Data for Effects of the Kinase Inhibitor Sorafenib on Serum Metabolism In Vivo using Non-targeted Metabolomics Analysis tissue). (Study ST000574)

(Analysis AN000884)

Values for each metabolite have been scaled by dividing by the mean across all factors

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Metabolite	F1	F2
2-Hydroxypyridine	0.9913	1.0098
3-Aminoisobutyric acid/beta-Alanine	1.0088	0.9874
3-Phosphoglyceric acid	0.9930	1.0078
5^-Deoxy-5^-(methylthio) adenosine	0.9739	1.0261
6-Hydroxynicotinic acid	0.9913	1.0097
Acetoacetate/2-Aminoisobutanoic acid	0.9971	1.0036
Adenine	0.9583	1.0370
Alanine	1.0103	0.9920
Aldopentoses	0.9953	1.0052
alpha Ketoglutaric acid	1.0216	0.9784
alpha-Monopalmitin	0.9818	1.0182
alpha-Monostearin	0.9589	1.0457
alpha-Tocopherol	0.9905	1.0105
Aminomalonic acid	0.9861	1.0154
Arachidonic acid (also Eicosapentaenoic acid)	0.9891	1.0122
Ascorbic acid/Isoascorbic acid	0.9955	1.0050
Aspartic acid	1.0132	0.9853
Benzoic acid	1.0059	0.9924
beta-Monopalmitin	0.9936	1.0071
beta-Monostearin	0.9972	1.0028
beta-Sitosterol	1.0045	0.9950
C13 hydrocarbon	1.0085	0.9906
C14 Hydrocarbon	1.0054	0.9946
C15 hydrocarbon	0.9965	1.0043
C16 Hydrocarbon	0.9714	1.0368
C18 Hydrocarbon	0.9846	1.0137
C19 hydrocarbon	1.0008	0.9992
C20 Hydrocarbon	0.9989	1.0013
Campesterol	0.9963	1.0041
Carnitine	0.9866	1.0148
Carnosine	0.9888	1.0124
Creatinine	1.0084	0.9906
deuterated Myristic Acid (RTL std)	0.9811	1.0189
Dihydroxyacetone phosphate	0.9941	1.0066
Disaccharide	0.9715	1.0316
Erythritol/Theitol	0.9945	1.0061
Ethanolamine	0.9980	1.0023
Fructose or similar ketohexose	0.9773	1.0252
Fumaric acid	0.9982	1.0023
gamma-Hydroxybutyric acid	0.9871	1.0143
Glucose and other aldohexoses	1.0039	0.9961
Glutamine	1.0092	0.9869
Glycerol	1.0017	0.9985
Glycine	0.9966	1.0038
Heptadecanoic acid/Octadecanol	0.9918	1.0102
Hexanoic acid (and/or Glycolic acid)	0.9965	1.0039
Hexitols	1.0032	0.9964
Hydroxyprolines	0.9937	1.0070
Hypoxanthine	0.9878	1.0136
Inosine/Adenosine	0.9805	1.0217
Isoleucine/Leucine	0.9984	1.0017
Lauric acid	0.9955	1.0045
Linoleic acid	0.9872	1.0142
Lysine	1.0021	0.9977
Malic acid	0.9660	1.0340
Malonic acid	1.0051	0.9944
Methionine sulfoxide	0.9822	1.0178
Myoinositol	0.9993	1.0007
Myoinositol-2-phosphate	0.9790	1.0210
Myristic acid or Pentadecanol	0.9915	1.0096
N-Methylalanine/2-Aminobutanoic acid/N-Ethylglycine	0.9784	1.0240
Nonanoic acid	0.9976	1.0026
O-Methylphosphate	0.9970	1.0033
O-Phosphocolamine	1.0115	0.9885
Palmitic acid	0.9817	1.0203
Pantothenic acid	0.9994	1.0007
Pentitols	0.9914	1.0095
Phenylalanine	0.9874	1.0112
Phosphoenolpyruvic acid	1.0036	0.9960
Proline	0.9913	1.0097
Pseudouridine	0.9924	1.0084
Pyruvic acid	1.0017	0.9982
Siloxanes	0.9750	1.0194
Spermidine	0.9791	1.0232
Squalene	0.9641	1.0399
Stearic acid	0.9744	1.0285
Sucrose and similar disaccharides	0.9983	1.0018
Taurine	0.9870	1.0115
Tetradecanedioic acid	0.9824	1.0196
Threonic acid/erythronic acid	1.0004	0.9995
Tiglic acid	1.0001	0.9999
Trisaccharide	0.9921	1.0061
Tryptamine/Norepinephrine	0.9865	1.0152
Uracil	1.0042	0.9953
Uric acid	1.0070	0.9930
Uridine	0.9930	1.0077

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Factors:

F1	Vehicle (PBS) Control Treatment:30 mg/kg Sorafenib Treatment
F2	Vehicle (PBS) Control Treatment:Vehicle (PBS) Control Treatment