Data for Analysis of the effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Muscle Metabolism In Vivo (Study ST000896)

(Analysis AN001458)

Values for each metabolite have been scaled by dividing by the mean across all factors

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

MetaboliteF1F2F3
1,5-Anhydroglucitol 0.9945 0.9987 1.0068
2-Aminoadipic acid 1.0040 1.0101 0.9858
2-Hydroxypyridine 0.9918 1.0036 1.0045
3-Aminoisobutyric acid/beta-Alanine 0.9932 1.0002 1.0066
3-Phosphoglyceric acid 0.9974 0.9989 1.0038
5^-Deoxy-5^-(methylthio) adenosine 0.9485 1.0092 1.0151
6-Hydroxynicotinic acid 0.9545 1.0078 1.0258
Acetoacetate/2-Aminoisobutanoic acid 0.9948 0.9771 1.0170
Adenine 0.9961 1.0090 0.9945
Adenosine-5-monophosphate 0.9614 1.0159 1.0239
Adenosine/Inosine 0.9709 1.0127 1.0165
Alanine 0.9970 0.9981 1.0054
Aldopentoses 0.9962 1.0038 NA
alpha Ketoglutaric acid 0.8629 0.9336 1.1018
alpha-Monopalmitin 0.9974 1.0032 0.9994
alpha-Monostearin 0.9982 1.0009 1.0009
alpha-Tocopherol 1.0120 0.9738 1.0328
Aminomalonic acid 0.9912 0.9950 1.0161
Arachidic acid/ 1-Heneicosanol 1.0027 0.9993 0.9977
Arachidonic acid (also Eicosapentaenoic acid) 0.9758 1.0084 1.0158
Ascorbic acid/Isoascorbic acid 0.9550 0.9806 1.0644
Asparagine 1.0311 0.9880 0.9625
Aspartic acid 1.0007 0.9888 1.0105
Benzoic acid 0.9971 1.0002 1.0027
beta-Hydroxybutyric acid 0.9919 1.0006 1.0075
beta-Monopalmitin 0.9937 1.0004 1.0058
beta-Monostearin 0.9979 1.0038 0.9982
beta-Sitosterol 0.9997 1.0009 0.9994
C10 hydrocarbon 1.0074 1.0138 0.9772
C11 hydrocarbon 1.0160 1.0152 0.9610
C12 hydrocarbon 1.0026 0.9915 1.0066
C13 hydrocarbon 0.9984 0.9997 1.0021
C14 Hydrocarbon 1.0011 1.0056 0.9925
C15 hydrocarbon 1.0061 0.9999 0.9940
C16 Hydrocarbon 0.9928 1.0045 1.0066
C17 hydrocarbon 1.0008 0.9953 1.0038
C18 Hydrocarbon 1.0081 0.9919 NA
C19 hydrocarbon 0.9970 1.0037 0.9993
C20 Hydrocarbon 1.0113 0.9974 0.9980
C21 Hydrocarbon 0.9979 1.0018 1.0003
C22 hydrocarbon 1.0085 0.9981 0.9939
C23 Hydrocarbon 0.9957 0.9951 1.0081
C24 Hydrocarbon 1.0009 1.0028 0.9980
C25 hydrocarbon 1.0021 0.9969 1.0019
Campesterol 0.9930 1.0043 1.0027
Carnitine 1.0000 NA NA
Carnosine 1.0059 1.0384 0.9506
Cholesterol 0.9962 1.0014 1.0024
Citric acid/isocitric acid 0.9965 1.0098 0.9937
Creatinine 0.9998 1.0078 0.9924
Decanoic acid 0.9752 1.0226 1.0044
Dehydroalanine (possibly from cysteine) 0.9973 0.9768 1.0231
Dehydroascorbic acid (possibly alpha-ketoglutarate) 0.9947 1.0121 0.9932
deuterated Myristic Acid (RTL std) 0.9988 1.0014 0.9998
Dihydroxyacetone phosphate 0.9727 1.0160 1.0113
Disaccharide 0.9878 1.0194 0.9928
Docosahexaenoic acid 0.9758 1.0057 1.0185
Docosanoic acid 0.9871 0.9574 1.0907
Erythritol/Theitol 0.9928 0.9908 1.0164
Ethanolamine 0.9653 1.0042 1.0458
Fructose-6-phosphate 0.9926 1.0102 0.9972
Fructose or similar ketohexose 0.9945 1.0074 0.9976
Fumaric acid 0.9943 0.9991 1.0066
gamma-Hydroxybutyric acid 1.0165 1.0132 0.9736
gamma-Tocopherol 0.9817 1.0050 1.0120
Glucose-6-phosphate or similar 0.9933 1.0113 0.9953
Glucose and other aldohexoses 0.9907 1.0043 1.0050
Glutamic acid 1.0011 0.9990 0.9998
Glutamine 0.9879 1.0053 1.0084
Glutathione (reduced) 1.0031 0.9968 0.9992
Glycerol 0.9955 0.9880 1.0155
Glycerol 1-phosphate 0.9893 1.0075 1.0032
Glycine 0.9951 0.9989 1.0060
Glyoxylic acid 0.9287 1.0957 1.0236
Gly-Pro 0.9675 NA 1.0162
Heptadecanoic acid/Octadecanol 1.0005 1.0041 0.9953
Hexanoic acid (and/or Glycolic acid) 1.0233 0.9967 0.9933
Hexitols 1.0090 0.9918 0.9993
Homoserine 1.0005 1.0000 0.9995
Hydroxyprolines 1.0017 1.0090 0.9876
Hypotaurine 0.9928 0.9850 1.0180
Hypoxanthine 0.9919 1.0586 0.9913
Inosine 5^-monophosphate 1.0303 1.0111 0.9793
Inosine/Adenosine 0.9690 1.0297 0.9962
Isoleucine/Leucine 0.9919 1.0072 1.0009
Lactic acid 0.9893 1.0064 1.0043
Lauric acid 0.9750 1.0125 NA
Linoleic acid 0.9889 1.0088 1.0012
Lysine 0.9924 1.0131 0.9945
Malic acid 0.9958 1.0010 1.0032
Malonic acid 0.9996 0.9772 1.0309
Methionine 0.9729 1.0173 1.0067
Methionine sulfoxide 0.9880 1.0131 1.0004
MSTFA artifact 0.9860 1.0016 1.0139
Myoinositol 0.9923 1.0082 0.9995
Myoinositol-2-phosphate 0.9968 1.0135 0.9897
Myristic acid or Pentadecanol 1.0013 1.0039 0.9948
N-Methylalanine/2-Aminobutanoic acid/N-Ethylglycine 1.0001 1.0007 0.9992
Nonadecanoic acid 0.9916 0.9994 1.0151
Nonanoic acid 0.9995 0.9898 1.0147
Oleic acid 1.0095 0.9987 0.9918
O-Methylphosphate 0.9964 1.0149 0.9887
O-Phosphocolamine 0.9795 1.0125 1.0081
Palmitic acid 0.9990 1.0035 0.9975
Palmitoleic acid 0.9681 1.0370 0.9954
Pantothenic acid 0.9981 1.0063 0.9956
Pentadecanoic acid/Hexadecanol 0.9958 1.0076 0.9970
Pentitols 0.9802 1.0234 0.9938
Phenol 0.9588 1.0144 1.0536
Phenylalanine 1.0004 1.0063 0.9933
Phosphoenolpyruvic acid 0.9987 0.9957 1.0032
Phosphoric acid 0.9965 1.0019 1.0016
Proline 0.9725 0.9828 1.0539
Prunetin or similar isoflavone 0.9873 1.0115 1.0013
Pseudouridine 1.0009 0.9745 1.0242
Pyrophosphate 0.9819 1.0221 0.9956
Pyrrole -2-carboxylic acid 0.9815 1.0044 1.0152
Pyruvic acid 0.9819 1.0240 0.9962
Serine 0.9903 1.0132 0.9965
Siloxanes_R1 0.9960 0.9923 1.0117
Siloxanes_R10 0.9261 0.9969 1.0385
Siloxanes_R11 1.0112 1.0630 0.9629
Siloxanes_R2 0.9831 0.9836 1.0333
Siloxanes_R3 0.9906 1.0006 1.0099
Siloxanes_R4 0.9890 0.9973 1.0137
Siloxanes_R5 0.9450 0.9843 1.0655
Siloxanes_R6 0.9880 1.0023 1.0096
Siloxanes_R7 0.9950 0.9917 1.0136
Siloxanes_R8 1.0178 1.0525 0.8946
Siloxanes_R9 0.9944 0.9853 1.0101
Spermidine 1.0341 0.9966 0.9586
Squalene 0.9878 1.0073 1.0049
Stearamide NA 1.1268 0.9577
Stearic acid 0.9999 1.0035 0.9966
Succinic acid 0.9940 1.0009 1.0051
Sucrose and similar disaccharides 0.9507 1.0067 1.0386
Taurine 1.0067 0.9804 1.0151
Tetradecanedioic acid 0.9733 1.0171 1.0163
Threonic acid/erythronic acid 1.0121 0.9910 0.9969
Threonine 0.9896 1.0070 1.0034
Tiglic acid 1.0095 0.9868 1.0124
Trisaccharide 0.9702 1.0204 0.9918
Tryptamine/Norepinephrine 1.0307 0.9750 1.0004
Tyrosine 0.9909 1.0130 0.9961
Unknown-possibly propylene glycol 1.0000 1.0051 0.9949
Uracil 1.0111 0.9862 0.9916
Urea 0.9991 1.0067 0.9942
Uric acid 1.0076 0.9924 1.0000
Uridine 0.9934 0.9986 1.0081
Valine 1.0058 1.0112 0.9830
Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1Treatment:40mg/kg Sun
F2Treatment:50mg/kg Erl
F3Treatment:PBS Ctl
  logo