Data for Effects of the Kinase Inhibitor Sorafenib on Liver Metabolism In Vivo using Non-targeted Metabolomics Analysis tissue). (Study ST000577)

(Analysis AN000887)

Values for each metabolite have been scaled by dividing by the mean across all factors

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Metabolite	F1	F2
2-Aminoadipic acid	1.0278	0.9806
2-Hydroxypyridine	1.0012	0.9988
3-Phosphoglyceric acid	1.0035	0.9965
Acetoacetate/2-Aminoisobutanoic acid	0.9893	1.0107
Adenosine/Inosine	0.9935	1.0065
Aldopentoses	1.0023	0.9977
alpha Ketoglutaric acid	1.0057	0.9943
alpha-Monopalmitin	0.9950	1.0050
alpha-Monostearin	0.9746	1.0254
alpha-Tocopherol	0.9925	1.0075
Aminomalonic acid	0.9694	1.0275
Arachidic acid/ 1-Heneicosanol	1.0080	0.9930
Arachidonic acid (also Eicosapentaenoic acid)	0.9988	1.0012
Ascorbic acid/Isoascorbic acid	0.9975	1.0025
Asparagine	0.9480	1.0468
Aspartic acid	0.9992	1.0008
Benzoic acid	0.9926	1.0052
beta-Hydroxybutyric acid	1.0102	0.9898
beta-Sitosterol	0.9985	1.0015
C10 hydrocarbon	1.0024	0.9983
C11 hydrocarbon	0.9976	1.0024
C12 hydrocarbon	1.0051	0.9949
C16 Hydrocarbon	0.9839	1.0161
C17 hydrocarbon	0.9906	1.0085
C25 hydrocarbon	0.9992	1.0008
Campesterol	0.9869	1.0131
Creatinine	0.9924	1.0061
Decanoic acid	1.0083	0.9935
Dehydroalanine (possibly from cysteine)	1.0010	0.9990
Dehydroascorbic acid (possibly alpha-ketoglutarate)	0.9798	1.0202
deuterated Myristic Acid (RTL std)	0.9922	1.0078
Dihydroxyacetone phosphate	0.9921	1.0089
Docosahexaenoic acid	0.9970	1.0027
Docosanoic acid	1.0067	0.9941
Erythritol/Theitol	0.9796	1.0204
Ethanolamine	1.0014	0.9986
Fructose or similar ketohexose	0.9971	1.0029
Fumaric acid	0.9993	1.0006
gamma-Hydroxybutyric acid	0.9996	1.0004
gamma-Tocopherol	0.9977	1.0023
Glutathione (reduced)	0.9882	1.0107
Glycerol 1-phosphate	0.9977	1.0023
Glyoxylic acid	1.0007	0.9994
Gly-Pro	0.9946	1.0054
Heptadecanoic acid/Octadecanol	0.9868	1.0132
Hexanoic acid (and/or Glycolic acid)	0.9984	1.0016
Hydroxyprolines	0.9775	1.0290
Inosine/Adenosine	0.9862	1.0138
Isoleucine/Leucine	1.0019	0.9981
Lactic acid	1.0076	0.9924
Lauric acid	0.9958	1.0042
Malonic acid	1.0035	0.9965
Methionine	0.9957	1.0039
Methionine sulfoxide	1.0158	0.9873
Myoinositol	1.0010	0.9990
Myoinositol-2-phosphate	0.9807	1.0193
Myristic acid or Pentadecanol	0.9892	1.0108
N-Methylalanine/2-Aminobutanoic acid/N-Ethylglycine	1.0040	0.9960
Nonadecanoic acid	0.9854	1.0146
Nonanoic acid	0.9862	1.0138
O-Methylphosphate	0.9972	1.0028
O-Phosphocolamine	0.9910	1.0081
Pantothenic acid	1.0077	0.9923
Pentadecanoic acid/Hexadecanol	0.9970	1.0030
Pentitols	0.9998	1.0002
Phenol	0.9993	1.0007
Phenylalanine	1.0001	0.9999
Phosphoenolpyruvic acid	0.9948	1.0057
Proline	1.0103	0.9886
Pseudouridine	0.9959	1.0041
Pyruvic acid	1.0198	0.9777
Serine	0.9944	1.0063
Siloxanes	1.0038	0.9967
Spermidine	0.9899	1.0101
Squalene	0.9701	1.0209
Stearamide	0.9886	1.0114
Stearic acid	0.9895	1.0092
Succinic acid	0.9837	1.0163
Sucrose and similar disaccharides	0.9915	1.0085
Taurine	1.0020	0.9980
Tetradecanedioic acid	0.9847	1.0153
Threonic acid/erythronic acid	0.9986	1.0014
Threonine	1.0003	0.9997
Tiglic acid	1.0029	0.9971
Trisaccharide	1.0134	0.9866
Tryptamine/Norepinephrine	0.9858	1.0142
Tyrosine	0.9845	1.0155
Unknown-possibly propylene glycol	1.0203	0.9797
Uracil	0.9959	1.0041
Urea	1.0027	0.9973

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Factors:

F1	Vehicle (PBS) Control Treatment:30 mg/kg Sorafenib Treatment
F2	Vehicle (PBS) Control Treatment:Vehicle (PBS) Control Treatment