Data for Murine bile acid profiles during CDI R20291 infection (Study ST000735)
(Analysis AN001149)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 | F19 | F20 | F21 | F22 | F23 | F24 | F25 | F26 | F27 | F28 | F29 | F30 | F31 | F32 | F33 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ALPHA-MURICHOLIC ACID | 0.0077 | 0.0106 | 0.0122 | 0.0947 | 0.0094 | 0.1320 | 2.7067 | 1.4830 | 4.7000 | 5.7264 | 0.8044 | 0.2827 | 0.0090 | 1.5038 | 0.0207 | 0.0106 | 0.0216 | 0.0148 | 0.0735 | 1.6487 | 1.9232 | 4.4723 | 0.0767 | 3.0278 | 4.4471 | 0.0130 | 0.4387 | 0.0253 | 2.9933 | 0.0634 | 0.5275 | 0.2842 | 0.4525 |
| AM022340 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 1.0000 | NA |
| BETA-MURICHOLIC ACID | 0.0014 | 0.0012 | 0.0011 | 0.1727 | 0.0027 | 0.1554 | 3.1473 | 1.7724 | 4.3193 | 3.1753 | 1.0008 | 0.5663 | 0.0010 | 0.7939 | 0.0008 | 0.0017 | 0.0239 | 0.0154 | 0.0957 | 1.7110 | 2.5502 | 5.0578 | 0.1438 | 2.0153 | 2.8500 | 0.0013 | 0.2549 | 0.0024 | 2.4192 | 0.0633 | 0.8509 | 1.1386 | 0.8743 |
| CHENODEOXYCHOLIC ACID | NA | NA | NA | NA | NA | NA | 0.7333 | 0.7196 | 0.5618 | 3.6956 | 0.6547 | 0.4311 | NA | NA | 0.0198 | NA | NA | NA | NA | 1.0490 | 1.0547 | 3.5989 | 0.0555 | 2.3522 | 1.2837 | NA | NA | NA | 1.5982 | 0.0271 | 0.5949 | 0.0477 | 0.6389 |
| CHOLIC ACID | 0.0008 | 0.0007 | 0.0010 | 0.2762 | 0.0557 | 0.6514 | 4.1908 | 2.4115 | 5.2749 | 4.1136 | 1.3740 | 0.5479 | 0.0005 | 0.1222 | 0.0007 | 0.0005 | 0.0656 | 0.1028 | 0.5287 | 1.8785 | 2.6012 | 5.2271 | 0.2463 | 1.7274 | 2.7943 | 0.0007 | 0.0221 | 0.0042 | 1.1930 | 0.4260 | 0.9654 | 0.4850 | 0.7329 |
| DEOXYCHOLIC ACID | 0.0516 | 0.0017 | 0.0643 | 0.1921 | 0.1142 | 0.1244 | 0.1451 | 0.3861 | 0.0574 | 3.8744 | 0.2074 | 0.1227 | 0.0371 | 5.8078 | 0.0283 | 0.0593 | 0.0921 | 0.2198 | 0.1529 | 0.1244 | 0.2056 | 0.1675 | 0.2328 | 5.0335 | 0.0310 | 0.0625 | 1.4664 | 0.2074 | 1.1943 | 0.0413 | 0.0804 | 6.0997 | 0.3861 |
| GLYCOCHENODEOXYCHOLIC ACID | 0.7677 | 0.7986 | 0.7698 | 0.4716 | 0.6019 | 0.9909 | 1.0695 | 2.6640 | 2.2537 | 1.9177 | 1.2992 | 0.5761 | 0.5195 | 0.4677 | 0.5990 | 0.3758 | 0.4412 | 0.5978 | 1.1518 | 0.8160 | 1.1701 | 2.8929 | 0.8733 | 0.9849 | 0.7729 | 0.5411 | 0.8484 | 0.9039 | 1.1094 | 0.8109 | 1.1500 | 0.8995 | 1.0768 |
| GLYCOCHOLIC ACID | NA | NA | NA | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GLYCODEOXYCHOLATE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.5049 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 2.4294 | NA | NA | 0.2999 | NA | 1.0114 | NA | NA | 2.1886 | 0.0610 |
| GLYCOURSODEOXYCHOLIC ACID | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| HYOCHOLIC ACID | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.8931 | NA | NA | NA | 1.8483 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 2.3391 | 0.6696 | NA | 1.3632 | 0.0530 | 1.5424 | 0.2722 | 0.2241 | 0.1239 | 0.3218 |
| HYODEOXYCHOLIC ACID | 0.0285 | 0.0342 | 0.0164 | 0.0382 | 0.0188 | 0.0419 | 1.0472 | 2.9701 | 1.3336 | 1.4607 | 1.1292 | 0.1135 | NA | 1.7010 | 0.0173 | 0.0066 | 0.0234 | 0.0577 | 0.0392 | 0.0367 | 4.4509 | 1.7195 | 0.0777 | 13.0783 | NA | NA | 1.5265 | NA | 0.5343 | NA | NA | NA | NA |
| LITHOCHOLIC ACID | NA | NA | NA | NA | 0.3070 | 0.1954 | 0.4379 | 0.6810 | 0.4432 | 1.2624 | 0.2082 | 0.2424 | NA | 4.5775 | 0.2804 | NA | NA | NA | NA | NA | 0.7899 | 0.3324 | NA | 4.3339 | NA | NA | 1.1207 | 0.3068 | 1.1607 | 0.1281 | 0.2445 | 1.2989 | 0.3469 |
| OMEGA-MURICHOLIC ACID | NA | NA | NA | NA | NA | NA | 0.5064 | 0.0898 | 0.8343 | 2.1176 | 0.2632 | 0.1069 | NA | 1.8826 | NA | NA | NA | NA | NA | 1.4349 | 0.4516 | 0.8522 | NA | 1.4068 | 2.1679 | NA | 2.1392 | NA | 1.7108 | 0.0195 | 0.6275 | 0.7133 | 0.4695 |
| TAURO-ALPHA-MURICHOLIC ACID | 0.0104 | 0.0168 | 0.0916 | NA | 0.0242 | NA | 0.0017 | NA | NA | NA | NA | NA | 0.0140 | 0.1442 | NA | NA | NA | 0.0143 | 29.7220 | NA | NA | 0.0063 | 0.0676 | NA | 0.0590 | 0.0500 | NA | 0.0867 | 0.0166 | 0.0040 | NA | NA | 0.0055 |
| TAURO-BETA-MURICHOLIC ACID | 0.0480 | 0.0811 | 0.3352 | 0.6970 | 0.1502 | 3.4678 | 1.1114 | 0.8074 | 0.5846 | 4.3110 | 1.5848 | 0.1401 | 0.0347 | 0.8886 | 0.0690 | 0.0634 | 0.3254 | 0.2387 | 10.1857 | 0.9671 | 0.1337 | 0.4753 | 0.7243 | 1.5980 | 0.6830 | 0.1342 | 0.0174 | 0.3617 | 0.1800 | 1.8598 | 0.2681 | 0.4660 | 0.2769 |
| TAUROCHENODEOXYCHOLIC ACID | 0.4274 | 0.5435 | 1.1086 | 0.6561 | 0.4938 | 2.5903 | 0.3972 | 1.3253 | 0.3549 | 0.4116 | 0.5706 | 0.4301 | 0.3369 | 0.3721 | 0.3821 | 0.3786 | 0.5589 | 0.5143 | 9.7465 | 0.4454 | 0.4810 | 0.3199 | 1.0910 | 0.4640 | 0.3326 | 0.5931 | 0.4627 | 1.0558 | 0.4549 | 1.0193 | 0.5649 | 0.7780 | 0.5307 |
| TAUROCHOLIC ACID | 0.1001 | 0.1490 | 0.6430 | 0.4421 | 0.1424 | 3.0699 | 0.0539 | 0.0665 | 0.1340 | 0.0744 | 0.1748 | 0.0389 | 0.0789 | 0.0330 | 0.1600 | 0.1492 | 0.1517 | 0.1090 | 19.9286 | 0.7563 | 0.0309 | 0.1289 | 0.4002 | 0.0250 | 0.0256 | 0.3734 | 0.0144 | 0.4095 | 0.0197 | 1.7273 | 0.0585 | 0.2445 | 0.0333 |
| TAURODEOXYCHOLATE | NA | NA | NA | NA | NA | NA | NA | 0.5626 | NA | 0.8812 | NA | NA | NA | 0.7322 | NA | NA | NA | NA | NA | NA | 0.4595 | NA | NA | 0.6837 | NA | NA | 0.8547 | NA | 0.9252 | NA | NA | 1.9895 | 0.7102 |
| TAUROHYOCHOLATE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.3841 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.4773 | NA | NA | 0.4427 | 0.5431 | 0.4575 | 3.5422 | 0.4045 | 0.3880 | 0.4280 |
| TAUROLITHOCHOLATE | NA | NA | NA | NA | 0.0492 | NA | NA | NA | NA | 0.8969 | 0.6617 | NA | NA | 0.9213 | 0.4619 | NA | NA | NA | 2.1050 | NA | NA | NA | NA | 2.0843 | NA | 1.5333 | 0.3228 | 1.3563 | 0.8396 | 0.2637 | 2.6534 | 0.4956 | 0.4110 |
| TAUROURSODEOXYCHOLIC ACID | 0.1206 | 0.2058 | 0.3569 | 0.3486 | 0.2283 | 2.0167 | 0.4555 | 1.7506 | 0.2164 | 0.5214 | 2.7005 | 0.1450 | 0.0854 | 0.2170 | 0.1927 | 0.1016 | 0.2592 | 0.3224 | 16.0552 | 0.2863 | 0.3569 | 0.2306 | 0.4093 | 1.7083 | 0.2380 | 0.1835 | 0.1626 | 0.3042 | 0.1911 | 1.0315 | 0.2610 | 0.2606 | 0.2683 |
| URSODEOXYCHOLIC ACID | NA | NA | NA | 0.1341 | NA | 0.0931 | 0.7228 | 3.8548 | 0.9772 | 2.1242 | 0.7639 | 0.2174 | NA | 1.2967 | NA | NA | NA | 0.0969 | 0.1119 | 0.4182 | 2.9358 | 2.2295 | 0.1914 | 5.1417 | 1.0400 | NA | NA | NA | 1.2090 | 0.0901 | 0.3329 | 0.2743 | 0.4447 |
Factors:
| F1 | SEX:F | TIMEPOINT:Day 0 | TREATMENT:no treatment |
| F2 | SEX:F | TIMEPOINT:Day 0 | TREATMENT:UDCA |
| F3 | SEX:F | TIMEPOINT:Day 0 | TREATMENT:vehicle |
| F4 | SEX:F | TIMEPOINT:Day 2 | TREATMENT:no treatment |
| F5 | SEX:F | TIMEPOINT:Day 2 | TREATMENT:UDCA |
| F6 | SEX:F | TIMEPOINT:Day 2 | TREATMENT:vehicle |
| F7 | SEX:F | TIMEPOINT:Day 4 | TREATMENT:no treatment |
| F8 | SEX:F | TIMEPOINT:Day 4 | TREATMENT:UDCA |
| F9 | SEX:F | TIMEPOINT:Day 4 | TREATMENT:vehicle |
| F10 | SEX:F | TIMEPOINT:Day 7 | TREATMENT:no treatment |
| F11 | SEX:F | TIMEPOINT:Day 7 | TREATMENT:UDCA |
| F12 | SEX:F | TIMEPOINT:Day 7 | TREATMENT:vehicle |
| F13 | SEX:F | TIMEPOINT:NA | TREATMENT:post antibiotics |
| F14 | SEX:F | TIMEPOINT:NA | TREATMENT:pre antibiotics |
| F15 | SEX:M | TIMEPOINT:Day 0 | TREATMENT:UDCA |
| F16 | SEX:M | TIMEPOINT:Day 0 | TREATMENT:vehicle |
| F17 | SEX:M | TIMEPOINT:Day 2 | TREATMENT:no treatment |
| F18 | SEX:M | TIMEPOINT:Day 2 | TREATMENT:UDCA |
| F19 | SEX:M | TIMEPOINT:Day 2 | TREATMENT:vehicle |
| F20 | SEX:M | TIMEPOINT:Day 4 | TREATMENT:no treatment |
| F21 | SEX:M | TIMEPOINT:Day 4 | TREATMENT:UDCA |
| F22 | SEX:M | TIMEPOINT:Day 4 | TREATMENT:vehicle |
| F23 | SEX:M | TIMEPOINT:Day 7 | TREATMENT:no treatment |
| F24 | SEX:M | TIMEPOINT:Day 7 | TREATMENT:UDCA |
| F25 | SEX:M | TIMEPOINT:Day 7 | TREATMENT:vehicle |
| F26 | SEX:M | TIMEPOINT:NA | TREATMENT:post antibiotics |
| F27 | SEX:M | TIMEPOINT:NA | TREATMENT:pre antibiotics |
| F28 | SEX:NA | TIMEPOINT:Day 0 | TREATMENT:day0 no challenge |
| F29 | SEX:NA | TIMEPOINT:Day 14 | TREATMENT:day14 post challenge |
| F30 | SEX:NA | TIMEPOINT:Day 2 | TREATMENT:day2 post challenge |
| F31 | SEX:NA | TIMEPOINT:Day 4 | TREATMENT:day4 post challenge |
| F32 | SEX:NA | TIMEPOINT:Day 7 | TREATMENT:day7 no challenge |
| F33 | SEX:NA | TIMEPOINT:Day 7 | TREATMENT:day7 post challenge |
