Data for Analysis of the effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Liver Metabolism In Vivo (Study ST000894)

(Analysis AN001456)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3
1,4:3,6-Dianhydroglucitol 0.9956 1.0015 NA
1,5-Anhydroglucitol 1.0054 0.9966 0.9980
1-Dodecanol 0.9980 0.9860 1.0441
1-Eicosanol/Nonadecanoic acid 0.9914 1.0022 1.0064
2-Aminoadipic acid 1.0036 0.9999 0.9965
2-Aminoethanethiol/Glycylphenylalanine 0.9566 1.0093 1.0291
2-Deoxyglucose-6-phosphate 1.0124 0.9861 1.0016
2-Hydroxybutyric acid 0.9972 1.0025 1.0003
2-Hydroxyglutaric acid 1.0082 0.9976 0.9952
2-Hydroxypyridine 1.0025 1.0014 0.9962
3-Aminoisobutyric acid/beta-Alanine 1.0019 0.9977 1.0005
3-Phosphoglyceric acid 0.9902 0.9991 1.0029
5-alpha-Coprostanol or similar oxysterol 1.0045 0.9972 0.9981
5^-Deoxy-5^-(methylthio) adenosine 1.0073 0.9947 0.9971
5-Hydroxylysine 0.9796 1.0063 1.0108
6-Hydroxynicotinic acid 0.9985 0.9853 1.0162
6-Methyluracil/Thymine 1.0298 0.9687 0.9944
Acetoacetate/2-Aminoisobutanoic acid 1.0013 0.9938 1.0049
Adenine 0.9947 0.9859 1.0220
Adenosine-5-monophosphate 1.0198 0.9986 0.9832
Adenosine/Inosine 1.0013 1.0003 0.9983
Alanine 1.0076 0.9958 0.9966
Aldopentoses 1.0124 0.9904 0.9971
Allantoin 1.0441 1.0216 0.9451
alpha-Monopalmitin 1.0012 0.9991 0.9997
alpha-Monostearin 1.0001 0.9985 1.0014
alpha-Tocopherol 0.9989 1.0013 0.9999
Aminomalonic acid 1.0049 0.9910 1.0041
Arachidic acid/ 1-Heneicosanol 0.9785 1.0131 1.0101
Arachidonic acid (also Eicosapentaenoic acid) 1.0062 0.9811 1.0115
Asparagine 1.0123 0.9796 1.0005
Aspartic acid 1.0050 0.9992 0.9958
Benzoic acid 1.0130 0.9943 0.9940
beta-Hydroxybutyric acid 0.9977 0.9981 1.0042
beta-Monopalmitin 1.0005 0.9998 0.9997
beta-Monostearin 1.0028 0.9981 0.9991
beta-Sitosterol 1.0067 1.0007 0.9926
C10 hydrocarbon 0.9974 1.0037 0.9990
C11 hydrocarbon 0.9998 1.0004 0.9999
C12 hydrocarbon 1.0066 0.9940 0.9994
C13 hydrocarbon 1.0023 0.9955 1.0022
C14 Hydrocarbon 0.9952 0.9964 1.0067
C15 hydrocarbon 0.9983 0.9992 1.0026
C16 Hydrocarbon 0.9899 1.0159 1.0022
C17 hydrocarbon 1.0064 0.9968 0.9968
C19 hydrocarbon 1.0026 0.9894 NA
C20 Hydrocarbon 0.9938 0.9979 1.0028
C21 Hydrocarbon 1.0002 0.9923 1.0074
C22 hydrocarbon 1.0040 0.9876 1.0294
C23 Hydrocarbon 1.0397 0.9928 0.9638
C25 hydrocarbon 0.9815 1.0074 NA
Campesterol 1.0027 1.0002 0.9972
Carnitine 1.0194 0.9942 0.9912
Cholesterol 1.0028 1.0005 0.9967
Cholic acid or similar bile acid 1.1362 0.8499 0.8777
Cytindine-5^-monophosphate 1.0000 NA NA
Decanoic acid 0.9975 0.9837 1.0192
Dehydroalanine (possibly from cysteine) 1.0005 1.0049 0.9946
Dehydroascorbic acid (possibly alpha-ketoglutarate) 1.0029 0.9972 0.9998
deuterated Myristic Acid (RTL std) 1.0017 0.9988 0.9995
Diethanolamine 1.0093 0.9849 1.0101
Dihydroxyacetone phosphate NA 1.0685 0.9658
Disaccharide 1.0128 0.9951 0.9921
Docosahexaenoic acid 0.9954 0.9968 1.0074
Erythritol/Theitol 0.9931 1.0036 1.0019
Erythronic acid 1.0048 0.9949 1.0008
Ethanolamine 0.9974 1.0064 0.9959
Flavonoid or short-chain cholesterol ester 0.9245 NA 1.0189
Fructose or similar ketohexose 1.0183 1.0085 0.9702
Fucosterol 1.0054 1.0183 0.9710
Fumaric acid 0.9940 0.9994 1.0066
gamma-Aminobutyric acid 0.9714 0.9566 1.0720
gamma-Hydroxybutyric acid 1.0071 1.0103 0.9479
gamma-Tocopherol 1.0036 0.9976 0.9982
Gluconic acid or similar sugar acid 0.9990 0.9968 1.0043
Glucose-6-phosphate or similar 1.0212 0.9757 1.0004
Glucose and other aldohexoses 0.9996 1.0012 0.9992
Glutamic acid 1.0044 1.0030 0.9926
Glutamine 0.9994 0.9972 1.0034
Glutathione (reduced) 1.0092 1.0013 0.9789
Glyceric acid 0.9985 0.9991 1.0025
Glycerol 0.9709 1.0030 1.0246
Glycerol 1-phosphate 1.0030 0.9930 1.0040
Glycine 1.0001 0.9997 1.0002
Glyoxylic acid 1.0032 0.9896 1.0049
Heptadecanoic acid/Octadecanol 0.9990 0.9944 1.0066
Hexanoic acid (and/or Glycolic acid) 1.0312 0.9728 0.9916
Hexitols 0.9949 0.9964 1.0087
Hexosamine 1.0022 1.0015 0.9963
Hexuronic acid 1.0075 0.9822 1.0103
Homoserine 1.0039 0.9911 1.0050
Hypotaurine 0.9721 1.0101 1.0189
Hypoxanthine 0.9914 1.0079 1.0006
Inosine/Adenosine 0.9813 1.0188 0.9999
Isoleucine/Leucine 1.0101 0.9941 0.9958
Ketopentose-5-phosphate 1.0197 1.0061 0.9767
Lactic acid 1.0007 0.9989 1.0004
Lauric acid 1.0111 1.0047 0.9847
Linoleic acid 1.0048 0.9976 0.9976
Lysine 1.0029 0.9902 1.0068
Maleic acid 0.9955 1.0093 0.9969
Malic acid 0.9979 1.0007 1.0014
Melezitose 1.0281 1.0006 0.9742
Methionine 1.0129 0.9922 0.9949
MSTFA artifact 1.0009 0.9992 0.9999
Myoinositol 1.0038 1.0020 0.9942
Myoinositol-2-phosphate 0.9894 NA 1.0071
Myristic acid or Pentadecanol 0.9985 0.9952 1.0063
N-Acetylglutamic acid 0.9908 0.9901 1.0163
Nicotinamide 1.0008 0.9972 1.0013
Nicotinic acid 0.9950 0.9852 1.0198
N-Methylalanine/2-Aminobutanoic acid/N-Ethylglycine 1.0096 0.9871 1.0033
Nonanoic acid 1.0072 0.9921 1.0007
Oleic acid 0.9932 1.0107 0.9961
O-Methylphosphate 1.0060 0.9997 0.9943
O-Phosphocolamine 0.9812 1.0032 1.0156
Ornithine 1.0001 0.9932 1.0066
Palmitic acid 1.0007 0.9986 1.0007
Palmitoleic acid 1.0092 0.9841 1.0098
Pantothenic acid 0.9785 1.0126 1.0063
Pentitols 1.0022 1.0001 0.9977
Pentonic acids 1.0354 0.9820 0.9843
Phenylalanine 1.0096 0.9933 0.9970
Phosphoric acid 1.0019 0.9994 0.9988
p-Hydroxyphenyllactic acid NA 0.9734 1.0266
possibly Malonic acid 0.9949 0.9970 1.0065
Proline 1.0125 0.9885 0.9977
Prunetin or similar isoflavone 1.0012 0.9952 1.0041
Pseudouridine 0.9928 1.0179 0.9952
Putrescine 0.9963 1.0068 0.9969
Pyridine-2,6-dicarboxylic acid 0.9686 0.9814 1.0454
Pyrophosphate 1.0696 0.8805 1.0166
Pyrrole -2-carboxylic acid 1.0123 1.0028 0.9814
Pyruvic acid 1.0052 0.9941 1.0007
Serine 1.0008 1.0036 0.9956
Serotonin 1.0076 1.0262 0.9747
Siloxanes_R1 0.9803 1.0001 1.0343
Siloxanes_R10 NA 0.9969 1.0020
Siloxanes_R11 1.0721 0.9931 0.9854
Siloxanes_R12 1.0412 NA 0.9863
Siloxanes_R2 0.9790 1.0010 1.0200
Siloxanes_R3 0.9982 1.0067 0.9952
Siloxanes_R4 0.9896 1.0013 1.0117
Siloxanes_R5 1.0001 0.9921 1.0078
Siloxanes_R6 1.0084 0.9893 1.0031
Siloxanes_R7 0.9793 1.0050 1.0142
Siloxanes_R8 0.9677 1.0149 1.0116
Siloxanes_R9 1.0118 0.9672 0.9973
Spermidine 1.0055 0.9939 1.0006
Spermine 1.0268 1.0215 0.9577
Sphingosine 1.0066 0.9919 0.9976
Squalene 1.0050 0.9956 0.9994
Stearamide 0.9946 0.9914 1.0159
Stearic acid 0.9988 0.9971 1.0041
Succinic acid 0.9999 1.0005 0.9996
Sucrose and similar disaccharides 1.0264 0.9972 0.9764
Taurine 0.9572 1.0468 1.0044
Tetradecanedioic acid 1.0460 1.0186 0.9384
Threonic acid 1.0036 0.9945 1.0013
Threonic acid/erythronic acid 1.0095 0.9801 1.0121
Threonine 1.0025 1.0034 0.9941
Tris 1.0579 0.9397 1.0024
Trisaccharide 1.0525 1.0026 0.9587
Tyrosine 0.9971 0.9964 1.0065
Unknown-possibly propylene glycol 1.0016 1.0066 0.9918
Uracil 0.9925 1.0076 0.9999
Urea 0.9996 0.9991 1.0013
Uric acid 1.0009 0.9858 1.0133
Uridine 0.9959 0.9975 1.0067
Uridine 5^-monophosphate 0.9960 0.9999 1.0040
Valine 1.0088 0.9924 0.9988
Xanthine 1.0342 0.9826 0.9490
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Factors:

F1Treatment:40mg/kg Sun
F2Treatment:50mg/kg Erl
F3Treatment:PBS Ctl
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