Data for Pharmacometabolomic analysis of rat hippocampus and plasma in response to chronic stress and albiflorin treament (Study ST000903)

(Analysis AN001470)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
1-Methyladenine 0.9074 0.8906 1.0777 1.1145
1-Methyladenosine 0.8777 0.9438 1.0643 1.1062
1-Methylhistidine 0.8312 1.1002 0.8338 1.2555
2-Arachidonylglycerol 1.5909 0.8764 0.8395 0.7133
3-Hydroxydodecanoylcarnitine 0.9437 1.1814 0.9124 0.9736
3-Hydroxyisovaleryl Carnitine 1.0636 0.9375 1.0059 0.9922
5,6-trans-25-Hydroxyvitamin D3 0.7990 1.0341 1.2901 0.8406
5-Hydroxyindoleacetic acid 0.7001 0.8556 0.8282 1.6376
5-Methyltetrahydrofolic acid 0.4417 1.1389 1.1724 1.2255
7-ketocholesterol 1.1875 1.1468 1.1849 0.4576
8-Hydroxy-deoxyguanosine 0.7254 1.3445 0.9377 1.0002
Acetylcholine 0.8737 0.9327 0.9741 1.2228
Adenine 1.0382 0.9988 1.0209 0.9396
Adenosine 1.0332 0.9941 1.1294 0.8272
Adenosine monophosphate 0.8981 0.6712 1.2207 1.1824
Alanine 0.8503 1.0894 0.8728 1.2035
Alpha-Tocopherol 0.9793 1.0469 1.0852 0.8778
Biotin 1.1613 0.9356 0.9270 0.9852
Butyrylcarnitine 0.8572 1.5048 0.8127 0.8486
Carnosine 1.0634 1.2543 0.7180 0.9996
Cer(d18:1/18:0) 1.1602 1.0199 0.8636 0.9732
Cer(d18:1/22:0) 0.9744 1.0314 0.9486 1.0521
Cer(d18:1/22:0 OH) 1.0412 1.0322 0.9912 0.9366
Cer(d18:1/23:0) 0.9489 0.9881 1.0115 1.0501
Cer(d18:1/24:0) 0.9629 1.0274 0.9936 1.0169
Cer(d18:1/24:1) 0.9959 0.9625 1.0559 0.9787
Cer(d18:1/24:2) 0.9463 0.9743 1.0110 1.0670
Cer(d18:1/25:0) 0.9736 0.9994 0.9717 1.0589
Cholesterol 1.2403 0.8838 1.0118 0.8626
Choline 0.9606 1.0965 0.9655 0.9818
CoQ9 1.0417 0.9617 1.2571 0.7072
CoQ9H2 1.0146 0.9708 1.1424 0.8543
Corticosterone 0.9627 0.8726 0.9075 1.2688
Cortisol 0.9453 1.1528 1.0007 0.9011
Creatine 0.9635 0.9995 0.9422 1.1020
Cysteamine 1.0061 1.0277 0.9835 0.9848
Cysteine 0.8848 0.9645 1.0867 1.0532
Cysteine-S-sulfate 1.4174 1.0350 0.5469 1.0574
Cytidine 0.7598 0.8003 1.1465 1.2751
Cytosine 0.9071 0.9529 1.0392 1.0959
Dihexosylcer(18:1/16:0) 0.7332 1.1619 1.0807 1.0141
Dihexosylcer(18:1/24:1) 0.7576 1.3859 0.8899 0.9802
Dimethylglycine 0.9217 0.9771 1.0815 1.0095
Dodecanoylcarnitine 1.2396 0.9287 0.9551 0.8822
Dodecenoylcarnitine 1.1093 0.9258 0.9377 1.0350
Dopamine 0.8960 1.1448 1.0252 0.9309
Epinephrine 1.0050 1.0328 0.9892 0.9744
Ethanolamine 0.9952 1.0133 0.9582 1.0385
Gamma-Aminobutyric acid 0.7274 1.2419 0.9188 1.1220
Glucosylceramide(18:1/16:0) 0.7353 1.1152 1.1097 1.0261
Glycerophosphocholine 1.1820 0.9646 1.0053 0.8475
Glycine 0.9261 1.0153 1.0169 1.0396
Histamine 0.9170 0.9402 1.0384 1.0996
Histidine 0.8489 0.9815 1.0716 1.0890
Homoarginine 0.5775 0.6788 1.8249 0.8158
Hydroxykynurenine 0.8417 1.0064 1.1009 1.0384
Hypotaurine 0.5815 1.6304 0.8877 0.9145
Indole 0.9507 0.8615 1.1103 1.0638
Isovalerylcarnitine 1.1007 0.8889 1.0834 0.9166
L-Acetylcarnitine 0.9674 1.0091 0.9982 1.0255
L-Asparagine 0.9025 1.0337 1.0492 1.0085
L-Carnitine 1.0163 1.0045 1.0093 0.9687
L-Glutamic acid 0.7964 0.8782 1.1185 1.1921
L-Glutamine 0.9528 1.0208 1.0363 0.9856
L-Glutarylcarnitine 0.7897 1.2830 0.9146 1.0233
L-Histidinol 0.8773 0.8840 1.3055 0.8950
Linoleylcarnitine 0.8978 0.9840 0.7641 1.3836
L-Kynurenine 0.8081 0.7594 0.9926 1.4408
L-leucine 0.9602 0.9512 1.0744 1.0050
L-Methionine 0.9092 0.9695 1.0067 1.1138
L-Palmitoylcarnitine 1.1229 0.9293 0.8978 1.0628
L-Phenylalanine 0.9606 0.9726 1.0439 1.0175
L-Serine 1.0114 1.0086 0.9883 0.9932
L-Tryptophan 0.8806 0.9254 1.1101 1.0701
L-Tyrosine 0.7965 0.9358 1.0905 1.1659
L-Valine 0.8649 1.0024 1.1532 0.9603
Lysine 0.9260 0.9984 1.0785 0.9872
LysoPC(16:0) 0.9816 1.0369 1.0365 0.9403
Malonylcarnitine 0.9789 0.9843 0.8864 1.1646
Melatonin 1.0678 0.9936 0.9426 1.0031
Metanephrine 0.8711 1.1154 0.9530 1.0664
Methionine sulfoxide 0.8914 1.2120 0.9566 0.9454
Myristoylcarnitine 1.1503 0.8911 0.9276 1.0400
N-alpha-Acetylarginine 0.7643 0.9726 0.7180 1.5804
Niacinamide 0.9950 1.0730 0.7886 1.1698
Nicotinamide N-oxide 0.9127 1.0708 0.9621 1.0591
N-oleoylethanolamine 1.3036 0.8277 0.9403 0.9359
Norepinephrine 0.8528 1.1234 1.0580 0.9586
Normetanephrine 0.8722 1.1078 0.9972 1.0231
Octadecanoylcarnitine 0.9827 0.8988 0.8997 1.2313
Oleoylcarnitine 1.0701 0.8936 0.7923 1.2700
Ornithine 0.9495 1.0950 0.9977 0.9580
Oxidized glutathione 0.7469 1.2455 1.2429 0.7343
PC(16:0/16:0) 0.8248 1.1148 0.9974 1.0633
PC(16:0/18:1) 0.9730 1.2484 1.0401 0.7334
PC(16:0/18:2) 0.8819 1.1651 1.1053 0.8345
PC(16:0/20:4) 0.9005 1.1677 1.0161 0.9137
PC(16:0/22:6) 0.9410 1.1540 0.9991 0.9059
PC(18:0/18:2) 0.8066 1.1327 1.1618 0.8786
PC(20:4/P-16:0) 0.8501 1.2101 0.9244 1.0249
PC(22:6/P-18:0) 0.9158 1.2543 0.9355 0.9024
Phosphorylcholine 0.6148 1.0574 1.0647 1.2549
Pipecolic acid 0.9272 0.9842 1.0531 1.0289
Propionylcarnitine 0.9442 1.0621 1.0887 0.8939
Purine 0.9450 0.9559 1.0895 0.9985
Retinal 1.1029 1.0240 0.7599 1.1432
Retinol 0.8419 0.9074 0.9721 1.2821
Riboflavin 0.4292 1.1303 1.2294 1.1824
Saccharopine 0.8218 1.2434 0.9862 0.9502
S-Adenosylmethionine 0.8833 1.0624 1.0842 0.9596
Sarcosine 0.8597 1.0759 0.8881 1.1903
Serotonin 0.8781 0.3178 1.3099 1.4554
Spermidine 1.0361 0.9548 1.0690 0.9314
Suberylcarnitine 0.8320 1.0671 1.0256 1.0721
Testosterone 1.0487 0.9296 0.9226 1.1088
Thiamine 0.6983 0.7809 1.3415 1.1366
Trihexosylcer(18:1/16:0) 0.7984 1.0819 0.9741 1.1488
Trimethylamine-N-oxide 1.0326 1.0466 1.1595 0.7414
Urea 0.9777 1.0272 0.9627 1.0371
Vitamin D3 0.9043 1.2553 0.9469 0.9001
Vitamin K2 0.9162 1.3084 0.8979 0.8902
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Factors:

F1Genotype:CUMS model | Treatment:Albiflorin
F2Genotype:CUMS model | Treatment:Fluoxetine
F3Genotype:CUMS model | Treatment:Saline
F4Genotype:Wild-type | Treatment:Saline
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