Data for Non-targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo (Study ST000623)
(Analysis AN001820)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 1,2-Propanediol | 0.9893 | 1.0276 | 0.9949 | 0.9984 |
| 1,5-Anhydroglucitol | 1.0140 | 1.0098 | 1.0167 | 0.9656 |
| 2-Aminoadipic Acid | 1.0219 | 1.0085 | 1.0038 | 0.9773 |
| 2-Hydroxybutyric Acid | 1.0360 | 0.9963 | 0.9947 | 0.9931 |
| 2-Hydroxyglutaric Acid | 1.0335 | 0.9912 | 1.0158 | 0.9771 |
| 2-Hydroxypyridine | 1.0053 | 1.0071 | 1.0036 | 0.9893 |
| 3-Phosphoglyceric Acid | 0.9266 | 1.0707 | 1.0251 | 0.9912 |
| 4-Hydroxymandelic Acid | 1.0146 | 1.0156 | 0.9911 | 0.9900 |
| Adenine | 1.0148 | 0.9745 | 1.0020 | 0.9959 |
| Adenosine | 1.0245 | 1.0241 | 0.9790 | 0.9926 |
| Adenosine-5-Monophosphate | 1.0265 | 1.0610 | 0.9317 | 1.0088 |
| Alanine | 1.0114 | 1.0042 | 1.0021 | 0.9882 |
| Alpha-Tocopherol | 0.9992 | 1.0187 | 1.0026 | 0.9885 |
| Aminomalonic Acid | 1.0012 | 1.0109 | 0.9980 | 0.9958 |
| Arachidonic Acid (Also Eicosapentaenoic Acid) | 1.0010 | 1.0087 | 1.0096 | 0.9854 |
| Asparagine | 1.0149 | 0.9739 | 1.0128 | 0.9903 |
| Aspartic Acid | 1.0180 | 1.0217 | 0.9907 | 0.9864 |
| Beta-Alanine | 0.9901 | 0.9892 | 0.9881 | 1.0239 |
| Beta-Hydroxybutyric Acid | 0.9922 | 0.9853 | 1.0090 | 1.0035 |
| Campesterol | 1.0071 | 1.0279 | 0.9717 | 1.0002 |
| Carnosine | 1.0257 | 1.0261 | 0.9605 | 1.0093 |
| Cholesterol | 0.9992 | 1.0027 | 1.0010 | 0.9982 |
| Citric Acid/Isocitric Acid | 1.0274 | 1.0052 | 0.9797 | 0.9995 |
| Creatinine | 0.9968 | 1.0106 | 0.9946 | 1.0023 |
| Dehydroascorbic Acid | 0.9518 | 0.9959 | 1.0007 | 1.0335 |
| Disaccharide | 0.9819 | 1.0570 | 0.9498 | 1.0338 |
| Ethanolamine | 1.0008 | 1.0225 | 1.0030 | 0.9853 |
| Fructose-6-Phosphate | 1.0145 | 1.0437 | 0.9610 | 1.0076 |
| Fructose Or Similar Ketohexose | 1.0245 | 1.0137 | 0.9831 | 0.9852 |
| Fumaric Acid | 1.0319 | 1.0320 | 0.9636 | 0.9991 |
| Gamma-Hydroxybutyric Acid/Ethylmalonic Acid | 0.9830 | 1.0280 | 1.0029 | 0.9944 |
| Glucose-6-Phosphate | 1.0266 | 1.0569 | 0.9352 | 1.0186 |
| Glucose And Other Aldohexoses | 0.9679 | 1.0209 | 0.9988 | 1.0122 |
| Glutamic Acid | 0.9669 | 1.0046 | 1.0310 | 0.9887 |
| Glutamine | 1.0019 | 1.0205 | 0.9926 | 0.9958 |
| Glycerol 1-Phosphate | 0.9888 | 1.0473 | 0.9785 | 1.0052 |
| Glycine | 1.0155 | 0.9923 | 0.9982 | 0.9953 |
| Hydroxyprolines | 1.0469 | 0.9818 | 1.0016 | 0.9762 |
| Hypotaurine | 0.9580 | 1.0104 | 1.0018 | 1.0256 |
| Hypoxanthine | 0.9956 | 1.0111 | 0.9852 | 1.0121 |
| Inosine | 1.0034 | 1.0355 | 0.9812 | 0.9987 |
| Isoleucine/Leucine | 0.9829 | 0.9863 | 1.0106 | 1.0077 |
| Ketopentose-5-Phosphate | 1.0143 | 1.0280 | 0.9735 | 1.0029 |
| Lactamide | 1.0192 | 1.0638 | 0.9045 | 1.0285 |
| Lactic Acid | 0.9947 | 1.0173 | 0.9885 | 1.0064 |
| Linoleic Acid | 1.0051 | 1.0005 | 1.0170 | 0.9793 |
| Lysine | 0.9928 | 1.0061 | 1.0021 | 0.9997 |
| Malic Acid | 1.0158 | 1.0178 | 0.9786 | 1.0020 |
| Maltose Or Similar Disaccharide | 1.0010 | 1.0239 | 0.9718 | 1.0156 |
| Myoinositol | 1.0030 | 0.9889 | 1.0221 | 0.9815 |
| Myoinositol-2-Phosphate | 1.0344 | 1.0089 | 0.9440 | 1.0035 |
| N-Acetylneuraminic Acid | 1.0128 | 1.0435 | 0.9863 | 0.9811 |
| N-Methylalanine/2-Aminobutanoic Acid/N-Ethylglycine | 0.9396 | 1.0355 | 1.0331 | 0.9894 |
| Oleic Acid | 0.9815 | 1.0096 | 1.0277 | 0.9798 |
| O-Methylphosphate | 1.0877 | 0.9196 | 0.9832 | 0.9985 |
| O-Phosphocolamine | 0.9775 | 1.0276 | 0.9711 | 1.0301 |
| Pantothenic Acid | 1.0095 | 1.0320 | 0.9845 | 0.9932 |
| Phenylalanine | 1.0008 | 1.0108 | 0.9998 | 0.9943 |
| Phosphoric Acid | 0.9969 | 1.0107 | 0.9895 | 1.0072 |
| Proline | 0.9846 | 0.9594 | 1.0305 | 1.0001 |
| Pyrophosphate | 1.0850 | 1.0226 | 0.9243 | 0.9951 |
| Serine | 1.0058 | 0.9985 | 1.0083 | 0.9886 |
| Siloxanes_R1 | 1.0421 | 1.0837 | 0.9969 | 0.9456 |
| Siloxanes_R2 | 0.9673 | 1.0532 | 0.9203 | 1.0616 |
| Siloxanes_R3 | 1.0098 | 0.9961 | 1.0003 | 0.9952 |
| Spermidine | 0.9327 | 0.9926 | 1.0386 | 1.0164 |
| Spermine | 0.9461 | 0.9954 | 1.0321 | 1.0061 |
| Squalene | 1.0541 | 1.0170 | 0.9810 | 0.9744 |
| Stearamide | 1.0516 | 1.0421 | 0.9507 | 0.9927 |
| Succinic Acid | 1.0067 | 1.0383 | 0.9826 | 0.9938 |
| Threonine | 1.0011 | 1.0074 | 0.9982 | 0.9973 |
| Trisaccharide | 0.9842 | 1.0628 | 0.9725 | 1.0066 |
| Tyrosine | 1.0040 | 1.0204 | 0.9841 | 1.0031 |
| Uracil | 0.9544 | 1.0049 | 0.9952 | 1.0327 |
| Urea | 1.0149 | 0.9988 | 0.9936 | 0.9970 |
| Uric Acid | 0.9680 | 0.9982 | 0.9775 | 1.0448 |
| Valine | 0.9569 | 0.9943 | 1.0143 | 1.0173 |
| Xanthine | 0.9904 | 1.0111 | 0.9672 | 1.0336 |
Factors:
| F1 | Gentotype:Control BF |
| F2 | Gentotype:Control LDE |
| F3 | Gentotype:GRMD BF |
| F4 | Gentotype:GRMD LDE |
