Data for Investigating large scale metabolomics in mice tissue lacking insulin receptors and IGF-1 receptors (Study ST000551)
(Analysis AN000842)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
---|---|---|---|---|---|---|---|---|
11-deoxy-PGF1? | 1.6381 | 1.0495 | 0.6561 | 0.6874 | 1.1463 | 1.0478 | 0.8623 | 0.9635 |
12,13S-epoxy-9Z,11-octadecadienoic acid | 0.9079 | 0.4009 | 1.0644 | 0.5402 | 1.2975 | 0.8942 | 0.7185 | 1.7463 |
12-amino-dodecanoic acid | 0.8303 | 0.8258 | 0.9095 | 0.7743 | 1.1285 | 0.8339 | 0.9284 | 1.5140 |
12-hydroxy-10-octadecynoic acid | 1.2487 | 0.9625 | 0.6710 | 0.9741 | 1.0283 | 1.1342 | 0.8961 | 1.0580 |
13,14-dihydro Prostaglandin F1? | 1.4873 | 1.1547 | 0.6372 | 0.7409 | 0.9479 | 1.1482 | 0.9256 | 1.0066 |
13H-Dibenzo[a,g]fluorene | 1.2883 | 0.7694 | 1.2036 | 1.3691 | 1.0909 | 0.9471 | 1.0034 | 0.5062 |
18-hydroxy-9S,10R-epoxy-stearic acid | 1.2621 | 0.9782 | 0.6991 | 0.9908 | 1.0176 | 1.1181 | 0.8848 | 1.0450 |
20-carboxy-LTB4 | 1.0151 | 1.0130 | 0.9614 | 0.9926 | 1.0125 | 1.0160 | 0.9974 | 0.9929 |
2,3-bis (4-Hydroxyphenyl) Propionitrile | 1.2248 | 1.0452 | 1.2151 | 1.6946 | 0.0001 | 1.0753 | 0.9455 | 1.0461 |
2-Amino-4-oxo-6-(1,2-dioxoprolyl)-7,8-dihydroxypteridine | 1.5078 | 1.5564 | 1.3144 | 0.4593 | 1.6278 | 1.0653 | 0.9332 | 0.0233 |
2-Aminomethylpyrimidine | 0.9578 | 1.1409 | 1.1197 | 1.1049 | 1.1863 | 0.9730 | 1.1078 | 0.5674 |
2S-aminoheptanoic acid | 0.8159 | 1.1326 | 1.1239 | 1.3445 | 0.5458 | 1.5343 | 1.0139 | 0.6635 |
3beta-(Acetyloxy)-5beta-methyl-6beta-chloroestr-9-en-17-one | 1.0116 | 1.0045 | 1.0040 | 0.9886 | 1.0140 | 1.0093 | 0.9871 | 0.9884 |
3-Buten-1-amine | 1.0145 | 0.9044 | 0.7085 | 0.8186 | 0.6894 | 0.8241 | 1.1828 | 1.5759 |
3-methyl pyruvic acid | 0.8210 | 1.1474 | 1.2941 | 1.0887 | 0.7386 | 1.2265 | 1.0258 | 0.7937 |
3R-aminononanoic acid | 1.4396 | 1.0314 | 1.7147 | 1.0381 | 1.8047 | 0.5684 | 0.8784 | 0.0001 |
4-Acetamido-2-amino-6-nitrotoluene | 1.2530 | 1.4055 | 1.4133 | 0.9386 | 1.2084 | 0.7910 | 1.1657 | 0.2289 |
4-Hydroxy-2,2^,4^,6^-tetrachlorobiphenyl | 0.0022 | 6.4013 | 0.0022 | 0.0022 | 2.6224 | 0.9264 | 0.0022 | 0.0022 |
5-Aminoimidazole ribonucleotide | 0.4381 | 0.7985 | 0.8185 | 0.9384 | 0.8564 | 0.9461 | 0.9589 | 1.8431 |
5-phosphoribosyl-1-diphosphate | 1.0128 | 0.9949 | 0.9774 | 0.9759 | 1.0237 | 1.0093 | 0.9916 | 1.0059 |
5S-HETE di-endoperoxide | 1.1050 | 0.7712 | 0.6555 | 1.0639 | 1.1311 | 1.0391 | 1.0956 | 0.9940 |
7-Hydroxydoxazosin | 1.0522 | 1.1478 | 1.1175 | 0.9281 | 1.1203 | 1.1060 | 1.1449 | 0.5274 |
7?-(Thiomethyl)spironolactone sulfone | 1.0243 | 1.0078 | 0.9911 | 0.9661 | 1.0118 | 1.0125 | 0.9788 | 1.0093 |
9,13-dihydroxy-10-ethoxy-11-octadecenoic acid | 1.4873 | 1.1547 | 0.6372 | 0.7410 | 0.9480 | 1.1482 | 0.9256 | 1.0066 |
9S-hydroxy-12R,13S-epoxy-10E,15Z-octadecadienoic acid | 0.5076 | 0.0011 | 0.9783 | 0.0011 | 0.9107 | 0.0011 | 0.1515 | 4.2636 |
ADMA | 0.9303 | 0.7867 | 0.7853 | 0.9964 | 0.7387 | 1.0459 | 0.9996 | 1.4785 |
Ala Asp Cys | 1.1562 | 1.2370 | 1.0462 | 1.0406 | 1.2150 | 1.1588 | 0.8159 | 0.5921 |
aminohippuric acid | 1.4078 | 1.4558 | 1.3309 | 0.5774 | 1.4432 | 1.1491 | 1.0449 | 0.0228 |
Amphotericin B | 1.0247 | 1.0365 | 0.9689 | 0.9704 | 1.0359 | 1.0043 | 0.9776 | 0.9947 |
Anandamide (20:2, n-6) | 0.3359 | 0.9063 | 0.6884 | 0.1746 | 2.6955 | 0.5533 | 0.8470 | 1.3600 |
Arborinine | 1.1740 | 1.2843 | 1.1398 | 1.0312 | 1.2633 | 1.1829 | 0.8050 | 0.4510 |
Arg Met His | 1.0181 | 1.0186 | 0.9872 | 0.9918 | 1.0171 | 1.0093 | 0.9729 | 0.9978 |
Benserazide | 0.5512 | 0.7141 | 0.6995 | 0.8884 | 0.7826 | 0.9629 | 1.0133 | 1.9157 |
Carnosine | 1.2499 | 1.4067 | 1.3858 | 0.8918 | 1.2450 | 0.8893 | 1.1177 | 0.2154 |
CAY10470 | 1.0124 | 1.0112 | 0.9858 | 0.9824 | 1.0291 | 1.0227 | 0.9747 | 0.9895 |
Cellobiose | 0.6844 | 1.7521 | 1.9806 | 0.6715 | 1.5176 | 0.9947 | 0.7112 | 0.2615 |
Chikusetsusaponin IV | 1.0148 | 1.0081 | 1.0031 | 0.9647 | 1.0186 | 0.9904 | 0.9963 | 1.0037 |
cis-Caryophyllene | 1.2519 | 0.9980 | 0.6857 | 1.0008 | 1.0331 | 1.0985 | 0.8855 | 1.0469 |
Creatine | 1.0460 | 1.0664 | 1.1831 | 0.9731 | 1.0797 | 1.0574 | 1.0614 | 0.6562 |
Creatinine | 1.1649 | 0.8211 | 1.1598 | 1.3694 | 1.1563 | 0.9336 | 1.0327 | 0.5190 |
Cytosine | 0.6212 | 0.7599 | 0.8881 | 0.6398 | 0.8185 | 1.0957 | 0.9924 | 1.7665 |
Deoxytubulosine | 1.0071 | 1.0375 | 0.9818 | 0.9478 | 1.0301 | 1.0287 | 0.9712 | 1.0033 |
?-D-Glucose | 0.7608 | 1.1908 | 1.2192 | 0.8072 | 0.9526 | 1.3012 | 1.0575 | 0.7775 |
Dinophysistoxin 1 | 1.0044 | 1.0162 | 1.0062 | 0.9564 | 0.9996 | 1.0194 | 0.9993 | 0.9988 |
Dioncopeltine A | 1.0012 | 1.0184 | 0.9936 | 0.9862 | 1.0236 | 1.0091 | 0.9793 | 0.9969 |
DL-2-Aminooctanoic acid | 1.5003 | 1.3715 | 1.4382 | 1.1392 | 0.3442 | 1.2022 | 1.0206 | 0.4532 |
D-Proline | 0.8699 | 1.0492 | 1.1171 | 1.1858 | 1.1693 | 1.0730 | 0.8335 | 0.8248 |
Duartin, Dimethyl Ether | 1.4724 | 0.7600 | 1.0227 | 0.6282 | 0.0334 | 1.0253 | 1.3260 | 1.4963 |
Emmotin A | 0.9486 | 0.9966 | 0.9685 | 0.9792 | 1.0103 | 1.0296 | 0.9674 | 1.0702 |
Estra-1,3,5(10)-triene-3,6alpha,17beta-triol triacetate | 1.4124 | 1.2926 | 1.0001 | 0.5849 | 1.2875 | 0.9438 | 0.6871 | 0.9755 |
Fampridine | 1.2609 | 0.8685 | 0.9380 | 0.4367 | 1.0024 | 0.8549 | 1.1329 | 1.2947 |
Farnesyl Thiosalicylic Acid | 1.0066 | 1.0122 | 0.9804 | 0.9752 | 1.0219 | 1.0219 | 0.9870 | 0.9957 |
Flusulfamide | 1.0168 | 1.0461 | 0.9679 | 0.9703 | 0.9985 | 1.0214 | 0.9987 | 0.9916 |
Gln Met Lys | 0.0028 | 8.2097 | 0.0028 | 0.0028 | 2.4579 | 0.0028 | 0.0028 | 0.0028 |
Glu Arg Pro | 0.8502 | 1.6761 | 1.7914 | 0.0008 | 1.4511 | 1.5648 | 1.0530 | 0.0008 |
?-Glutamyl-?-cyanoalanine | 0.4654 | 0.6323 | 0.7037 | 0.5103 | 0.6693 | 1.0385 | 0.9482 | 2.3595 |
Glutathione, oxidized | 0.7008 | 0.8466 | 1.3392 | 0.6191 | 0.7888 | 0.8622 | 0.9977 | 1.5972 |
Gly Met Cys | 1.1454 | 1.2741 | 1.0549 | 1.0245 | 1.1957 | 1.1740 | 0.8162 | 0.5888 |
Guanidylic acid (guanosine monophosphate) | 0.0007 | 0.7966 | 0.0007 | 0.0007 | 0.3097 | 0.9965 | 0.6119 | 4.0666 |
Heliamine | 0.9127 | 0.9754 | 0.8995 | 0.9711 | 1.0343 | 1.0029 | 0.9976 | 1.1282 |
Hexaflumuron | 1.0184 | 1.0289 | 0.9923 | 0.9809 | 1.0161 | 0.9953 | 0.9824 | 0.9993 |
His Glu Asn | 1.0181 | 1.0259 | 0.9849 | 0.9782 | 1.0142 | 0.9973 | 0.9828 | 1.0072 |
His Thr Leu | 1.0010 | 1.0134 | 0.9880 | 0.9839 | 1.0139 | 1.0077 | 0.9902 | 1.0032 |
Horhammericine | 1.0307 | 1.0015 | 0.9785 | 0.9787 | 1.0239 | 1.0121 | 0.9826 | 0.9948 |
Hypoxanthine | 1.0268 | 1.1735 | 1.3134 | 1.0089 | 1.1269 | 1.1004 | 1.0206 | 0.4706 |
Ile Pro | 0.9538 | 1.2001 | 1.1613 | 0.9788 | 0.9402 | 1.3131 | 1.1988 | 0.4275 |
Inosine 5^-monophosphate (IMP) | 1.0360 | 1.2017 | 1.3567 | 0.9892 | 1.1414 | 1.1151 | 1.0060 | 0.4248 |
Irbesartan | 1.0318 | 1.1234 | 0.9122 | 0.9341 | 0.9928 | 1.0729 | 0.9635 | 1.0013 |
Isoprene | 0.9932 | 1.0744 | 1.4496 | 0.9011 | 1.2892 | 0.9367 | 0.7764 | 0.7688 |
Isopropylamine | 1.2107 | 1.0776 | 1.1433 | 1.1267 | 0.7861 | 1.0374 | 0.9964 | 0.7914 |
Istamycin C1 | 0.6548 | 0.8809 | 0.8933 | 0.8324 | 1.1294 | 1.3661 | 0.8736 | 1.1860 |
L-Anserine | 1.3744 | 1.4708 | 1.3909 | 0.5256 | 1.4223 | 1.1462 | 1.0222 | 0.0747 |
Leu Leu Pro | 1.5170 | 1.4244 | 1.5607 | 0.5375 | 1.5441 | 1.1501 | 0.7986 | 0.0005 |
Leu Ser Trp | 1.0464 | 3.5236 | 0.0012 | 0.0012 | 3.8399 | 0.6039 | 0.0012 | 0.0012 |
Levan | 0.6108 | 1.6346 | 2.2216 | 0.7802 | 1.7064 | 0.8053 | 0.7170 | 0.1308 |
L-Glutamate | 0.6918 | 0.6737 | 0.9134 | 1.1083 | 0.8851 | 0.9206 | 0.8876 | 1.6284 |
L-Glutamic acid dibutyl ester | 0.8265 | 0.5927 | 1.1076 | 1.3116 | 1.9119 | 0.4112 | 1.0412 | 0.7295 |
L-Glutamic acid n-butyl ester | 1.1875 | 1.0181 | 1.1081 | 1.1090 | 1.0056 | 0.9599 | 0.9159 | 0.8340 |
L-Histidine | 0.9561 | 1.1007 | 1.1406 | 1.1248 | 1.1887 | 0.9652 | 1.0820 | 0.5917 |
L-Threonine | 0.6675 | 0.8632 | 1.1352 | 1.0320 | 0.9166 | 1.0199 | 0.9012 | 1.3303 |
L-Valine | 0.9152 | 1.1967 | 1.2940 | 0.8809 | 1.1748 | 1.0293 | 0.8753 | 0.7963 |
Lycoflexine | 1.0077 | 1.0225 | 0.9864 | 0.9947 | 1.0199 | 1.0126 | 0.9772 | 0.9919 |
Lys Trp His | 1.0177 | 1.0144 | 0.9802 | 0.9496 | 1.0115 | 1.0315 | 0.9899 | 1.0022 |
Lys Val | 1.1096 | 0.9346 | 0.9304 | 0.7443 | 1.0581 | 1.1322 | 1.1555 | 0.8624 |
Mycosporine | 0.8712 | 1.0337 | 1.7857 | 0.9767 | 1.0765 | 1.0227 | 0.9878 | 0.4903 |
N1-(5-Phospho-D-ribosyl)-AMP | 1.2706 | 0.9047 | 1.1234 | 1.1305 | 1.1615 | 0.9791 | 1.0415 | 0.5393 |
N-Acryloylglycine | 0.4913 | 0.8692 | 0.9437 | 0.9852 | 0.9148 | 0.9979 | 1.1532 | 1.3715 |
Nafoxidine | 0.0015 | 7.2799 | 0.0015 | 0.0015 | 3.0235 | 0.0015 | 0.0015 | 0.0015 |
N(alpha)-t-Butoxycarbonyl-L-leucine | 0.6103 | 1.0800 | 2.5891 | 1.1952 | 1.1137 | 0.3288 | 0.9246 | 0.5701 |
N-Hydroxymethylnicotinamide | 1.1547 | 1.2235 | 1.1003 | 0.8513 | 0.9631 | 1.1702 | 1.0979 | 0.6085 |
Niacinamide | 1.0313 | 1.0871 | 1.2683 | 0.9517 | 1.1180 | 1.0798 | 1.0307 | 0.5934 |
NU 7026 | 0.0010 | 0.5846 | 2.8407 | 0.0010 | 2.1463 | 1.2183 | 0.2605 | 0.9150 |
N-Valerylglycine methyl ester | 0.0024 | 0.0024 | 0.0024 | 0.0024 | 0.0024 | 0.0024 | 3.8928 | 2.2639 |
Ovaliflavanone A | 1.0143 | 1.0257 | 0.9759 | 0.9730 | 1.0181 | 1.0055 | 0.9917 | 1.0002 |
Oxypurinol | 0.7143 | 0.9343 | 1.0730 | 0.6735 | 0.8011 | 0.9792 | 1.0263 | 1.5492 |
PA(15:0/0:0) | 1.6721 | 1.3761 | 0.3852 | 0.7332 | 0.9880 | 1.0942 | 1.0121 | 0.8710 |
PA(20:0/18:0) | 0.7005 | 1.8878 | 0.8432 | 0.4615 | 1.1667 | 0.9347 | 1.1134 | 1.0214 |
Pantetheine | 0.3756 | 1.0997 | 0.7804 | 1.0815 | 1.4091 | 1.4874 | 0.8881 | 0.8232 |
PD 0325901 | 1.0161 | 1.0433 | 0.9761 | 0.9584 | 1.0422 | 1.0206 | 0.9814 | 0.9776 |
Phenylpyruvic acid | 0.8677 | 1.4608 | 0.9368 | 0.8705 | 1.1882 | 1.2493 | 1.0111 | 0.6106 |
Phthalide | 0.0011 | 7.9086 | 0.0011 | 0.2171 | 2.0787 | 0.3980 | 0.0011 | 0.0011 |
PI(20:5(5Z,8Z,11Z,14Z,17Z)/14:1(9Z)) | 1.0129 | 1.0100 | 0.9801 | 0.9759 | 1.0187 | 1.0237 | 0.9779 | 1.0025 |
Pro Gly Gln | 1.3835 | 1.1212 | 1.1944 | 0.8237 | 2.0305 | 0.6883 | 1.0722 | 0.0005 |
Pro Ile Gln | 1.2920 | 1.1919 | 1.1805 | 0.6444 | 1.2305 | 1.0548 | 0.9950 | 0.5934 |
Pro Leu Cys | 1.4038 | 1.4456 | 0.9325 | 0.7938 | 1.2914 | 1.4589 | 0.9516 | 0.1137 |
Prostaglandin D1 Alcohol | 1.4448 | 1.1400 | 0.6627 | 0.7466 | 0.9625 | 1.1380 | 0.9366 | 1.0070 |
Pro Val Tyr | 0.0027 | 7.0788 | 0.0027 | 0.0027 | 2.2582 | 0.8814 | 0.0027 | 0.0027 |
Pyridine | 1.0140 | 1.0712 | 1.2584 | 0.9794 | 1.1028 | 1.0601 | 1.0564 | 0.6044 |
Rimocidine | 1.0122 | 1.0229 | 0.9840 | 0.9779 | 1.0204 | 1.0172 | 0.9818 | 0.9926 |
(S)-AL 8810 | 1.0073 | 1.0238 | 0.9755 | 0.9799 | 1.0179 | 1.0134 | 0.9867 | 1.0001 |
Streptidine | 0.6550 | 1.3172 | 1.5124 | 0.8887 | 1.2043 | 1.2557 | 1.2928 | 0.1279 |
Sulfadoxine glucuronide | 0.6165 | 0.6434 | 3.0127 | 0.2549 | 1.1928 | 0.3985 | 1.2728 | 0.6567 |
Sulfamethazine | 1.0153 | 1.0327 | 0.9921 | 0.9688 | 1.0172 | 1.0058 | 0.9849 | 0.9955 |
Taurine | 1.0344 | 1.0940 | 1.1378 | 1.0758 | 1.0701 | 1.1060 | 1.0168 | 0.6242 |
Tetradecylamine | 0.9432 | 0.9728 | 0.9519 | 0.9759 | 1.0664 | 1.0251 | 0.9899 | 1.0334 |
Tetrahydropteridine | 1.0209 | 1.3770 | 3.7632 | 0.0007 | 1.2718 | 0.3102 | 0.9693 | 0.0007 |
Threonate | 0.4974 | 0.8305 | 0.9579 | 0.5916 | 0.5396 | 1.0397 | 0.9330 | 2.1378 |
Tiludronic acid | 0.9826 | 1.0633 | 0.9847 | 0.9676 | 1.0278 | 1.0012 | 0.9888 | 0.9988 |
Tris(butoxyethyl)phosphate | 0.8611 | 1.0145 | 0.7676 | 0.6304 | 1.1344 | 0.9143 | 0.9144 | 1.5317 |
Trovafloxacin | 1.1245 | 0.9070 | 0.9274 | 1.0240 | 1.0675 | 0.9936 | 0.9390 | 1.0060 |
Tyr Arg Thr | 1.0112 | 1.0058 | 0.9890 | 0.9665 | 1.0101 | 1.0176 | 0.9926 | 1.0036 |
Urapidil | 1.0186 | 1.0444 | 0.9685 | 0.9561 | 1.0235 | 1.0085 | 0.9853 | 1.0038 |
Uridine monophosphate (UMP) | 0.0009 | 0.9682 | 0.0009 | 0.0009 | 0.3421 | 0.9935 | 0.3556 | 4.2123 |
Val Ile Pro | 1.5396 | 1.2979 | 1.4126 | 0.6036 | 1.5385 | 0.9408 | 0.8854 | 0.1957 |
W146 | 1.0162 | 1.0011 | 0.9828 | 0.9799 | 1.0135 | 1.0031 | 0.9898 | 1.0098 |
Zopiclone | 0.9872 | 1.0241 | 0.9278 | 0.9410 | 1.0633 | 1.0751 | 1.0019 | 0.9668 |
Factors:
F1 | Group:CD | Genotype:Irlox | Diet:Chow |
F2 | Group:Control | Genotype:IGFR lox | Diet:Chow |
F3 | Group:Control | Genotype:Irlox | Diet:Chow |
F4 | Group:Control | Genotype:IRlox IGFR lox | Diet:Chow |
F5 | Group:HFD | Genotype:Irlox | Diet:High Fat Diet |
F6 | Group:IGFRKO | Genotype:IGFR -/- | Diet:Chow |
F7 | Group:IRKO | Genotype:IR -/- | Diet:Chow |
F8 | Group:MIGIRKO | Genotype:IR -/- IGFR -/- | Diet:Chow |