Data for Identification of altered metabolic pathways in Alzheimer's disease, mild cognitive impairment and cognitively normals using Metabolomics (CSF) (Study ST000047)

(Analysis AN000082)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3
1-(6-[5]-ladderane-hexanoyl)-2-(8-[3]-ladderane-octanyl)-sn-glycerophosphoethanolamine 1.1503 0.9947 0.8546
1-(8-[3]-ladderane-octanoyl-2-(8-[3]-ladderane-octanyl)-sn-glycerol 1.0370 0.9954 0.9792
1alpha,25-dihydroxy-11alpha-phenylvitaminD3/1alpha,25-dihydroxy-11alpha-phenylcholecalciferol 0.9907 1.0172 0.9921
1-Aminocyclopropane-1-carboxylicacid 0.9930 1.0049 1.0002
1-Hydroxy-2-naphthoicacid 0.9852 1.0647 0.9463
1-Hydroxy-2-naphthoicacid-1.3924078 0.9893 1.0957 0.8831
1-Hydroxy-2-naphthoicacid-1.5557164 1.5929 0.6325 0.3092
1-Hydroxy-2-naphthoicacid-2.9663975 1.0323 0.9715 0.9962
1-Hydroxy-2-naphthoicacid-3.249221 0.9793 1.0669 0.9550
2,3-Dichloro-4-(a-hydroxy-2-thenyl)phenoxyaceticacid 0.9766 1.0033 1.0181
2,3-Dioxogulonicacid 0.9043 1.0295 1.0662
2,4-DINITROPHENOL 1.0475 0.9295 1.0229
2,5-Dimethoxycinnamicacid 0.9584 1.1838 0.9047
2-Amino-3-hydroxy-5-nitrobenzophenone 0.9003 0.9586 1.1204
2-amino-4^-hydroxy-Propiophenone 0.9644 1.0150 1.0206
2-Furoicacid 0.8968 1.0214 1.0818
2-Furoicacid-1.0400704 0.9298 0.5500 1.2745
2-Furoicacid-1.418544 0.9260 0.9207 1.1281
2H-1-Benzopyran-6-aceticacid,7-hydroxy-8-methoxy-2-oxo- 1.1559 1.1204 0.7381
2H-Indol-2-one,4-[2-(dipropylamino)ethyl]-1,3-dihydro-7-hydroxy-glucuronide 0.9687 1.0183 1.0073
2-Hydroxyethanesulfonate 0.9716 1.0077 1.0207
2-Hydroxyethinylestradiol 0.9472 0.9921 1.0607
2-Hydroxyethinylestradiol-10.332443 1.0216 0.9810 0.9975
2-Keto-glutaramicacid 1.0094 1.0364 0.9554
2-Methyl-3-ketovalericacid 1.0156 0.8373 1.1471
2-Methyl-3-ketovalericacid-3.9406526 1.0404 0.7191 1.2418
2-propyl-tridecanoicacid 0.9988 0.9899 1.0113
2-Pyrrolidinone 0.9731 1.0412 0.9868
3-Amino-3-(4-hydroxyphenyl)propanoate 0.8787 0.9282 1.1932
3-(a-Naphthoxy)lacticacid 1.2048 0.7768 0.9616
3-Dehydroquinicacid 1.1133 1.0829 0.7170
3-Deoxy-D-glycero-D-galacto-2-nonulosonicacid 1.0142 0.9818 1.0040
3-(Imidazol-4-yl)-2-oxopropylphosphate 0.7603 1.0874 1.1193
3-Methylpimelicacid 1.1410 0.8883 1.0339
3-Methylsubericacid 1.0234 0.9742 1.0024
4,4-Bis(p-fluorophenyl)butyricacid 1.0727 0.9141 1.0208
4,8-dimethyl-dodecanoicacid 0.9859 0.9962 1.0179
4-Amino-7-chloroquinoline 0.9782 0.9837 1.0387
,4-Dihydroxyphenylpropionicacid 0.9386 0.8900 1.1869
4-Hydroxytacrine 1.1541 0.8781 0.9389
4-Methylumbelliferylbeta-D-glucuronide 0.9632 1.0694 0.8434
5-[2-(hydroxymethyl)-5-methylphenoxy]-2,2-dimethyl-Pentanoicacid(GemfibrozilM4) 1.0557 0.9252 1.0192
5,6-Dihydrouridine 1.0909 0.9319 0.9779
6,7-DICHLORO-3-HYDROXY-2-QUINOXALINECARBOXYLICACID 0.9568 0.8419 1.2177
6b,11b,16a,17a,21-Pentahydroxypregna-1,4-diene-3,20-dione16,17-acetonide 0.9933 1.1012 0.9456
6-Hydroxynicotinicacid 1.0209 1.0081 0.9710
6-Methoxy-2-naphthylaceticacid 1.0506 0.9807 0.9661
7-hydroxy-10E,16-heptadecadien-8-ynoicacid 0.9785 1.0016 1.0198
8-hydroxymianseringlucuronide 0.9253 1.1242 0.9513
9(S)-HODE-d4 0.9916 1.0008 1.0078
Acetazolamide 0.9157 1.0492 0.9667
Acetoaceticacid 0.9618 0.9134 1.1248
Acetoaceticacid-1.2563984 1.1603 0.9837 0.8505
Acetoin 0.9349 1.1659 0.8992
Acetoin-3.5720763 0.9764 1.0066 1.0171
Acetylaminodantrolene 0.9552 1.0661 0.9812
Acipimox 1.1036 0.9563 0.9357
a-hydroxybutyrate 0.8896 1.0849 1.0255
a-hydroxyisovalerate 0.7527 1.0366 1.2106
a-hydroxyisovalerate-3.5743096 1.0451 0.9759 0.9790
AlaPheArg 1.0857 0.9030 1.0105
alpha-hydroxyisobutyrate 0.9995 0.8602 1.1403
alpha-hydroxyisobutyrate-1.2596271 1.0279 1.0532 0.9306
alpha-hydroxyisobutyrate-2.5388858 1.1077 1.0018 0.8904
altretamine 0.8932 1.2054 0.9169
ANABASAMINE 1.0517 0.9675 0.9805
Arginine 1.0436 1.0572 0.9064
AsnGlnGln 0.9492 1.1043 0.9149
AspAsp 1.0679 1.1344 0.7801
AspAsp-0.9946096 0.9145 1.1412 0.9828
AspGlu 1.0173 0.9697 1.0147
Atovaquone 0.9354 1.2882 0.9231
BENZANTHRONE 0.9692 1.1078 0.8937
BENZANTHRONE-2.6784797 0.8768 1.1218 1.0014
BENZANTHRONE-3.2888675 0.9436 1.0911 0.9653
BENZANTHRONE-3.462548 0.9942 0.9976 1.0060
BENZANTHRONE-3.5734656 0.9609 1.0562 0.9829
BENZANTHRONE-3.7885036 0.9259 1.0738 1.0003
beta-Alanine 1.1560 0.6528 1.1095
beta-Alanine-0.95868075 0.9605 1.0937 0.9458
beta-Alanine-2.1040177 0.9692 0.9822 1.0480
beta-D-Glucopyranosiduronicacid,2-(1H-indol-4-yloxy)-1-[[(1-methylethyl)amino]methyl]ethyl 0.8811 1.1779 0.9256
beta-D-Glucopyranosiduronicacid,2-(1H-indol-4-yloxy)-1-[[(1-methylethyl)amino]methyl]ethyl-10.241287 1.1328 0.7634 1.0900
beta-hydroxybutyrate 1.4282 1.1762 0.4409
b-Glucose 0.9025 0.9431 1.1512
Biotinamide 0.9208 0.9895 1.0788
Bromopyruvicacid 1.0081 0.9841 1.0093
B-ureidoisobutyricacid 0.9429 1.1063 0.9508
Ceramide(d18:1/26:1(17Z)) 0.9884 1.0044 1.0062
Cer(d18:0/18:0) 0.8549 0.9770 1.1910
CerP(d18:1/22:0) 1.0855 0.9424 0.9205
Chloralhydrate 1.0052 0.9783 1.0160
Chlorogenicacid 0.9905 0.9693 1.0402
Cilastatin 0.9440 1.0468 1.0092
cis-3-(6-Hydroxy-7-methoxy-5-benzofuranyl)acrylicacid 1.0291 1.4981 0.5789
cis-3-(6-Hydroxy-7-methoxy-5-benzofuranyl)acrylicacid-0.9427811 0.8681 1.2295 0.7816
cis-3-(6-Hydroxy-7-methoxy-5-benzofuranyl)acrylicacid-1.3130308 1.0105 0.9881 1.0014
Citraconicacid 0.9545 0.4940 1.4507
clavuloneI 1.0088 1.0124 0.9813
Creatine 0.9661 1.0545 0.9794
Creatinine 1.0414 0.9946 0.9640
cysteine 0.7880 1.0912 1.1115
D1-2-Hydroxymethylethisterone 1.0617 0.8824 1.0559
D1-2-Hydroxymethylethisterone-11.336955 0.9291 1.3008 0.8007
D1-2-Hydroxymethylethisterone-11.481426 1.0420 0.9204 1.0376
D-Biotin 0.9419 1.0197 1.0285
Dehydroascorbicacid 0.9070 0.9938 1.0993
Deoxyribose 1.0814 0.9798 0.9368
Deoxyribose-2.4220703 0.9587 1.0291 1.0128
Deoxyuridinemonophosphate(dUMP) 0.9818 1.0458 0.9739
D-Homoserine 1.0057 0.9636 1.0307
Diacetyl 0.9225 1.0421 1.0367
Diacetyl-1.0001581 1.0899 0.9434 0.9406
Diacetyl-1.2288649 0.9764 1.1967 0.8269
DICHLORODIPHENYLTRICHLOROETHANE 1.0819 1.1421 0.7423
Dihydromyricetin 1.0822 0.9520 0.9658
Dihydroxyacetone(glycerone) 0.9867 0.9878 1.0255
Dihydroxyacetone(glycerone)-1.2817216 1.0074 1.0481 0.9445
Dihydroxyacetone(glycerone)-1.3654007 0.7164 1.1143 1.1478
Dihydroxyacetone(glycerone)-1.4241207 0.9821 0.8002 1.2375
Diphenylmethylphosphineoxide 0.8293 1.1613 1.0158
Ellagicacid 1.0652 0.9857 0.9509
Embelin 0.9969 1.0041 0.9990
Embelin-10.833458 0.9936 0.9870 1.0194
Embelin-14.146105 1.0166 0.9864 0.9970
Embelin-9.5837 1.0175 1.0021 0.9804
EPIAFZELECHIN(2R,3R)(-) 0.9447 1.0804 0.9749
Erythromycin 0.9428 1.0508 0.9988
ethylmalonicacid 0.9929 1.1125 0.8415
Fenofibrate 1.0162 1.0318 0.9520
Fenoterolsulfate 1.0050 0.9385 1.0564
Furan2,5-dicarboxylicacid 0.9108 1.0069 1.0734
Glucoheptonicacid 1.1366 1.1050 0.7331
Glutaconicacid 0.8686 1.0247 1.1104
Glutaconicacid-1.257499 0.9281 1.0028 1.0691
Glutaconicacid-1.6951267 0.8979 1.1084 0.9903
Glutaconicacid-1.7573386 0.8765 1.1002 1.0409
Glutamate 0.9341 1.0146 1.0513
Glutamicacidg-semialdehyde 0.9070 1.1418 0.9702
Glutaral(Glutaraldehyde) 0.9160 1.0470 1.0370
glyceraldehyde 1.0125 0.9799 1.0050
Glycericacid 0.9478 1.0939 0.9583
Glycine 0.9465 1.0293 1.0242
Glycolaldehyde 0.9688 1.0445 0.9867
Glycolicacid 0.9553 1.0539 0.9907
Glyoxylicacid 0.9633 1.0272 1.0088
GlyTyrAsn 1.0285 1.0580 0.9187
GPEtn(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) 1.0351 1.0304 0.9324
GPSer(18:1(9Z)/18:2(9Z,12Z))[U] 0.9118 1.1183 1.0308
Gulonicacid 1.0499 0.9478 1.0005
Gummiferol 0.8547 1.2562 0.9123
Histidine 0.9992 0.9746 1.0262
Hydroxythiopental 1.0260 1.0256 0.9492
Imidazolone 0.5568 1.2149 0.8668
Iridotrialglucoside 1.1004 0.9958 0.8633
Isoacitretin 0.7715 1.2517 0.9106
Isoacitretin-10.681391 1.0617 0.9244 1.0139
Isoacitretin-10.914413 1.0387 0.9589 1.0024
isoamylnitrite 0.9535 0.9693 1.0773
ISOEUGENITOL 0.8919 0.6470 1.5760
ISOLIQUIRITIGENIN 0.9634 1.0384 0.9982
ISOPIMPINELLIN 0.9183 0.9604 1.1038
KOBUSONE 0.9903 1.0198 0.9898
L-2-Aminoadipicacid 0.8788 0.9862 1.0937
Lactaldehyde 0.9079 1.0444 1.0204
Lactaldehyde-2.5392027 0.8981 1.1154 0.9866
L-arabitol 0.9777 1.0215 1.0008
L-Asparticacidb-semialdehyde 0.9039 1.0467 1.0568
L-Asparticacidb-semialdehyde-1.218115 1.0268 0.9870 1.0016
Lauricacid 0.9926 0.9925 1.0149
Leucine 0.9715 0.9373 1.0912
L-gamma-Cyano-gamma-aminobutyricacid 1.0067 0.9698 1.0248
Lipoamide 0.8895 0.6860 1.4939
Lipoamide-0.91015834 1.0443 1.0069 0.9364
L-Serine 0.9547 1.0010 1.0480
LysTrpArg 1.0282 0.9664 1.0063
LysTrpArg-12.785133 0.9579 1.0169 1.0261
Mannitol 0.9812 1.0245 0.9943
Melphalan 1.0095 1.1827 0.7852
MetGluLys 0.9495 1.0480 1.0025
MethoxsalenMetabolite 0.7604 0.7530 1.4266
methyl8-[2-(2-formyl-vinyl)-3-hydroxy-5-oxo-cyclopentyl]-octanoate 1.0170 0.9789 1.0011
Methylglyoxal 1.0073 1.0863 0.9064
Methylglyoxal-1.0395479 0.8130 0.9668 1.1698
Methylglyoxal-1.2867774 0.9937 1.0631 0.9432
MetLysSer 0.9596 1.0309 1.0095
Metyrosine 0.9701 1.0177 1.0121
m-Salicylicacid 1.0800 1.0131 0.9251
N-Acetyl-a-neuraminicacid 0.9487 1.0276 1.0220
N-Acetylgalactosamine4-sulphate 0.9298 1.0379 1.0374
N-Acetyl-L-Histidine 0.8929 1.1461 0.9566
N-Didesethylquinagolide 1.1639 0.6725 1.1554
N-gamma-Acetyl-N-2-formyl-5-methoxykynurenamine 1.1932 0.8776 0.9320
N-Lignoceroylsphingosine 1.0347 1.0105 0.9532
ORTHOTHYMOTINICACID 0.9885 0.9981 1.0130
OSTHOL 1.2635 0.8344 0.9509
Oxalaceticacid 0.9241 1.0170 1.0589
Oxaloglutarate 0.9678 1.0178 1.0144
Oxipurinol 0.8936 0.9765 1.1299
Oxipurinol-1.6297603 1.0306 1.0291 0.9334
OXOLINICACID 1.0750 0.9994 0.9230
PantothenicAcid 0.8741 0.9713 1.1504
Parahydroxyphenylaceticacid 0.9224 1.0748 1.0053
PenicillinG 0.8924 1.2064 0.9012
Phenol 0.9903 1.0901 0.9385
Phenol-3.8949444 1.3127 0.8220 0.6193
Phenylsulfate 0.9856 1.0238 0.9905
Phenylsulfate-3.894887 1.5544 0.8851 0.6306
Phosphatidylglycerol 0.9851 0.9422 1.0837
p-HYDROXYCINNAMALDEHYDE 0.9813 0.9838 1.0349
Procarbazine 0.9910 1.0330 0.9751
ProHisTrp 0.9548 1.1780 0.9257
ProLysPro 0.8599 1.0464 1.0593
Propionylglycinemethylester 1.0026 1.0269 0.9818
PROTOVERATRINEA 0.8990 1.0365 1.0610
Pseudouridine 1.0750 0.9714 0.9537
PURPUROGALLIN 1.1480 1.1453 0.7070
Pyrocatechol 0.8657 0.9698 1.1741
Pyrocatecholsulfate 0.9233 1.0423 1.0295
PYROGALLIN 1.1296 1.1064 0.6342
Pyroglutamicacid 1.0183 1.1426 0.8305
Pyroglutamicacid-1.3865262 0.5856 1.0441 1.3546
Pyroglutamicacid-1.5248408 0.8241 1.2340 0.9419
Pyruvicacid 0.8183 1.5849 0.5908
Pyruvicacid-1.0026177 0.9759 0.4759 1.4485
Pyruvicacid-1.127027 1.1391 0.4580 1.0039
Pyruvicacid-1.2604657 0.9562 0.9964 1.0474
Pyruvicacid-3.0151846 0.8880 1.0814 1.0616
Quinicacid 1.0022 0.8759 1.0980
(R)-3-Methyl-2-oxobutanoate 0.8436 1.0679 0.9602
Ribonicacid 0.9216 0.9683 1.1101
Ribonicacid-3.0933578 1.1755 0.7428 1.0454
Ribulose 0.9491 0.9453 1.1039
(S)-2-Hydroxyglutarate 1.3631 0.8085 0.9450
Sedoheptulose 1.0125 0.9764 1.0261
SM(d18:0/16:0) 1.0301 1.0752 0.8583
S-Succinyldihydrolipoamide 1.0818 1.1213 0.7951
Succinicanhydride 0.9150 1.0307 1.0543
Succinicanhydride-1.0287684 1.1000 0.3715 1.5536
TacrolimusmetaboliteM-IV 0.8398 1.0696 1.0165
Taurine 1.0768 0.8434 1.0384
Tetrahydrofuran 1.0504 1.0005 0.9491
threo-Isocitricacid 0.9743 1.0109 1.0145
threo-Isocitricacid-1.0347548 0.9959 0.5348 1.4693
Threonate 0.9185 1.0922 0.9950
TrpProHis 0.9518 0.9825 1.0561
TrpProHis-10.745563 1.1655 0.9646 0.8839
Tryptophan 0.9816 0.9355 1.0829
Uricacid 1.0537 0.9627 0.9836
Zalcitabine 1.0525 0.8681 1.0926
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Factors:

F1Cognitive Status:AD
F2Cognitive Status:CN
F3Cognitive Status:MCI
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