Data for Nonalcoholic steatohepatitis (NASH) changes with S.Q. Leptin administrations (Study ST000677)
(Analysis AN001040)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| CerP 34:1; [M-H]-@5.96 | 0.9913 | 1.4175 | 0.8214 | 1.0336 | 1.0288 | 0.7449 |
| CL 66:1; [M-2H](2-)@6.29 | 0.8763 | 2.3076 | 0.6796 | 1.0602 | 0.9381 | 0.4283 |
| CL 70:5; [M-2H](2-)@6.00 | 0.8145 | 1.5120 | 0.9885 | 1.1081 | 0.7474 | 0.9140 |
| CL 74:3; [M-2H](2-)@7.01 | 0.7910 | 1.6489 | 1.2819 | 1.0359 | 0.7809 | 0.7933 |
| FFA(16:0) | 1.0627 | 1.2602 | 0.9711 | 0.9743 | 0.8621 | 0.9600 |
| FFA(18:0) | 1.0265 | 1.2437 | 1.0009 | 0.9929 | 0.8697 | 0.9484 |
| FFA(18:1) | 1.2471 | 1.1523 | 0.9288 | 0.9072 | 0.8859 | 0.9471 |
| FFA(18:2) | 1.1959 | 1.1177 | 0.8937 | 0.9003 | 0.8609 | 1.1029 |
| FFA(20:0) | 0.9251 | 1.1125 | 1.0570 | 1.0549 | 0.8464 | 1.0123 |
| FFA(20:1) | 1.3833 | 0.9959 | 0.8394 | 0.8943 | 0.8711 | 0.9743 |
| FFA(20:2) | 1.3092 | 1.0237 | 0.8879 | 0.8989 | 0.9049 | 0.9775 |
| FFA(20:4) Arachidonic acid | 1.2692 | 1.0444 | 0.7771 | 0.9314 | 0.7726 | 1.1476 |
| FFA(22:0) | 0.7450 | 0.6735 | 1.2612 | 1.0904 | 1.0242 | 1.1483 |
| FFA(22:2) | 1.2309 | 0.8411 | 0.9355 | 1.0154 | 0.8742 | 0.9308 |
| FFA(22:3) | 1.0606 | 0.8756 | 0.9235 | 1.0075 | 1.0117 | 1.0239 |
| FFA(24:0) | 0.8560 | 0.9037 | 1.0783 | 1.1175 | 0.7978 | 1.1320 |
| FFA(24:1) | 0.8752 | 0.6251 | 1.0577 | 1.0940 | 1.0738 | 1.0848 |
| FFA(24:2) | 1.0642 | 1.0010 | 0.8104 | 1.0578 | 0.8013 | 1.1040 |
| FFA(24:3) | 1.3145 | 0.8595 | 0.8280 | 1.0373 | 0.6442 | 1.0577 |
| lysoPE 16:0; [M-H]-@1.69 | 0.9858 | 1.0526 | 0.9904 | 1.0269 | 0.7904 | 1.1371 |
| lysoPE 18:0; [M-H]-@2.49 | 1.0368 | 1.0102 | 0.9094 | 1.0058 | 0.8144 | 1.1766 |
| lysoPE 18:1; [M-H]-@1.86 | 0.8350 | 0.9242 | 1.1802 | 0.9642 | 0.8686 | 1.3654 |
| lysoPE 18:2; [M-H]-@1.40 | 0.7744 | 0.9778 | 1.0441 | 1.0305 | 0.9842 | 1.2308 |
| lysoPE 20:3; [M-H]-@1.68 | 0.7593 | 0.7559 | 0.9468 | 0.9912 | 1.4636 | 1.0763 |
| lysoPE 20:4; [M-H]-@1.37 | 1.0663 | 0.7598 | 0.8644 | 1.0079 | 0.8944 | 1.2492 |
| lysoPE 20:5; [M-H]-@1.13 | 0.6424 | 0.3780 | 0.8805 | 1.0836 | 1.1200 | 1.6561 |
| lysoPE 22:4; [M-H]-@1.99 | 1.2588 | 1.1614 | 0.6466 | 0.7786 | 0.9966 | 1.3030 |
| lysoPE 22:5; [M-H]-@1.58 | 1.0907 | 0.8085 | 1.0124 | 0.8472 | 0.9783 | 1.3766 |
| lysoPE 22:6; [M-H]-@1.34 | 0.8121 | 0.5802 | 0.9672 | 0.9801 | 1.0692 | 1.5296 |
| N-(15Z-tetracosenoyl)-sphing-4-enine; [M-H]-@8.52 | 1.0841 | 0.9058 | 1.1323 | 1.0542 | 0.8141 | 0.9217 |
| N-(hexadecanoyl)-sphing-4-enine; [M-H]-@6.89 | 0.7901 | 0.6858 | 1.1784 | 1.0831 | 1.0785 | 1.0980 |
| N-(tetracosanoyl)-sphing-4-enine; [M-H]-@8.96 | 0.9737 | 0.7442 | 1.1293 | 1.0599 | 0.9998 | 0.9797 |
| PA 34:2; [M-H]-@6.38 | 0.9092 | 0.6999 | 1.4450 | 0.9221 | 1.1241 | 1.0822 |
| PC 28:0; [M-Ac-H]-@5.41 | 0.9327 | 1.4247 | 1.2875 | 0.9925 | 0.8256 | 0.8068 |
| PC 30:0; [M-Ac-H]-@6.11 | 1.0131 | 1.2371 | 0.9332 | 1.0995 | 0.7803 | 0.8565 |
| PC 30:1; [M-Ac-H]-@5.55 | 0.9847 | 1.2458 | 0.9167 | 1.0679 | 0.9915 | 0.7622 |
| PC 32:0; [M-Ac-H]-@6.77 | 1.0248 | 1.0086 | 0.8895 | 1.0654 | 0.8325 | 1.0497 |
| PC 32:1; [M-Ac-H]-@6.25 | 0.9253 | 1.4932 | 0.6935 | 1.0064 | 1.0531 | 0.9071 |
| PC 32:2; [M-Ac-H]-@5.74 | 0.9250 | 0.9025 | 1.4692 | 1.0461 | 0.9361 | 0.8086 |
| PC 33:1; [M-Ac-H]-@6.59 | 0.9216 | 1.2314 | 0.8451 | 1.0045 | 1.0432 | 0.9998 |
| PC 33:2; [M-Ac-H]-@6.11 | 0.9332 | 1.0757 | 1.1194 | 1.0548 | 0.7753 | 1.0559 |
| PC 34:3; [M-Ac-H]-@5.93 | 1.0036 | 0.9991 | 1.0212 | 1.0674 | 0.8643 | 0.9601 |
| PC 34:4; [M-Ac-H]-@5.62 | 0.8855 | 0.5148 | 1.5091 | 1.0898 | 1.0451 | 0.8820 |
| PC 35:2; [M-Ac-H]-@6.70 | 1.0569 | 0.8234 | 1.1390 | 1.0429 | 0.9246 | 0.9245 |
| PC 35:3; [M-Ac-H]-@6.26 | 0.7223 | 1.3847 | 0.9106 | 1.1145 | 0.7590 | 1.1474 |
| PC 36:1; [M-Ac-H]-@7.50 | 0.9392 | 1.0732 | 0.8839 | 1.0468 | 0.9340 | 1.0666 |
| PC 36:3; [M-Ac-H]-@6.54 | 1.0110 | 1.0985 | 1.0337 | 1.0371 | 0.8381 | 0.9725 |
| PC 36:5; [M-Ac-H]-@5.84 | 0.8881 | 0.6652 | 0.8037 | 1.1297 | 0.9131 | 1.2876 |
| PC 37:2; [M-Ac-H]-@7.38 | 0.9674 | 1.3548 | 1.0463 | 0.8691 | 1.0500 | 1.0316 |
| PC 37:3; [M-Ac-H]-@6.86 | 0.9135 | 0.9281 | 0.7930 | 1.2851 | 0.9090 | 0.7270 |
| PC 37:4; [M-Ac-H]-@6.68 | 1.0363 | 1.1681 | 0.8271 | 1.0829 | 0.9445 | 0.8168 |
| PC 37:6; [M-Ac-H]-@5.92 | 0.7472 | 0.4983 | 1.4993 | 1.0583 | 1.1044 | 1.0981 |
| PC 38:2; [M-Ac-H]-@7.64 | 1.1449 | 1.4439 | 0.7973 | 0.9722 | 0.8638 | 0.8471 |
| PC 38:3; [M-Ac-H]-@7.26 | 1.0337 | 1.1320 | 0.8672 | 1.0321 | 0.9153 | 0.9656 |
| PC 38:4; [M-Ac-H]-@6.89 | 1.2744 | 0.7455 | 0.7649 | 1.0739 | 0.7217 | 1.0664 |
| PC 38:5; [M-Ac-H]-@6.52 | 1.0901 | 0.7328 | 0.8870 | 1.0614 | 0.8450 | 1.1451 |
| PC 38:7; [M-Ac-H]-@5.65 | 0.8601 | 0.6090 | 1.0737 | 1.0500 | 1.1956 | 1.0858 |
| PC 40:2; [M-Ac-H]-@8.28 | 0.7727 | 0.7388 | 1.0008 | 1.1914 | 1.3903 | 0.6398 |
| PC 40:4; [M-Ac-H]-@7.45 | 1.2565 | 0.8503 | 0.7217 | 1.0147 | 0.8733 | 1.0356 |
| PC 40:5; [M-Ac-H]-@7.22 | 0.8837 | 0.6216 | 1.1092 | 1.0003 | 1.2572 | 1.0765 |
| PC 40:6; [M-Ac-H]-@6.81 | 0.9763 | 0.7141 | 0.9503 | 1.0619 | 0.9388 | 1.1722 |
| PC 40:7; [M-Ac-H]-@6.36 | 1.0448 | 0.6856 | 0.9236 | 1.0862 | 1.0145 | 0.9852 |
| PC 42:10; [M-Ac-H]-@5.85 | 1.1033 | 1.0799 | 0.5710 | 0.9922 | 0.9887 | 1.1244 |
| PE 32:0; [M-H]-@6.81 | 0.9708 | 0.6344 | 0.6114 | 1.1296 | 1.6495 | 0.5897 |
| PE 32:1; [M-H]-@6.31 | 0.8775 | 1.9570 | 0.7041 | 1.0568 | 1.0564 | 0.5336 |
| PE 34:1; [M-H]-@6.94 | 0.8597 | 1.3014 | 0.9463 | 1.1184 | 0.8964 | 0.8493 |
| PE 34:2; [M-H]-@6.48 | 0.6962 | 0.9381 | 1.3463 | 1.1670 | 1.0922 | 0.7337 |
| PE 34:3; [M-H]-@6.05 | 0.8435 | 1.2739 | 0.8789 | 1.1522 | 0.8381 | 0.9137 |
| PE 35:2; [M-H]-@6.76 | 0.8846 | 1.1691 | 1.1770 | 1.0976 | 1.0030 | 0.6923 |
| PE 36:0; [M-H]-@7.95 | 1.1551 | 0.8587 | 0.8179 | 0.9036 | 1.3125 | 0.9213 |
| PE 36:1; [M-H]-@7.53 | 0.8101 | 1.0939 | 1.2735 | 1.0659 | 0.8291 | 1.0255 |
| PE 36:2; [M-H]-@7.07 | 0.7874 | 1.2829 | 1.1596 | 1.1165 | 0.8796 | 0.8371 |
| PE 36:3; [M-H]-@6.62 | 0.8124 | 1.2854 | 1.1137 | 1.1079 | 0.8490 | 0.8833 |
| PE 36:4; [M-H]-@6.28 | 1.0477 | 1.1355 | 0.9164 | 1.0826 | 0.8527 | 0.8564 |
| PE 36:5; [M-H]-@6.02 | 0.7299 | 0.9481 | 0.6705 | 1.2387 | 0.9296 | 1.1279 |
| PE 37:4; [M-H]-@6.72 | 1.0624 | 1.0514 | 0.8726 | 1.0449 | 0.9883 | 0.8745 |
| PE 38:1; [M-H]-@7.53 | 0.9633 | 0.7620 | 1.2195 | 0.9490 | 0.8607 | 1.3196 |
| PE 38:2; [M-H]-@6.95 | 1.1493 | 1.1159 | 0.9315 | 1.0720 | 0.6706 | 0.9307 |
| PE 38:3; [M-H]-@7.31 | 0.9222 | 1.4404 | 0.9765 | 1.0887 | 1.0255 | 0.5932 |
| PE 38:4; [M-H]-@7.02 | 1.1230 | 0.9849 | 0.9163 | 1.0985 | 0.7602 | 0.9119 |
| PE 38:5; [M-H]-@6.57 | 0.9751 | 0.8953 | 0.9266 | 1.1439 | 0.7571 | 1.0590 |
| PE 38:6; [M-H]-@6.20 | 0.7736 | 0.5820 | 1.3571 | 1.2189 | 0.8719 | 0.9598 |
| PE 40:4; [M-H]-@7.50 | 1.0728 | 0.8970 | 0.8532 | 1.0930 | 0.8426 | 1.0098 |
| PE 40:5; [M-H]-@7.25 | 0.9656 | 0.8366 | 0.9013 | 1.1071 | 1.0355 | 0.9353 |
| PE 40:6; [M-H]-@6.97 | 0.9660 | 0.8917 | 0.8707 | 1.1723 | 0.7873 | 1.0143 |
| PE 40:7; [M-H]-@6.47 | 0.8565 | 0.7967 | 1.2474 | 1.1322 | 0.8107 | 1.0428 |
| PE 40:8; [M-H]-@6.04 | 0.9261 | 0.9564 | 0.9384 | 1.1063 | 0.7341 | 1.1866 |
| PG 33:0; [M-H]-@6.10 | 1.0632 | 0.8507 | 1.5397 | 0.9685 | 0.6168 | 1.1121 |
| PG 36:2; [M-H]-@6.08 | 1.0731 | 0.9201 | 0.8437 | 1.1102 | 0.8209 | 0.9820 |
| PG 38:4; [M-H]-@6.07 | 0.8813 | 1.2635 | 0.8293 | 1.0104 | 1.1891 | 0.8832 |
| PI 34:1; [M-H]-@5.71 | 0.9092 | 1.3112 | 0.6137 | 1.0798 | 1.2213 | 0.7635 |
| PI 34:2; [M-H]-@5.26 | 1.1009 | 1.6470 | 0.6210 | 1.0127 | 0.8098 | 0.8474 |
| PI 36:2; [M-H]-@5.92 | 1.1067 | 1.2968 | 0.8662 | 1.0312 | 0.7722 | 0.9042 |
| PI 36:4; [M-H]-@5.26 | 1.3691 | 1.0533 | 0.6467 | 0.9823 | 0.7428 | 1.0063 |
| PI 37:4; [M-H]-@5.59 | 1.0016 | 1.0155 | 1.0244 | 0.9868 | 0.9952 | 1.0068 |
| PI 38:3; [M-H]-@6.10 | 1.3575 | 0.9212 | 0.8050 | 0.9798 | 0.7257 | 1.0272 |
| PI 38:4; [M-H]-@5.88 | 1.3799 | 0.9023 | 0.6680 | 1.0690 | 0.6144 | 1.0045 |
| PI 38:5; [M-H]-@5.40 | 0.9101 | 0.7927 | 0.7680 | 1.0938 | 0.9795 | 1.2142 |
| PI 38:6; [M-H]-@5.14 | 0.8597 | 1.3156 | 0.8164 | 0.9600 | 0.9413 | 1.2510 |
| PI 40:5; [M-H]-@5.99 | 1.2010 | 1.0545 | 0.7845 | 1.0356 | 0.7750 | 0.9813 |
| PI 40:6; [M-H]-@5.83 | 0.9863 | 0.9268 | 0.7303 | 0.9841 | 0.9933 | 1.2908 |
| plasmenyl-PE 32:1; [M-H]-@6.67 | 0.7811 | 0.8940 | 1.2341 | 1.1541 | 0.9596 | 0.8873 |
| plasmenyl-PE 34:1; [M-H]-@7.27 | 0.9156 | 1.0740 | 0.9205 | 1.0866 | 0.7544 | 1.1596 |
| plasmenyl-PE 34:2; [M-H]-@6.78 | 0.9252 | 1.1461 | 0.9237 | 1.1034 | 0.7343 | 1.0775 |
| plasmenyl-PE 34:3; [M-H]-@6.42 | 0.6797 | 0.6316 | 1.6762 | 1.2160 | 0.6792 | 1.0388 |
| plasmenyl-PE 36:1; [M-H]-@7.82 | 1.0214 | 1.0045 | 0.8380 | 1.0914 | 0.6771 | 1.1861 |
| plasmenyl-PE 36:2; [M-H]-@7.36 | 0.9600 | 1.0774 | 0.8881 | 1.1248 | 0.7135 | 1.0714 |
| plasmenyl-PE 36:3; [M-H]-@7.00 | 0.9546 | 1.1898 | 0.8492 | 1.1430 | 0.6749 | 1.0258 |
| plasmenyl-PE 36:4; [M-H]-@6.73 | 1.0574 | 1.1402 | 0.7025 | 1.0758 | 0.5966 | 1.2548 |
| plasmenyl-PE 36:5; [M-H]-@6.36 | 0.5845 | 0.6822 | 0.7575 | 1.3144 | 0.7225 | 1.4714 |
| plasmenyl-PE 38:2; [M-H]-@7.97 | 1.0727 | 1.1452 | 0.8653 | 1.0577 | 0.9011 | 0.8603 |
| plasmenyl-PE 38:3; [M-H]-@7.62 | 0.9614 | 0.8855 | 0.9947 | 1.0748 | 0.8010 | 1.1558 |
| plasmenyl-PE 38:4; [M-H]-@7.31 | 1.0345 | 1.0982 | 0.8294 | 1.0449 | 0.6570 | 1.2405 |
| plasmenyl-PE 38:5; [M-H]-@6.83 | 0.9904 | 1.1375 | 0.8079 | 1.0980 | 0.6649 | 1.1556 |
| plasmenyl-PE 38:6; [M-H]-@6.62 | 1.0175 | 0.9277 | 0.8304 | 1.0677 | 0.7681 | 1.2117 |
| plasmenyl-PE 40:3; [M-H]-@8.13 | 1.1268 | 0.9242 | 0.8459 | 1.0775 | 0.6985 | 1.1047 |
| plasmenyl-PE 40:5; [M-H]-@7.35 | 1.0035 | 0.9076 | 0.7370 | 1.1368 | 0.7853 | 1.1279 |
| plasmenyl-PE 40:6; [M-H]-@7.27 | 1.0521 | 0.9894 | 0.8439 | 1.0761 | 0.7758 | 1.0883 |
| plasmenyl-PE 42:5; [M-H]-@7.95 | 0.9387 | 0.9125 | 0.6220 | 1.0870 | 0.8021 | 1.3870 |
Factors:
| F1 | visit:closeout |
| F2 | visit:initial visit |
| F3 | visit:intitial visit |
| F4 | visit:month 1 |
| F5 | visit:month 12 |
| F6 | visit:visit 1 |
