Data for Large Scale C18 Profiling of the Effects of Curcumin Supplementation of Older Adults: Relation to Vascular Function (Study ST000566)
(Analysis AN000870)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| 10-Deoxymethynolide | 1.1747 | 1.2291 | 0.8551 | 0.9052 | NA | 0.7611 |
| (+)-12a-Hydroxyerythynone | 1.0981 | 1.0713 | 1.0181 | 1.0526 | NA | 0.7409 |
| 13S-hydroperoxy-9Z,11E,14Z-octadecatrienoic acid | 0.8299 | 1.2988 | 0.8321 | 1.6393 | NA | 0.4152 |
| 1,6-Anhydro-?-D-glucose | 1.0574 | 1.0671 | 0.9277 | 1.0514 | NA | 0.8771 |
| 1-L-Leucyl-L-Proline | 1.0593 | 1.1339 | 1.0390 | 1.1144 | NA | 0.6368 |
| 1-Methyladenosine | 0.6593 | 1.0704 | 1.2559 | 1.7960 | NA | 0.3321 |
| 2-Amino-3-methyl-1-butanol | 1.0756 | 1.0887 | 0.9633 | 1.0206 | NA | 0.8272 |
| 2-Iodophenol | 1.0137 | 1.0102 | 1.0035 | 1.0236 | NA | 0.9475 |
| 2-Oxo-10-methylthiodecanoic acid | 0.9370 | 0.9853 | 0.9489 | 0.9871 | NA | 1.1482 |
| 2-oxo-3-methylvaleric acid | 1.0851 | 1.2233 | 0.8791 | 1.1213 | NA | 0.6472 |
| 2S-amino-3-oxo-butanoic acid | 1.2604 | 1.5396 | 0.7862 | 0.9731 | NA | 0.3093 |
| 3?,11?-Dihydroxy-12-oxo-5?-cholan-24-oic Acid | 0.7298 | 0.9541 | 1.1151 | 1.0174 | NA | 1.2381 |
| 3-Butynoate | 1.1098 | 0.9388 | 0.7692 | 1.0668 | NA | 1.0967 |
| 3-Isochromanone | 1.0026 | 1.0062 | 1.0324 | 1.0232 | NA | 0.9383 |
| 3-ketosphingosine | 1.0900 | 1.4240 | 0.8091 | 0.9397 | NA | 0.6459 |
| 3^-Methoxy-E,E-dienoestrol | 0.9097 | 1.1092 | 0.8284 | 1.0202 | NA | 1.1190 |
| 3-Methyl-L-histidine | 1.0079 | 1.0402 | 1.2245 | 1.0041 | NA | 0.7329 |
| 3-O-Methyl-myo-inositol | 1.2007 | 1.1497 | 1.0108 | 1.3897 | NA | 0.2277 |
| 3-(Pyrazol-1-yl)-L-alanine | 1.0248 | 0.9202 | 0.9954 | 0.9880 | NA | 1.0783 |
| 3-Pyridylacetic acid | 1.2289 | 1.3304 | 0.9966 | 0.9304 | NA | 0.4285 |
| 4-Oxoproline | 1.0221 | 0.9161 | 0.9201 | 0.8610 | NA | 1.2739 |
| 5,7,3^,5^-Tetrahydroxy-3,6,8,4^-tetramethoxyflavone 3^-glucoside | 1.0274 | 1.2051 | 0.9841 | 1.0890 | NA | 0.6664 |
| 5,7,4^-Trihydroxyflavanone 7-sulfate | 1.0063 | 1.1320 | 0.9822 | 1.0405 | NA | 0.8208 |
| 5-Formiminotetrahydrofolic acid | 1.0404 | 1.1765 | 0.9985 | 1.0929 | NA | 0.6673 |
| 5-Methylcytidine | 0.8968 | 0.7891 | 0.9138 | 1.0148 | NA | 1.4253 |
| 6-methyltetrahydropterin | 0.8787 | 0.7882 | 0.9153 | 0.7153 | NA | 1.7236 |
| 7-hydroxy-5-heptynoic acid | 1.0404 | 1.0366 | 1.0006 | 0.9971 | NA | 0.9141 |
| 8E-Heptadecenedioic acid | 1.1595 | 1.1637 | 1.0043 | 0.9893 | NA | 0.6366 |
| AFMK | 1.0450 | 1.1489 | 1.0968 | 1.3336 | NA | 0.3788 |
| Allodeoxycholic Acid | 1.0430 | 1.3423 | 0.8093 | 1.0291 | NA | 0.7097 |
| AMPA | 0.9743 | 1.1289 | 0.6688 | 0.9821 | NA | 1.2062 |
| Azaserine | 1.0779 | 0.9258 | 1.0226 | 1.1429 | NA | 0.8420 |
| Benzenamine sulfate | 0.8284 | 0.5132 | 1.1411 | 1.3224 | NA | 1.3221 |
| b-Glucose | 1.0175 | 1.0222 | 1.0003 | 1.0137 | NA | 0.9417 |
| C17 Sphinganine | 1.0186 | 0.9770 | 1.0346 | 1.0416 | NA | 0.9342 |
| Caproic acid | 0.9362 | 0.8797 | 1.2178 | 1.0878 | NA | 0.9266 |
| Caproic acid + 1.6348685 | 0.9299 | 0.8790 | 1.2030 | 1.1150 | NA | 0.9231 |
| Celiprolol | 1.3957 | 1.3984 | 0.6110 | 0.8402 | NA | 0.6022 |
| Cetraxate | 1.0090 | 1.0080 | 1.0059 | 1.0200 | NA | 0.9566 |
| cis-Caryophyllene | 0.6882 | 0.7122 | 1.3017 | 0.8900 | NA | 1.5073 |
| Corey PG-Lactone Diol | 1.2608 | 1.1501 | 0.7873 | 0.9941 | NA | 0.7334 |
| Corey PG-Lactone Diol + 6.739769 | 1.3560 | 1.1239 | 0.5676 | 0.9581 | NA | 0.8919 |
| Creatinine | 1.0252 | 1.0002 | 1.0558 | 1.0445 | NA | 0.8779 |
| Desmethylmianserin glucuronide | 1.0229 | 1.1426 | 1.0630 | 1.1273 | NA | 0.6342 |
| Diethyl Oxalpropionate | 1.2985 | 1.7800 | 0.8047 | 0.8368 | NA | 0.1003 |
| DL-2-Aminooctanoic acid | 1.0538 | 1.0072 | 1.0997 | 1.1245 | NA | 0.7222 |
| DL-?-Leucine | 1.1064 | 1.0993 | 0.8778 | 0.9849 | NA | 0.8924 |
| DL-?-Lipoic Acid | 1.0195 | 0.9842 | 1.0913 | 1.0157 | NA | 0.8965 |
| DL-pipecolic acid | 1.1326 | 1.2048 | 0.8893 | 1.0071 | NA | 0.7106 |
| (E)-2-Methylglutaconic acid | 0.9806 | 1.0158 | 0.9401 | 1.1481 | NA | 0.9221 |
| edetate | 1.0230 | 1.0499 | 0.9667 | 1.0235 | NA | 0.9257 |
| Fexofenadine | 1.0205 | 1.2087 | 0.9183 | 1.1373 | NA | 0.6864 |
| Glycerophospho-N-Arachidonoyl Ethanolamine | 0.8349 | 1.1081 | 1.2352 | 1.2853 | NA | 0.5820 |
| Gly Pro | 0.9801 | 0.8858 | 0.9085 | 0.9465 | NA | 1.2880 |
| HBA | 1.1617 | 1.1845 | 0.6184 | 0.9187 | NA | 1.0343 |
| Heptanoic acid, 2-amino-, (R)-; (R)-2-Aminoheptanoic acid | 1.0362 | 1.0174 | 1.0240 | 1.0448 | NA | 0.8748 |
| Hippuric acid | 1.1486 | 1.0252 | 1.0349 | 1.1744 | NA | 0.6070 |
| Indoleacrylic acid | 0.9605 | 0.9262 | 0.9618 | 0.9933 | NA | 1.1712 |
| Isobutyronitrile | 0.9698 | 0.9601 | 0.8821 | 0.8859 | NA | 1.2955 |
| L-Arginine | 0.9749 | 0.9278 | 0.9223 | 0.9990 | NA | 1.1842 |
| Levobunolol glucuronide | 1.2449 | 1.0755 | 0.8376 | 1.1295 | NA | 0.6644 |
| L-Glutamic acid dibutyl ester | 1.2142 | 1.2797 | 1.0385 | 1.0056 | NA | 0.3945 |
| L-Glutamic acid n-butyl ester | 1.1267 | 1.1908 | 0.9717 | 1.0443 | NA | 0.6223 |
| L-Glutamic acid n-butyl ester + 1.5990624 | 1.1251 | 1.1984 | 0.9723 | 1.0418 | NA | 0.6173 |
| L-Valine | 1.0569 | 1.1256 | 0.8787 | 0.9266 | NA | 0.9722 |
| Lys Asn Pro | 1.0651 | 1.2801 | 0.8115 | 0.7244 | NA | 1.0365 |
| Lysine | 1.1767 | 0.9195 | 1.0037 | 1.3279 | NA | 0.5821 |
| LysoPE(0:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) | 0.8910 | 1.0864 | 1.2138 | 1.3448 | NA | 0.5071 |
| methyl-10-hydroperoxy-8E,12Z,15Z-octadecatrienoate | 1.1281 | 1.2904 | 0.8123 | 1.0183 | NA | 0.6790 |
| Metipranolol | 1.2878 | 1.1231 | 0.7946 | 0.9324 | NA | 0.7839 |
| Mycalamide A | 0.8183 | 1.4113 | 1.8078 | 0.8123 | NA | 0.1619 |
| Myxothiazol Z | 1.0519 | 0.8868 | 1.1158 | 1.0349 | NA | 0.9301 |
| N2-Succinylglutamic acid | 1.1322 | 0.5973 | 1.3748 | 1.0438 | NA | 0.9204 |
| N6-Acetyl-N6-hydroxy-L-lysine | 1.3466 | 1.0316 | 0.9937 | 1.1636 | NA | 0.4217 |
| N-Acetylputrescine | 1.1022 | 1.0676 | 0.9314 | 0.9147 | NA | 0.9489 |
| N-Hydroxymethylnicotinamide | 0.8163 | 1.2765 | 1.1975 | 1.3796 | NA | 0.3581 |
| N,N-Diethylglycine | 0.9901 | 0.8550 | 1.2383 | 1.1463 | NA | 0.8199 |
| N-Oleoyl-L-Serine | 1.1392 | 1.3259 | 0.8736 | 1.1177 | NA | 0.4765 |
| N-palmitoyl serine | 1.1521 | 1.2271 | 0.8437 | 1.1660 | NA | 0.5575 |
| o-Methyldopamine (3-methoxytyramine) | 1.0891 | 1.0560 | 1.0476 | 0.9887 | NA | 0.8004 |
| PE(21:0/20:1(11Z)) | 0.9157 | 0.9991 | 0.8735 | 0.8913 | NA | 1.3158 |
| Phe Gly Trp | 0.9896 | 0.3262 | 0.5808 | 0.9150 | NA | 2.2501 |
| Phe Phe Thr | 1.0703 | 1.0579 | 1.0366 | 1.1001 | NA | 0.7265 |
| Quinaprilat | 0.9685 | 0.9763 | 0.9121 | 0.9379 | NA | 1.2025 |
| S-(2-Methylpropionyl)-dihydrolipoamide-E | 1.2788 | 0.9786 | 0.8088 | 0.8358 | NA | 1.0359 |
| Scyphostatin A | 0.9009 | 1.3025 | 0.9969 | 1.2044 | NA | 0.5807 |
| Senecivernine | 1.0545 | 1.0488 | 0.9462 | 1.0217 | NA | 0.9117 |
| Symmetric Dimethylarginine | 1.0481 | 1.0499 | 0.9959 | 1.0352 | NA | 0.8591 |
| Tetrahydrocorticosterone | 1.1901 | 1.3795 | 0.6687 | 0.8803 | NA | 0.7678 |
| Tetrahydropalmatine | 1.0577 | 1.2849 | 0.8384 | 0.9835 | NA | 0.7738 |
| THTC | 0.9805 | 0.9598 | 0.9562 | 0.9646 | NA | 1.1418 |
| Tiletamine | 0.9296 | 1.2015 | 0.9207 | 1.2282 | NA | 0.7120 |
| Trans-2, 3, 4-Trimethoxycinnamate | 0.8081 | 1.0084 | 1.6006 | 1.5854 | NA | 0.1084 |
| Trp Phe | 1.0674 | 1.1238 | 1.0569 | 1.2295 | NA | 0.5156 |
| Urea | 0.9941 | 1.0223 | 1.1449 | 1.1096 | NA | 0.7449 |
| Uric acid | 1.0335 | 1.0024 | 1.0494 | 1.0693 | NA | 0.8488 |
| Uridine | 1.0960 | 0.8793 | 1.0790 | 1.0919 | NA | 0.8694 |
| Ursodeoxycholic acid 3-sulfate | 1.5201 | 1.8634 | 0.3985 | 0.8661 | NA | 0.1018 |
| Valdecoxib | 1.0366 | 1.1247 | 1.0478 | 1.0677 | NA | 0.7084 |
| (Z)-N-(2-hydroxyethyl)hexadec-7-enamide | 0.9232 | 1.2651 | 0.8714 | 1.0484 | NA | 0.8593 |
Factors:
| F1 | group:Old-Curcumin | Time point:Post |
| F2 | group:Old-Curcumin | Time point:Pre |
| F3 | group:Old-Placebo | Time point:Post |
| F4 | group:Old-Placebo | Time point:Pre |
| F5 | group:young | Time point:Baseline |
| F6 | group:young | Time point:Pre |
