Data for Trace 13C-glucose, 13C-glutamine, and 13C-serine in genetically engineered pancreatic cell lines through free fatty acids (part I) (Study ST000642)
(Analysis AN000974)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
13C-myristate m0 | NA | NA | NA | NA | NA | 3.4516 | 1.1548 | 0.8999 | 0.8770 | 0.9735 | 0.9428 | 0.8954 | 0.6507 | 0.5996 | 0.5407 | 0.7319 | 0.6582 | 0.6239 |
13C-myristate m1 | NA | NA | NA | NA | NA | 0.0000 | 0.5912 | 1.1101 | 1.2195 | 1.0373 | 1.0717 | 0.9998 | 1.0142 | 1.2968 | 1.2118 | 1.0849 | 1.2100 | 1.1527 |
13C-myristate m10 | NA | NA | NA | NA | NA | 0.0000 | 0.9584 | 1.0631 | 1.0358 | 0.9953 | 1.0449 | 1.1175 | 1.1589 | 1.1232 | 1.1558 | 1.0611 | 1.1597 | 1.1264 |
13C-myristate m11 | NA | NA | NA | NA | NA | 0.0000 | 0.9723 | 1.0560 | 1.0161 | 1.0511 | 1.0433 | 0.9978 | 1.1052 | 1.1944 | 1.2039 | 1.1076 | 1.1095 | 1.1429 |
13C-myristate m12 | NA | NA | NA | NA | NA | 0.0000 | 0.9783 | 1.0822 | 1.0833 | 1.0159 | 1.0086 | 1.0522 | 1.1278 | 1.1251 | 1.1813 | 1.1083 | 1.0793 | 1.1578 |
13C-myristate m13 | NA | NA | NA | NA | NA | 0.0000 | 0.9116 | 0.9631 | 1.0247 | 0.9417 | 1.0128 | 0.9111 | 1.1711 | 1.2628 | 1.2469 | 1.2085 | 1.1596 | 1.1859 |
13C-myristate m14 | NA | NA | NA | NA | NA | 0.0000 | 0.9248 | 1.0364 | 1.0436 | 1.0056 | 1.0047 | 1.0028 | 1.1505 | 1.2041 | 1.2074 | 1.1317 | 1.1402 | 1.1482 |
13C-myristate m15 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-myristate m16 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-myristate m2 | NA | NA | NA | NA | NA | 0.0000 | 0.8609 | 0.9690 | 1.0281 | 1.0541 | 1.0666 | 1.0599 | 1.1676 | 1.1392 | 1.1729 | 1.1052 | 1.2055 | 1.1709 |
13C-myristate m3 | NA | NA | NA | NA | NA | 0.0000 | 0.9370 | 1.0493 | 1.0466 | 0.9964 | 0.9929 | 0.9919 | 1.1472 | 1.2165 | 1.2140 | 1.1367 | 1.1278 | 1.1438 |
13C-myristate m4 | NA | NA | NA | NA | NA | 0.0000 | 0.8127 | 0.9775 | 1.0522 | 1.0598 | 1.0776 | 1.0611 | 1.1491 | 1.1504 | 1.1726 | 1.0980 | 1.2170 | 1.1721 |
13C-myristate m5 | NA | NA | NA | NA | NA | 0.0000 | 0.9136 | 1.0116 | 1.0062 | 0.9611 | 0.9567 | 0.9576 | 1.1753 | 1.2281 | 1.2334 | 1.1928 | 1.1733 | 1.1902 |
13C-myristate m6 | NA | NA | NA | NA | NA | 0.0000 | 0.9620 | 1.0626 | 1.0378 | 0.9994 | 1.0433 | 1.1178 | 1.1580 | 1.1203 | 1.1565 | 1.0593 | 1.1558 | 1.1272 |
13C-myristate m7 | NA | NA | NA | NA | NA | 0.0000 | 0.9586 | 0.9759 | 1.0499 | 1.1013 | 0.9389 | 0.9643 | 1.1185 | 1.2001 | 1.2280 | 1.1352 | 1.1563 | 1.1728 |
13C-myristate m8 | NA | NA | NA | NA | NA | 0.0000 | 0.9534 | 0.9714 | 1.0306 | 1.0025 | 1.0829 | 1.1141 | 1.1369 | 1.1112 | 1.1313 | 1.1002 | 1.1819 | 1.1836 |
13C-myristate m9 | NA | NA | NA | NA | NA | 0.0000 | 0.9899 | 1.0222 | 1.0496 | 1.0425 | 0.9614 | 1.0221 | 1.1555 | 1.1404 | 1.2167 | 1.1156 | 1.1035 | 1.1805 |
13C-oleate m0 | NA | NA | NA | NA | NA | 2.7559 | 1.0011 | 0.9919 | 1.0039 | 1.0980 | 1.1326 | 1.1207 | 0.6420 | 0.6155 | 0.5979 | 0.6852 | 0.6846 | 0.6707 |
13C-oleate m1 | NA | NA | NA | NA | NA | 0.0000 | 1.3718 | 1.0143 | 1.0197 | 1.1554 | 1.0290 | 1.3375 | 0.5546 | 1.1126 | 0.9265 | 0.9425 | 2.1848 | 0.3512 |
13C-oleate m10 | NA | NA | NA | NA | NA | 0.0000 | 0.9738 | 0.9275 | 1.0421 | 0.9099 | 0.8666 | 1.1469 | 1.1948 | 0.9760 | 1.2221 | 1.0864 | 1.2905 | 1.3635 |
13C-oleate m11 | NA | NA | NA | NA | NA | 0.0000 | 1.1664 | 0.9810 | 0.7814 | 0.8299 | 0.8663 | 0.8993 | 1.4327 | 1.1867 | 1.2500 | 1.2990 | 1.0747 | 1.2326 |
13C-oleate m12 | NA | NA | NA | NA | NA | 0.0000 | 0.9794 | 0.9542 | 1.0066 | 0.8137 | 0.8535 | 0.9893 | 1.2774 | 1.1518 | 1.3162 | 1.1785 | 1.2769 | 1.2027 |
13C-oleate m13 | NA | NA | NA | NA | NA | 0.0000 | 0.9297 | 0.9290 | 1.0097 | 0.8289 | 0.7964 | 0.9050 | 1.3484 | 1.3865 | 1.2865 | 1.2295 | 1.1539 | 1.1964 |
13C-oleate m14 | NA | NA | NA | NA | NA | 0.0000 | 1.0330 | 0.9962 | 0.9565 | 0.8997 | 0.9024 | 0.9674 | 1.2423 | 1.1730 | 1.2870 | 1.1416 | 1.1908 | 1.2101 |
13C-oleate m15 | NA | NA | NA | NA | NA | 0.0000 | 0.9879 | 1.0161 | 1.0143 | 0.8474 | 0.7299 | 0.8076 | 1.2645 | 1.3215 | 1.3120 | 1.2992 | 1.2407 | 1.1589 |
13C-oleate m16 | NA | NA | NA | NA | NA | 0.0000 | 1.0395 | 1.0091 | 1.0017 | 0.9174 | 0.8657 | 0.8698 | 1.2297 | 1.2375 | 1.2528 | 1.1907 | 1.1693 | 1.2168 |
13C-oleate m17 | NA | NA | NA | NA | NA | 0.0000 | 0.9696 | 0.9218 | 0.9013 | 0.7595 | 0.7640 | 0.7678 | 1.3661 | 1.4544 | 1.1888 | 1.3475 | 1.2657 | 1.2936 |
13C-oleate m18 | NA | NA | NA | NA | NA | 0.0000 | 0.9696 | 0.9747 | 0.9420 | 0.9179 | 0.8870 | 0.8774 | 1.2398 | 1.2966 | 1.2606 | 1.2182 | 1.1920 | 1.2242 |
13C-oleate m19 | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-oleate m2 | NA | NA | NA | NA | NA | 0.0000 | 1.1789 | 1.2131 | 1.2164 | 1.1499 | 1.1933 | 1.2076 | 0.9114 | 0.9677 | 1.0018 | 0.9814 | 0.9803 | 0.9983 |
13C-oleate m3 | NA | NA | NA | NA | NA | 0.0000 | 2.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-oleate m4 | NA | NA | NA | NA | NA | 0.0000 | 1.2916 | 1.3209 | 1.1834 | 1.2801 | 1.4515 | 1.2483 | 1.0449 | 0.6783 | 0.8890 | 1.0297 | 0.8475 | 0.7349 |
13C-oleate m5 | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-oleate m6 | NA | NA | NA | NA | NA | 0.0000 | 0.2373 | NA | NA | NA | NA | 1.1097 | NA | NA | NA | 0.3679 | 1.7182 | 2.5670 |
13C-oleate m7 | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-oleate m8 | NA | NA | NA | NA | NA | 0.0000 | 0.5540 | 0.6157 | 0.7859 | 0.8725 | 1.0164 | 1.2338 | 1.3883 | 0.9810 | 1.0121 | 0.8365 | 1.8651 | 1.8386 |
13C-oleate m9 | NA | NA | NA | NA | NA | 0.0000 | 1.4716 | 1.1891 | 0.8653 | 0.7512 | 0.8957 | 1.3341 | 1.4533 | 0.4621 | 1.3571 | 0.9703 | 1.0288 | 1.2215 |
13C-palmitate m0 | NA | NA | NA | NA | NA | 1.7651 | 1.2374 | 0.9201 | 1.0334 | 1.1783 | 1.0981 | 0.8768 | 0.8296 | 0.6872 | 0.7973 | 0.9223 | 0.7581 | 0.8964 |
13C-palmitate m1 | NA | NA | NA | NA | NA | 0.0219 | NA | 1.8951 | NA | NA | NA | NA | NA | 0.4337 | 0.6419 | 1.2980 | 1.7094 | NA |
13C-palmitate m10 | NA | NA | NA | NA | NA | 0.0000 | 0.8217 | 1.0396 | 0.9631 | 0.7538 | 0.8604 | 1.1824 | 1.3175 | 1.2732 | 1.3013 | 1.0705 | 1.2782 | 1.1382 |
13C-palmitate m11 | NA | NA | NA | NA | NA | NA | 0.6466 | 1.0331 | 0.9087 | 0.7123 | 0.8194 | 1.0894 | 1.1338 | 1.2408 | 1.1908 | 0.9629 | 1.2488 | 1.0133 |
13C-palmitate m12 | NA | NA | NA | NA | NA | 0.0000 | 0.7227 | 1.1380 | 1.0067 | 0.7689 | 0.9001 | 1.2003 | 1.2339 | 1.3358 | 1.2339 | 1.0600 | 1.2876 | 1.1120 |
13C-palmitate m13 | NA | NA | NA | NA | NA | NA | 0.6372 | 1.0632 | 0.8978 | 0.6800 | 0.7704 | 1.0265 | 1.1260 | 1.3652 | 1.2080 | 1.0289 | 1.1796 | 1.0170 |
13C-palmitate m14 | NA | NA | NA | NA | NA | 0.0000 | 0.6921 | 1.1363 | 0.9527 | 0.7819 | 0.8814 | 1.1642 | 1.2162 | 1.4324 | 1.2555 | 1.0861 | 1.2808 | 1.1204 |
13C-palmitate m15 | NA | NA | NA | NA | NA | 0.0000 | 0.6244 | 1.0310 | 0.8553 | 0.7383 | 0.8174 | 1.0117 | 1.2459 | 1.5461 | 1.2999 | 1.2100 | 1.4066 | 1.2134 |
13C-palmitate m16 | NA | NA | NA | NA | NA | 0.0000 | 0.6587 | 1.0692 | 0.9368 | 0.7538 | 0.8427 | 1.1146 | 1.2307 | 1.4578 | 1.2921 | 1.1540 | 1.3379 | 1.1516 |
13C-palmitate m17 | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-palmitate m18 | NA | NA | NA | NA | NA | 0.0000 | 0.7605 | 1.0556 | 0.9217 | 0.7763 | 0.7861 | 1.4101 | 1.1257 | 1.3336 | 1.1656 | 1.1661 | 1.3345 | 1.1644 |
13C-palmitate m19 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-palmitate m2 | NA | NA | NA | NA | NA | NA | 0.9146 | 1.0371 | 0.9421 | 1.0938 | 1.0607 | 1.5176 | 0.8805 | 0.9589 | 0.9577 | 0.6456 | 0.9688 | 1.0226 |
13C-palmitate m3 | NA | NA | NA | NA | NA | NA | 0.6749 | 0.9454 | 1.8189 | NA | 1.8561 | 0.5736 | 0.2589 | 1.7023 | 0.8249 | 0.0610 | 1.5690 | 0.7148 |
13C-palmitate m4 | NA | NA | NA | NA | NA | 0.0024 | 0.6554 | 0.7872 | 1.0144 | 0.8193 | 0.9885 | 1.6869 | 1.2766 | 0.7983 | 0.9193 | 0.9522 | 1.8911 | 1.2084 |
13C-palmitate m5 | NA | NA | NA | NA | NA | NA | 0.5379 | 0.9597 | 0.7992 | 0.9802 | 1.0304 | 1.5674 | 1.0295 | 0.9313 | 0.8740 | 0.9681 | 1.0181 | 1.3044 |
13C-palmitate m6 | NA | NA | NA | NA | NA | 0.0000 | 0.6384 | 0.7876 | 0.9554 | 0.6281 | 1.0143 | 1.6287 | 1.1691 | 0.9645 | 1.0856 | 0.9097 | 1.7955 | 1.4232 |
13C-palmitate m7 | NA | NA | NA | NA | NA | NA | 0.6305 | 0.9008 | 0.8442 | 0.7841 | 0.8251 | 1.2968 | 1.0037 | 1.0732 | 1.0698 | 1.0176 | 1.3852 | 1.1690 |
13C-palmitate m8 | NA | NA | NA | NA | NA | 0.0000 | 0.6199 | 0.9449 | 0.9498 | 0.7749 | 0.9646 | 1.4050 | 1.1323 | 1.1882 | 1.2113 | 1.0450 | 1.4864 | 1.2777 |
13C-palmitate m9 | NA | NA | NA | NA | NA | NA | 0.8296 | 0.9899 | 0.8944 | 0.6762 | 0.7636 | 1.0142 | 1.2747 | 1.2032 | 1.2308 | 0.9971 | 1.1172 | 1.0092 |
13C-stearate m0 | NA | NA | NA | NA | NA | 1.7295 | 1.2826 | 0.9553 | 1.0631 | 1.3224 | 1.2503 | 0.9071 | 0.7778 | 0.6718 | 0.6718 | 0.8385 | 0.6944 | 0.8355 |
13C-stearate m1 | NA | NA | NA | NA | NA | 0.0000 | NA | NA | 3.7651 | 0.2679 | 0.2437 | 1.4884 | NA | 0.5507 | 0.5507 | NA | 1.1335 | NA |
13C-stearate m10 | NA | NA | NA | NA | NA | 0.0000 | 0.5863 | 0.8432 | 1.0209 | 0.5886 | 0.7042 | 1.3256 | 1.2478 | 1.3164 | 1.3164 | 1.0221 | 1.6218 | 1.4069 |
13C-stearate m11 | NA | NA | NA | NA | NA | 0.0000 | 0.7542 | 1.0341 | 0.7718 | 0.5496 | 0.6399 | 1.1067 | 1.3459 | 1.4175 | 1.4175 | 1.2462 | 1.4577 | 1.2589 |
13C-stearate m12 | NA | NA | NA | NA | NA | 0.0000 | 0.6088 | 1.0398 | 0.8779 | 0.5330 | 0.6640 | 1.2053 | 1.3178 | 1.4243 | 1.4243 | 1.1287 | 1.5000 | 1.2762 |
13C-stearate m13 | NA | NA | NA | NA | NA | 0.0000 | 0.6984 | 1.1409 | 0.8943 | 0.5531 | 0.6073 | 1.1035 | 1.3609 | 1.5098 | 1.5098 | 1.1689 | 1.2873 | 1.1657 |
13C-stearate m14 | NA | NA | NA | NA | NA | 0.0000 | 0.6581 | 1.0701 | 0.9407 | 0.5391 | 0.6612 | 1.1600 | 1.3152 | 1.4455 | 1.4455 | 1.1630 | 1.3874 | 1.2145 |
13C-stearate m15 | NA | NA | NA | NA | NA | 0.0000 | 0.6367 | 1.1087 | 0.9147 | 0.5446 | 0.6308 | 1.1183 | 1.3442 | 1.4616 | 1.4616 | 1.2678 | 1.3543 | 1.1565 |
13C-stearate m16 | NA | NA | NA | NA | NA | 0.0000 | 0.6104 | 1.0847 | 0.9144 | 0.5283 | 0.6616 | 1.1096 | 1.3196 | 1.4758 | 1.4758 | 1.2364 | 1.3842 | 1.1992 |
13C-stearate m17 | NA | NA | NA | NA | NA | 0.0000 | 0.4732 | 1.0422 | 0.8898 | 0.6137 | 0.5681 | 0.8966 | 1.3442 | 1.5419 | 1.5419 | 1.3634 | 1.4950 | 1.2301 |
13C-stearate m18 | NA | NA | NA | NA | NA | 0.0000 | 0.5751 | 1.0252 | 0.8611 | 0.5386 | 0.6258 | 1.0503 | 1.3316 | 1.4981 | 1.4981 | 1.2882 | 1.4373 | 1.2706 |
13C-stearate m19 | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-stearate m2 | NA | NA | NA | NA | NA | 0.0000 | 0.7891 | 1.3364 | 1.0940 | 0.7574 | 0.9715 | 1.5206 | 1.0328 | 1.1077 | 1.1077 | 1.0609 | 1.1975 | 1.0244 |
13C-stearate m3 | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-stearate m4 | NA | NA | NA | NA | NA | 0.0000 | 1.0461 | 1.5358 | 1.3349 | 1.1834 | 1.4352 | 2.5015 | 0.2320 | 0.3822 | 0.3822 | 0.5315 | 1.3021 | 1.1332 |
13C-stearate m5 | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-stearate m6 | NA | NA | NA | NA | NA | 0.0000 | NA | NA | 0.4544 | 0.4726 | 1.0657 | 1.8378 | 0.0983 | NA | NA | NA | 2.5690 | 1.5023 |
13C-stearate m7 | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
13C-stearate m8 | NA | NA | NA | NA | NA | 0.0000 | 0.6173 | 0.5230 | 0.7672 | 0.5045 | 0.8554 | 1.6209 | 1.2498 | 1.0533 | 1.0533 | 0.9552 | 2.1098 | 1.6903 |
13C-stearate m9 | NA | NA | NA | NA | NA | 0.0000 | 1.1552 | 0.8443 | 0.9249 | 1.4607 | 0.7401 | 1.2756 | 1.2539 | 1.2501 | 1.2501 | 0.3179 | 1.2182 | 1.3090 |
Factors:
F1 | experiment:20_PSPH B7 + Dox (PKM1)_0 hr_No label | tracer:No Label | time:- |
F2 | experiment:21_PSPH B7 + Dox (PKM1)_0 hr_No label | tracer:No Label | time:- |
F3 | experiment:22_PSPH B7 + Dox (PKM1)_0 hr_No label | tracer:No Label | time:- |
F4 | experiment:23_PSPH B7 - Dox (PKM2)_0 hr_No label | tracer:No Label | time:- |
F5 | experiment:24_PSPH B7 - Dox (PKM2)_0 hr_No label | tracer:No Label | time:- |
F6 | experiment:25_PSPH B7 - Dox (PKM2)_0 hr_No label | tracer:No Label | time:- |
F7 | experiment:26_PSPH B7 + Dox (PKM1)_24 hr_13C-glucose | tracer:13C-glucose | time:24 |
F8 | experiment:27_PSPH B7 + Dox (PKM1)_24 hr_13C-glucose | tracer:13C-glucose | time:24 |
F9 | experiment:28_PSPH B7 + Dox (PKM1)_24 hr_13C-glucose | tracer:13C-glucose | time:24 |
F10 | experiment:29_PSPH B7 - Dox (PKM2)_24 hr_13C-glucose | tracer:13C-glucose | time:24 |
F11 | experiment:30_PSPH B7 - Dox (PKM2)_24 hr_13C-glucose | tracer:13C-glucose | time:24 |
F12 | experiment:31_PSPH B7 - Dox (PKM2)_24 hr_13C-glucose | tracer:13C-glucose | time:24 |
F13 | experiment:32_PSPH B7 + Dox (PKM1)_48 hr_13C-glucose | tracer:13C-glucose | time:48 |
F14 | experiment:33_PSPH B7 + Dox (PKM1)_48 hr_13C-glucose | tracer:13C-glucose | time:48 |
F15 | experiment:34_PSPH B7 + Dox (PKM1)_48 hr_13C-glucose | tracer:13C-glucose | time:48 |
F16 | experiment:35_PSPH B7 - Dox (PKM2)_48 hr_13C-glucose | tracer:13C-glucose | time:48 |
F17 | experiment:36_PSPH B7 - Dox (PKM2)_48 hr_13C-glucose | tracer:13C-glucose | time:48 |
F18 | experiment:37_PSPH B7 - Dox (PKM2)_48 hr_13C-glucose | tracer:13C-glucose | time:48 |