Data for Metabolic profiling reveals biochemical pathways and potential biomarkers associated with the pathogenesis of Krabbe disease (Study ST000352)

(Analysis AN000573)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
10-heptadecenoate (17:1n7) 0.8931 1.1338 0.9223 1.0508
10-nonadecenoate (19:1n9) 0.6753 0.7874 1.0905 1.4467
12-HETE 0.8826 0.8010 1.3697 0.9467
15-HETE 1.0216 0.9731 1.0328 0.9725
15-methylpalmitate (isobar with 2-methylpalmitate) 1.0119 0.9831 0.9695 1.0355
1-arachidonoylglycerophosphoethanolamine* 1.1158 0.9714 1.0802 0.8326
1-arachidonoylglycerophosphoinositol* 0.9083 0.7674 1.2309 1.0934
1-arachidonylglycerol 0.8739 0.7438 1.1967 1.1856
1-docosahexaenoylglycerol (1-monodocosahexaenoin) 0.9585 1.0713 0.9752 0.9949
1-docosahexaenoylglycerophosphocholine (22:6n3)* 0.7674 0.7453 1.3126 1.1747
1-docosahexaenoylglycerophosphoethanolamine* 1.0138 0.9136 1.1674 0.9052
1-eicosenoylglycerophosphoethanolamine (20:1n9)* 0.7331 0.7764 1.4467 1.0438
1-linoleoylglycerol (1-monolinolein) 0.9317 1.0221 1.0554 0.9977
1-myristoylglycerol (1-monomyristin) 1.0315 1.1756 0.8564 0.9072
1-oleoylglycerol (1-monoolein) 0.7634 0.9135 1.2484 1.0747
1-oleoylglycerophosphoethanolamine 1.0300 0.8675 1.1219 0.9806
1-oleoylglycerophosphoglycerol* 0.7633 0.9928 1.1584 1.0854
1-oleoylglycerophosphoinositol* 1.0620 1.2885 0.7544 0.8951
1-oleoylglycerophosphoserine 0.9990 0.9535 1.0682 0.9793
1-oleoylplasmenylethanolamine* 0.9274 0.8041 1.3725 0.8960
1-palmitoleoylglycerophosphoethanolamine* 1.3314 0.9763 0.9840 0.7083
1-palmitoylglycerophosphoethanolamine 1.2060 1.0000 0.9514 0.8427
1-palmitoylglycerophosphoglycerol* 0.7984 1.1429 1.0204 1.0383
1-palmitoylglycerophosphoinositol* 0.9686 1.0830 1.0291 0.9192
1-palmitoylglycerophosphoserine* 1.3540 1.0498 0.8061 0.7901
1-palmitoylplasmenylethanolamine* 1.0825 0.9500 1.0870 0.8805
1-stearoylglycerophosphoinositol 1.1678 0.9190 1.0182 0.8951
1-stearoylglycerophosphoserine* 1.1559 1.0368 0.9151 0.8922
1-stearoylplasmenylethanolamine* 0.8229 0.8304 1.2869 1.0598
2-arachidonoyl glycerol 0.7983 0.8594 1.1856 1.1568
2-arachidonoylglycerophosphoinositol* 0.8378 0.8409 1.1929 1.1085
2-ethylhexanoate (isobar with 2-propylpentanoate) 1.0842 1.0479 0.9271 0.9408
2-hydroxypalmitate 1.2180 1.0816 0.8893 0.8111
2-hydroxystearate 1.1572 0.9952 0.8863 0.9613
2-linoleoylglycerol (2-monolinolein) 0.7510 0.9987 1.0881 1.0799
2-oleoylglycerophosphoethanolamine* 0.9048 0.7474 1.2826 1.0652
2-oleoylglycerophosphoglycerol* 0.6783 0.7742 1.4178 1.1297
2-oleoylglycerophosphoserine* 0.9642 0.7829 1.1462 1.1067
2-palmitoleoylglycerophosphoethanolamine* 0.9423 1.0498 1.0714 0.9427
2-stearoylglycerophosphoinositol* 1.1541 0.8866 0.9883 0.9710
3-(4-hydroxyphenyl)lactate 1.0396 1.0385 0.8496 1.0723
3^-dephosphocoenzyme A 0.9349 0.9562 1.0174 1.0915
3-indoxyl sulfate 0.5094 0.4628 1.2447 1.7830
5-HETE 0.9682 0.9034 1.0690 1.0594
5-oxoproline 0.9058 0.9342 1.0497 1.1104
adenosine 5^-diphosphate (ADP) 0.9676 1.0890 0.8320 1.1115
adenosine 5^-triphosphate (ATP) 0.8337 1.0196 1.1190 1.0118
adenylosuccinate 0.9097 0.9077 1.0010 1.1705
adrenate (22:4n6) 0.9585 1.0377 0.9332 1.0706
anserine 0.8754 0.8907 1.1078 1.1261
arachidate (20:0) 0.9106 0.8756 1.0977 1.1160
arachidonate (20:4n6) 0.8454 0.8776 1.1863 1.0907
caproate (6:0) 1.1885 1.1462 0.7765 0.8887
carnosine 0.7083 0.7135 1.3523 1.2259
cis-aconitate 1.0750 1.1766 0.8576 0.8908
coenzyme A 0.9354 0.8882 0.9128 1.2636
dihomo-linoleate (20:2n6) 0.9804 1.0029 0.9514 1.0653
dihomo-linolenate (20:3n3 or n6) 0.9591 1.0574 1.0090 0.9745
dihydroxyacetone phosphate (DHAP) 0.8383 1.0119 1.0556 1.0942
docosadienoate (22:2n6) 0.9058 0.9331 1.0730 1.0881
docosahexaenoate (DHA; 22:6n3) 0.8047 0.9264 1.1633 1.1056
docosapentaenoate (n3 DPA; 22:5n3) 0.7967 1.0369 1.0895 1.0769
docosapentaenoate (n6 DPA; 22:5n6) 0.9561 1.1640 0.9188 0.9612
eicosapentaenoate (EPA; 20:5n3) 0.9747 1.0551 1.0807 0.8896
eicosenoate (20:1n9 or 11) 0.7457 0.7540 1.2777 1.2226
erucate (22:1n9) 0.6847 0.7031 1.3257 1.2865
flavin adenine dinucleotide (FAD) 0.8355 0.8736 1.1313 1.1597
flavin mononucleotide (FMN) 1.2064 1.0871 0.8141 0.8925
guanosine 5^-diphospho-fucose 1.0705 1.1097 0.8511 0.9686
histidine 1.0383 1.0693 0.9967 0.8957
homocarnosine 0.5628 0.6094 1.4195 1.4084
hypoxanthine 1.0532 0.9718 1.0234 0.9516
inosine 1.0208 1.0267 0.9547 0.9978
Isobar: fructose 1,6-diphosphate, glucose 1,6-diphosphate, myo-inositol 1,4 or 1,3-diphosphate 0.7098 0.9701 1.0902 1.2050
linoleate (18:2n6) 0.9998 1.0846 0.9755 0.9402
linolenate [alpha or gamma; (18:3n3 or 6)] 1.0159 1.2157 0.9437 0.8247
maltopentaose NA 1.0000 NA NA
maltotetraose 0.7131 1.2151 NA NA
margarate (17:0) 0.9041 1.0114 0.9894 1.0951
mead acid (20:3n9) 1.0452 1.1346 0.9997 0.8205
myristate (14:0) 1.1311 1.1325 0.9594 0.7770
myristoleate (14:1n5) 1.1569 1.1233 0.9909 0.7278
N-acetylalanine 0.8339 0.9245 1.1279 1.1300
N-acetylaspartate (NAA) 0.8780 0.8808 1.0654 1.1757
N-acetylmethionine 0.9450 0.8834 1.1910 0.9807
N-acetylthreonine 1.1885 1.1332 0.8510 0.8274
nonadecanoate (19:0) 0.8608 0.9256 1.0499 1.1637
oleic ethanolamide 0.7394 0.7033 1.2233 1.3340
palmitate (16:0) 0.9583 0.9174 1.0811 1.0432
palmitoleate (16:1n7) 1.0874 1.1516 0.9715 0.7895
palmitoyl ethanolamide 0.6869 0.6927 1.2612 1.3592
pelargonate (9:0) 1.0364 1.0226 1.0022 0.9388
pentadecanoate (15:0) 1.0584 1.0405 0.9502 0.9508
prostaglandin D2 1.0002 1.2137 1.0268 0.7593
prostaglandin E2 1.0026 1.1386 1.0000 0.8588
pseudouridine 1.1949 1.2567 0.7739 0.7745
S-adenosylhomocysteine (SAH) 1.0307 0.9213 0.9985 1.0495
stearate (18:0) 0.9398 0.8692 1.1196 1.0714
succinate 1.1334 1.0684 0.8748 0.9319
tauro(alpha + beta)muricholate 1.0148 0.8717 1.0487 1.0647
taurocholate 1.3913 1.2262 0.7021 0.6804
UDP-glucuronate 1.1950 1.2726 0.7601 0.7724
uridine 1.0169 1.0643 0.9635 0.9553
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Factors:

F1age:P15 | genotype:Twitcher
F2age:P15 | genotype:Wild Type
F3age:P22 | genotype:Twitcher
F4age:P22 | genotype:Wild Type
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