Data for Diet, genetics and gut microbiome drive dynamic changes in plasma metabolites [plasma] (Study ST000879)

(Analysis AN001430)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10F11F12
2-hydroxyglutaric acid 0.8040 0.6037 1.9399 0.7105 0.9038 1.5655 0.6330 0.5235 1.3643 0.6026 0.6955 1.8886
2-Phosphoglyceric acid 1.2777 0.3525 0.2959 1.9344 0.6363 0.9256 2.5312 0.6457 0.3370 1.6994 0.6957 0.4927
3^,5^ cyclic AMP 0.6898 0.9887 1.2515 1.3547 1.2431 0.7213 1.1420 0.9102 1.0344 0.7703 1.0143 0.9425
3-Indolepropionic acid 0.4723 1.3955 1.0006 NA NA NA NA NA NA NA NA NA
3-methyladipate/pimelate 1.5186 1.1905 0.9377 1.2408 0.9690 0.8153 0.8740 0.7210 0.4976 1.1210 1.0349 0.7475
3-Phosphoglyceric acid 1.2180 0.3852 0.2793 1.8717 0.6181 0.9175 2.6784 0.6442 0.2977 1.7799 0.6310 0.4987
4-Hydroxybenzaldehyde 1.0781 0.8775 0.8410 1.0925 1.4128 1.0327 0.6998 1.2436 0.6262 1.1890 1.0181 0.8491
4-Pyridoxic acid 1.1645 1.1729 1.4315 1.0016 0.6791 1.2901 0.5808 0.7822 1.3588 0.7789 0.7645 1.1030
5-methyl-THF 1.0379 1.0303 1.2179 0.8181 1.0677 0.9318 0.8485 1.3768 0.9545 0.8004 0.9166 1.0540
6-Phosphogluconic acid 1.3034 0.1988 0.2495 1.4917 0.3558 0.9610 1.8074 1.1540 0.3394 2.8277 0.6728 0.4508
Adenine 1.4937 0.4647 0.8099 1.3390 0.5205 1.8594 1.0906 0.5783 2.9441 0.6256 0.9021 0.1912
adenylosuccinate 0.6691 NA NA 1.2988 0.1959 0.8562 2.2829 1.3712 0.3265 1.4937 0.4643 0.3074
Adipic acid 1.2214 0.9052 0.6381 1.9030 1.0726 0.5763 1.3747 0.9449 0.4139 1.3615 1.0481 0.4497
ADP 1.3857 0.1646 0.3075 1.4233 0.2138 1.7791 2.6417 0.7407 0.6253 1.4827 0.5210 0.5415
Alpha-hydoxy butyric acid 0.5985 0.7864 0.9646 1.0646 0.8703 1.2514 0.8522 0.9469 1.2494 0.9861 1.1487 1.2721
Aminoadipic acid NA NA NA NA 0.6431 NA 0.5977 NA NA NA 1.3796 NA
AMP 1.4049 0.1009 0.1834 1.4697 0.2098 1.4306 2.7577 0.9886 0.5152 1.6277 0.5823 0.5249
beta-hydroxybutyric acid 0.7935 0.5502 0.7676 1.6965 0.7982 0.5382 1.7944 0.8526 0.7152 1.8359 0.6017 0.9978
CDP 0.7724 NA 0.2404 1.3225 0.2951 1.4573 1.7865 1.1367 0.5683 1.5448 0.6012 0.4007
Cholic acid 0.8964 0.6002 3.4561 NA NA NA NA 0.3502 NA NA NA NA
Citric acid 0.9370 0.9343 0.9879 1.1632 1.2165 0.9529 0.9932 0.8207 0.9723 0.9977 1.0148 1.0064
CMP 1.0285 0.0809 0.3209 1.3729 0.2674 1.1829 2.9565 1.0119 0.6150 2.4538 0.2967 0.2429
Cystathionine 0.7256 1.2180 1.2919 0.7712 1.3896 0.8062 0.7224 0.7722 NA 0.1825 1.3556 0.8427
Cytidine 1.0391 0.9340 0.7739 1.0581 1.1113 0.7856 1.1715 0.7674 0.9820 1.0970 1.0608 1.1629
DHAP/glyceraldehyde 3P 1.3357 0.4038 0.6054 1.4363 0.5719 1.0895 1.9811 0.9807 0.6482 1.3370 0.5978 0.6119
Erythrose 4-phosphate 1.2026 0.3009 0.4642 1.3508 0.3986 1.6226 2.7628 0.7988 0.4930 1.5342 0.5608 0.3766
Fructose-6-phosphate 1.0003 0.3182 0.5845 1.3015 0.4467 1.8040 2.7023 1.0288 0.5247 1.3580 0.4813 0.3457
fumarate/maleate 0.9423 0.9666 0.7420 1.2156 1.4580 0.6555 1.0700 1.1590 0.5755 1.0901 1.3080 0.7531
GDP 1.2776 0.2309 0.3415 1.4827 0.2921 1.8425 2.2668 0.8122 0.5725 1.5224 0.4527 0.7415
Glucuronic acid 1.4592 1.8244 1.9851 1.1969 0.9988 0.5783 0.9645 0.8025 0.4191 0.7489 0.7079 0.5606
Glutathione 0.8963 1.5530 3.8609 0.6029 0.4633 1.8544 0.7446 0.6911 0.5568 0.3220 0.5193 0.6505
Glycerol 3-phosphate 1.1222 1.0418 1.4996 1.2499 0.6758 1.3265 1.3721 0.8321 0.5719 1.1201 0.7496 0.5633
glycocholate-d4 (internal standard) 0.8408 1.1149 1.2907 0.8362 0.9445 1.2099 0.7682 0.9127 1.0919 0.8168 0.9324 1.3136
Glycocholic Acid 3.3215 0.2629 6.8793 0.9308 0.2582 0.2944 0.2299 0.1946 0.4331 0.3337 0.1413 0.3633
glycodeoxycholate/glycochenodeoxycholate 0.5889 1.0577 0.8327 0.7178 1.2402 1.0451 0.8685 1.1155 1.2779 0.8325 1.4805 0.9008
GMP 0.9219 0.2387 0.2067 1.1730 0.3694 1.3457 2.6341 1.3842 0.3465 1.5335 0.5051 0.1910
Guanosine 1.5183 1.2836 0.3165 1.0587 0.3631 0.5327 2.6917 0.7495 0.6356 1.5832 0.6988 0.3974
Hexose 0.9910 1.0154 1.0517 1.0050 0.9459 1.1521 0.8802 0.9529 1.0937 0.8909 0.9624 1.0717
hexose diphosphate 1.3743 0.2280 0.3647 1.6180 0.3802 1.0514 3.4522 0.6268 0.3437 1.3019 0.5664 0.5338
Hippuric acid 0.8173 5.1352 0.5255 0.7690 0.7540 0.6616 0.5705 0.6611 0.3033 0.6230 0.5996 0.4614
Hypoxanthine 1.7248 1.3318 0.9432 2.1557 0.3641 1.2642 1.3503 0.7160 0.5631 0.7749 0.4833 0.3145
IMP 1.7954 0.0303 0.1903 1.3769 0.0798 1.3869 3.6842 0.3522 0.4559 1.4441 0.5355 0.3300
Indoxyl sulfate 0.1857 1.1837 4.2728 0.7690 0.8930 0.2464 0.8666 0.1387 2.1838 0.2013 0.8663 NA
Inosine 1.7299 1.5706 1.2667 1.4480 0.2082 1.0977 1.5424 0.8418 0.6901 1.0011 0.3988 0.2714
inosine-15N4 (internal standard) 0.9955 1.0182 0.9520 1.0462 0.9786 1.0312 1.0022 0.9726 0.9697 1.0301 0.9813 1.0105
Isocitric acid 1.1152 0.5145 0.6831 1.3869 1.4877 0.9592 0.9585 0.9739 0.7777 1.1688 1.0432 0.8521
Kynurenine 0.9156 1.0789 0.7657 1.1745 0.9628 0.9916 1.1693 1.0779 0.6945 1.5346 0.8893 0.6868
Lactic acid 0.9212 1.1113 1.1496 1.0090 1.1272 1.1944 0.8283 0.8572 1.1053 0.7181 1.0248 0.9912
Lactose 0.8847 0.0465 0.1151 0.5188 0.0614 4.1570 2.6184 1.4578 1.2760 0.4376 0.0732 0.1323
Malic acid 0.8830 0.9955 0.7032 1.2105 1.5556 0.6211 1.0998 1.1765 0.5610 1.0486 1.3015 0.7694
Methylmalonic acid 1.1479 1.0308 0.8266 1.2409 1.0177 1.4174 0.8415 1.0791 0.6586 0.7728 1.0668 0.8086
mevalonate 5-phosphate 0.4420 0.3936 1.2269 0.8156 0.9601 1.2860 0.6601 NA 0.9002 1.2313 0.7507 1.3024
Myo-inositol 1.3628 1.2725 1.2454 1.3736 0.7259 1.1157 1.3609 0.6360 0.6323 0.9506 0.7058 0.6540
NADP+ 0.4992 NA 0.3805 1.1958 0.6523 1.0508 1.7213 1.1405 0.4250 1.6850 0.4894 1.0056
Orotic acid 1.0949 1.0309 0.8011 1.0300 1.6682 0.7361 0.9081 0.9191 0.7959 1.0776 1.1826 0.7057
Oxalic acid 0.9389 1.0051 0.8669 1.0710 0.8323 1.0536 1.1839 1.1882 0.8861 1.1822 0.9135 0.8451
Oxoglutaric acid 0.8557 1.1630 1.3526 0.8979 1.5663 0.8738 0.6614 0.8597 0.8586 0.6361 1.3237 1.0392
Pantothenic acid 0.7754 0.8974 1.5199 0.9430 1.0186 1.7625 0.5800 0.7753 1.1517 0.5712 0.8261 1.3089
pentose monophosphate 1.4177 0.5696 0.9150 1.5169 0.5579 1.2356 1.3705 0.9433 0.7866 1.4668 0.5428 0.6560
Phosphocreatine 1.0205 0.4947 0.6430 1.2401 0.9494 1.4576 1.5128 0.6354 0.8385 1.4240 0.7854 0.9096
Phosphoenolpyruvic acid 1.1833 0.5245 0.4826 1.4256 0.8021 0.8679 2.4112 0.8462 0.5030 1.2779 0.9434 0.6030
phosphotyrosine 1.4246 0.7337 1.1030 1.0718 1.1506 1.0685 0.8772 0.9580 0.8936 1.0118 1.0112 0.7694
Propionic acid 1.0845 0.8532 0.7167 1.2796 1.4220 0.4897 0.8448 0.8572 1.2230 1.3022 1.3013 0.5152
Quinolinic acid 0.6954 1.2569 1.8110 0.6876 1.1158 0.9289 0.8249 0.9441 1.2760 0.9473 0.9061 0.8087
Sorbitol 0.9309 1.0675 0.9569 1.1216 1.0325 1.2232 0.8280 0.9557 1.0794 0.8590 0.9637 0.9707
Succinic acid 1.1003 1.1628 1.0529 1.2089 0.9346 1.1650 0.8393 0.9354 0.7951 0.8206 1.0999 0.8986
Sucrose 0.6417 0.2958 0.3905 1.0399 1.3785 1.9792 1.3604 1.0315 0.9774 0.4707 1.3710 0.9110
Taurocholic acid 2.6789 0.0090 6.1165 2.9003 0.0042 0.0359 0.2252 0.0095 0.0137 0.9352 0.0077 0.3431
taurodeoxycholate/taurochenodeoxycholate 2.5180 0.0109 6.8261 1.9290 0.0039 0.0289 0.1483 0.0149 0.0309 0.4906 0.0083 0.2290
Thymine 0.7706 0.4661 1.4464 0.9707 0.5282 1.0287 2.0777 0.6869 1.6419 0.8696 0.4259 1.1990
thymine-d4 (internal standard) 1.0681 1.1200 1.1473 0.9754 0.9673 0.9497 0.9911 0.8779 1.0626 0.9256 0.9914 0.9604
Trans-Aconitic acid 0.9445 0.8845 0.9099 1.2427 1.3320 0.9856 0.9273 0.8442 0.8918 1.0282 1.0467 0.9401
UDP 1.0685 0.0624 0.1437 1.2757 0.1274 1.8518 3.3236 1.2827 0.4852 1.7041 0.2516 0.2092
UDP-glucose 1.0773 0.2151 0.3712 1.2300 0.5125 1.9432 2.4783 1.0406 0.4752 1.5229 0.3936 0.5830
UDP-glucuronic acid 1.4047 NA 0.4555 1.0630 0.3417 0.7846 2.0496 1.4996 0.9492 1.2782 0.6011 0.6459
UMP 1.1112 0.0720 0.2051 1.1750 0.1666 1.5333 3.0061 1.3088 0.4815 1.7796 0.2549 0.2765
Uracil 1.1305 0.5824 0.7840 1.5296 0.8356 1.0815 1.2864 0.7496 1.1032 1.2198 0.8010 0.8425
Uric acid 0.0342 0.0227 4.3262 3.0488 0.0311 0.0389 0.1739 0.0270 4.9950 0.0899 0.0244 0.0194
Uridine 1.0652 0.8800 0.8376 1.5927 0.9189 1.2172 0.9493 1.0768 0.7511 0.8663 1.1423 0.6618
Xanthine 1.2639 1.3633 0.7518 1.5271 0.8766 1.0591 1.2047 0.9470 0.4187 0.9030 0.9696 0.6533
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Factors:

F1Diet:Chow | Treatment:none | Strain:129Jax
F2Diet:Chow | Treatment:none | Strain:129Tac
F3Diet:Chow | Treatment:none | Strain:B6Jax
F4Diet:HFD | Treatment:metronidazole | Strain:129Jax
F5Diet:HFD | Treatment:metronidazole | Strain:129Tac
F6Diet:HFD | Treatment:metronidazole | Strain:B6Jax
F7Diet:HFD | Treatment:placebo | Strain:129Jax
F8Diet:HFD | Treatment:placebo | Strain:129Tac
F9Diet:HFD | Treatment:placebo | Strain:B6Jax
F10Diet:HFD | Treatment:vancomycin | Strain:129Jax
F11Diet:HFD | Treatment:vancomycin | Strain:129Tac
F12Diet:HFD | Treatment:vancomycin | Strain:B6Jax
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