Data for Use of Aspartate Dehydrogenase by cancer cells (Study ST000154)
(Analysis AN000245)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 |
|---|---|---|---|---|---|---|---|---|---|
| 2 or 3-phosphoglycerate_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 2 or 3-phosphoglycerate_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 2 or 3-phosphoglycerate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 2 or 3-phosphoglycerate_2PG/3PG | 0.2202 | 1.5230 | 1.2763 | 0.2415 | 0.2596 | 0.1505 | 0.2013 | 1.8010 | 3.0434 |
| 3-Glycerophosphate | 0.6768 | 0.7606 | 0.5202 | 0.0812 | 0.0239 | 0.0010 | 1.2425 | 2.3880 | 3.3060 |
| 3-Glycerophosphate_13C_1 | 2.7069 | 0.0192 | 0.0164 | 0.4897 | 0.0260 | 0.0037 | 4.3198 | 0.0507 | 0.0583 |
| 3-Glycerophosphate_13C_2 | 2.9213 | 0.0128 | 0.0230 | 0.5374 | 0.0475 | 0.0438 | 5.0662 | 0.0086 | 0.0103 |
| 3-Glycerophosphate_13C_3 | 0.9859 | NA | NA | NA | NA | NA | 1.0141 | NA | NA |
| 3-phosphoglyceraldehyde | NA | 0.8144 | 0.4878 | 0.3872 | NA | NA | NA | 1.2422 | 1.4273 |
| 3-phosphoglyceraldehyde_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3-phosphoglyceraldehyde_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3-phosphoglyceraldehyde_13C_3 | 0.4746 | 0.3433 | NA | 0.3275 | NA | NA | NA | 1.5210 | 2.3256 |
| 6-Phosphogluconate | 0.8377 | 2.0052 | 1.7634 | 0.3752 | 0.4000 | 0.6684 | 0.5716 | 0.8039 | 1.5746 |
| 6-Phosphogluconate_13C_1 | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA |
| 6-Phosphogluconate_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 6-Phosphogluconate_13C_3 | 0.7247 | NA | 2.4221 | NA | NA | NA | 0.4392 | NA | 1.5254 |
| 6-Phosphogluconate_13C_4 | 0.7247 | NA | 2.4221 | NA | NA | NA | 0.4392 | NA | 1.5254 |
| 6-Phosphogluconate_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 6-Phosphogluconate_13C_6 | 1.0041 | NA | 1.1856 | NA | NA | NA | 0.8059 | NA | 1.1901 |
| Acetyl-CoA | 0.8337 | 1.6771 | 1.0890 | 0.6279 | 0.7018 | 0.7802 | 0.4268 | 1.7626 | 1.1010 |
| Acetyl-CoA_13C_1 | 0.9229 | 1.6910 | 0.0958 | 0.6291 | 1.4919 | 0.1016 | 1.0336 | 1.9258 | 0.2080 |
| Acetyl-CoA_13C_2 | 0.7004 | 0.3159 | 2.0123 | 0.2100 | 0.4598 | 1.7186 | 0.5312 | 0.2979 | 2.7539 |
| Adenosine diphosphate | 3.3450 | 0.4431 | 0.2456 | 1.2242 | 0.3115 | 0.3533 | 1.7610 | 0.7058 | 0.6104 |
| Adenosine diphosphate_13C_1 | 2.8689 | 0.3337 | 0.0523 | 0.9862 | 0.5369 | 0.0462 | 3.5065 | 0.5850 | 0.0843 |
| Adenosine diphosphate_13C_2 | 2.3554 | 0.1342 | 0.7238 | 0.6341 | 0.2497 | 1.0132 | 2.1532 | 0.1703 | 1.5662 |
| Adenosine diphosphate_13C_3 | 3.2727 | 0.0626 | 0.0628 | 1.1339 | 0.0300 | 0.0409 | 4.2558 | 0.0353 | 0.1060 |
| Adenosine diphosphate_13C_4 | 1.9305 | NA | 0.0108 | 0.4279 | NA | NA | 1.6297 | NA | 0.0124 |
| Adenosine diphosphate_13C_5 | 1.7292 | NA | NA | 0.6629 | NA | NA | 0.6079 | NA | NA |
| Adenosine monophosphate | 3.8829 | 0.3861 | 0.2269 | 0.9621 | 0.3668 | 0.3348 | 1.9368 | 0.5821 | 0.3215 |
| Adenosine monophosphate_13C_1 | 3.3959 | 0.2564 | 0.0222 | 0.6415 | 0.3849 | 0.0362 | 3.7721 | 0.4462 | 0.0445 |
| Adenosine monophosphate_13C_2 | 3.2857 | 0.1170 | 0.5419 | 0.5106 | 0.1662 | 0.6742 | 2.6847 | 0.1521 | 0.8675 |
| Adenosine monophosphate_13C_3 | 3.4883 | 0.0079 | 0.0197 | 0.8610 | 0.0313 | 0.0335 | 4.1914 | 0.0096 | 0.0305 |
| Adenosine monophosphate_13C_4 | 3.4073 | 0.0027 | 0.0022 | 0.3919 | 0.0012 | 0.0111 | 2.5147 | NA | 0.0072 |
| Adenosine monophosphate_13C_5 | 2.3451 | 0.0562 | NA | 0.4093 | NA | NA | 0.8735 | NA | 0.0600 |
| Adenosine triphosphate | 1.4772 | 1.1276 | 0.7358 | 0.5757 | 0.8875 | 0.5461 | 0.7052 | 1.5050 | 1.4399 |
| Adenosine triphosphate_13C_1 | 1.4843 | 1.1895 | 0.1874 | 0.5760 | 1.7052 | 0.1821 | 1.6824 | 1.7200 | 0.2730 |
| Adenosine triphosphate_13C_2 | 0.7393 | 0.3149 | 1.7340 | 0.2252 | 0.4396 | 1.6365 | 0.5759 | 0.3388 | 2.9959 |
| Adenosine triphosphate_13C_3 | 2.9316 | 0.1128 | 0.2128 | 1.1699 | 0.2378 | 0.1415 | 3.3819 | 0.1022 | 0.4104 |
| Adenosine triphosphate_13C_4 | 2.4252 | 0.0350 | 0.0947 | 0.5928 | NA | 0.0337 | 1.8472 | NA | 0.1035 |
| Adenosine triphosphate_13C_5 | 2.0052 | NA | NA | 0.6568 | NA | NA | 0.6389 | 0.0974 | NA |
| Aspartate | 1.4919 | 1.5619 | 3.3844 | 0.7439 | 0.0859 | 0.0950 | 0.5601 | 0.5884 | 0.9816 |
| Aspartate_13C_1 | 0.6469 | 3.5305 | 0.0687 | 0.3290 | 3.5124 | 0.0611 | 0.2241 | 1.1782 | 0.0280 |
| Aspartate_13C_2 | 3.6670 | 0.4291 | 0.0481 | 2.0153 | 0.0954 | 0.0675 | 1.2761 | 0.1257 | 0.0010 |
| Aspartate_13C_3 | 3.2162 | 2.0328 | 0.1259 | 1.2967 | 0.1514 | 0.1441 | 1.2801 | 0.2329 | 0.3171 |
| Aspartate_13C_4 | 0.7795 | NA | NA | 0.5324 | NA | NA | 0.2543 | NA | 5.3014 |
| Citrate or Isocitrate | 0.4087 | 2.2026 | 1.7853 | 0.3940 | 0.1288 | 0.1315 | 0.3769 | 1.4676 | 2.1046 |
| Citrate or Isocitrate_13C_1 | 1.9137 | 0.0366 | 0.0897 | 1.8509 | 0.3232 | NA | 2.1522 | 0.0494 | 0.0495 |
| Citrate or Isocitrate_13C_2 | 1.7234 | NA | NA | 3.1118 | 0.0235 | 0.0197 | 1.5295 | NA | NA |
| Citrate or Isocitrate_13C_3 | 2.5735 | 0.0792 | 0.0794 | 2.1450 | 0.3579 | 0.3241 | 2.7970 | 0.1180 | 0.2937 |
| Citrate or Isocitrate_13C_4 | 1.5831 | 0.1667 | NA | 0.9866 | NA | NA | 1.5338 | 0.3546 | 0.0015 |
| Citrate or Isocitrate_13C_5 | 1.2175 | NA | NA | 0.5715 | NA | NA | 1.0682 | NA | NA |
| Citrate or Isocitrate_13C_6 | 1.1529 | 0.9674 | NA | 1.1951 | NA | NA | 0.7804 | NA | 0.6474 |
| Erythrose 4-phosphate | 0.3172 | 1.8064 | 1.3717 | 0.2699 | 0.3688 | 0.7541 | 0.3898 | 1.7907 | 1.9314 |
| Erythrose 4-phosphate_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Erythrose 4-phosphate_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Erythrose 4-phosphate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Erythrose 4-phosphate_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Fructose 1,6-bisphosphate | 0.1456 | 0.6816 | 0.6255 | 0.1754 | 0.4758 | 0.3697 | 0.1070 | 2.3507 | 4.0687 |
| Fructose 1,6-bisphosphate_13C_1 | 0.2720 | 0.2360 | NA | 0.3345 | 2.8978 | 1.3033 | 0.4281 | 0.2289 | 1.4388 |
| Fructose 1,6-bisphosphate_13C_2 | 1.1272 | 0.9327 | 1.0903 | 1.7073 | 0.1803 | 0.1326 | 1.9788 | 0.7492 | 0.8251 |
| Fructose 1,6-bisphosphate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Fructose 1,6-bisphosphate_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Fructose 1,6-bisphosphate_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Fructose 1,6-bisphosphate_13C_6 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Glucose 6-phosphate or fructose-6-phosphate | 0.3978 | 1.0672 | 0.8506 | 0.1875 | 0.1289 | 0.1426 | 0.2627 | 2.0313 | 3.6410 |
| Glucose 6-phosphate or fructose-6-phosphate_13C_1 | 0.4906 | 0.3447 | 0.9892 | 0.6308 | 1.6517 | 1.8206 | 1.9340 | 0.1646 | 0.6772 |
| Glucose 6-phosphate or fructose-6-phosphate_13C_2 | 2.0583 | 0.0556 | 0.0877 | 0.8676 | 0.0557 | 0.0723 | 3.8518 | 0.0270 | 0.0377 |
| Glucose 6-phosphate or fructose-6-phosphate_13C_3 | 0.1402 | NA | NA | 0.1047 | NA | NA | 1.8717 | NA | NA |
| Glucose 6-phosphate or fructose-6-phosphate_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Glucose 6-phosphate or fructose-6-phosphate_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Glucose 6-phosphate or fructose-6-phosphate_13C_6 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Glutamate | 1.6386 | 0.7299 | 1.6321 | 0.5784 | 0.1349 | 0.0888 | 1.5810 | 0.7957 | 1.7276 |
| Glutamate_13C_1 | 0.2044 | 1.9295 | 0.0002 | 0.0607 | 1.9367 | NA | 0.2970 | 1.9049 | NA |
| Glutamate_13C_2 | 2.4184 | 0.0273 | 0.0232 | 0.8703 | 0.0398 | 0.0111 | 2.9634 | 0.0265 | NA |
| Glutamate_13C_3 | 2.0195 | NA | 0.0026 | 0.6864 | NA | 0.0055 | 2.8452 | NA | 0.0044 |
| Glutamate_13C_4 | 1.6247 | 0.0031 | 0.0013 | 0.5532 | 0.0038 | NA | 2.1526 | 0.0003 | NA |
| Glutamate_13C_5 | 1.1530 | NA | NA | 0.3678 | 0.0045 | NA | 1.6003 | NA | NA |
| Lactate | 0.6637 | 1.2293 | 1.0452 | 0.5531 | NA | NA | 0.4984 | 1.5266 | 1.2009 |
| Lactate_13C_1 | 2.2216 | 0.2779 | 0.1598 | 1.2310 | NA | NA | 1.0933 | 0.3332 | 0.8719 |
| Lactate_13C_2 | 1.3626 | NA | NA | 0.8925 | NA | NA | 1.0050 | NA | 0.0047 |
| Lactate_13C_3 | 1.6270 | NA | NA | 0.4753 | NA | NA | 0.3219 | NA | NA |
| Malate | 0.8024 | 1.8369 | 1.3547 | 0.8691 | 0.1023 | 0.0250 | 0.7334 | 1.0449 | 1.3077 |
| Malate_13C_1 | 2.4239 | 0.0033 | 0.1347 | 2.0047 | 0.0836 | 0.2214 | 2.7471 | 0.0340 | 0.0412 |
| Malate_13C_2 | 2.5293 | 0.0053 | 0.0470 | 2.9169 | 0.1257 | 0.0719 | 2.6245 | 0.0077 | 0.0114 |
| Malate_13C_3 | 2.1487 | 0.0099 | NA | 0.8510 | 0.0192 | 0.0235 | 2.2921 | NA | NA |
| Malate_13C_4 | 1.0968 | NA | 0.0362 | 1.2667 | NA | NA | 1.2539 | NA | 0.1116 |
| Malonyl-CoA | 0.7841 | 1.7463 | 1.0902 | 0.2451 | 0.3619 | 0.4381 | 1.5716 | 1.5979 | 1.1648 |
| Malonyl-CoA_13C_1 | 1.0176 | 1.8766 | 0.1235 | 0.3395 | 1.0166 | NA | 0.9432 | 1.7959 | 0.0337 |
| Malonyl-CoA_13C_2 | 0.4518 | 0.0960 | 1.9393 | 3.1754 | 0.0665 | 0.7124 | 0.1271 | 0.1765 | 2.7057 |
| Malonyl-CoA_13C_3 | 0.7739 | 3.5983 | 0.3501 | 0.1698 | NA | 0.1138 | 0.4264 | 2.0857 | NA |
| Nicotinamide Adenine Dinucleotide oxidized | 0.3904 | 1.8020 | 0.7096 | 0.3250 | 1.2494 | 0.9360 | 0.2476 | 2.6531 | 0.6869 |
| Nicotinamide Adenine Dinucleotide oxidized_13C_1 | 0.7774 | 1.4701 | 0.7092 | 0.5105 | 1.1539 | 0.1917 | 0.6093 | 2.3794 | 1.1987 |
| Nicotinamide Adenine Dinucleotide oxidized_13C_2 | 1.1212 | 0.5297 | 1.4311 | 0.5865 | 0.4107 | 1.6147 | 1.0347 | 0.7394 | 1.5320 |
| Nicotinamide Adenine Dinucleotide oxidized_13C_3 | 1.5366 | 0.0367 | 1.5408 | 0.4507 | 0.0552 | 0.0743 | 1.5811 | 0.0586 | 3.6659 |
| Nicotinamide Adenine Dinucleotide oxidized_13C_4 | 3.6356 | 0.0162 | 0.0593 | 1.2894 | 0.0082 | 0.0083 | 3.4839 | 0.0063 | 0.1617 |
| Nicotinamide Adenine Dinucleotide oxidized_13C_5 | 2.2013 | NA | 0.0267 | 0.7046 | NA | NA | 2.3836 | 0.0082 | 0.0143 |
| Nicotinamide Adenine Dinucleotide reduced | 0.2141 | 1.7448 | 0.7598 | 0.1164 | 1.2264 | 0.8179 | 0.2704 | 2.9501 | 0.9001 |
| Nicotinamide Adenine Dinucleotide reduced_13C_1 | 0.4132 | 1.3796 | 0.6966 | 0.2184 | 1.0667 | 0.2103 | 0.6227 | 2.5965 | 1.5328 |
| Nicotinamide Adenine Dinucleotide reduced_13C_2 | 0.6252 | 0.5134 | 1.5035 | 0.2565 | 0.4367 | 1.5872 | 1.1387 | 0.8238 | 2.1149 |
| Nicotinamide Adenine Dinucleotide reduced_13C_3 | 0.7892 | 0.0549 | 1.4895 | 0.3022 | 0.0525 | 0.0598 | 1.5659 | 0.0603 | 4.6256 |
| Nicotinamide Adenine Dinucleotide reduced_13C_4 | 2.3623 | 0.0103 | 0.0981 | 0.7582 | 0.0147 | 0.0194 | 4.5419 | 0.0035 | 0.1988 |
| Nicotinamide Adenine Dinucleotide reduced_13C_5 | 1.9669 | 0.0126 | 0.0255 | 0.5761 | NA | 0.0038 | 4.3699 | 0.0029 | 0.0455 |
| Phosphoenolpyruvate | 0.2488 | 1.3570 | 1.3992 | 0.4133 | 0.2447 | 0.3578 | NA | 1.2417 | 1.6102 |
| Phosphoenolpyruvate_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Phosphoenolpyruvate_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Phosphoenolpyruvate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Ribose-5-phosphate or xylulose 5-phosphate | 0.0509 | 0.7625 | 0.4258 | 0.0525 | 0.2913 | 0.2022 | 0.0581 | 3.0578 | 3.1527 |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_3 | NA | NA | NA | NA | NA | NA | 1.0000 | NA | NA |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_4 | NA | NA | NA | NA | NA | NA | 1.0000 | NA | NA |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_5 | NA | NA | NA | NA | NA | NA | 1.0000 | NA | NA |
| Sedoheptulose 7-phosphate | 0.3381 | 0.4603 | 0.3669 | 0.0933 | 0.1064 | 0.1280 | 1.3192 | 2.3791 | 3.8087 |
| Sedoheptulose 7-phosphate_13C_1 | 0.5035 | NA | NA | NA | NA | NA | 2.4118 | NA | 0.0847 |
| Sedoheptulose 7-phosphate_13C_2 | 0.5235 | NA | NA | 0.1302 | NA | NA | 2.3463 | NA | NA |
| Sedoheptulose 7-phosphate_13C_3 | 0.5965 | 0.0013 | NA | 0.1272 | NA | NA | 2.3603 | NA | NA |
| Sedoheptulose 7-phosphate_13C_4 | 0.6034 | 0.0007 | NA | 0.2253 | NA | NA | 2.3211 | NA | NA |
| Sedoheptulose 7-phosphate_13C_5 | 0.3439 | 0.4530 | NA | NA | NA | NA | 2.0208 | NA | NA |
| Sedoheptulose 7-phosphate_13C_6 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Sedoheptulose 7-phosphate_13C_7 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Sucrose | 1.2831 | 1.1201 | 1.0345 | 2.5391 | 0.0667 | 0.0388 | 1.4501 | 0.6075 | 0.8600 |
| Sucrose_13C_1 | 1.8554 | 0.0380 | 0.0645 | 2.2510 | 0.1391 | 0.2427 | 2.2083 | 0.0012 | 0.0218 |
| Sucrose_13C_2 | NA | NA | NA | 1.0000 | NA | NA | NA | NA | NA |
| Sucrose_13C_3 | 0.2574 | NA | NA | 1.1617 | NA | NA | 1.1397 | NA | NA |
| Sucrose_13C_4 | NA | 1.6274 | 0.9086 | NA | NA | NA | 0.4640 | NA | NA |
Factors:
| F1 | Type:Noxa high clone | Treatment:13C labeled glucose |
| F2 | Type:Noxa high clone | Treatment:15N alpha nitrogen labeled glutamine |
| F3 | Type:Noxa high clone | Treatment:15N amide nitrogen labeled glutamine |
| F4 | Type:Noxa high plasmid | Treatment:13C labeled glucose |
| F5 | Type:Noxa high plasmid | Treatment:15N alpha nitrogen labeled glutamine |
| F6 | Type:Noxa high plasmid | Treatment:15N amide nitrogen labeled glutamine |
| F7 | Type:Noxa low clone | Treatment:13C labeled glucose |
| F8 | Type:Noxa low clone | Treatment:15N alpha nitrogen labeled glutamine |
| F9 | Type:Noxa low clone | Treatment:15N amide nitrogen labeled glutamine |
