Data for Diet, genetics and gut microbiome drive dynamic changes in plasma metabolites [plasma] (Study ST000879)
(Analysis AN001430)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
2-hydroxyglutaric acid | 0.8040 | 0.6037 | 1.9399 | 0.7105 | 0.9038 | 1.5655 | 0.6330 | 0.5235 | 1.3643 | 0.6026 | 0.6955 | 1.8886 |
2-Phosphoglyceric acid | 1.2777 | 0.3525 | 0.2959 | 1.9344 | 0.6363 | 0.9256 | 2.5312 | 0.6457 | 0.3370 | 1.6994 | 0.6957 | 0.4927 |
3^,5^ cyclic AMP | 0.6898 | 0.9887 | 1.2515 | 1.3547 | 1.2431 | 0.7213 | 1.1420 | 0.9102 | 1.0344 | 0.7703 | 1.0143 | 0.9425 |
3-Indolepropionic acid | 0.4723 | 1.3955 | 1.0006 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
3-methyladipate/pimelate | 1.5186 | 1.1905 | 0.9377 | 1.2408 | 0.9690 | 0.8153 | 0.8740 | 0.7210 | 0.4976 | 1.1210 | 1.0349 | 0.7475 |
3-Phosphoglyceric acid | 1.2180 | 0.3852 | 0.2793 | 1.8717 | 0.6181 | 0.9175 | 2.6784 | 0.6442 | 0.2977 | 1.7799 | 0.6310 | 0.4987 |
4-Hydroxybenzaldehyde | 1.0781 | 0.8775 | 0.8410 | 1.0925 | 1.4128 | 1.0327 | 0.6998 | 1.2436 | 0.6262 | 1.1890 | 1.0181 | 0.8491 |
4-Pyridoxic acid | 1.1645 | 1.1729 | 1.4315 | 1.0016 | 0.6791 | 1.2901 | 0.5808 | 0.7822 | 1.3588 | 0.7789 | 0.7645 | 1.1030 |
5-methyl-THF | 1.0379 | 1.0303 | 1.2179 | 0.8181 | 1.0677 | 0.9318 | 0.8485 | 1.3768 | 0.9545 | 0.8004 | 0.9166 | 1.0540 |
6-Phosphogluconic acid | 1.3034 | 0.1988 | 0.2495 | 1.4917 | 0.3558 | 0.9610 | 1.8074 | 1.1540 | 0.3394 | 2.8277 | 0.6728 | 0.4508 |
Adenine | 1.4937 | 0.4647 | 0.8099 | 1.3390 | 0.5205 | 1.8594 | 1.0906 | 0.5783 | 2.9441 | 0.6256 | 0.9021 | 0.1912 |
adenylosuccinate | 0.6691 | NA | NA | 1.2988 | 0.1959 | 0.8562 | 2.2829 | 1.3712 | 0.3265 | 1.4937 | 0.4643 | 0.3074 |
Adipic acid | 1.2214 | 0.9052 | 0.6381 | 1.9030 | 1.0726 | 0.5763 | 1.3747 | 0.9449 | 0.4139 | 1.3615 | 1.0481 | 0.4497 |
ADP | 1.3857 | 0.1646 | 0.3075 | 1.4233 | 0.2138 | 1.7791 | 2.6417 | 0.7407 | 0.6253 | 1.4827 | 0.5210 | 0.5415 |
Alpha-hydoxy butyric acid | 0.5985 | 0.7864 | 0.9646 | 1.0646 | 0.8703 | 1.2514 | 0.8522 | 0.9469 | 1.2494 | 0.9861 | 1.1487 | 1.2721 |
Aminoadipic acid | NA | NA | NA | NA | 0.6431 | NA | 0.5977 | NA | NA | NA | 1.3796 | NA |
AMP | 1.4049 | 0.1009 | 0.1834 | 1.4697 | 0.2098 | 1.4306 | 2.7577 | 0.9886 | 0.5152 | 1.6277 | 0.5823 | 0.5249 |
beta-hydroxybutyric acid | 0.7935 | 0.5502 | 0.7676 | 1.6965 | 0.7982 | 0.5382 | 1.7944 | 0.8526 | 0.7152 | 1.8359 | 0.6017 | 0.9978 |
CDP | 0.7724 | NA | 0.2404 | 1.3225 | 0.2951 | 1.4573 | 1.7865 | 1.1367 | 0.5683 | 1.5448 | 0.6012 | 0.4007 |
Cholic acid | 0.8964 | 0.6002 | 3.4561 | NA | NA | NA | NA | 0.3502 | NA | NA | NA | NA |
Citric acid | 0.9370 | 0.9343 | 0.9879 | 1.1632 | 1.2165 | 0.9529 | 0.9932 | 0.8207 | 0.9723 | 0.9977 | 1.0148 | 1.0064 |
CMP | 1.0285 | 0.0809 | 0.3209 | 1.3729 | 0.2674 | 1.1829 | 2.9565 | 1.0119 | 0.6150 | 2.4538 | 0.2967 | 0.2429 |
Cystathionine | 0.7256 | 1.2180 | 1.2919 | 0.7712 | 1.3896 | 0.8062 | 0.7224 | 0.7722 | NA | 0.1825 | 1.3556 | 0.8427 |
Cytidine | 1.0391 | 0.9340 | 0.7739 | 1.0581 | 1.1113 | 0.7856 | 1.1715 | 0.7674 | 0.9820 | 1.0970 | 1.0608 | 1.1629 |
DHAP/glyceraldehyde 3P | 1.3357 | 0.4038 | 0.6054 | 1.4363 | 0.5719 | 1.0895 | 1.9811 | 0.9807 | 0.6482 | 1.3370 | 0.5978 | 0.6119 |
Erythrose 4-phosphate | 1.2026 | 0.3009 | 0.4642 | 1.3508 | 0.3986 | 1.6226 | 2.7628 | 0.7988 | 0.4930 | 1.5342 | 0.5608 | 0.3766 |
Fructose-6-phosphate | 1.0003 | 0.3182 | 0.5845 | 1.3015 | 0.4467 | 1.8040 | 2.7023 | 1.0288 | 0.5247 | 1.3580 | 0.4813 | 0.3457 |
fumarate/maleate | 0.9423 | 0.9666 | 0.7420 | 1.2156 | 1.4580 | 0.6555 | 1.0700 | 1.1590 | 0.5755 | 1.0901 | 1.3080 | 0.7531 |
GDP | 1.2776 | 0.2309 | 0.3415 | 1.4827 | 0.2921 | 1.8425 | 2.2668 | 0.8122 | 0.5725 | 1.5224 | 0.4527 | 0.7415 |
Glucuronic acid | 1.4592 | 1.8244 | 1.9851 | 1.1969 | 0.9988 | 0.5783 | 0.9645 | 0.8025 | 0.4191 | 0.7489 | 0.7079 | 0.5606 |
Glutathione | 0.8963 | 1.5530 | 3.8609 | 0.6029 | 0.4633 | 1.8544 | 0.7446 | 0.6911 | 0.5568 | 0.3220 | 0.5193 | 0.6505 |
Glycerol 3-phosphate | 1.1222 | 1.0418 | 1.4996 | 1.2499 | 0.6758 | 1.3265 | 1.3721 | 0.8321 | 0.5719 | 1.1201 | 0.7496 | 0.5633 |
glycocholate-d4 (internal standard) | 0.8408 | 1.1149 | 1.2907 | 0.8362 | 0.9445 | 1.2099 | 0.7682 | 0.9127 | 1.0919 | 0.8168 | 0.9324 | 1.3136 |
Glycocholic Acid | 3.3215 | 0.2629 | 6.8793 | 0.9308 | 0.2582 | 0.2944 | 0.2299 | 0.1946 | 0.4331 | 0.3337 | 0.1413 | 0.3633 |
glycodeoxycholate/glycochenodeoxycholate | 0.5889 | 1.0577 | 0.8327 | 0.7178 | 1.2402 | 1.0451 | 0.8685 | 1.1155 | 1.2779 | 0.8325 | 1.4805 | 0.9008 |
GMP | 0.9219 | 0.2387 | 0.2067 | 1.1730 | 0.3694 | 1.3457 | 2.6341 | 1.3842 | 0.3465 | 1.5335 | 0.5051 | 0.1910 |
Guanosine | 1.5183 | 1.2836 | 0.3165 | 1.0587 | 0.3631 | 0.5327 | 2.6917 | 0.7495 | 0.6356 | 1.5832 | 0.6988 | 0.3974 |
Hexose | 0.9910 | 1.0154 | 1.0517 | 1.0050 | 0.9459 | 1.1521 | 0.8802 | 0.9529 | 1.0937 | 0.8909 | 0.9624 | 1.0717 |
hexose diphosphate | 1.3743 | 0.2280 | 0.3647 | 1.6180 | 0.3802 | 1.0514 | 3.4522 | 0.6268 | 0.3437 | 1.3019 | 0.5664 | 0.5338 |
Hippuric acid | 0.8173 | 5.1352 | 0.5255 | 0.7690 | 0.7540 | 0.6616 | 0.5705 | 0.6611 | 0.3033 | 0.6230 | 0.5996 | 0.4614 |
Hypoxanthine | 1.7248 | 1.3318 | 0.9432 | 2.1557 | 0.3641 | 1.2642 | 1.3503 | 0.7160 | 0.5631 | 0.7749 | 0.4833 | 0.3145 |
IMP | 1.7954 | 0.0303 | 0.1903 | 1.3769 | 0.0798 | 1.3869 | 3.6842 | 0.3522 | 0.4559 | 1.4441 | 0.5355 | 0.3300 |
Indoxyl sulfate | 0.1857 | 1.1837 | 4.2728 | 0.7690 | 0.8930 | 0.2464 | 0.8666 | 0.1387 | 2.1838 | 0.2013 | 0.8663 | NA |
Inosine | 1.7299 | 1.5706 | 1.2667 | 1.4480 | 0.2082 | 1.0977 | 1.5424 | 0.8418 | 0.6901 | 1.0011 | 0.3988 | 0.2714 |
inosine-15N4 (internal standard) | 0.9955 | 1.0182 | 0.9520 | 1.0462 | 0.9786 | 1.0312 | 1.0022 | 0.9726 | 0.9697 | 1.0301 | 0.9813 | 1.0105 |
Isocitric acid | 1.1152 | 0.5145 | 0.6831 | 1.3869 | 1.4877 | 0.9592 | 0.9585 | 0.9739 | 0.7777 | 1.1688 | 1.0432 | 0.8521 |
Kynurenine | 0.9156 | 1.0789 | 0.7657 | 1.1745 | 0.9628 | 0.9916 | 1.1693 | 1.0779 | 0.6945 | 1.5346 | 0.8893 | 0.6868 |
Lactic acid | 0.9212 | 1.1113 | 1.1496 | 1.0090 | 1.1272 | 1.1944 | 0.8283 | 0.8572 | 1.1053 | 0.7181 | 1.0248 | 0.9912 |
Lactose | 0.8847 | 0.0465 | 0.1151 | 0.5188 | 0.0614 | 4.1570 | 2.6184 | 1.4578 | 1.2760 | 0.4376 | 0.0732 | 0.1323 |
Malic acid | 0.8830 | 0.9955 | 0.7032 | 1.2105 | 1.5556 | 0.6211 | 1.0998 | 1.1765 | 0.5610 | 1.0486 | 1.3015 | 0.7694 |
Methylmalonic acid | 1.1479 | 1.0308 | 0.8266 | 1.2409 | 1.0177 | 1.4174 | 0.8415 | 1.0791 | 0.6586 | 0.7728 | 1.0668 | 0.8086 |
mevalonate 5-phosphate | 0.4420 | 0.3936 | 1.2269 | 0.8156 | 0.9601 | 1.2860 | 0.6601 | NA | 0.9002 | 1.2313 | 0.7507 | 1.3024 |
Myo-inositol | 1.3628 | 1.2725 | 1.2454 | 1.3736 | 0.7259 | 1.1157 | 1.3609 | 0.6360 | 0.6323 | 0.9506 | 0.7058 | 0.6540 |
NADP+ | 0.4992 | NA | 0.3805 | 1.1958 | 0.6523 | 1.0508 | 1.7213 | 1.1405 | 0.4250 | 1.6850 | 0.4894 | 1.0056 |
Orotic acid | 1.0949 | 1.0309 | 0.8011 | 1.0300 | 1.6682 | 0.7361 | 0.9081 | 0.9191 | 0.7959 | 1.0776 | 1.1826 | 0.7057 |
Oxalic acid | 0.9389 | 1.0051 | 0.8669 | 1.0710 | 0.8323 | 1.0536 | 1.1839 | 1.1882 | 0.8861 | 1.1822 | 0.9135 | 0.8451 |
Oxoglutaric acid | 0.8557 | 1.1630 | 1.3526 | 0.8979 | 1.5663 | 0.8738 | 0.6614 | 0.8597 | 0.8586 | 0.6361 | 1.3237 | 1.0392 |
Pantothenic acid | 0.7754 | 0.8974 | 1.5199 | 0.9430 | 1.0186 | 1.7625 | 0.5800 | 0.7753 | 1.1517 | 0.5712 | 0.8261 | 1.3089 |
pentose monophosphate | 1.4177 | 0.5696 | 0.9150 | 1.5169 | 0.5579 | 1.2356 | 1.3705 | 0.9433 | 0.7866 | 1.4668 | 0.5428 | 0.6560 |
Phosphocreatine | 1.0205 | 0.4947 | 0.6430 | 1.2401 | 0.9494 | 1.4576 | 1.5128 | 0.6354 | 0.8385 | 1.4240 | 0.7854 | 0.9096 |
Phosphoenolpyruvic acid | 1.1833 | 0.5245 | 0.4826 | 1.4256 | 0.8021 | 0.8679 | 2.4112 | 0.8462 | 0.5030 | 1.2779 | 0.9434 | 0.6030 |
phosphotyrosine | 1.4246 | 0.7337 | 1.1030 | 1.0718 | 1.1506 | 1.0685 | 0.8772 | 0.9580 | 0.8936 | 1.0118 | 1.0112 | 0.7694 |
Propionic acid | 1.0845 | 0.8532 | 0.7167 | 1.2796 | 1.4220 | 0.4897 | 0.8448 | 0.8572 | 1.2230 | 1.3022 | 1.3013 | 0.5152 |
Quinolinic acid | 0.6954 | 1.2569 | 1.8110 | 0.6876 | 1.1158 | 0.9289 | 0.8249 | 0.9441 | 1.2760 | 0.9473 | 0.9061 | 0.8087 |
Sorbitol | 0.9309 | 1.0675 | 0.9569 | 1.1216 | 1.0325 | 1.2232 | 0.8280 | 0.9557 | 1.0794 | 0.8590 | 0.9637 | 0.9707 |
Succinic acid | 1.1003 | 1.1628 | 1.0529 | 1.2089 | 0.9346 | 1.1650 | 0.8393 | 0.9354 | 0.7951 | 0.8206 | 1.0999 | 0.8986 |
Sucrose | 0.6417 | 0.2958 | 0.3905 | 1.0399 | 1.3785 | 1.9792 | 1.3604 | 1.0315 | 0.9774 | 0.4707 | 1.3710 | 0.9110 |
Taurocholic acid | 2.6789 | 0.0090 | 6.1165 | 2.9003 | 0.0042 | 0.0359 | 0.2252 | 0.0095 | 0.0137 | 0.9352 | 0.0077 | 0.3431 |
taurodeoxycholate/taurochenodeoxycholate | 2.5180 | 0.0109 | 6.8261 | 1.9290 | 0.0039 | 0.0289 | 0.1483 | 0.0149 | 0.0309 | 0.4906 | 0.0083 | 0.2290 |
Thymine | 0.7706 | 0.4661 | 1.4464 | 0.9707 | 0.5282 | 1.0287 | 2.0777 | 0.6869 | 1.6419 | 0.8696 | 0.4259 | 1.1990 |
thymine-d4 (internal standard) | 1.0681 | 1.1200 | 1.1473 | 0.9754 | 0.9673 | 0.9497 | 0.9911 | 0.8779 | 1.0626 | 0.9256 | 0.9914 | 0.9604 |
Trans-Aconitic acid | 0.9445 | 0.8845 | 0.9099 | 1.2427 | 1.3320 | 0.9856 | 0.9273 | 0.8442 | 0.8918 | 1.0282 | 1.0467 | 0.9401 |
UDP | 1.0685 | 0.0624 | 0.1437 | 1.2757 | 0.1274 | 1.8518 | 3.3236 | 1.2827 | 0.4852 | 1.7041 | 0.2516 | 0.2092 |
UDP-glucose | 1.0773 | 0.2151 | 0.3712 | 1.2300 | 0.5125 | 1.9432 | 2.4783 | 1.0406 | 0.4752 | 1.5229 | 0.3936 | 0.5830 |
UDP-glucuronic acid | 1.4047 | NA | 0.4555 | 1.0630 | 0.3417 | 0.7846 | 2.0496 | 1.4996 | 0.9492 | 1.2782 | 0.6011 | 0.6459 |
UMP | 1.1112 | 0.0720 | 0.2051 | 1.1750 | 0.1666 | 1.5333 | 3.0061 | 1.3088 | 0.4815 | 1.7796 | 0.2549 | 0.2765 |
Uracil | 1.1305 | 0.5824 | 0.7840 | 1.5296 | 0.8356 | 1.0815 | 1.2864 | 0.7496 | 1.1032 | 1.2198 | 0.8010 | 0.8425 |
Uric acid | 0.0342 | 0.0227 | 4.3262 | 3.0488 | 0.0311 | 0.0389 | 0.1739 | 0.0270 | 4.9950 | 0.0899 | 0.0244 | 0.0194 |
Uridine | 1.0652 | 0.8800 | 0.8376 | 1.5927 | 0.9189 | 1.2172 | 0.9493 | 1.0768 | 0.7511 | 0.8663 | 1.1423 | 0.6618 |
Xanthine | 1.2639 | 1.3633 | 0.7518 | 1.5271 | 0.8766 | 1.0591 | 1.2047 | 0.9470 | 0.4187 | 0.9030 | 0.9696 | 0.6533 |
Factors:
F1 | Diet:Chow | Treatment:none | Strain:129Jax |
F2 | Diet:Chow | Treatment:none | Strain:129Tac |
F3 | Diet:Chow | Treatment:none | Strain:B6Jax |
F4 | Diet:HFD | Treatment:metronidazole | Strain:129Jax |
F5 | Diet:HFD | Treatment:metronidazole | Strain:129Tac |
F6 | Diet:HFD | Treatment:metronidazole | Strain:B6Jax |
F7 | Diet:HFD | Treatment:placebo | Strain:129Jax |
F8 | Diet:HFD | Treatment:placebo | Strain:129Tac |
F9 | Diet:HFD | Treatment:placebo | Strain:B6Jax |
F10 | Diet:HFD | Treatment:vancomycin | Strain:129Jax |
F11 | Diet:HFD | Treatment:vancomycin | Strain:129Tac |
F12 | Diet:HFD | Treatment:vancomycin | Strain:B6Jax |