Data for Analysis of the effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Liver Metabolism In Vivo (Study ST000894)
(Analysis AN001456)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 |
---|---|---|---|
1,4:3,6-Dianhydroglucitol | 0.9956 | 1.0015 | NA |
1,5-Anhydroglucitol | 1.0054 | 0.9966 | 0.9980 |
1-Dodecanol | 0.9980 | 0.9860 | 1.0441 |
1-Eicosanol/Nonadecanoic acid | 0.9914 | 1.0022 | 1.0064 |
2-Aminoadipic acid | 1.0036 | 0.9999 | 0.9965 |
2-Aminoethanethiol/Glycylphenylalanine | 0.9566 | 1.0093 | 1.0291 |
2-Deoxyglucose-6-phosphate | 1.0124 | 0.9861 | 1.0016 |
2-Hydroxybutyric acid | 0.9972 | 1.0025 | 1.0003 |
2-Hydroxyglutaric acid | 1.0082 | 0.9976 | 0.9952 |
2-Hydroxypyridine | 1.0025 | 1.0014 | 0.9962 |
3-Aminoisobutyric acid/beta-Alanine | 1.0019 | 0.9977 | 1.0005 |
3-Phosphoglyceric acid | 0.9902 | 0.9991 | 1.0029 |
5-alpha-Coprostanol or similar oxysterol | 1.0045 | 0.9972 | 0.9981 |
5^-Deoxy-5^-(methylthio) adenosine | 1.0073 | 0.9947 | 0.9971 |
5-Hydroxylysine | 0.9796 | 1.0063 | 1.0108 |
6-Hydroxynicotinic acid | 0.9985 | 0.9853 | 1.0162 |
6-Methyluracil/Thymine | 1.0298 | 0.9687 | 0.9944 |
Acetoacetate/2-Aminoisobutanoic acid | 1.0013 | 0.9938 | 1.0049 |
Adenine | 0.9947 | 0.9859 | 1.0220 |
Adenosine-5-monophosphate | 1.0198 | 0.9986 | 0.9832 |
Adenosine/Inosine | 1.0013 | 1.0003 | 0.9983 |
Alanine | 1.0076 | 0.9958 | 0.9966 |
Aldopentoses | 1.0124 | 0.9904 | 0.9971 |
Allantoin | 1.0441 | 1.0216 | 0.9451 |
alpha-Monopalmitin | 1.0012 | 0.9991 | 0.9997 |
alpha-Monostearin | 1.0001 | 0.9985 | 1.0014 |
alpha-Tocopherol | 0.9989 | 1.0013 | 0.9999 |
Aminomalonic acid | 1.0049 | 0.9910 | 1.0041 |
Arachidic acid/ 1-Heneicosanol | 0.9785 | 1.0131 | 1.0101 |
Arachidonic acid (also Eicosapentaenoic acid) | 1.0062 | 0.9811 | 1.0115 |
Asparagine | 1.0123 | 0.9796 | 1.0005 |
Aspartic acid | 1.0050 | 0.9992 | 0.9958 |
Benzoic acid | 1.0130 | 0.9943 | 0.9940 |
beta-Hydroxybutyric acid | 0.9977 | 0.9981 | 1.0042 |
beta-Monopalmitin | 1.0005 | 0.9998 | 0.9997 |
beta-Monostearin | 1.0028 | 0.9981 | 0.9991 |
beta-Sitosterol | 1.0067 | 1.0007 | 0.9926 |
C10 hydrocarbon | 0.9974 | 1.0037 | 0.9990 |
C11 hydrocarbon | 0.9998 | 1.0004 | 0.9999 |
C12 hydrocarbon | 1.0066 | 0.9940 | 0.9994 |
C13 hydrocarbon | 1.0023 | 0.9955 | 1.0022 |
C14 Hydrocarbon | 0.9952 | 0.9964 | 1.0067 |
C15 hydrocarbon | 0.9983 | 0.9992 | 1.0026 |
C16 Hydrocarbon | 0.9899 | 1.0159 | 1.0022 |
C17 hydrocarbon | 1.0064 | 0.9968 | 0.9968 |
C19 hydrocarbon | 1.0026 | 0.9894 | NA |
C20 Hydrocarbon | 0.9938 | 0.9979 | 1.0028 |
C21 Hydrocarbon | 1.0002 | 0.9923 | 1.0074 |
C22 hydrocarbon | 1.0040 | 0.9876 | 1.0294 |
C23 Hydrocarbon | 1.0397 | 0.9928 | 0.9638 |
C25 hydrocarbon | 0.9815 | 1.0074 | NA |
Campesterol | 1.0027 | 1.0002 | 0.9972 |
Carnitine | 1.0194 | 0.9942 | 0.9912 |
Cholesterol | 1.0028 | 1.0005 | 0.9967 |
Cholic acid or similar bile acid | 1.1362 | 0.8499 | 0.8777 |
Cytindine-5^-monophosphate | 1.0000 | NA | NA |
Decanoic acid | 0.9975 | 0.9837 | 1.0192 |
Dehydroalanine (possibly from cysteine) | 1.0005 | 1.0049 | 0.9946 |
Dehydroascorbic acid (possibly alpha-ketoglutarate) | 1.0029 | 0.9972 | 0.9998 |
deuterated Myristic Acid (RTL std) | 1.0017 | 0.9988 | 0.9995 |
Diethanolamine | 1.0093 | 0.9849 | 1.0101 |
Dihydroxyacetone phosphate | NA | 1.0685 | 0.9658 |
Disaccharide | 1.0128 | 0.9951 | 0.9921 |
Docosahexaenoic acid | 0.9954 | 0.9968 | 1.0074 |
Erythritol/Theitol | 0.9931 | 1.0036 | 1.0019 |
Erythronic acid | 1.0048 | 0.9949 | 1.0008 |
Ethanolamine | 0.9974 | 1.0064 | 0.9959 |
Flavonoid or short-chain cholesterol ester | 0.9245 | NA | 1.0189 |
Fructose or similar ketohexose | 1.0183 | 1.0085 | 0.9702 |
Fucosterol | 1.0054 | 1.0183 | 0.9710 |
Fumaric acid | 0.9940 | 0.9994 | 1.0066 |
gamma-Aminobutyric acid | 0.9714 | 0.9566 | 1.0720 |
gamma-Hydroxybutyric acid | 1.0071 | 1.0103 | 0.9479 |
gamma-Tocopherol | 1.0036 | 0.9976 | 0.9982 |
Gluconic acid or similar sugar acid | 0.9990 | 0.9968 | 1.0043 |
Glucose-6-phosphate or similar | 1.0212 | 0.9757 | 1.0004 |
Glucose and other aldohexoses | 0.9996 | 1.0012 | 0.9992 |
Glutamic acid | 1.0044 | 1.0030 | 0.9926 |
Glutamine | 0.9994 | 0.9972 | 1.0034 |
Glutathione (reduced) | 1.0092 | 1.0013 | 0.9789 |
Glyceric acid | 0.9985 | 0.9991 | 1.0025 |
Glycerol | 0.9709 | 1.0030 | 1.0246 |
Glycerol 1-phosphate | 1.0030 | 0.9930 | 1.0040 |
Glycine | 1.0001 | 0.9997 | 1.0002 |
Glyoxylic acid | 1.0032 | 0.9896 | 1.0049 |
Heptadecanoic acid/Octadecanol | 0.9990 | 0.9944 | 1.0066 |
Hexanoic acid (and/or Glycolic acid) | 1.0312 | 0.9728 | 0.9916 |
Hexitols | 0.9949 | 0.9964 | 1.0087 |
Hexosamine | 1.0022 | 1.0015 | 0.9963 |
Hexuronic acid | 1.0075 | 0.9822 | 1.0103 |
Homoserine | 1.0039 | 0.9911 | 1.0050 |
Hypotaurine | 0.9721 | 1.0101 | 1.0189 |
Hypoxanthine | 0.9914 | 1.0079 | 1.0006 |
Inosine/Adenosine | 0.9813 | 1.0188 | 0.9999 |
Isoleucine/Leucine | 1.0101 | 0.9941 | 0.9958 |
Ketopentose-5-phosphate | 1.0197 | 1.0061 | 0.9767 |
Lactic acid | 1.0007 | 0.9989 | 1.0004 |
Lauric acid | 1.0111 | 1.0047 | 0.9847 |
Linoleic acid | 1.0048 | 0.9976 | 0.9976 |
Lysine | 1.0029 | 0.9902 | 1.0068 |
Maleic acid | 0.9955 | 1.0093 | 0.9969 |
Malic acid | 0.9979 | 1.0007 | 1.0014 |
Melezitose | 1.0281 | 1.0006 | 0.9742 |
Methionine | 1.0129 | 0.9922 | 0.9949 |
MSTFA artifact | 1.0009 | 0.9992 | 0.9999 |
Myoinositol | 1.0038 | 1.0020 | 0.9942 |
Myoinositol-2-phosphate | 0.9894 | NA | 1.0071 |
Myristic acid or Pentadecanol | 0.9985 | 0.9952 | 1.0063 |
N-Acetylglutamic acid | 0.9908 | 0.9901 | 1.0163 |
Nicotinamide | 1.0008 | 0.9972 | 1.0013 |
Nicotinic acid | 0.9950 | 0.9852 | 1.0198 |
N-Methylalanine/2-Aminobutanoic acid/N-Ethylglycine | 1.0096 | 0.9871 | 1.0033 |
Nonanoic acid | 1.0072 | 0.9921 | 1.0007 |
Oleic acid | 0.9932 | 1.0107 | 0.9961 |
O-Methylphosphate | 1.0060 | 0.9997 | 0.9943 |
O-Phosphocolamine | 0.9812 | 1.0032 | 1.0156 |
Ornithine | 1.0001 | 0.9932 | 1.0066 |
Palmitic acid | 1.0007 | 0.9986 | 1.0007 |
Palmitoleic acid | 1.0092 | 0.9841 | 1.0098 |
Pantothenic acid | 0.9785 | 1.0126 | 1.0063 |
Pentitols | 1.0022 | 1.0001 | 0.9977 |
Pentonic acids | 1.0354 | 0.9820 | 0.9843 |
Phenylalanine | 1.0096 | 0.9933 | 0.9970 |
Phosphoric acid | 1.0019 | 0.9994 | 0.9988 |
p-Hydroxyphenyllactic acid | NA | 0.9734 | 1.0266 |
possibly Malonic acid | 0.9949 | 0.9970 | 1.0065 |
Proline | 1.0125 | 0.9885 | 0.9977 |
Prunetin or similar isoflavone | 1.0012 | 0.9952 | 1.0041 |
Pseudouridine | 0.9928 | 1.0179 | 0.9952 |
Putrescine | 0.9963 | 1.0068 | 0.9969 |
Pyridine-2,6-dicarboxylic acid | 0.9686 | 0.9814 | 1.0454 |
Pyrophosphate | 1.0696 | 0.8805 | 1.0166 |
Pyrrole -2-carboxylic acid | 1.0123 | 1.0028 | 0.9814 |
Pyruvic acid | 1.0052 | 0.9941 | 1.0007 |
Serine | 1.0008 | 1.0036 | 0.9956 |
Serotonin | 1.0076 | 1.0262 | 0.9747 |
Siloxanes_R1 | 0.9803 | 1.0001 | 1.0343 |
Siloxanes_R10 | NA | 0.9969 | 1.0020 |
Siloxanes_R11 | 1.0721 | 0.9931 | 0.9854 |
Siloxanes_R12 | 1.0412 | NA | 0.9863 |
Siloxanes_R2 | 0.9790 | 1.0010 | 1.0200 |
Siloxanes_R3 | 0.9982 | 1.0067 | 0.9952 |
Siloxanes_R4 | 0.9896 | 1.0013 | 1.0117 |
Siloxanes_R5 | 1.0001 | 0.9921 | 1.0078 |
Siloxanes_R6 | 1.0084 | 0.9893 | 1.0031 |
Siloxanes_R7 | 0.9793 | 1.0050 | 1.0142 |
Siloxanes_R8 | 0.9677 | 1.0149 | 1.0116 |
Siloxanes_R9 | 1.0118 | 0.9672 | 0.9973 |
Spermidine | 1.0055 | 0.9939 | 1.0006 |
Spermine | 1.0268 | 1.0215 | 0.9577 |
Sphingosine | 1.0066 | 0.9919 | 0.9976 |
Squalene | 1.0050 | 0.9956 | 0.9994 |
Stearamide | 0.9946 | 0.9914 | 1.0159 |
Stearic acid | 0.9988 | 0.9971 | 1.0041 |
Succinic acid | 0.9999 | 1.0005 | 0.9996 |
Sucrose and similar disaccharides | 1.0264 | 0.9972 | 0.9764 |
Taurine | 0.9572 | 1.0468 | 1.0044 |
Tetradecanedioic acid | 1.0460 | 1.0186 | 0.9384 |
Threonic acid | 1.0036 | 0.9945 | 1.0013 |
Threonic acid/erythronic acid | 1.0095 | 0.9801 | 1.0121 |
Threonine | 1.0025 | 1.0034 | 0.9941 |
Tris | 1.0579 | 0.9397 | 1.0024 |
Trisaccharide | 1.0525 | 1.0026 | 0.9587 |
Tyrosine | 0.9971 | 0.9964 | 1.0065 |
Unknown-possibly propylene glycol | 1.0016 | 1.0066 | 0.9918 |
Uracil | 0.9925 | 1.0076 | 0.9999 |
Urea | 0.9996 | 0.9991 | 1.0013 |
Uric acid | 1.0009 | 0.9858 | 1.0133 |
Uridine | 0.9959 | 0.9975 | 1.0067 |
Uridine 5^-monophosphate | 0.9960 | 0.9999 | 1.0040 |
Valine | 1.0088 | 0.9924 | 0.9988 |
Xanthine | 1.0342 | 0.9826 | 0.9490 |
Factors:
F1 | Treatment:40mg/kg Sun |
F2 | Treatment:50mg/kg Erl |
F3 | Treatment:PBS Ctl |