Data for Inhibition of autophagy/proteasome degradation or inhibition of protein synthesis in models of muscle insulin resistance affect TCA cycle (Study ST000513)

(Analysis AN000786)

Values for each metabolite have been scaled by dividing by the mean across all factors

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Metabolite	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12
cis-Aconitic Acid	0.4718	0.4718	0.6291	4.9538	0.4128	0.4718	0.9436	0.7077	0.4718	0.7549	0.5111	0.8650
Citrate	0.9966	0.9536	0.7133	0.7963	0.7963	0.8794	0.7059	0.8012	0.8579	0.8207	1.5340	1.4379
Fumarate	1.0308	0.8246	0.6151	0.7326	0.8223	0.6370	0.6602	0.5444	0.9683	0.8887	1.6003	1.5070
Glutamate	0.3425	0.6230	0.6771	0.6796	0.4477	0.5602	0.2502	0.4096	0.9033	0.9422	1.9558	2.1211
Isocitrate	1.2504	0.9660	0.5835	0.7737	0.2227	4.3452	0.0860	0.4376	2.9541	1.4849	0.1094	0.8258
Ketoglutarate	0.7507	1.0101	1.8200	1.5015	0.7849	0.6825	0.8872	0.9555	0.7917	1.1466	0.6597	1.0010
Lactate	1.2164	1.2037	1.1107	1.1205	1.1734	0.5157	1.1234	0.9734	1.0643	0.9609	0.7711	0.7176
Malate	1.0053	0.8091	0.5950	0.6810	0.7384	0.5561	0.6377	0.5158	0.9888	0.9437	1.5681	1.6312
Oxaloacetate	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Succinate	0.9647	0.9740	0.8871	1.4071	1.2175	1.1577	1.6766	1.3040	0.6866	0.8170	0.6520	0.9070

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Factors:

F1	group:Control/Colch | genotype:Irlox
F2	group:Control/Colch | genotype:Irlox IGFRlox
F3	group:Control/Saline | genotype:Irlox
F4	group:Control/Saline | genotype:Irlox IGFRlox
F5	group:HFD+Colch | genotype:Irlox
F6	group:HFD+Colch | genotype:Irlox IGFRlox
F7	group:HFD/Saline | genotype:Irlox
F8	group:HFD/Saline | genotype:Irlox IGFRlox
F9	group:IRKO/Colch | genotype:IR -/-
F10	group:IRKO/Saline | genotype:IR -/-
F11	group:MIGIRKO/Colch | genotype:IR -/- IGFR -/-
F12	group:MIGIRKO/Saline | genotype:IR -/- IGFR -/-