Data for Sprague Dawley rats Nicotine alters brain oxidative metabolism (Study ST000235)
(Analysis AN000353)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 1,3-DIAMINOPROPANE | 0.8043 | 1.1762 | 1.1370 | 0.8657 |
| 1-AMINOCYCLOPROPANE-1-CARBOXYLATE | 1.0705 | 0.9195 | 1.0215 | 0.9868 |
| 2-HYDROXYPHENYLACETIC ACID | 1.0350 | 0.9794 | 0.9919 | 0.9928 |
| 3-HYDROXY-3-METHYLGLUTARATE | 1.0918 | 0.8503 | 0.9483 | 1.1252 |
| 3-METHYLHISTAMINE | 0.3149 | 1.5983 | 1.7362 | 0.2579 |
| 3-UREIDOPROPIONATE | 1.1832 | 0.9207 | 1.6342 | 0.1564 |
| 4-AMINOBUTANOATE | 0.9066 | 1.0527 | 1.0794 | 0.9558 |
| 4-GUANIDINOBUTANOATE | 0.9422 | 1.0590 | 1.0834 | 0.9033 |
| 5,6-DIHYDROURACIL | 0.8933 | 1.0679 | 1.0970 | 0.9334 |
| 5-AMINOLEVULINIC ACID | 1.6862 | 0.6804 | 0.7875 | 0.8239 |
| 5-AMINOPENTANOATE | 0.9438 | 0.9925 | 1.0980 | 0.9608 |
| 5-OXO-L-PROLINE | 0.9758 | 0.8848 | 1.0062 | 1.1522 |
| ADENINE | 1.1889 | 0.7474 | 0.7845 | 1.3191 |
| ADENOSINE 5^-MONOPHOSPHATE | 1.0997 | 0.9117 | 0.8738 | 1.1313 |
| ALPHA-AMINOADIPATE | 1.1274 | 0.7866 | 0.8009 | 1.3258 |
| BETA-ALANINE | 1.0240 | 0.9348 | 0.9803 | 1.0697 |
| Caffeine-D3 | 1.0345 | 1.0077 | 0.9766 | 0.9784 |
| CARNOSINE | 0.7596 | 1.3615 | 1.1207 | 0.7237 |
| CITRULLINE | 0.8529 | 0.9842 | 1.3305 | 0.8084 |
| CMP | 0.8821 | 1.0721 | 1.0422 | 1.0042 |
| Creatine | 1.0110 | 0.9745 | 0.9694 | 1.0514 |
| Creatine-D3 | 1.0163 | 1.0439 | 1.0150 | 0.9140 |
| Creatinine | 0.7826 | 1.0709 | 1.1885 | 0.9521 |
| CYTIDINE | 1.3779 | 0.5710 | 0.6149 | 1.4985 |
| CYTIDINE 5^-DIPHOSPHOCHOLINE | 0.7407 | 1.1269 | 1.1556 | 0.9736 |
| DEOXYCARNITINE | 0.9045 | 0.9512 | 0.9405 | 1.2329 |
| DEOXYCYTIDINE | 1.2859 | 0.6736 | 0.6376 | 1.4604 |
| D-GLUCOSE 6-PHOSPHATE | 1.1165 | 0.9023 | 1.0247 | 0.9503 |
| D-RIBOSE 5-PHOSPHATE | 0.6945 | 1.0163 | 1.6351 | 0.6047 |
| ETHANOLAMINE PHOSPHATE | 0.9958 | 0.9705 | 0.9705 | 1.0723 |
| Glutamine | 0.9856 | 0.9866 | 1.0257 | 1.0024 |
| GLYCEROL | 1.0340 | 0.9570 | 0.9827 | 1.0300 |
| GLYCINE | 0.9502 | 0.9705 | 1.0672 | 1.0137 |
| HYPOXANTHINE | 0.9635 | 1.0067 | 1.0283 | 1.0017 |
| L-ALLOTHREONINE | 0.8449 | 1.0806 | 1.1099 | 0.9597 |
| L-ANSERINE | 0.8778 | 1.1618 | 1.0362 | 0.9133 |
| L-ARGININE | 0.8244 | 1.1042 | 1.2249 | 0.8245 |
| L-ASPARAGINE | 1.0045 | 0.9690 | 1.0518 | 0.9712 |
| L-ASPARTATE | 0.8304 | 1.1182 | 1.1936 | 0.8374 |
| L-CARNITINE | 0.8709 | 1.0730 | 1.0572 | 0.9987 |
| L-CYSTATHIONINE | 0.7954 | 1.4612 | 1.1885 | 0.4912 |
| LEUCINE | 0.8790 | 1.0452 | 1.1686 | 0.8939 |
| L-HISTIDINE | 0.8806 | 1.0669 | 1.1690 | 0.8669 |
| L-LYSINE | 0.7907 | 1.0529 | 1.2632 | 0.8779 |
| L-METHIONINE | 0.8713 | 1.0306 | 1.1678 | 0.9204 |
| L-ORNITHINE | 0.8894 | 1.0035 | 1.2209 | 0.8700 |
| L-SERINE | 0.9406 | 0.9569 | 1.1551 | 0.9398 |
| L-THREONINE | 0.8829 | 1.0476 | 1.0999 | 0.9653 |
| MANNOSE | 0.9964 | 0.9883 | 1.0215 | 0.9929 |
| N-ACETYL-D-GALACTOSAMINE | 1.0999 | 1.0112 | 0.8489 | 1.0457 |
| N-ACETYL-DL-GLUTAMIC ACID | 0.9225 | 1.0340 | 1.0779 | 0.9607 |
| N-ACETYL-L-ALANINE | 0.9288 | 0.7129 | 1.6003 | 0.7235 |
| N-ACETYL-L-ASPARTIC ACID | 1.0745 | 0.9011 | 0.8740 | 1.1719 |
| N-ACETYLNEURAMINATE | 1.0399 | 0.9460 | 0.9688 | 1.0518 |
| NALPHA-ACETYL-L-LYSINE | 0.7796 | 1.0218 | 1.2233 | 0.9717 |
| NEPSILON,NEPSILON,NEPSILON-TRIMETHYLLYSINE | 1.1230 | 0.9781 | 0.9559 | 0.9349 |
| NICOTINAMIDE | 0.9318 | 1.0422 | 1.0407 | 0.9831 |
| NICOTINATE | 0.2514 | 1.6470 | 0.1941 | 2.0371 |
| N(PAI)-METHYL-L-HISTIDINE | 0.9998 | 1.0014 | 0.9982 | 1.0008 |
| O-ACETYL-L-SERINE | 1.1999 | 0.8111 | 0.8455 | 1.1640 |
| O-PHOSPHO-DL-SERINE | 1.1242 | 0.9055 | 0.8365 | 1.1530 |
| OROTIC ACID | 0.9242 | 1.0485 | 1.0229 | 1.0051 |
| Phenylalanine | 0.8085 | 1.0817 | 1.2426 | 0.8482 |
| Phenylalanine-HCOOH | 0.8055 | 1.0754 | 1.2677 | 0.8302 |
| PHOSPHOCHOLINE | 1.0919 | 0.8808 | 0.9003 | 1.1450 |
| PIPECOLATE | 0.9129 | 0.9739 | 1.0826 | 1.0350 |
| Proline | 0.9032 | 1.0158 | 1.1710 | 0.8972 |
| PUTRESCINE | 1.0090 | 1.0549 | 0.9264 | 1.0110 |
| PYRIDOXAL | 0.9267 | 0.9928 | 0.9839 | 1.1104 |
| PYRIDOXAL 5^-PHOSPHATE | 1.0705 | 1.0605 | 1.0131 | 0.8354 |
| (R)-MALATE | 0.9271 | 1.0149 | 1.0508 | 1.0083 |
| SPERMIDINE | 0.8748 | 1.1588 | 1.0824 | 0.8674 |
| SUCCINATE | 0.8713 | 1.5593 | 0.8022 | 0.7338 |
| TAURINE | 1.2263 | 0.7526 | 0.7662 | 1.2914 |
| THIAMINE MONOPHOSPHATE | 0.9257 | 0.9912 | 0.9903 | 1.1061 |
| Tryptophan | 0.7942 | 1.0844 | 1.2990 | 0.7970 |
| Tryptophan-2,3,3-D3 | 1.0405 | 1.0214 | 0.9817 | 0.9502 |
| Tryptophan-2,3,3-D3-NH3 | 1.0317 | 1.0243 | 1.0044 | 0.9310 |
| Tryptophan-NH3 | 0.7978 | 1.0798 | 1.3078 | 0.7882 |
| Tyrosine | 0.8326 | 1.0407 | 1.2368 | 0.8742 |
| URACIL | 0.9597 | 1.0168 | 1.0412 | 0.9797 |
| URATE | 0.9160 | 1.0207 | 0.7975 | 1.3037 |
Factors:
| F1 | Treatment:Nicotine | Dosage:6mg/kg |
| F2 | Treatment:Nicotine + Oral contraceptives | Dosage:6mg/kg Nicotine |
| F3 | Treatment:Oral contraceptives | Dosage:1 mL |
| F4 | Treatment:Saline | Dosage:2 mL |
