Data for Murine gastrointestinal bile acid profiles before and after antibiotics (Study ST000196)

(Analysis AN000298)

Values for each metabolite have been scaled by dividing by the mean across all factors

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Metabolite	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12	F13	F14	F15	F16	F17	F18	F19	F20	F21	F22	F23	F24	F25	F26
3a,7a,12a-trihydroxycholestanoic acid	0.0318	0.7292	0.2091	0.6175	1.0403	1.9595	1.5994	0.3012	1.3422	0.7617	1.6926	0.6284	1.4895	2.6048	0.1122	0.6343	1.9406	1.6859	0.0603	0.5663	0.3370	0.1756	0.1286	1.1820	0.6380	2.0963
?a-Muricholic acid	1.7861	1.0281	2.0944	2.3258	1.3873	1.6289	0.0037	0.0184	1.3613	0.6615	0.0128	0.0032	0.0033	0.3324	0.1405	0.2901	2.5016	0.1843	1.8178	0.1760	0.8173	0.0512	2.6307	1.3111	2.6467	1.4557
b-Muricholic acid	1.8129	1.1880	1.8777	1.5569	0.7230	1.5111	0.0033	0.0102	2.1163	0.8504	0.0102	0.0052	0.0026	0.4310	0.2837	0.5711	2.5932	0.4254	1.6526	0.1289	0.6958	0.0333	2.4607	1.6867	2.2783	1.2533
Chenodeoxycholic acid	0.9346	1.2000	2.1678	0.9764	0.5438	2.0133	0.0295	0.0884	2.1192	0.2497	0.0368	0.0181	0.0080	0.2524	0.1450	0.3471	1.0503	0.4539	0.9620	0.3400	0.4729	0.1343	1.6024	2.2338	4.3110	2.3882
Cholic acid	1.5021	0.9578	1.8873	1.3639	0.9681	1.8887	0.1478	0.0691	1.7316	0.7344	0.1933	0.0166	0.0258	0.3144	0.2906	0.7338	2.2412	0.6093	1.6227	0.3561	0.5656	0.0829	2.2851	1.6021	2.3297	1.0235
Deoxycholic acid	0.4839	0.3697	2.0526	0.4833	7.9607	1.4375	0.0000	0.0002	1.3096	1.7601	0.0013	0.0003	0.0321	0.4434	0.0375	0.0009	0.0159	0.0004	2.3532	0.0150	0.1844	0.0028	0.6563	0.6097	3.4107	0.8339
Glychocholic acid	1.9940	0.3991	0.8869	0.1806	1.8603	1.6641	0.0727	0.2177	1.1419	0.6308	0.0268	0.0194	0.0695	0.2983	0.1967	0.0508	4.1210	0.0568	0.8062	0.2612	0.1296	0.0051	2.6212	3.5043	2.0676	0.6115
Glycochenodeoxycholic acid	0.9906	0.8542	0.8766	0.5892	3.1304	1.8174	0.7490	0.5589	1.3373	0.8453	0.5271	0.3718	0.9457	0.6222	0.1788	0.2641	1.0320	0.2569	0.6474	0.8156	0.2778	0.1680	0.9715	2.7950	1.5325	1.2613
Glycodeoxycholic acid	0.3809	0.4025	1.3381	0.2787	6.7084	1.2183	0.0060	0.0234	1.8307	1.2173	0.0185	0.0042	0.0292	0.2103	0.0257	0.0090	0.0147	0.0227	0.7155	0.0463	0.0935	0.0631	0.4228	1.8668	2.3335	0.6988
Glycohyocholic acid	1.0261	1.3384	0.5649	0.9721	1.2469	0.9256	2.7181	0.4003	0.3646	0.2764	1.3160	1.2382	0.5667	0.3856	0.1172	0.7185	1.4044	0.6526	0.8609	0.7529	0.5452	0.1873	1.0719	2.5444	1.9979	0.7295
Glycohyodeoxycholic acid	1.0393	1.0092	0.8410	0.3679	3.0535	1.1225	1.9292	0.4040	1.4401	0.4274	0.9117	0.5236	1.0134	0.4464	0.0781	0.3332	1.2545	0.3606	0.8008	0.9855	0.3613	0.0918	0.7770	1.7469	1.9621	1.3746
Glycolithocholic acid	0.5479	0.8771	0.8099	1.2763	4.3056	1.2014	0.2091	0.2632	1.1833	2.9571	0.1999	0.2011	0.4761	0.8349	0.2244	0.3263	0.4855	0.1569	1.6100	0.8396	0.5425	0.2713	1.7161	0.3424	1.6265	0.8200
Glycoursodeoxycholic acid	1.1590	0.3609	0.7425	0.1838	2.0128	0.6518	0.6130	0.1073	1.0498	0.8050	0.1894	0.1824	0.1775	0.1725	0.2138	0.0738	6.8156	0.1284	0.6896	0.3389	0.1135	0.0908	1.3143	2.7736	1.6341	0.6503
g-Muricholic acid (hyocholic acid)	1.1388	1.5251	1.4312	3.7941	0.3534	1.2909	0.0086	0.0031	2.4799	0.2629	0.0072	0.0015	0.0020	0.5516	0.5842	0.0894	2.7461	0.2153	0.8026	0.0358	0.0549	0.0253	1.0115	3.5306	3.1127	0.5762
Hyodeoxycholic acid	1.2442	1.6621	1.6986	3.1074	1.5262	2.1905	0.0053	0.0093	1.4867	0.9564	0.0071	0.0029	0.0096	0.5558	0.1615	0.1531	0.7490	0.1237	1.9675	0.0486	1.6571	0.0868	1.5317	1.7925	2.4262	2.3206
Isolithocholic acid	0.0946	0.1782	1.1185	0.7316	7.0160	1.6791	0.0415	0.0786	0.9610	1.4420	0.1987	0.0934	0.7181	0.8283	0.1365	0.1730	0.4676	0.1380	2.5106	0.4208	0.4074	1.2836	0.6221	0.6119	1.0970	0.8968
Lithocholic acid	0.2653	0.1432	2.0106	0.5917	7.5534	1.7852	0.0163	0.0295	1.4596	2.1784	0.0655	0.0155	1.0056	0.6166	0.1070	0.0888	0.1817	0.0330	1.2795	1.4963	0.1681	1.3025	0.6121	0.3976	1.4360	0.8511
Tauro-alpha-muricholic acid	0.4583	0.8894	1.3210	1.3962	2.1042	1.7788	1.0557	0.4951	0.9560	0.4892	1.9805	0.1717	0.7018	0.5429	0.0785	0.3473	2.0223	2.3152	0.4804	0.4999	0.6993	0.0711	0.7373	1.4315	0.8341	1.2989
Tauro-beta-muricholic acid	0.4412	1.1408	0.9650	0.8058	3.0550	1.4158	1.0281	0.5279	1.1719	0.7128	0.9208	0.6078	0.5423	0.6040	0.1253	0.8091	1.7319	1.0706	0.5454	0.7023	0.3509	0.1288	0.9674	1.3833	1.7881	1.1416
Taurochenodeoxycholic acid	0.0442	0.4820	1.1305	0.0155	5.1971	2.5547	1.2418	0.4907	3.1506	0.2787	1.2596	0.1157	0.3793	0.4282	0.0066	0.2595	0.1101	0.8240	0.1635	0.3273	0.0070	0.0272	0.3959	2.3716	0.9057	1.1330
Taurocholic acid	0.3914	0.5722	0.5713	0.1209	3.7491	1.5318	1.3497	0.7214	1.3667	1.0217	1.4819	0.7795	0.8821	0.7977	0.0663	0.7757	0.8045	2.1297	0.3038	0.7474	0.0768	0.1187	0.8223	0.9013	1.3037	1.0083
Taurodeoxycholic acid	0.0415	0.2220	0.6615	0.0127	10.0040	1.8966	0.0017	0.0061	5.4837	0.5499	0.0009	0.0003	0.0024	0.1480	0.0009	0.0050	0.0011	0.0012	0.1805	0.0344	0.0050	0.0014	0.2084	1.4781	0.8947	0.8065
TAUROHYODEOXYCHOLIC ACID	0.1980	1.0076	1.1856	0.2536	3.9511	1.9006	0.5134	0.5754	0.9326	0.6190	1.0362	0.4202	0.6137	0.4033	0.0437	0.5477	1.8578	1.2183	0.6468	0.6313	0.1179	0.0910	0.6573	1.4784	1.6990	1.3775
Taurolithocolic acid	0.9827	0.2102	2.3039	0.2481	1.9721	1.5871	0.0921	0.8256	3.0872	0.3084	0.1657	0.1570	0.2069	0.5537	0.0502	0.3358	0.1022	0.0909	0.3144	1.8387	0.1881	0.8763	0.4300	0.7793	6.1393	0.6615
Ursodeoxycholic acid	0.7861	0.4808	0.8651	0.4714	8.0935	2.7894	0.0037	0.0023	1.4081	2.4746	0.0064	0.0023	0.0025	0.1652	0.1213	0.1314	1.4314	0.0673	0.5064	0.0180	0.1255	0.0093	0.8131	0.6469	2.0486	0.5208
w-Muricholic acid	1.7694	1.0793	1.2192	2.5665	1.7426	2.2733	0.0102	0.0089	1.8782	1.4716	0.0124	0.0065	0.0084	0.8801	0.4847	0.2906	1.0351	0.2201	2.6014	0.0100	1.5729	0.0656	1.9017	1.1607	1.9422	1.4066

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Factors:

F1	Recovery:five week recovery | Gender:female | Treatment:Cefoperazone treated
F2	Recovery:five week recovery | Gender:male | Treatment:Cefoperazone treated
F3	Recovery:four week recovery | Gender:female | Treatment:Cefoperazone treated
F4	Recovery:four week recovery | Gender:male | Treatment:Cefoperazone treated
F5	Recovery:na | Gender:female | Treatment:No antibiotics
F6	Recovery:na | Gender:male | Treatment:No antibiotics
F7	Recovery:no recovery | Gender:female | Treatment:Cefoperazone treated
F8	Recovery:no recovery | Gender:female | Treatment:IP clindamycin
F9	Recovery:no recovery | Gender:female | Treatment:Kanamycin treated
F10	Recovery:no recovery | Gender:female | Treatment:Metronidazole treated
F11	Recovery:no recovery | Gender:female | Treatment:Vancomycin treated
F12	Recovery:no recovery | Gender:male | Treatment:Cefoperazone treated
F13	Recovery:no recovery | Gender:male | Treatment:IP clindamycin
F14	Recovery:no recovery | Gender:male | Treatment:Kanamycin treated
F15	Recovery:no recovery | Gender:male | Treatment:Metronidazole treated
F16	Recovery:no recovery | Gender:male | Treatment:Vancomycin treated
F17	Recovery:one week recovery | Gender:female | Treatment:Cefoperazone treated
F18	Recovery:one week recovery | Gender:male | Treatment:Cefoperazone treated
F19	Recovery:six week recovery | Gender:female | Treatment:Cefoperazone treated
F20	Recovery:six week recovery | Gender:female | Treatment:Cefoperazone treated IP clindamycin
F21	Recovery:six week recovery | Gender:male | Treatment:Cefoperazone treated
F22	Recovery:six week recovery | Gender:male | Treatment:Cefoperazone treated IP clindamycin
F23	Recovery:three week recovery | Gender:female | Treatment:Cefoperazone treated
F24	Recovery:three week recovery | Gender:male | Treatment:Cefoperazone treated
F25	Recovery:two week recovery | Gender:female | Treatment:Cefoperazone treated
F26	Recovery:two week recovery | Gender:male | Treatment:Cefoperazone treated