889 | 0.5277 | 0.2909 | 0.6618 |
| adenosine | 0.9680 | 1.0663 | 0.8841 | 1.0004 | 1.2577 | 0.8235 |
| ADMA | 1.1998 | 1.3241 | 1.3353 | 1.0495 | 1.0867 | 0.0045 |
| alanine | 0.3497 | 0.4009 | 0.3504 | 0.3415 | 0.3138 | 4.1354 |
| allantoin | NA | NA | NA | NA | NA | NA |
| alpha-glycerophosphocholine | 0.4455 | 0.4598 | 0.4636 | 0.3970 | 0.4171 | 3.8171 |
| anserine | NA | NA | NA | NA | NA | 1.0000 |
| anthranilic acid | 1.1129 | 0.9836 | 0.8011 | 0.7997 | 1.0324 | 1.3105 |
| arginine | 1.1201 | 1.7099 | 1.1022 | 0.9221 | 0.9001 | 0.2456 |
| arginine[13]C1[15]N1 | 1.0615 | 0.9969 | 0.9677 | 0.8557 | 0.8809 | 1.2373 |
| arginine [13]C5 | NA | NA | NA | NA | NA | NA |
| arginine[15]N | 1.0807 | 1.2228 | 1.0092 | 0.8677 | 0.8891 | 0.9305 |
| argininosuccinate | NA | NA | NA | NA | NA | NA |
| asparagine | 0.4802 | 0.5048 | 0.4903 | 0.4444 | 0.4334 | 3.6470 |
| aspartate | 0.5466 | 0.6717 | 0.5305 | 0.5028 | 0.5054 | 3.2429 |
| beta-alanine | 0.3796 | 0.4189 | 0.3431 | 0.3647 | 0.3307 | 4.1630 |
| betaine | 0.3773 | 0.3649 | 0.3774 | 0.3857 | 0.3724 | 4.1224 |
| butyrobetaine | NA | NA | NA | NA | NA | NA |
| C10:2 carnitine | NA | NA | NA | NA | NA | NA |
| C10 carnitine | NA | NA | NA | NA | NA | NA |
| C12:1 carnitine | NA | NA | NA | NA | NA | 1.0000 |
| C12 carnitine | NA | NA | NA | NA | NA | 1.0000 |
| C14:1 carnitine | NA | NA | NA | NA | NA | 1.0000 |
| C14:2 carnitine | NA | NA | NA | NA | NA | 1.0000 |
| C14 carnitine | 0.0070 | 0.0050 | 0.0083 | 0.0101 | 0.0113 | 2.1568 |
| C16 carnitine | 0.0264 | 0.0215 | 0.0270 | 0.0329 | 0.0265 | 5.8658 |
| C18:1 carnitine | 0.0771 | 0.0649 | 0.0815 | 0.1000 | 0.0746 | 5.6019 |
| C18:2 carnitine | NA | NA | 0.0077 | 0.0087 | 0.0085 | 1.8263 |
| C18 carnitine | 0.2120 | 0.1889 | 0.2116 | 0.2246 | 0.2111 | 4.9517 |
| C20:4 carnitine | 0.0778 | 0.0679 | 0.0597 | 0.0981 | 0.0828 | 3.4602 |
| C20 carnitine | 0.5243 | 0.5174 | 0.5215 | 0.5015 | 0.5249 | 3.4104 |
| C26 carnitine | 0.5454 | 0.5914 | 0.5825 | 0.4768 | 0.5180 | 3.2859 |
| C2 carnitine | 0.2890 | 0.2325 | 0.2936 | 0.3520 | 0.2771 | 4.5558 |
| C3 carnitine | 0.3000 | 0.2299 | 0.3013 | 0.3708 | 0.2897 | 4.5083 |
| C3-DC-CH3 carnitine | 0.1688 | 0.1925 | 0.1747 | 0.1746 | 0.1596 | 4.3059 |
| C4 carnitine | 0.3302 | 0.2945 | 0.2749 | 0.3300 | 0.2561 | 2.7636 |
| C4-OH carnitine | 0.5104 | 0.4304 | 0.5435 | 0.5315 | 0.5185 | 2.5467 |
| C5:1 carnitine | NA | NA | NA | NA | NA | 1.0000 |
| C5 carnitine | 0.4690 | 0.5104 | 0.4483 | 0.5470 | 0.4893 | 3.5360 |
| C6 carnitine | NA | NA | NA | NA | NA | NA |
| C7 carnitine | NA | NA | NA | NA | NA | 1.0000 |
| C8 carnitine | NA | NA | NA | NA | NA | NA |
| cAMP | 0.7556 | 1.0180 | 0.9777 | 1.1463 | 0.9056 | 1.2498 |
| carnitine | 0.5220 | 0.4269 | 0.5456 | 0.6305 | 0.4811 | 3.3939 |
| carnosine | 0.8825 | 0.8868 | 0.9803 | 0.9271 | 0.8098 | 1.4818 |
| choline | 0.6828 | 0.6778 | 0.6752 | 0.5624 | 0.8268 | 2.5751 |
| citrulline | 0.4551 | 0.6687 | 0.3698 | 0.3900 | 0.3444 | 3.7720 |
| citrulline[13]C1[15]N1 | NA | NA | NA | NA | NA | NA |
| citrulline[13]C5 | NA | NA | NA | NA | NA | NA |
| citrulline[15]N | NA | NA | NA | NA | NA | NA |
| cotinine | 0.9240 | 1.0721 | 1.8634 | 0.7172 | 0.8628 | 0.9791 |
| creatine | 0.2197 | 0.1873 | 0.2382 | 0.2637 | 0.2046 | 4.8864 |
| creatinine | 0.3171 | 0.3389 | 0.3421 | 0.3908 | 0.3130 | 4.2981 |
| cytosine | 1.2665 | 1.2966 | 1.1879 | 0.9246 | 1.2097 | 0.1147 |
| dimethylglycine | 1.0665 | 1.1490 | 0.9947 | 0.9522 | 0.9679 | 0.8697 |
| GABA | NA | NA | NA | NA | NA | NA |
| glucose | NA | NA | NA | NA | NA | NA |
| glutamate | 0.3367 | 0.5167 | 0.3205 | 0.3110 | 0.2977 | 4.2175 |
| glutamate[13]C3[15]N1 | NA | NA | NA | NA | NA | NA |
| glutamate[13]C5 | NA | NA | NA | NA | NA | NA |
| glutamate[15]N | NA | NA | NA | NA | NA | 1.0000 |
| glutamine | 0.1432 | 0.1475 | 0.1455 | 0.1612 | 0.1326 | 5.2700 |
| glutamine[13]C1[15]N1 | NA | NA | NA | NA | NA | NA |
| glutamine[13]C5 | 0.2611 | 0.2249 | 0.2392 | 0.2319 | 0.1997 | 4.8432 |
| glutamine[15]N | NA | NA | NA | NA | NA | 1.0000 |
| glycine | 0.2160 | 0.2627 | 0.2516 | 0.2178 | 0.1668 | 3.8492 |
| histamine | 0.9529 | 1.2222 | 0.9030 | 0.7423 | 0.8530 | 1.6375 |
| histidine | 0.5154 | 0.6131 | 0.5236 | 0.4885 | 0.4539 | 3.4056 |
| homocysteine | NA | NA | NA | NA | NA | NA |
| isoleucine | 0.1780 | 0.1960 | 0.1826 | 0.1912 | 0.1427 | 5.1095 |
| kynurenic acid | 1.0072 | 1.2634 | 1.0469 | 0.9357 | 0.9846 | 0.7622 |
| leucine | 0.3214 | 0.3452 | 0.3244 | 0.3038 | 0.1469 | 4.5582 |
| lysine | 1.2244 | 1.2767 | 1.2828 | 1.0931 | 1.0134 | 0.1096 |
| methionine | 0.1093 | 0.1191 | 0.1170 | 0.1237 | 0.0982 | 5.4328 |
| methionine sulfoxide | 0.2673 | 0.2903 | 0.2517 | 0.2693 | 0.2303 | 4.6912 |
| methylthioadenosine | 1.1794 | 1.1319 | 1.1465 | 1.2328 | 1.1567 | 0.1527 |
| N-carbamoyl-beta-alanine | NA | NA | NA | NA | NA | NA |
| niacinamide | 0.8495 | 0.7476 | 0.7780 | 0.6786 | 0.8037 | 2.1425 |
| NMMA | 1.0863 | 1.1817 | 1.1383 | 0.9386 | 0.9835 | 0.0148 |
| ornithine | 1.1839 | 1.4205 | 1.2376 | 1.0416 | 1.0450 | 0.0713 |
| ornithine[13]C1[15]N1 | 1.1942 | 1.1340 | 1.1823 | 1.0155 | 1.0615 | 0.4125 |
| ornithine [13]C5 | NA | NA | NA | NA | NA | NA |
| ornithine[15]N | 1.2155 | 1.2509 | 1.2191 | 1.0219 | 1.0509 | 0.2417 |
| phenylalanine | 0.2000 | 0.2151 | 0.2062 | 0.2144 | 0.1774 | 4.9869 |
| phenylalanine-d8 | 1.0349 | 0.9790 | 1.0772 | 0.9690 | 1.0166 | 0.9233 |
| phosphocholine | 1.1686 | 1.3456 | 1.1890 | 0.9949 | 1.2971 | 0.0049 |
| phosphoethanolamine | 1.0305 | 1.0833 | 1.0167 | 0.8209 | 1.0486 | NA |
| pipecholic acid[13]C1[15]N1 | NA | NA | NA | NA | NA | NA |
| pipecolic acid | 0.5898 | 0.6630 | 0.7129 | 0.6985 | 0.3760 | 2.3358 |
| pipecolic acid [13]C5 | NA | NA | NA | NA | NA | NA |
| pipecolic acid[15]N | NA | NA | NA | NA | NA | NA |
| proline | 1.1592 | 1.2617 | 1.1778 | 0.9891 | 0.0980 | 1.3142 |
| proline[13]C1[15]N1 | 0.0832 | 0.1189 | NA | NA | NA | 1.2997 |
| proline [13]C5 | NA | NA | NA | NA | NA | NA |
| proline[15]N | 0.2470 | 0.2369 | 0.2489 | 0.2425 | 0.1164 | 4.9084 |
| putrescine | 1.2741 | 1.2204 | 1.2359 | 1.1304 | 1.1334 | 0.0058 |
| pyroglutamic acid | 0.1468 | 0.1562 | 0.1543 | 0.1628 | 0.1282 | 5.2517 |
| s-adenosylmethionine | 1.2207 | 1.3824 | 1.1991 | 0.9565 | 1.1848 | 0.0565 |
| sarcosine | NA | NA | NA | NA | NA | NA |
| SDMA | NA | NA | NA | NA | NA | NA |
| serine | 0.4181 | 0.4883 | 0.4035 | 0.4044 | 0.3858 | 3.8999 |
| spermidine | 1.1810 | 1.2280 | 1.1484 | 0.9814 | 1.1209 | 0.0105 |
| taurine | 0.5494 | 0.6694 | 0.6096 | 0.6183 | 0.5524 | 3.0008 |
| thiamine | 0.9973 | 1.0773 | 1.0449 | 0.8805 | 1.0132 | 0.9868 |
| threonine | 0.7243 | 0.7551 | 0.7079 | 0.6499 | 0.5535 | 2.6093 |
| thymidine | 0.7994 | 1.0953 | 0.6195 | 1.4404 | 1.2391 | NA |
| trans-hydroxyproline | 0.3707 | 0.3787 | 0.3656 | 0.3545 | 0.2754 | 4.2551 |
| trans-hydroxyproline[13]C1[15]N1 | NA | NA | NA | NA | NA | NA |
| trans-hydroxyproline [13]C5 | NA | NA | NA | NA | NA | NA |
| trans-hydroxyproline[15]N | NA | NA | NA | NA | NA | NA |
| trimethylamine-N-oxide | 1.0173 | 1.1977 | 1.0291 | 1.0423 | 1.1283 | 0.5853 |
| tryptophan | 0.2768 | 0.3321 | 0.2970 | 0.3004 | 0.2297 | 4.5640 |
| tyrosine | 0.3266 | 0.3667 | 0.3505 | 0.3221 | 0.2694 | 4.3648 |
| valine | 0.3686 | 0.3895 | 0.3844 | 0.3666 | 0.3526 | 4.1383 |
| valine-d8 | 0.9889 | 0.9810 | 1.0495 | 0.9812 | 1.0368 | 0.9626 |
| xanthosine | 1.1483 | 1.0308 | 0.9574 | 0.9670 | 1.1511 | 0.3236 |
Factors:
| F1 | Sample source:infected RBC (iRBC) | Parasite_type:del OAT 6491 bulk | Parasite_line:Dd2∆OATAPR2 bulk | Timepoint:10 h |
| F2 | Sample source:infected RBC (iRBC) | Parasite_type:del OAT D12 clone A6 | Parasite_line:Dd2∆OATAPR2 clone 2 | Timepoint:10 h |
| F3 | Sample source:infected RBC (iRBC) | Parasite_type:del OAT D12 clone B9 | Parasite_line:Dd2∆OATAPR2 clone 1 | Timepoint:10 h |
| F4 | Sample source:infected RBC (iRBC) | Parasite_type:del OAT D12 clone F7 | Parasite_line:Dd2∆OATAPR2 clone 3 | Timepoint:10 h |
| F5 | Sample source:infected RBC (iRBC) | Parasite_type:del OAT D12 | Parasite_line:Dd2∆OAT C1 | Timepoint:10 h |
| F6 | Sample source:uninfected RBC (uRBC) | Parasite_type:uninfected RBCs | Parasite_line:Control RBCs | Timepoint:10 h |
