Data for Diet, genetics and gut microbiome drive dynamic changes in plasma metabolites [plasma] (Study ST000879)
(Analysis AN001431)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
11-HETE | 1.9611 | 0.0531 | 0.1008 | 1.6518 | 0.3795 | 0.8044 | 3.2351 | 0.1124 | 0.0828 | 1.8178 | 0.4127 | 0.1041 |
12S-HETE | 2.7502 | 0.0218 | 0.7095 | 1.4710 | 0.0699 | 0.9634 | 2.5996 | 0.2705 | 0.1847 | 1.6315 | 1.0795 | 0.1756 |
15S-HETE | 3.6232 | 0.0293 | 0.3042 | 1.1764 | 0.3234 | 0.7804 | 3.1781 | 0.0515 | 0.1132 | 1.2386 | 0.2611 | 0.0562 |
5-HETE | 1.2666 | 0.3929 | 0.3824 | 1.8649 | 0.7679 | 0.9554 | 3.0573 | 0.4581 | 0.4543 | 1.0624 | 0.5929 | 0.5903 |
8.11.14-Eicosatrienoic acid | 0.8376 | 0.3824 | 0.7596 | 2.9491 | 0.5915 | 0.7634 | 0.9799 | 0.7555 | 0.7693 | 1.6410 | 0.6970 | 0.8135 |
Adrenic Acid | 0.4971 | 0.2592 | 0.4370 | 1.5167 | 0.8102 | 1.0338 | 1.3173 | 1.0708 | 1.1307 | 1.6157 | 0.9164 | 1.2543 |
Alpha-muricholic acid | 3.4332 | 0.6307 | NA | 0.9124 | 0.0457 | NA | 0.0597 | 0.2031 | 1.9704 | NA | 0.4829 | NA |
Arachidonic acid | 0.7421 | 0.3782 | 0.9009 | 2.3805 | 0.6982 | 1.0536 | 1.1556 | 0.9535 | 0.8326 | 1.1674 | 0.7442 | 0.9683 |
Beta-muricholic acid | 2.3025 | 0.7624 | 0.1913 | 3.5062 | 0.1963 | 0.1313 | 1.3919 | 0.1019 | 2.5741 | 0.4944 | 0.1571 | 0.2033 |
Chenodeoxycholic Acid | 0.4514 | 1.0825 | 0.3558 | NA | NA | NA | NA | NA | 2.0277 | NA | NA | NA |
Cholic acid | 2.4979 | 2.3908 | 3.7503 | 0.1119 | 0.0093 | 0.0128 | 0.0636 | 0.6146 | 0.0432 | 0.0396 | NA | NA |
Deoxycholic acid | 1.1429 | 1.4829 | 1.4515 | 1.0429 | 0.1992 | 1.3346 | 1.6968 | 0.9293 | 1.6883 | 0.3635 | 0.2807 | 0.3110 |
DHA | 1.4557 | 1.4132 | 1.6574 | 1.1296 | 0.5477 | 0.9548 | 0.8011 | 0.7752 | 0.9111 | 0.9019 | 0.6022 | 1.0145 |
DPA | 1.6847 | 0.8652 | 1.4123 | 1.6540 | 0.4391 | 0.8556 | 0.8782 | 0.6060 | 0.8965 | 1.2952 | 0.4677 | 1.0488 |
Eicosapentaenoic acid | 2.9708 | 2.3226 | 3.3683 | 0.6848 | 0.2051 | 0.5471 | 0.3959 | 0.3494 | 0.5497 | 0.4361 | 0.2575 | 0.5048 |
Gamma-linolenic acid | 1.2592 | 0.5317 | 0.9303 | 1.8475 | 0.5910 | 1.0034 | 0.9495 | 0.7595 | 0.9521 | 1.5076 | 0.6079 | 1.0428 |
Glycochenodeoxycholic acid | 3.2965 | 0.0922 | 6.9724 | 0.6679 | 0.0885 | 0.2715 | 0.0427 | 0.0467 | 0.2124 | 0.0455 | 0.0656 | 0.3119 |
Glycocholic Acid | 4.3866 | 0.0204 | 5.0283 | 0.7838 | NA | 0.0046 | 0.1498 | 0.0281 | 0.0288 | 0.1137 | 0.0012 | 0.0322 |
Glycodeoxycholic acid | 2.1378 | 0.4196 | 2.9169 | 0.6989 | 0.2763 | 0.7981 | NA | 0.2843 | 0.8674 | 0.1427 | 0.2561 | 1.1142 |
Glycoursodeoxycholic acid | 5.2664 | 0.0119 | 3.2750 | 0.9715 | NA | 0.0186 | 0.0088 | NA | 0.0091 | 0.0321 | NA | 0.0409 |
Hyodeoxycholic acid/Ursodeoxycholic acid | 0.3345 | 1.6133 | 0.9707 | 3.5112 | 0.0396 | 1.6579 | 0.7571 | 1.0457 | 0.4733 | 0.1519 | 0.3439 | 0.1486 |
Linoleic acid | 1.3068 | 0.2872 | 0.8633 | 2.1842 | 0.5252 | 0.9703 | 0.9676 | 0.6626 | 0.8190 | 1.8723 | 0.5106 | 0.9966 |
Lithocholic acid glycine conjugate | NA | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
LTB4 | 0.9220 | NA | 0.2640 | 0.7955 | NA | 0.6505 | 1.7711 | NA | NA | 1.0621 | NA | NA |
Myristic acid | 1.7713 | 0.5066 | 1.0847 | 1.4253 | 0.5945 | 1.1442 | 0.9152 | 0.6189 | 1.0033 | 1.3554 | 0.4614 | 1.1404 |
Myristoleic acid | 1.1066 | 0.7416 | 1.4852 | 1.6232 | 0.7269 | 0.6899 | 0.8345 | 0.9294 | 1.0228 | 1.3062 | 0.5660 | 1.0890 |
Oleic acid | 1.2032 | 0.2387 | 0.8580 | 1.7903 | 0.5546 | 1.0797 | 0.9330 | 0.7438 | 0.9591 | 1.9273 | 0.5630 | 1.1137 |
Palmitic acid | 1.3655 | 0.5296 | 1.0316 | 1.3313 | 0.6560 | 1.0774 | 1.0071 | 0.7983 | 0.9110 | 1.5904 | 0.6338 | 1.0759 |
Palmitoleic acid | 2.5107 | 0.4438 | 1.0118 | 1.5770 | 0.3673 | 0.8345 | 0.8720 | 0.5930 | 0.7409 | 1.8334 | 0.2978 | 0.9207 |
PGE2 | 2.0860 | 0.6959 | 0.8034 | 0.9582 | 0.7772 | 0.9328 | 1.1840 | 0.6627 | 0.7869 | 1.4370 | 0.8534 | 0.7734 |
PGE2-d4 (internal standard) | 0.9913 | 1.0092 | 1.0004 | 0.9716 | 1.0044 | 1.0378 | 0.9969 | 1.0003 | 0.9913 | 0.9678 | 1.0085 | 1.0206 |
PGF2alpha | 2.1127 | NA | NA | 0.3599 | NA | 0.1254 | 0.3840 | NA | NA | 1.7799 | NA | NA |
Sphingosine-1-phosphate | 0.9724 | 1.1013 | 0.7862 | 1.1256 | 1.1054 | 0.8705 | 0.9064 | 1.1812 | 0.7864 | 0.9954 | 1.2375 | 0.8782 |
Stearic acid | 0.6847 | 0.2362 | 0.4342 | 2.0847 | 0.6869 | 0.8004 | 1.4691 | 1.0441 | 0.7598 | 1.9967 | 0.8604 | 0.8013 |
Taurochenodeoxycholic acid | 2.0893 | 0.0077 | 7.8095 | 2.9467 | 0.0029 | 0.0346 | 0.1358 | 0.0079 | 0.0072 | 0.5364 | 0.0055 | 0.1190 |
Taurocholic acid | 0.1517 | 0.0460 | 0.0144 | 0.4248 | 0.0398 | 0.0897 | 2.8101 | 0.0736 | 0.0466 | 7.1805 | 0.0653 | 0.4208 |
Taurodeoxycholic acid | 5.2019 | 0.0302 | 3.6789 | 0.0133 | NA | 0.0050 | 0.1231 | 0.0440 | 0.0734 | 0.0046 | 0.0002 | 0.0001 |
Taurohyodeoxycholic acid | 3.4558 | 0.0109 | 3.8218 | 4.0769 | 0.0028 | 0.0309 | 0.2655 | 0.0101 | 0.0154 | 0.8786 | 0.0061 | 0.1306 |
Taurolithocholic acid | 2.7896 | 0.2162 | 8.1361 | 0.7579 | 0.2123 | 0.0838 | 0.5786 | 0.1442 | 0.0757 | 0.5403 | 0.1689 | 0.0803 |
tauromuricholic acid | 2.9245 | 0.0049 | 0.3536 | 4.1241 | 0.0073 | 0.0440 | 1.0439 | 0.0035 | 2.7537 | 0.5535 | 0.0070 | 0.0185 |
Tauroursodeoxycholic acid | 3.4558 | 0.0109 | 3.8218 | 4.0769 | 0.0028 | 0.0309 | 0.2655 | 0.0101 | 0.0154 | 0.8786 | 0.0061 | 0.1306 |
Factors:
F1 | Diet:Chow | Treatment:none | Strain:129Jax |
F2 | Diet:Chow | Treatment:none | Strain:129Tac |
F3 | Diet:Chow | Treatment:none | Strain:B6Jax |
F4 | Diet:HFD | Treatment:metronidazole | Strain:129Jax |
F5 | Diet:HFD | Treatment:metronidazole | Strain:129Tac |
F6 | Diet:HFD | Treatment:metronidazole | Strain:B6Jax |
F7 | Diet:HFD | Treatment:placebo | Strain:129Jax |
F8 | Diet:HFD | Treatment:placebo | Strain:129Tac |
F9 | Diet:HFD | Treatment:placebo | Strain:B6Jax |
F10 | Diet:HFD | Treatment:vancomycin | Strain:129Jax |
F11 | Diet:HFD | Treatment:vancomycin | Strain:129Tac |
F12 | Diet:HFD | Treatment:vancomycin | Strain:B6Jax |