Data for Analysis of the effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Heart, Metabolism In Vivo (Study ST000893)
(Analysis AN001455)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 |
|---|---|---|---|
| 1,5-Anhydroglucitol | 0.9896 | 1.0062 | 1.0042 |
| 1-Eicosanol/Nonadecanoic acid | 0.9961 | 0.9838 | 1.0167 |
| 2-Aminoadipic acid | 0.9938 | 1.0095 | 0.9967 |
| 2-Hydroxyglutaric acid | 1.0576 | 0.9818 | 0.9732 |
| 2-Hydroxypyridine | 0.9975 | 1.0067 | 0.9958 |
| 3-Aminoisobutyric acid/beta-Alanine | 1.0351 | 1.0182 | 0.9762 |
| 3-Indolelactic acid/Tryptophan | 0.9668 | 1.0074 | 1.0120 |
| 3-Phosphoglyceric acid | 0.9828 | 1.0330 | 0.9857 |
| 4-Hydroxypyridine | 0.9947 | 1.0058 | 0.9918 |
| 5-alpha-Coprostanol or similar oxysterol | 1.0030 | 1.0072 | 0.9941 |
| 5^-Deoxy-5^-(methylthio) adenosine | 0.9824 | 1.0085 | 1.0091 |
| 6-Hydroxynicotinic acid | 0.9560 | 1.0211 | 1.0250 |
| 6-Methyluracil | 1.0043 | 1.0036 | 0.9957 |
| Adenine | 0.9937 | 1.0070 | 0.9994 |
| Adenosine-5-monophosphate | 0.9885 | 1.0098 | 1.0017 |
| Adenosine/Inosine | 0.9914 | 1.0112 | 0.9974 |
| Alanine | 0.9972 | 1.0027 | 1.0001 |
| alpha-Monopalmitin | 0.9968 | 1.0049 | 0.9983 |
| alpha-Monostearin | 1.0002 | 1.0032 | 0.9966 |
| alpha-Tocopherol | 0.9925 | 1.0231 | 0.9860 |
| Aminomalonic acid | 1.0043 | 1.0261 | 0.9065 |
| Arachidic acid/ 1-Heneicosanol | 1.0034 | 1.0119 | 0.9851 |
| Arachidonic acid (also Eicosapentaenoic acid) | 0.9793 | 0.9979 | 1.0228 |
| Arginine | 0.9942 | 0.9668 | 1.0448 |
| Asparagine | 1.0307 | 1.0164 | 0.9370 |
| Aspartic acid | 0.9960 | 0.9991 | 1.0049 |
| Benzoic acid | 0.9935 | 1.0083 | 0.9982 |
| beta-Hydroxybutyric acid | 0.9929 | 1.0127 | 0.9944 |
| beta-Monopalmitin | 0.9878 | 1.0049 | 1.0072 |
| beta-Monostearin | 0.9950 | 1.0043 | 1.0006 |
| beta-Sitosterol | 0.9775 | 1.0267 | 0.9983 |
| C10 hydrocarbon | 1.0014 | 1.0020 | 0.9962 |
| C11 hydrocarbon | 0.9897 | 1.0066 | 1.0037 |
| C12 hydrocarbon | 0.9977 | 1.0098 | 0.9926 |
| C13 hydrocarbon | 0.9982 | 1.0094 | 0.9924 |
| C14 Hydrocarbon | 1.0073 | 1.0098 | 0.9818 |
| C15 hydrocarbon | 1.0016 | 1.0084 | 0.9899 |
| C16 Hydrocarbon | 1.0021 | 1.0002 | 0.9976 |
| C17 hydrocarbon | 0.9898 | 1.0011 | 1.0092 |
| C19 hydrocarbon | 0.9563 | 1.0248 | 1.0335 |
| C20 Hydrocarbon | 1.0293 | 0.9845 | 0.9764 |
| C21 Hydrocarbon | 1.0075 | 1.0032 | 0.9900 |
| C22 hydrocarbon | 1.0413 | 1.0028 | 0.9679 |
| C23 Hydrocarbon | 1.0176 | 0.9913 | 0.9999 |
| C24 Hydrocarbon | 1.0013 | 1.0040 | 0.9941 |
| C25 hydrocarbon | 1.0097 | 0.9925 | 0.9966 |
| Campesterol | 0.9912 | 1.0096 | 0.9993 |
| Chenodeoxycholic acid | 0.9898 | 1.1285 | 0.9511 |
| Cholesterol | 0.9958 | 1.0023 | 1.0019 |
| Citric acid/isocitric acid | 0.9880 | 1.0087 | 1.0033 |
| Creatinine | 0.9962 | 1.0145 | 0.9893 |
| Decanoic acid | 0.9690 | 1.0169 | 1.0057 |
| Dehydroalanine (possibly from cysteine) | 0.9879 | 0.9988 | 1.0133 |
| Dehydroascorbic acid (possibly alpha-ketoglutarate) | 0.9949 | 1.0089 | 0.9961 |
| deuterated Myristic Acid (RTL std) | 0.9939 | 1.0076 | 0.9985 |
| Diethanolamine | 1.0369 | 0.9877 | 0.9693 |
| Dihydroxyacetone phosphate | 1.0143 | 1.0197 | 0.9708 |
| Disaccharide | 0.9919 | 0.9973 | 1.0120 |
| Docosahexaenoic acid | 0.9815 | 0.9993 | 1.0193 |
| Docosanoic acid | 1.0045 | 1.0274 | 0.9690 |
| Ethanolamine | 0.9889 | 0.9870 | 1.0241 |
| Fructose or similar ketohexose | 0.9594 | 1.0067 | 1.0217 |
| Fumaric acid | 0.9776 | 1.0151 | 1.0073 |
| gamma-Tocopherol | 1.0436 | 0.9732 | 0.9965 |
| Glucose-6-phosphate or similar | 0.9859 | 0.9891 | 1.0250 |
| Glucose and other aldohexoses | 0.9874 | 1.0090 | 1.0036 |
| Glutamic acid | 0.9962 | 1.0057 | 0.9980 |
| Glutamine | 1.0184 | 1.0242 | 0.9574 |
| Glycerol | 0.9873 | 1.0344 | 0.9919 |
| Glycerol 1-phosphate | 0.9890 | 1.0035 | 1.0075 |
| Glycine | 0.9970 | 1.0085 | 0.9945 |
| Glycolic acid | 0.9917 | 1.0172 | 0.9930 |
| Glyoxylic acid | 0.9836 | 0.9956 | 1.0498 |
| Gly-Pro | 1.0229 | 1.0096 | 0.9675 |
| Heptadecanoic acid/Octadecanol | 0.9936 | 1.0068 | 0.9997 |
| Hexanoic acid (and/or Glycolic acid) | 0.9989 | 1.0056 | 0.9961 |
| Hexitols | 0.9810 | 1.0102 | 1.0069 |
| Histidine | 1.0053 | 1.0003 | 0.9891 |
| Homoserine | 0.9936 | 1.0140 | 0.9924 |
| Hydroxyprolines | 0.9967 | 1.0116 | 0.9802 |
| Hypotaurine | 0.9860 | 1.0045 | 1.0095 |
| Hypoxanthine | 0.9886 | 1.0036 | 1.0074 |
| Inosine 5^-monophosphate | 1.0046 | 0.9613 | 1.0543 |
| Inosine/Adenosine | 0.9688 | 1.0129 | 1.0203 |
| Isoleucine/Leucine | 1.0231 | 0.9955 | 0.9854 |
| Ketopentose-5-phosphate | 1.0113 | 0.9929 | 0.9975 |
| Lactic acid | 0.9953 | 1.0051 | 0.9996 |
| Linoleic acid | 0.9922 | 1.0009 | 1.0069 |
| Lysine | 1.0059 | 1.0069 | 0.9872 |
| Maleic acid | 1.0084 | 1.0454 | 0.9777 |
| Malic acid | 0.9958 | 1.0026 | 1.0015 |
| Methionine | 0.9994 | 1.0122 | 0.9896 |
| Methionine sulfoxide | 0.9874 | 0.9923 | 1.0233 |
| MSTFA artifact | 0.9874 | 1.0103 | 1.0024 |
| Myoinositol | 0.9974 | 1.0064 | 0.9962 |
| Myoinositol-2-phosphate | 0.9778 | 1.0003 | 1.0220 |
| Myristic acid or Pentadecanol | 0.9977 | 1.0075 | 0.9948 |
| N-Acetylneuraminic acid | 1.0229 | 0.9764 | 1.0258 |
| Nicotinamide | 0.9894 | 1.0135 | 0.9972 |
| Nicotinic acid | 1.0037 | 1.0228 | 0.9753 |
| N-Methylalanine/2-Aminobutanoic acid/N-Ethylglycine | 0.9838 | 1.0101 | 1.0107 |
| Nonanoic acid | 0.9651 | 0.9989 | 1.0372 |
| Oleic acid | 0.9867 | 0.9993 | 1.0140 |
| O-Methylphosphate | 0.9815 | 1.0047 | 1.0138 |
| O-Phosphocolamine | 0.9842 | 1.0006 | 1.0152 |
| Palmitic acid | 0.9968 | 1.0057 | 0.9975 |
| Palmitoleic acid | 1.0158 | 0.9848 | 0.9994 |
| Pantothenic acid | 0.9881 | 1.0076 | 1.0043 |
| Pentadecanoic acid/Hexadecanol | 0.9853 | 1.0145 | 0.9986 |
| Pentitols | 1.0157 | 1.0053 | 0.9806 |
| Phenol | 0.9989 | 1.0111 | 0.9900 |
| Phenylalanine | 0.9985 | 1.0074 | 0.9941 |
| Phosphoenolpyruvic acid | 0.9548 | 1.0189 | 1.0096 |
| Phosphoric acid | 0.9945 | 1.0072 | 0.9983 |
| p-Hydroxyphenyllactic acid | 0.9799 | 1.0030 | 1.0155 |
| possibly Erythritol/Theitol | 1.0169 | 1.0046 | 0.9778 |
| Prunetin or similar isoflavone | 0.9847 | 1.0138 | 1.0014 |
| Pseudouridine | 0.9780 | 1.0130 | 1.0105 |
| Putrescine | 1.0016 | 0.9974 | NA |
| Pyrophosphate | 0.9999 | 1.0085 | 0.9916 |
| Pyrrole -2-carboxylic acid | 0.9849 | 1.0142 | 0.9925 |
| Pyruvic acid | 1.0036 | 0.9950 | 1.0018 |
| Serine | 1.0047 | 1.0185 | 0.9768 |
| Siloxanes_R1 | 1.0014 | 0.9974 | 1.0012 |
| Siloxanes_R2 | 0.9655 | 1.0152 | 1.0192 |
| Siloxanes_R3 | 1.0038 | 1.0019 | 0.9944 |
| Siloxanes_R4 | 0.9677 | 0.9928 | 1.0474 |
| Siloxanes_R5 | 0.9846 | 1.0108 | 1.0047 |
| Siloxanes_R6 | 0.9563 | 1.0258 | 1.0179 |
| Siloxanes_R7 | 0.9410 | 1.0327 | 1.0237 |
| Siloxanes_R8 | NA | 0.9963 | 1.0110 |
| Spermidine | 1.0028 | 1.0174 | 0.9798 |
| Spermine | 1.0431 | 0.9630 | 0.9696 |
| Squalene | 0.9897 | 1.0083 | 1.0020 |
| Stearamide | 0.9864 | 0.9867 | 1.0243 |
| Stearic acid | 0.9977 | 1.0035 | 0.9988 |
| Succinic acid | 0.9904 | 1.0062 | 1.0034 |
| Sucrose and similar disaccharides | 0.9966 | 1.0040 | 1.0004 |
| Taurine | 0.9975 | 0.9967 | 1.0058 |
| Threonic acid/erythronic acid | 1.0092 | 1.0413 | 0.9694 |
| Threonine | 0.9912 | 1.0160 | 0.9927 |
| Tiglic acid | 0.9960 | 0.9953 | 1.0151 |
| Tris | 0.9977 | 1.0717 | 0.9329 |
| Tryptamine/Norepinephrine | 0.9730 | 0.9826 | 1.0386 |
| Tyrosine | 0.9860 | 1.0199 | 0.9941 |
| Unknown-possibly propylene glycol | 1.0129 | 0.9848 | 1.0025 |
| Uracil | 1.0285 | 0.9739 | 0.9980 |
| Urea | 0.9918 | 1.0112 | 0.9969 |
| Uric acid | 1.0069 | 0.9828 | 1.0094 |
| Uridine | 1.0009 | 0.9968 | 1.0025 |
| Valine | 1.0188 | 0.9997 | 0.9834 |
| Xanthine (and/or Cytindine-5^-monophosphate) | 1.0334 | 0.9794 | 1.0108 |
Factors:
| F1 | Treatment:40mg/kg Sun |
| F2 | Treatment:50mg/kg Erl |
| F3 | Treatment:PBS Ctl |
