Data for Metabolic profiling reveals biochemical pathways and potential biomarkers associated with the pathogenesis of Krabbe disease (Study ST000352)
(Analysis AN000573)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 |
---|---|---|---|---|
10-heptadecenoate (17:1n7) | 0.8931 | 1.1338 | 0.9223 | 1.0508 |
10-nonadecenoate (19:1n9) | 0.6753 | 0.7874 | 1.0905 | 1.4467 |
12-HETE | 0.8826 | 0.8010 | 1.3697 | 0.9467 |
15-HETE | 1.0216 | 0.9731 | 1.0328 | 0.9725 |
15-methylpalmitate (isobar with 2-methylpalmitate) | 1.0119 | 0.9831 | 0.9695 | 1.0355 |
1-arachidonoylglycerophosphoethanolamine* | 1.1158 | 0.9714 | 1.0802 | 0.8326 |
1-arachidonoylglycerophosphoinositol* | 0.9083 | 0.7674 | 1.2309 | 1.0934 |
1-arachidonylglycerol | 0.8739 | 0.7438 | 1.1967 | 1.1856 |
1-docosahexaenoylglycerol (1-monodocosahexaenoin) | 0.9585 | 1.0713 | 0.9752 | 0.9949 |
1-docosahexaenoylglycerophosphocholine (22:6n3)* | 0.7674 | 0.7453 | 1.3126 | 1.1747 |
1-docosahexaenoylglycerophosphoethanolamine* | 1.0138 | 0.9136 | 1.1674 | 0.9052 |
1-eicosenoylglycerophosphoethanolamine (20:1n9)* | 0.7331 | 0.7764 | 1.4467 | 1.0438 |
1-linoleoylglycerol (1-monolinolein) | 0.9317 | 1.0221 | 1.0554 | 0.9977 |
1-myristoylglycerol (1-monomyristin) | 1.0315 | 1.1756 | 0.8564 | 0.9072 |
1-oleoylglycerol (1-monoolein) | 0.7634 | 0.9135 | 1.2484 | 1.0747 |
1-oleoylglycerophosphoethanolamine | 1.0300 | 0.8675 | 1.1219 | 0.9806 |
1-oleoylglycerophosphoglycerol* | 0.7633 | 0.9928 | 1.1584 | 1.0854 |
1-oleoylglycerophosphoinositol* | 1.0620 | 1.2885 | 0.7544 | 0.8951 |
1-oleoylglycerophosphoserine | 0.9990 | 0.9535 | 1.0682 | 0.9793 |
1-oleoylplasmenylethanolamine* | 0.9274 | 0.8041 | 1.3725 | 0.8960 |
1-palmitoleoylglycerophosphoethanolamine* | 1.3314 | 0.9763 | 0.9840 | 0.7083 |
1-palmitoylglycerophosphoethanolamine | 1.2060 | 1.0000 | 0.9514 | 0.8427 |
1-palmitoylglycerophosphoglycerol* | 0.7984 | 1.1429 | 1.0204 | 1.0383 |
1-palmitoylglycerophosphoinositol* | 0.9686 | 1.0830 | 1.0291 | 0.9192 |
1-palmitoylglycerophosphoserine* | 1.3540 | 1.0498 | 0.8061 | 0.7901 |
1-palmitoylplasmenylethanolamine* | 1.0825 | 0.9500 | 1.0870 | 0.8805 |
1-stearoylglycerophosphoinositol | 1.1678 | 0.9190 | 1.0182 | 0.8951 |
1-stearoylglycerophosphoserine* | 1.1559 | 1.0368 | 0.9151 | 0.8922 |
1-stearoylplasmenylethanolamine* | 0.8229 | 0.8304 | 1.2869 | 1.0598 |
2-arachidonoyl glycerol | 0.7983 | 0.8594 | 1.1856 | 1.1568 |
2-arachidonoylglycerophosphoinositol* | 0.8378 | 0.8409 | 1.1929 | 1.1085 |
2-ethylhexanoate (isobar with 2-propylpentanoate) | 1.0842 | 1.0479 | 0.9271 | 0.9408 |
2-hydroxypalmitate | 1.2180 | 1.0816 | 0.8893 | 0.8111 |
2-hydroxystearate | 1.1572 | 0.9952 | 0.8863 | 0.9613 |
2-linoleoylglycerol (2-monolinolein) | 0.7510 | 0.9987 | 1.0881 | 1.0799 |
2-oleoylglycerophosphoethanolamine* | 0.9048 | 0.7474 | 1.2826 | 1.0652 |
2-oleoylglycerophosphoglycerol* | 0.6783 | 0.7742 | 1.4178 | 1.1297 |
2-oleoylglycerophosphoserine* | 0.9642 | 0.7829 | 1.1462 | 1.1067 |
2-palmitoleoylglycerophosphoethanolamine* | 0.9423 | 1.0498 | 1.0714 | 0.9427 |
2-stearoylglycerophosphoinositol* | 1.1541 | 0.8866 | 0.9883 | 0.9710 |
3-(4-hydroxyphenyl)lactate | 1.0396 | 1.0385 | 0.8496 | 1.0723 |
3^-dephosphocoenzyme A | 0.9349 | 0.9562 | 1.0174 | 1.0915 |
3-indoxyl sulfate | 0.5094 | 0.4628 | 1.2447 | 1.7830 |
5-HETE | 0.9682 | 0.9034 | 1.0690 | 1.0594 |
5-oxoproline | 0.9058 | 0.9342 | 1.0497 | 1.1104 |
adenosine 5^-diphosphate (ADP) | 0.9676 | 1.0890 | 0.8320 | 1.1115 |
adenosine 5^-triphosphate (ATP) | 0.8337 | 1.0196 | 1.1190 | 1.0118 |
adenylosuccinate | 0.9097 | 0.9077 | 1.0010 | 1.1705 |
adrenate (22:4n6) | 0.9585 | 1.0377 | 0.9332 | 1.0706 |
anserine | 0.8754 | 0.8907 | 1.1078 | 1.1261 |
arachidate (20:0) | 0.9106 | 0.8756 | 1.0977 | 1.1160 |
arachidonate (20:4n6) | 0.8454 | 0.8776 | 1.1863 | 1.0907 |
caproate (6:0) | 1.1885 | 1.1462 | 0.7765 | 0.8887 |
carnosine | 0.7083 | 0.7135 | 1.3523 | 1.2259 |
cis-aconitate | 1.0750 | 1.1766 | 0.8576 | 0.8908 |
coenzyme A | 0.9354 | 0.8882 | 0.9128 | 1.2636 |
dihomo-linoleate (20:2n6) | 0.9804 | 1.0029 | 0.9514 | 1.0653 |
dihomo-linolenate (20:3n3 or n6) | 0.9591 | 1.0574 | 1.0090 | 0.9745 |
dihydroxyacetone phosphate (DHAP) | 0.8383 | 1.0119 | 1.0556 | 1.0942 |
docosadienoate (22:2n6) | 0.9058 | 0.9331 | 1.0730 | 1.0881 |
docosahexaenoate (DHA; 22:6n3) | 0.8047 | 0.9264 | 1.1633 | 1.1056 |
docosapentaenoate (n3 DPA; 22:5n3) | 0.7967 | 1.0369 | 1.0895 | 1.0769 |
docosapentaenoate (n6 DPA; 22:5n6) | 0.9561 | 1.1640 | 0.9188 | 0.9612 |
eicosapentaenoate (EPA; 20:5n3) | 0.9747 | 1.0551 | 1.0807 | 0.8896 |
eicosenoate (20:1n9 or 11) | 0.7457 | 0.7540 | 1.2777 | 1.2226 |
erucate (22:1n9) | 0.6847 | 0.7031 | 1.3257 | 1.2865 |
flavin adenine dinucleotide (FAD) | 0.8355 | 0.8736 | 1.1313 | 1.1597 |
flavin mononucleotide (FMN) | 1.2064 | 1.0871 | 0.8141 | 0.8925 |
guanosine 5^-diphospho-fucose | 1.0705 | 1.1097 | 0.8511 | 0.9686 |
histidine | 1.0383 | 1.0693 | 0.9967 | 0.8957 |
homocarnosine | 0.5628 | 0.6094 | 1.4195 | 1.4084 |
hypoxanthine | 1.0532 | 0.9718 | 1.0234 | 0.9516 |
inosine | 1.0208 | 1.0267 | 0.9547 | 0.9978 |
Isobar: fructose 1,6-diphosphate, glucose 1,6-diphosphate, myo-inositol 1,4 or 1,3-diphosphate | 0.7098 | 0.9701 | 1.0902 | 1.2050 |
linoleate (18:2n6) | 0.9998 | 1.0846 | 0.9755 | 0.9402 |
linolenate [alpha or gamma; (18:3n3 or 6)] | 1.0159 | 1.2157 | 0.9437 | 0.8247 |
maltopentaose | NA | 1.0000 | NA | NA |
maltotetraose | 0.7131 | 1.2151 | NA | NA |
margarate (17:0) | 0.9041 | 1.0114 | 0.9894 | 1.0951 |
mead acid (20:3n9) | 1.0452 | 1.1346 | 0.9997 | 0.8205 |
myristate (14:0) | 1.1311 | 1.1325 | 0.9594 | 0.7770 |
myristoleate (14:1n5) | 1.1569 | 1.1233 | 0.9909 | 0.7278 |
N-acetylalanine | 0.8339 | 0.9245 | 1.1279 | 1.1300 |
N-acetylaspartate (NAA) | 0.8780 | 0.8808 | 1.0654 | 1.1757 |
N-acetylmethionine | 0.9450 | 0.8834 | 1.1910 | 0.9807 |
N-acetylthreonine | 1.1885 | 1.1332 | 0.8510 | 0.8274 |
nonadecanoate (19:0) | 0.8608 | 0.9256 | 1.0499 | 1.1637 |
oleic ethanolamide | 0.7394 | 0.7033 | 1.2233 | 1.3340 |
palmitate (16:0) | 0.9583 | 0.9174 | 1.0811 | 1.0432 |
palmitoleate (16:1n7) | 1.0874 | 1.1516 | 0.9715 | 0.7895 |
palmitoyl ethanolamide | 0.6869 | 0.6927 | 1.2612 | 1.3592 |
pelargonate (9:0) | 1.0364 | 1.0226 | 1.0022 | 0.9388 |
pentadecanoate (15:0) | 1.0584 | 1.0405 | 0.9502 | 0.9508 |
prostaglandin D2 | 1.0002 | 1.2137 | 1.0268 | 0.7593 |
prostaglandin E2 | 1.0026 | 1.1386 | 1.0000 | 0.8588 |
pseudouridine | 1.1949 | 1.2567 | 0.7739 | 0.7745 |
S-adenosylhomocysteine (SAH) | 1.0307 | 0.9213 | 0.9985 | 1.0495 |
stearate (18:0) | 0.9398 | 0.8692 | 1.1196 | 1.0714 |
succinate | 1.1334 | 1.0684 | 0.8748 | 0.9319 |
tauro(alpha + beta)muricholate | 1.0148 | 0.8717 | 1.0487 | 1.0647 |
taurocholate | 1.3913 | 1.2262 | 0.7021 | 0.6804 |
UDP-glucuronate | 1.1950 | 1.2726 | 0.7601 | 0.7724 |
uridine | 1.0169 | 1.0643 | 0.9635 | 0.9553 |
Factors:
F1 | age:P15 | genotype:Twitcher |
F2 | age:P15 | genotype:Wild Type |
F3 | age:P22 | genotype:Twitcher |
F4 | age:P22 | genotype:Wild Type |