Data for Diet, genetics and gut microbiome drive dynamic changes in plasma metabolites [cecal] (Study ST000880)
(Analysis AN001434)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2-hydroxyglutaric acid | 3.1438 | 1.5806 | 4.5185 | 0.0978 | 0.3794 | 0.0453 | 1.1022 | 0.6564 | 1.1628 | 0.0287 | 0.1289 | 0.0351 |
| 3^,5^ cyclic AMP | NA | NA | NA | NA | NA | NA | 0.4428 | 0.4860 | NA | 1.1813 | 1.6526 | 0.6185 |
| 3-hydroxybenzoate | 1.2396 | 0.8407 | 1.1286 | 0.0509 | 0.1276 | 0.0506 | 2.5257 | 0.6905 | 2.5948 | 0.5964 | 1.0515 | 0.8978 |
| 3-hydroxykynurenate | NA | NA | NA | 0.7410 | 1.0541 | 0.9493 | 1.6637 | 0.4871 | 1.7621 | 0.9238 | 0.8997 | 0.3958 |
| 3-methyladipate-pimelate | 2.0388 | 2.1047 | 2.7189 | 0.4835 | 0.6057 | 0.4621 | 1.0845 | 0.5928 | 0.9801 | 0.3484 | 0.5663 | 0.4440 |
| 4-Hydroxybenzaldehyde | 2.9089 | 1.4179 | 0.9453 | 0.3713 | 0.5702 | 0.3806 | 0.8392 | 1.0716 | 1.2573 | 0.6253 | 0.4349 | 1.1637 |
| 4-Hydroxyphenylpyruvic acid | 1.7261 | 0.8574 | 0.9081 | NA | NA | NA | 0.7435 | 1.0303 | 0.5883 | NA | NA | NA |
| 4-Pyridoxic acid | 2.4542 | 2.0456 | 2.5864 | 0.6643 | 0.5685 | 0.3893 | 0.8707 | 0.5139 | 0.7426 | 0.4680 | 0.6599 | 0.4332 |
| Adenine | 1.9887 | 1.6523 | 1.5043 | 1.2369 | 0.7759 | 1.8063 | 0.8583 | 0.6158 | 0.5944 | 0.4845 | 0.3486 | 0.2602 |
| Adipic acid | 1.5814 | 1.1027 | 1.3565 | 0.8202 | 0.9679 | 0.7289 | 0.8873 | 0.8450 | 1.0183 | 0.9786 | 0.9604 | 0.7743 |
| ADP | 0.8810 | 0.8926 | 1.8751 | NA | NA | NA | NA | NA | NA | NA | NA | 0.1553 |
| Alpha-hydoxy butyric acid | 0.9348 | 1.1899 | 0.8193 | 0.7426 | 3.1597 | 0.4536 | 0.6720 | 0.5276 | 0.8694 | 0.8320 | 0.8301 | 0.9238 |
| Aminoadipic acid | 1.4691 | 1.2249 | 1.7119 | 0.5640 | 0.4453 | 0.8178 | 1.6101 | 0.5920 | 1.7715 | 0.3599 | 0.4810 | 0.5205 |
| AMP | 1.0763 | 0.7531 | 1.4895 | NA | NA | NA | 0.2141 | NA | NA | NA | NA | NA |
| beta-hydroxybutyric acid | 0.5707 | 0.4762 | 0.1866 | 2.8529 | 1.7359 | 0.2971 | 0.2593 | 0.1083 | 0.0971 | 2.3870 | 1.2107 | 1.3889 |
| Chenodeoxycholic Acid | 1.4249 | 1.3421 | 0.7983 | NA | NA | 0.0197 | 0.6504 | 1.5371 | 1.9186 | NA | 0.0112 | NA |
| Cholic acid | 0.6885 | 2.5688 | 0.2593 | 0.1177 | 0.3643 | 0.2149 | 1.0189 | 1.7748 | 2.5552 | NA | 0.0033 | NA |
| Citric acid | 2.1164 | 0.9619 | 2.3027 | 0.2609 | 0.4092 | 0.3671 | 0.4352 | 0.5146 | 0.6920 | 1.7318 | 0.4472 | 2.0866 |
| CMP | 2.4223 | 1.4167 | 2.4939 | 0.3785 | 0.4755 | NA | 0.4946 | 0.3718 | 0.2705 | 0.1165 | 0.2282 | NA |
| Cystathionine | 1.0859 | 1.8024 | 0.8033 | 0.5255 | 0.5971 | 0.5939 | 0.9424 | NA | 0.8634 | 1.0603 | 0.5416 | 1.7851 |
| Cytidine | 1.7152 | 1.0272 | 1.1745 | 0.0951 | 0.0443 | 0.0824 | 0.8155 | 0.7840 | 1.2548 | 1.5513 | 0.1991 | 3.3002 |
| dCMP | 2.7911 | 1.5740 | 2.2638 | 1.2296 | 0.9008 | 0.0600 | 1.7015 | 0.3556 | 0.5731 | 0.3052 | 0.5012 | 0.0600 |
| dTMP | 3.1489 | 0.8331 | 1.9753 | 0.1741 | 0.4856 | NA | 0.4819 | 0.3365 | 0.5858 | NA | 0.2993 | NA |
| Erythrose 4-phosphate | 1.5195 | 1.8027 | 0.2441 | NA | NA | 0.1173 | NA | NA | 0.0427 | NA | 0.0624 | 0.0473 |
| FMN | 1.3588 | 0.7791 | 1.2331 | NA | NA | NA | NA | 0.3455 | 0.1829 | NA | NA | NA |
| Folic acid | 0.5638 | NA | NA | 1.1036 | 1.4318 | 0.7849 | NA | NA | NA | 1.0570 | 0.7376 | 0.9965 |
| Fructose-6-phosphate | 4.8588 | 4.2581 | 0.6157 | 0.0401 | 0.0292 | 0.0916 | 0.0397 | 0.1024 | 0.0619 | 0.0225 | 0.0515 | 0.0428 |
| fumarate/maleate | 2.3542 | 2.2975 | 3.3074 | 0.3029 | 0.9114 | 0.4027 | 0.3676 | 0.4788 | 0.3664 | 0.3946 | 0.4407 | 0.4907 |
| Gentisic acid | 3.1681 | 3.4446 | 3.2055 | 0.0291 | 0.1020 | 0.0344 | 0.0592 | 0.1856 | 0.0665 | NA | 0.0230 | NA |
| Glucuronic acid | 0.3132 | 0.3641 | 0.2556 | 0.4430 | 0.8677 | 0.3901 | 0.1524 | 0.0838 | 0.1109 | 4.2714 | 0.8093 | 3.7524 |
| Glycerol 3-phosphate | 2.3793 | 1.4661 | 4.3860 | 0.5510 | 0.4937 | 0.0469 | 0.7787 | 0.7272 | 0.2845 | 0.1276 | 0.1687 | 0.0347 |
| glycocholate-d4 (Internal standard) | 1.1156 | 1.1024 | 0.9435 | 0.9666 | 1.0904 | 0.9741 | 0.8767 | 1.0436 | 1.0843 | 0.9206 | 0.9243 | 0.9439 |
| Glycocholic Acid | 0.6385 | 1.8719 | 0.2624 | 0.3364 | 0.3025 | 0.6545 | 0.9879 | 1.6170 | 3.7476 | 0.2979 | 0.3696 | 0.7294 |
| Guanine | 1.3506 | 1.7896 | 1.6601 | 1.2013 | 0.1292 | 0.9374 | 1.2170 | 0.9087 | 1.2508 | 0.6939 | 0.1951 | 0.8314 |
| Guanosine | 1.2740 | 0.4820 | 1.3360 | 0.1797 | 0.0659 | 0.1806 | 0.4225 | 0.2802 | 0.3914 | 2.7429 | 0.1837 | 4.5451 |
| Hexose | 2.9031 | 3.0333 | 2.3367 | 0.0905 | 0.0871 | 0.0639 | 1.4116 | 1.0220 | 1.0068 | 0.1037 | 0.1495 | 0.1260 |
| hydroxyphenylacetate | 1.3089 | 1.0999 | 1.5283 | 0.8750 | 0.4910 | 0.2179 | 3.2912 | 1.7180 | 0.7467 | 0.1887 | 0.3033 | 0.1604 |
| Hypoxanthine | 2.6589 | 2.4937 | 2.7941 | 0.2665 | 0.1281 | 0.2004 | 1.5018 | 0.9590 | 1.2040 | 0.0878 | 0.0891 | 0.0650 |
| Indoxyl sulfate | 0.0125 | 0.1349 | NA | 2.0062 | 1.6602 | 0.0393 | 0.6752 | 0.6596 | NA | 1.4801 | 1.7377 | 0.0346 |
| Inosine | 3.4523 | 0.9967 | 3.7246 | 0.1492 | 0.0935 | 0.2989 | 0.6010 | 0.4481 | 0.3790 | 0.9980 | 0.1918 | 1.3480 |
| inosine-15N4 (Internal standard) | 0.7722 | 0.9457 | 0.5804 | 1.0902 | 1.2726 | 1.1545 | 0.6929 | 1.0079 | 0.9519 | 1.1537 | 1.1968 | 1.0764 |
| Isocitric acid | 0.5732 | 0.7278 | 0.5576 | 1.1673 | 1.8743 | 0.8721 | 0.2055 | 0.5656 | 0.1758 | 2.0065 | 1.2059 | 1.8492 |
| Kynurenine | 1.0593 | 1.0532 | 0.6697 | 0.8414 | 0.8396 | 0.5908 | 0.9374 | 0.7866 | 1.5259 | 1.4314 | NA | 0.9608 |
| Lactic acid | 0.5407 | 1.3423 | 0.6055 | 1.4984 | 1.4471 | 0.8588 | 0.6623 | 0.4539 | 0.5582 | 1.4795 | 0.5968 | 1.8579 |
| Lactose | 2.2911 | 3.1806 | 1.8397 | 0.2173 | 0.2045 | 0.1881 | 0.1847 | 0.1885 | 0.2043 | 1.6544 | 0.3302 | 1.7264 |
| Lithocholic acid | 1.2532 | 0.9761 | 1.0146 | NA | NA | NA | 0.5070 | 0.4731 | 1.2781 | NA | NA | NA |
| Malic acid | 2.8948 | 3.0368 | 3.8113 | 0.1842 | 0.5198 | 0.1660 | 0.3144 | 0.3788 | 0.3492 | 0.3029 | 0.3103 | 0.4344 |
| NAD+ | 1.0954 | 0.5007 | 1.9612 | NA | NA | NA | 0.7195 | 0.2253 | 0.9075 | NA | NA | NA |
| Nicotinic acid | 2.6359 | 2.4347 | 2.8812 | 0.5264 | 0.3871 | 0.2018 | 1.2533 | 0.8138 | 0.9298 | 0.1701 | 0.1492 | 0.0869 |
| nicotinic acid mononucleotide | 0.8979 | NA | 1.1361 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Orotic acid | 0.9532 | 1.1935 | 1.9294 | 0.6700 | 1.3132 | 0.3877 | 0.1845 | 0.0790 | 0.6752 | 0.8612 | 1.3506 | 2.6348 |
| Oxalic acid | 1.7471 | 1.2048 | 1.3582 | 0.5837 | 1.1623 | 0.4217 | 1.7782 | 0.7453 | 1.2211 | 0.4535 | 0.9045 | 0.5092 |
| Oxoglutaric acid | 1.6781 | 0.7361 | 1.2210 | NA | NA | NA | 0.6629 | 0.5720 | 1.0487 | NA | NA | NA |
| Pantothenic acid | 1.5730 | 2.2652 | 3.9155 | 0.2979 | 0.2655 | 0.2055 | 0.8824 | 1.1890 | 1.5016 | 0.1401 | 0.2941 | 0.1989 |
| pentose monophosphate | 1.4355 | 0.3363 | 1.3979 | NA | NA | NA | 0.0555 | NA | NA | NA | NA | NA |
| phosphotyrosine | 2.1650 | 1.2868 | NA | 0.4367 | NA | NA | 0.5088 | NA | 0.7105 | 0.5077 | NA | NA |
| Propionic acid | 1.2162 | 1.0518 | 1.4867 | 0.7807 | 1.1959 | 0.5196 | 0.7083 | 0.6569 | 1.1358 | 0.5899 | 1.5587 | 0.9524 |
| Quinolinic acid | 0.6945 | 1.5388 | 2.8206 | 1.1318 | 0.8212 | 0.4106 | 0.9025 | 0.6011 | 0.8110 | 1.1722 | 1.0245 | 0.5263 |
| Sorbitol | 1.1255 | 1.4027 | 1.0690 | 0.4058 | 0.1723 | 0.3073 | 0.2587 | 0.1361 | 0.1558 | 4.5415 | 0.1398 | 2.3030 |
| Succinic acid | 0.9007 | 2.6101 | 1.6503 | 1.2128 | 1.4593 | 0.6476 | 1.0322 | 0.4974 | 0.8686 | 0.1285 | 1.0523 | 0.1027 |
| Sucrose | 2.3239 | 1.6825 | 0.9056 | 0.5919 | 0.6410 | 0.5578 | 0.4749 | 0.5124 | 0.4703 | 1.7102 | 0.7647 | 1.3413 |
| Taurocholic acid | 0.2114 | 0.1631 | 0.0081 | 1.4042 | 1.5916 | 1.4430 | 1.1091 | 0.7583 | 0.9880 | 1.2116 | 1.5308 | 1.3330 |
| taurodeoxycholate-taurochenodeoxycholate | 0.5122 | 0.2030 | 0.0231 | 0.6512 | 0.9230 | 1.0802 | 1.3831 | 1.9541 | 2.9442 | 0.5371 | 0.8170 | 0.7274 |
| Thymine | 1.9059 | 1.6189 | 2.4410 | 0.4150 | 0.3570 | 0.2832 | 1.1849 | 0.9259 | 0.9723 | 0.8149 | 0.3205 | 1.1207 |
| thymine-d4 (Internal standard) | 0.9500 | 0.9813 | 0.8016 | 0.9824 | 1.2471 | 1.0496 | 0.8104 | 1.0285 | 1.0097 | 1.0221 | 1.1175 | 0.9500 |
| Trans-Aconitic acid | NA | NA | 1.4171 | 0.8019 | 1.0964 | NA | NA | NA | NA | NA | NA | 0.6846 |
| Uracil | 2.4996 | 1.9025 | 2.8890 | 0.3393 | 0.2947 | 0.1499 | 1.3100 | 0.9972 | 1.1805 | 0.3108 | 0.3281 | 0.2707 |
| Uric acid | 0.5509 | 0.3721 | 1.2446 | 2.3300 | 0.3150 | 2.6925 | 0.2809 | 0.3968 | 0.3565 | 1.1297 | 0.2565 | 2.1355 |
| Uridine | 1.7917 | 0.8982 | 1.8906 | 0.3938 | 0.2405 | 0.4206 | 0.6864 | 0.6135 | 0.6895 | 1.1298 | 0.2506 | 3.2174 |
| Xanthine | 2.4431 | 1.7688 | 3.8498 | 0.5227 | 0.0806 | 0.9207 | 0.7840 | 0.7777 | 0.9291 | 0.3166 | 0.0451 | 0.2743 |
| Xanthurenic acid | 0.0975 | 0.1577 | 0.1116 | 1.8725 | 0.9380 | 0.5323 | 4.8044 | 0.8263 | 0.9695 | 0.2708 | 0.8053 | 0.3921 |
Factors:
| F1 | Diet:Chow | Treatment:none | Strain:129Jax |
| F2 | Diet:Chow | Treatment:none | Strain:129Tac |
| F3 | Diet:Chow | Treatment:none | Strain:B6Jax |
| F4 | Diet:HFD | Treatment:metronidazole | Strain:129Jax |
| F5 | Diet:HFD | Treatment:metronidazole | Strain:129Tac |
| F6 | Diet:HFD | Treatment:metronidazole | Strain:B6Jax |
| F7 | Diet:HFD | Treatment:placebo | Strain:129Jax |
| F8 | Diet:HFD | Treatment:placebo | Strain:129Tac |
| F9 | Diet:HFD | Treatment:placebo | Strain:B6Jax |
| F10 | Diet:HFD | Treatment:vancomycin | Strain:129Jax |
| F11 | Diet:HFD | Treatment:vancomycin | Strain:129Tac |
| F12 | Diet:HFD | Treatment:vancomycin | Strain:B6Jax |
