Data for Gut Microbiota Modulate Brain Insulin Sensitivity and Neurobehavior (Study ST000885)

(Analysis AN001442)

Values for each metabolite have been scaled by dividing by the mean across all factors

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Metabolite	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12
1-methylhistamine	1.1865	1.1419	0.4587	1.4266	1.5325	0.7471	1.0089	1.2177	0.5379	1.0475	1.2348	0.5309
2-deoxycytidine	0.1545	0.3244	2.4000	0.1616	0.3499	2.4404	0.1882	0.3311	2.6127	0.2016	0.3097	2.3860
3-indoleacetic acid	0.1035	0.0798	3.9105	0.0678	0.0945	0.2762	0.1227	0.0892	3.1082	0.0994	0.0775	3.8154
5-adenosylhomocysteine	0.8355	2.0194	0.0037	0.9535	2.1482	0.0057	0.9568	2.2151	0.0047	1.0250	1.8219	0.0028
5-HIAA	0.8720	0.7965	1.9326	0.9932	0.8384	0.8875	0.8811	0.8347	1.1002	0.8700	0.8752	1.1175
5-hydroxytryptophan	0.9031	0.4998	0.2255	0.8299	0.5537	3.5556	0.7937	0.5397	1.8287	0.7882	0.6385	0.8152
5-hydroxytryptophol	0.8189	0.8315	1.4740	0.8222	0.8409	1.0877	0.8626	0.8277	1.3983	0.8219	0.8138	1.3709
5-methoxytryptophol	0.7876	0.8371	1.4784	0.9853	0.7063	1.2451	0.7923	0.8052	1.3841	0.9583	0.7176	1.3003
acetylcholine	0.6513	1.6944	0.0001	0.6016	1.4352	0.0000	0.6106	1.5068	0.0001	0.7981	1.4689	0.0000
adenine	0.8147	1.4736	0.2083	1.1862	1.5232	0.8111	1.3145	1.4879	0.5780	1.0976	1.4253	0.1105
adenosine	1.4962	1.5608	0.0008	1.4428	1.5417	0.0032	1.4490	1.5389	0.0008	1.4912	1.5474	0.0011
ADMA	0.4882	0.5691	1.9862	0.5005	0.5583	1.7524	0.4938	0.5498	1.9610	0.5001	0.5572	2.0001
alanine	0.8676	1.1567	0.8983	0.9019	1.1797	0.8228	0.9068	1.1266	0.9791	0.9792	1.1364	1.0286
alpha-glycerophosphocholine	1.4551	1.3136	0.2054	1.4726	1.3205	0.1927	1.5162	1.3085	0.1865	1.4748	1.3936	0.2393
anthranilic acid	0.5832	0.5066	2.0482	0.5700	0.5173	1.9329	0.5674	0.4446	1.9570	0.5789	0.4719	1.7501
argininosuccinate	0.9178	1.4487	0.0083	0.9796	1.2024	0.0034	0.9572	1.0977	NA	1.0533	1.0029	0.0069
asparagine	1.2346	1.5079	0.1572	1.2760	1.5705	0.1876	1.2553	1.5312	0.2337	1.2779	1.5489	0.2651
aspartate	1.5567	1.3816	0.0039	1.6774	1.4539	0.0022	1.5629	1.3612	0.0021	1.6796	1.4288	0.0027
beta-alanine	1.2641	1.3408	0.3283	1.3246	1.3038	0.3330	1.4396	1.4008	0.3135	1.3705	1.3200	0.3152
betaine	0.8386	0.8481	1.5933	0.7652	0.8119	1.3306	0.7072	0.7709	1.3514	0.7650	0.7735	1.4052
butyrobetaine	0.9438	1.6319	0.7064	0.9112	1.6521	0.3148	0.8667	1.5818	0.3802	1.0731	1.5826	0.3407
C10:2 carnitine	0.0873	0.0403	2.6704	0.5886	0.3533	1.9204	0.5404	0.3584	2.2902	0.5338	0.4112	2.1372
C10 carnitine	0.2962	0.1759	2.8173	0.2214	0.1268	2.4853	0.2105	0.1341	2.6969	0.2107	0.1569	2.3382
C12:1 carnitine	0.3149	0.1280	2.8690	0.5815	0.2167	2.1637	0.4110	0.1731	2.4322	0.4208	0.2378	1.9815
C12 carnitine	1.5140	0.8231	1.2411	1.1092	0.6466	0.9464	0.9939	0.6706	1.1252	1.1427	0.8351	0.9701
C14:1 carnitine	0.6002	0.2884	2.4630	0.4544	0.2446	2.1513	0.3851	0.2400	2.2611	0.4590	0.2933	2.0688
C14:2 carnitine	0.1971	0.1058	2.8795	0.2030	0.1176	2.4716	0.1762	0.1130	2.7342	0.1938	0.1417	2.5336
C14 carnitine	1.3987	1.2181	0.7245	1.2419	1.0773	0.5228	1.0933	1.0986	0.6198	1.3460	1.1703	0.5290
C16 carnitine	0.9698	0.9213	1.1586	1.0239	0.8600	1.3231	0.8881	0.8523	1.1191	0.9809	0.8809	1.0260
C16-OH carnitine	1.7407	1.3610	0.4555	1.5429	1.0182	0.3856	1.3385	1.0166	0.4482	1.3273	1.0687	0.3873
C18:1 carnitine	1.5097	1.0623	0.5949	1.4438	1.0333	0.6668	1.2978	0.9909	0.5870	1.3515	0.9818	0.5543
C18:1-OH carnitine	1.6407	1.2665	0.5237	1.5812	1.0093	0.4733	1.3266	1.0190	0.5422	1.3150	0.9332	0.4660
C18:2 carnitine	0.6401	0.6858	1.7870	0.6516	0.7196	2.0727	0.5655	0.6314	1.3985	0.5756	0.7606	1.4536
C18 carnitine	1.4642	1.0451	0.4082	1.7440	1.0327	0.5922	1.5242	1.0331	0.4819	1.4296	0.8646	0.5043
C20:4 carnitine	1.5627	1.6777	0.2221	1.4658	1.3835	0.1900	1.3728	1.3194	0.1740	1.3547	1.2003	0.1546
C20 carnitine	1.2715	1.0105	0.5793	1.2971	0.9673	0.9520	1.2185	1.0173	0.8903	1.1536	0.8733	0.8187
C22:6 carnitine	1.5827	1.5671	0.9218	1.1241	1.1091	0.3282	1.2743	1.1009	0.2901	1.2676	1.1308	0.3240
C2 carnitine	1.0218	1.0615	1.3462	0.8250	0.9232	1.0798	0.7755	0.9069	1.1661	0.7864	0.9624	1.1159
C3 carnitine	0.3823	0.2324	4.4452	0.2320	0.1937	1.6766	0.1976	0.2006	2.0936	0.1941	0.1974	1.8266
C3-DC carnitine	1.2351	0.9078	1.2456	1.2076	0.8073	1.1012	1.0397	0.7894	1.1225	1.0041	0.7918	0.7825
C3-DC-CH3 carnitine	1.4372	1.1679	0.5558	1.3366	1.1626	0.4074	1.3382	1.1616	0.4879	1.4061	1.1350	0.4599
C4 carnitine	0.8088	0.4366	3.6534	0.5462	0.3524	1.2804	0.5145	0.4163	1.7179	0.4992	0.4170	1.2816
C4-OH carnitine	1.2351	0.9078	1.2456	1.2076	0.8073	1.1012	1.0397	0.7894	1.1225	1.0041	0.7918	0.7825
C5:1 carnitine	1.2238	1.3370	0.6340	1.0402	1.2847	0.4751	1.1422	1.3368	0.5418	1.2105	1.3064	0.4744
C5 carnitine	1.4774	1.4436	0.6881	1.0501	1.1775	0.3646	1.2034	1.3215	0.4295	1.2254	1.2798	0.3476
C5-DC carnitine	0.7674	0.7197	0.4532	1.5991	1.3950	0.4942	1.3752	1.4505	0.5467	1.3650	1.4812	0.4526
C6 carnitine	0.7651	0.2894	3.3230	0.5670	0.2204	1.4959	0.5163	0.2444	1.8983	0.4891	0.3130	1.8060
C7 carnitine	1.3700	1.0349	0.9635	1.3550	0.9856	0.3539	1.4356	1.1078	0.4867	1.3707	1.2022	0.3932
C8 carnitine	1.6396	0.8394	1.4785	1.0484	0.6505	1.0331	0.9318	0.7277	1.0580	0.7896	0.7826	1.0290
C9 carnitine	1.0783	0.8558	2.3880	0.7035	0.6445	1.0879	0.8602	0.6325	1.2863	0.6893	0.6456	1.0789
cAMP	1.1159	1.0848	0.9577	1.1764	1.1002	0.7582	1.0431	0.9771	0.8610	1.0674	1.0760	0.8117
carnitine	1.2631	1.1993	1.0406	1.1179	1.0421	0.5541	1.1364	1.0898	0.6991	1.1491	1.0215	0.7066
carnosine	1.5684	1.3136	0.0607	1.9978	1.4399	0.0540	1.6358	1.1661	0.0610	1.5670	1.2414	0.0606
choline	1.2451	1.2073	0.4838	1.2780	1.1879	0.5137	1.3509	1.2317	0.5204	1.3598	1.1887	0.4791
citrulline	1.4845	1.2624	0.5649	1.3741	1.1412	0.3342	1.2681	1.1084	0.5158	1.3803	1.1698	0.4588
cotinine	0.5359	0.4206	2.1104	0.6431	0.3821	2.0216	0.5172	0.4055	2.0570	0.5931	0.2720	1.9820
creatine	1.3115	1.2350	0.5833	1.2737	1.2170	0.5309	1.2333	1.1953	0.5026	1.2381	1.2194	0.5054
creatinine	0.5726	0.6549	2.8967	0.4577	0.5748	1.6370	0.4894	0.6163	1.4537	0.5608	0.5982	1.3975
cytosine	0.9116	1.3899	0.5950	0.9488	1.4078	0.6238	1.0099	1.3952	0.6289	1.1484	1.3427	0.5894
dimethylglycine	0.7815	0.7614	2.0113	0.8516	0.8272	1.2607	0.8849	0.8676	1.0943	0.8760	0.7397	1.0192
DOPA	0.4766	0.6367	1.8663	0.5383	0.6923	1.9189	0.5152	0.6247	1.8144	0.4426	0.6624	1.7347
dopamine	0.3704	1.8355	0.2243	2.3751	2.0771	0.2300	0.3887	1.5937	0.2725	0.8312	1.8354	0.1952
epinephrine	1.3586	1.2073	0.4710	1.2669	1.2325	0.5917	1.1251	1.1485	0.6199	1.2586	1.2050	0.5594
GABA	1.5088	1.4040	0.0007	1.5991	1.4322	0.0006	1.6407	1.5160	0.0005	1.5757	1.4210	0.0006
glutamate	1.4785	1.5807	0.0222	1.4360	1.5640	0.0162	1.3745	1.5115	0.0146	1.4352	1.6227	0.0166
glycine	1.4093	1.3898	0.4696	1.4292	1.4012	0.1539	1.3295	1.3238	0.2177	1.3626	1.3752	0.2097
guanidinoacetic acid	1.9147	1.4293	0.0775	2.1154	1.3372	0.0701	1.3741	1.0605	0.0689	1.4766	1.1892	0.0725
guanine	1.6780	1.1234	0.0039	1.8337	1.2246	0.0047	1.7987	1.0665	0.0052	2.1246	1.2709	0.0047
histidine	0.7412	1.0831	1.0188	1.0570	1.1628	0.8797	0.7775	1.0647	1.1338	0.7947	1.0464	1.2497
homocysteine	0.5841	0.6406	2.0622	0.4447	0.5936	1.7282	0.5386	0.5841	1.7946	0.4944	0.5452	1.8971
hydroxyproline	1.3885	1.6903	0.8759	1.0251	1.1199	0.5946	0.7940	0.9953	0.6854	0.9669	1.1076	0.7607
hypoxanthine	1.2607	1.1750	0.0192	1.3203	1.1880	0.0079	1.3035	1.1755	0.0354	1.2595	1.1663	0.0217
isoleucine	0.2791	0.2601	2.2217	0.2864	0.2772	2.4239	0.3023	0.2698	2.4763	0.2824	0.2803	2.5215
kynurenic acid	0.0044	0.0039	3.2562	0.0071	0.6999	2.3464	0.0051	0.0035	2.8454	0.0083	0.0029	2.6514
kynurenine	0.0608	0.0614	3.4598	0.0640	0.0475	3.3010	0.0356	0.0408	2.0714	0.0485	0.0327	2.3006
leucine	0.3938	0.3039	2.1989	0.4196	0.3582	2.2392	0.3714	0.3235	2.0733	0.3786	0.3620	2.4809
lysine	1.0204	0.9801	0.4387	1.2333	1.1721	0.5391	1.2590	1.1731	0.8311	1.3025	1.1968	0.8927
methionine	0.5311	0.5864	2.0211	0.5178	0.5821	1.8510	0.4837	0.5388	1.8472	0.5096	0.5298	1.9210
methionine sulfoxide	0.4044	0.2748	2.9905	0.4356	0.2578	1.8415	0.4460	0.2586	2.1450	0.3867	0.2388	2.2262
methylthioadenosine	1.3323	1.6635	0.0010	1.3279	1.6018	0.0010	1.5517	1.6704	0.0011	1.3390	1.5641	0.0009
mevalonic acid	1.0762	0.9738	0.9938	0.9744	0.8873	1.1205	1.0769	1.0122	0.9517	0.9264	0.9647	1.0379
N-acetylserotonin	0.9863	1.7751	0.1386	1.1625	1.8876	0.3396	1.0179	1.7548	0.2051	1.1920	1.4212	0.1464
N-carbamoyl-beta-alanine	0.2932	0.3555	1.5810	0.3293	0.4072	2.5916	0.3237	0.4394	2.8976	0.2882	0.4656	1.9157
niacinamide	1.5869	1.4359	0.0700	1.6799	1.1911	0.0443	1.5343	1.6133	0.0360	1.4587	1.4248	0.0382
N-methyltryptamine	0.7723	0.5391	1.3476	1.1196	0.5235	1.8297	0.7205	0.7153	1.7001	0.9174	0.7516	1.0833
NMMA	0.8999	0.9779	1.8500	0.7833	0.8314	1.0600	0.7757	0.7948	1.1908	0.7892	0.7486	1.2623
ornithine	1.2631	0.8624	1.4179	1.2075	0.6761	0.7807	1.1615	0.6337	1.0551	1.1849	0.6563	1.1354
phenylalanine	0.2344	0.2443	2.5409	0.2323	0.2435	2.3748	0.2412	0.2478	2.5884	0.2244	0.2313	2.4686
phenylalanine-d8	0.7273	0.6532	1.5730	0.7154	0.6835	1.7138	0.7600	0.6980	1.5260	0.7142	0.6836	1.5046
phosphocholine	1.8168	1.0381	0.0626	1.8644	1.1449	0.0604	1.8869	1.1477	0.0564	1.7657	1.2251	0.0752
phosphoethanolamine	1.3006	1.6372	0.0078	1.3707	1.6586	0.0061	1.3659	1.6449	0.0051	1.4394	1.6187	0.0067
picolinic acid	1.5549	1.4691	0.0438	1.5547	1.4614	0.0289	1.4916	1.4404	0.0225	1.5397	1.4616	0.0239
pipecolic acid	1.3737	1.4857	0.1233	1.4237	1.5225	0.1199	1.4041	1.5150	0.1356	1.3684	1.4737	0.1249
proline	0.6873	0.7903	1.2622	0.7109	0.7959	1.3060	0.7306	0.7865	1.6447	0.7362	0.7580	1.7432
putrescine	1.4706	1.2985	0.5526	1.2729	1.0992	0.5031	1.2075	1.1281	0.5384	1.2589	1.1780	0.5377
sarcosine	1.4300	1.1948	0.4573	1.4486	1.2297	0.4134	1.2888	1.2149	0.3732	1.3899	1.2525	0.3817
SDMA	1.1110	1.1193	0.8445	1.0970	1.0957	0.8569	0.9955	0.9947	0.8966	1.0536	1.0262	0.9245
serine	0.9698	1.5837	0.2260	1.1417	1.7755	0.2109	1.0639	1.6774	0.2507	1.1602	1.6920	0.2718
serotonin	0.8403	0.7878	0.2106	0.7958	0.8181	3.0205	0.6165	0.8113	1.6366	0.7953	0.9404	0.6928
spermidine	2.0504	1.2452	0.0104	1.7998	1.1287	0.0096	1.8555	1.0177	0.0062	1.8708	1.1296	0.0094
spermine	1.5661	1.0280	0.4995	1.4095	1.1144	0.3253	1.5198	1.1955	0.4346	1.5352	1.0926	0.3478
taurine	1.0351	1.6944	0.3271	0.9975	1.6450	0.3406	0.9576	1.6270	0.3096	1.1551	1.5993	0.3113
thiamine	1.3094	1.1552	1.0219	1.1183	0.9772	0.7427	1.1491	0.9890	0.8419	1.0952	0.9294	0.6905
thymidine	1.3918	1.4935	0.2381	1.2259	1.3723	0.2537	1.4413	1.3774	0.2297	1.3118	1.3620	0.3402
thymine	0.4472	0.5061	2.2417	0.3625	0.4946	2.0980	0.4110	0.4413	2.0879	0.4259	0.4875	1.8901
thyroxine	0.0854	0.0728	3.0771	0.0630	0.0476	2.7646	0.0761	0.0456	3.1446	0.0721	0.0437	2.3513
triiodothyronine	1.0599	1.0604	0.8362	1.4070	1.0137	0.8866	1.0053	0.8851	1.0222	1.1456	0.9935	0.7523
trimethylamine-N-oxide	0.7929	0.7871	4.7442	0.5556	0.5345	0.4589	0.6162	0.6265	1.2964	0.5486	0.5356	0.4295
tryptamine	NA	NA	1.1041	NA	NA	1.0532	NA	NA	0.9259	NA	NA	0.9168
tryptophan	0.1558	0.1146	3.1246	0.1784	0.1382	2.7544	0.1705	0.1307	2.5451	0.1619	0.1300	2.2589
tyramine	0.8270	0.9656	1.2101	1.4089	0.9176	1.4311	0.7680	0.8046	0.9865	0.8159	0.8951	1.0377
tyrosine	0.5847	0.4908	1.6793	0.6291	0.5680	1.6499	0.6450	0.5695	2.0190	0.6321	0.5345	1.9363
valine	0.6898	0.6229	1.3950	0.7541	0.7248	1.4228	0.8011	0.7208	1.6632	0.7819	0.7436	1.6390
valine-d8	1.3362	1.2720	0.4176	1.3086	1.2641	0.3776	1.3324	1.3171	0.4073	1.3101	1.3136	0.3947
xanthosine	0.9485	1.7441	0.0172	2.0107	1.9021	0.0702	1.0401	1.7801	0.0539	1.0548	1.5287	0.0179

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Factors:

F1	Diet:Chow | Treatment:none | Tissue:hypothalamus
F2	Diet:Chow | Treatment:none | Tissue:nucleus accumbens
F3	Diet:Chow | Treatment:none | Tissue:plasma
F4	Diet:HFD | Treatment:metronidazole | Tissue:hypothalamus
F5	Diet:HFD | Treatment:metronidazole | Tissue:nucleus accumbens
F6	Diet:HFD | Treatment:metronidazole | Tissue:plasma
F7	Diet:HFD | Treatment:none | Tissue:hypothalamus
F8	Diet:HFD | Treatment:none | Tissue:nucleus accumbens
F9	Diet:HFD | Treatment:none | Tissue:plasma
F10	Diet:HFD | Treatment:vancomycin | Tissue:hypothalamus
F11	Diet:HFD | Treatment:vancomycin | Tissue:nucleus accumbens
F12	Diet:HFD | Treatment:vancomycin | Tissue:plasma