Data for Replication study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate (Study ST000548)

(Analysis AN000836)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
2HG EIC Results 0.6151 0.2551 1.6234 3.9405
2HG TIC Results 0.6253 0.2914 1.4840 3.9662
Asp EIC Results 0.3455 0.1086 3.5449 2.8828
Asp TIC Results 0.3882 0.1352 3.2503 3.0135
Glu EIC Results 1.7143 0.1913 2.1613 0.1896
Glu TIC Results 1.7016 0.2506 2.0031 0.2392
Ratio of 2HG/Glu EIC 0.2083 0.6604 0.1735 5.1193
Ratio of 2HG/Glu TIC 0.2270 0.6436 0.2012 4.8095
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Factors:

F1Time Point:CS-24h | Sample Source:293T HEK cell line
F2Time Point:CS-48h | Sample Source:293T HEK cell line
F3Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells
F4Time Point:QC | Sample Source:-
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