Data for Analysis of the effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Muscle Metabolism In Vivo (Study ST000896)
(Analysis AN001458)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 |
---|---|---|---|
1,5-Anhydroglucitol | 0.9945 | 0.9987 | 1.0068 |
2-Aminoadipic acid | 1.0040 | 1.0101 | 0.9858 |
2-Hydroxypyridine | 0.9918 | 1.0036 | 1.0045 |
3-Aminoisobutyric acid/beta-Alanine | 0.9932 | 1.0002 | 1.0066 |
3-Phosphoglyceric acid | 0.9974 | 0.9989 | 1.0038 |
5^-Deoxy-5^-(methylthio) adenosine | 0.9485 | 1.0092 | 1.0151 |
6-Hydroxynicotinic acid | 0.9545 | 1.0078 | 1.0258 |
Acetoacetate/2-Aminoisobutanoic acid | 0.9948 | 0.9771 | 1.0170 |
Adenine | 0.9961 | 1.0090 | 0.9945 |
Adenosine-5-monophosphate | 0.9614 | 1.0159 | 1.0239 |
Adenosine/Inosine | 0.9709 | 1.0127 | 1.0165 |
Alanine | 0.9970 | 0.9981 | 1.0054 |
Aldopentoses | 0.9962 | 1.0038 | NA |
alpha Ketoglutaric acid | 0.8629 | 0.9336 | 1.1018 |
alpha-Monopalmitin | 0.9974 | 1.0032 | 0.9994 |
alpha-Monostearin | 0.9982 | 1.0009 | 1.0009 |
alpha-Tocopherol | 1.0120 | 0.9738 | 1.0328 |
Aminomalonic acid | 0.9912 | 0.9950 | 1.0161 |
Arachidic acid/ 1-Heneicosanol | 1.0027 | 0.9993 | 0.9977 |
Arachidonic acid (also Eicosapentaenoic acid) | 0.9758 | 1.0084 | 1.0158 |
Ascorbic acid/Isoascorbic acid | 0.9550 | 0.9806 | 1.0644 |
Asparagine | 1.0311 | 0.9880 | 0.9625 |
Aspartic acid | 1.0007 | 0.9888 | 1.0105 |
Benzoic acid | 0.9971 | 1.0002 | 1.0027 |
beta-Hydroxybutyric acid | 0.9919 | 1.0006 | 1.0075 |
beta-Monopalmitin | 0.9937 | 1.0004 | 1.0058 |
beta-Monostearin | 0.9979 | 1.0038 | 0.9982 |
beta-Sitosterol | 0.9997 | 1.0009 | 0.9994 |
C10 hydrocarbon | 1.0074 | 1.0138 | 0.9772 |
C11 hydrocarbon | 1.0160 | 1.0152 | 0.9610 |
C12 hydrocarbon | 1.0026 | 0.9915 | 1.0066 |
C13 hydrocarbon | 0.9984 | 0.9997 | 1.0021 |
C14 Hydrocarbon | 1.0011 | 1.0056 | 0.9925 |
C15 hydrocarbon | 1.0061 | 0.9999 | 0.9940 |
C16 Hydrocarbon | 0.9928 | 1.0045 | 1.0066 |
C17 hydrocarbon | 1.0008 | 0.9953 | 1.0038 |
C18 Hydrocarbon | 1.0081 | 0.9919 | NA |
C19 hydrocarbon | 0.9970 | 1.0037 | 0.9993 |
C20 Hydrocarbon | 1.0113 | 0.9974 | 0.9980 |
C21 Hydrocarbon | 0.9979 | 1.0018 | 1.0003 |
C22 hydrocarbon | 1.0085 | 0.9981 | 0.9939 |
C23 Hydrocarbon | 0.9957 | 0.9951 | 1.0081 |
C24 Hydrocarbon | 1.0009 | 1.0028 | 0.9980 |
C25 hydrocarbon | 1.0021 | 0.9969 | 1.0019 |
Campesterol | 0.9930 | 1.0043 | 1.0027 |
Carnitine | 1.0000 | NA | NA |
Carnosine | 1.0059 | 1.0384 | 0.9506 |
Cholesterol | 0.9962 | 1.0014 | 1.0024 |
Citric acid/isocitric acid | 0.9965 | 1.0098 | 0.9937 |
Creatinine | 0.9998 | 1.0078 | 0.9924 |
Decanoic acid | 0.9752 | 1.0226 | 1.0044 |
Dehydroalanine (possibly from cysteine) | 0.9973 | 0.9768 | 1.0231 |
Dehydroascorbic acid (possibly alpha-ketoglutarate) | 0.9947 | 1.0121 | 0.9932 |
deuterated Myristic Acid (RTL std) | 0.9988 | 1.0014 | 0.9998 |
Dihydroxyacetone phosphate | 0.9727 | 1.0160 | 1.0113 |
Disaccharide | 0.9878 | 1.0194 | 0.9928 |
Docosahexaenoic acid | 0.9758 | 1.0057 | 1.0185 |
Docosanoic acid | 0.9871 | 0.9574 | 1.0907 |
Erythritol/Theitol | 0.9928 | 0.9908 | 1.0164 |
Ethanolamine | 0.9653 | 1.0042 | 1.0458 |
Fructose-6-phosphate | 0.9926 | 1.0102 | 0.9972 |
Fructose or similar ketohexose | 0.9945 | 1.0074 | 0.9976 |
Fumaric acid | 0.9943 | 0.9991 | 1.0066 |
gamma-Hydroxybutyric acid | 1.0165 | 1.0132 | 0.9736 |
gamma-Tocopherol | 0.9817 | 1.0050 | 1.0120 |
Glucose-6-phosphate or similar | 0.9933 | 1.0113 | 0.9953 |
Glucose and other aldohexoses | 0.9907 | 1.0043 | 1.0050 |
Glutamic acid | 1.0011 | 0.9990 | 0.9998 |
Glutamine | 0.9879 | 1.0053 | 1.0084 |
Glutathione (reduced) | 1.0031 | 0.9968 | 0.9992 |
Glycerol | 0.9955 | 0.9880 | 1.0155 |
Glycerol 1-phosphate | 0.9893 | 1.0075 | 1.0032 |
Glycine | 0.9951 | 0.9989 | 1.0060 |
Glyoxylic acid | 0.9287 | 1.0957 | 1.0236 |
Gly-Pro | 0.9675 | NA | 1.0162 |
Heptadecanoic acid/Octadecanol | 1.0005 | 1.0041 | 0.9953 |
Hexanoic acid (and/or Glycolic acid) | 1.0233 | 0.9967 | 0.9933 |
Hexitols | 1.0090 | 0.9918 | 0.9993 |
Homoserine | 1.0005 | 1.0000 | 0.9995 |
Hydroxyprolines | 1.0017 | 1.0090 | 0.9876 |
Hypotaurine | 0.9928 | 0.9850 | 1.0180 |
Hypoxanthine | 0.9919 | 1.0586 | 0.9913 |
Inosine 5^-monophosphate | 1.0303 | 1.0111 | 0.9793 |
Inosine/Adenosine | 0.9690 | 1.0297 | 0.9962 |
Isoleucine/Leucine | 0.9919 | 1.0072 | 1.0009 |
Lactic acid | 0.9893 | 1.0064 | 1.0043 |
Lauric acid | 0.9750 | 1.0125 | NA |
Linoleic acid | 0.9889 | 1.0088 | 1.0012 |
Lysine | 0.9924 | 1.0131 | 0.9945 |
Malic acid | 0.9958 | 1.0010 | 1.0032 |
Malonic acid | 0.9996 | 0.9772 | 1.0309 |
Methionine | 0.9729 | 1.0173 | 1.0067 |
Methionine sulfoxide | 0.9880 | 1.0131 | 1.0004 |
MSTFA artifact | 0.9860 | 1.0016 | 1.0139 |
Myoinositol | 0.9923 | 1.0082 | 0.9995 |
Myoinositol-2-phosphate | 0.9968 | 1.0135 | 0.9897 |
Myristic acid or Pentadecanol | 1.0013 | 1.0039 | 0.9948 |
N-Methylalanine/2-Aminobutanoic acid/N-Ethylglycine | 1.0001 | 1.0007 | 0.9992 |
Nonadecanoic acid | 0.9916 | 0.9994 | 1.0151 |
Nonanoic acid | 0.9995 | 0.9898 | 1.0147 |
Oleic acid | 1.0095 | 0.9987 | 0.9918 |
O-Methylphosphate | 0.9964 | 1.0149 | 0.9887 |
O-Phosphocolamine | 0.9795 | 1.0125 | 1.0081 |
Palmitic acid | 0.9990 | 1.0035 | 0.9975 |
Palmitoleic acid | 0.9681 | 1.0370 | 0.9954 |
Pantothenic acid | 0.9981 | 1.0063 | 0.9956 |
Pentadecanoic acid/Hexadecanol | 0.9958 | 1.0076 | 0.9970 |
Pentitols | 0.9802 | 1.0234 | 0.9938 |
Phenol | 0.9588 | 1.0144 | 1.0536 |
Phenylalanine | 1.0004 | 1.0063 | 0.9933 |
Phosphoenolpyruvic acid | 0.9987 | 0.9957 | 1.0032 |
Phosphoric acid | 0.9965 | 1.0019 | 1.0016 |
Proline | 0.9725 | 0.9828 | 1.0539 |
Prunetin or similar isoflavone | 0.9873 | 1.0115 | 1.0013 |
Pseudouridine | 1.0009 | 0.9745 | 1.0242 |
Pyrophosphate | 0.9819 | 1.0221 | 0.9956 |
Pyrrole -2-carboxylic acid | 0.9815 | 1.0044 | 1.0152 |
Pyruvic acid | 0.9819 | 1.0240 | 0.9962 |
Serine | 0.9903 | 1.0132 | 0.9965 |
Siloxanes_R1 | 0.9960 | 0.9923 | 1.0117 |
Siloxanes_R10 | 0.9261 | 0.9969 | 1.0385 |
Siloxanes_R11 | 1.0112 | 1.0630 | 0.9629 |
Siloxanes_R2 | 0.9831 | 0.9836 | 1.0333 |
Siloxanes_R3 | 0.9906 | 1.0006 | 1.0099 |
Siloxanes_R4 | 0.9890 | 0.9973 | 1.0137 |
Siloxanes_R5 | 0.9450 | 0.9843 | 1.0655 |
Siloxanes_R6 | 0.9880 | 1.0023 | 1.0096 |
Siloxanes_R7 | 0.9950 | 0.9917 | 1.0136 |
Siloxanes_R8 | 1.0178 | 1.0525 | 0.8946 |
Siloxanes_R9 | 0.9944 | 0.9853 | 1.0101 |
Spermidine | 1.0341 | 0.9966 | 0.9586 |
Squalene | 0.9878 | 1.0073 | 1.0049 |
Stearamide | NA | 1.1268 | 0.9577 |
Stearic acid | 0.9999 | 1.0035 | 0.9966 |
Succinic acid | 0.9940 | 1.0009 | 1.0051 |
Sucrose and similar disaccharides | 0.9507 | 1.0067 | 1.0386 |
Taurine | 1.0067 | 0.9804 | 1.0151 |
Tetradecanedioic acid | 0.9733 | 1.0171 | 1.0163 |
Threonic acid/erythronic acid | 1.0121 | 0.9910 | 0.9969 |
Threonine | 0.9896 | 1.0070 | 1.0034 |
Tiglic acid | 1.0095 | 0.9868 | 1.0124 |
Trisaccharide | 0.9702 | 1.0204 | 0.9918 |
Tryptamine/Norepinephrine | 1.0307 | 0.9750 | 1.0004 |
Tyrosine | 0.9909 | 1.0130 | 0.9961 |
Unknown-possibly propylene glycol | 1.0000 | 1.0051 | 0.9949 |
Uracil | 1.0111 | 0.9862 | 0.9916 |
Urea | 0.9991 | 1.0067 | 0.9942 |
Uric acid | 1.0076 | 0.9924 | 1.0000 |
Uridine | 0.9934 | 0.9986 | 1.0081 |
Valine | 1.0058 | 1.0112 | 0.9830 |
Factors:
F1 | Treatment:40mg/kg Sun |
F2 | Treatment:50mg/kg Erl |
F3 | Treatment:PBS Ctl |