Data for TCA Isotopmer metabolomics of H3K27M Cells grown in regular media, glutamine enriched regular media, and glucose encriched regular media (Part-III) (Study ST001025)

(Analysis AN001682)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10F11F12F13F14F15F16F17F18F19F20
2-Hydroxyglutarate M0 1.0529 0.9628 1.0084 0.9197 1.0542 0.9969 0.7174 0.9024 0.7719 1.0904 1.0391 1.0265 1.0158 1.0327 1.0099 0.9766 1.0291 0.9822 1.0361 1.0444
2-Hydroxyglutarate M+1 0.3512 0.4432 1.2000 0.4859 NA 0.3207 1.4565 0.4315 1.2479 0.6065 1.0516 1.3520 0.6609 1.4211 1.4747 0.7084 1.1956 0.6795 1.0712 1.0069
2-Hydroxyglutarate M+2 1.4661 0.2283 2.6683 0.4922 NA 2.3290 1.4137 2.2264 1.2985 0.3833 0.7561 0.1068 0.4461 0.4838 0.1634 0.6095 NA 0.3466 NA 0.2639
2-Hydroxyglutarate M+3 0.3576 2.0862 0.9740 2.6346 0.2172 0.0417 4.8326 0.1141 4.2008 0.0066 1.1144 0.6698 0.7466 0.5023 0.8994 0.9169 0.7312 0.9023 0.6398 0.6932
2-Hydroxyglutarate M+4 0.4494 0.1412 0.5329 0.1733 0.0385 0.2504 1.3611 0.3467 1.0015 NA 0.8282 0.0321 1.3169 0.3274 NA 2.3905 0.6784 2.2171 0.6720 0.5553
2-Hydroxyglutarate M+5 0.3206 1.7441 0.2482 2.0387 0.0422 0.0032 3.9213 0.0042 3.5136 0.1336 0.5533 0.6306 1.1906 0.4616 0.8963 1.5995 0.6969 1.5543 0.6587 0.6025
2-Hydroxyglutarate M+6 0.7000 NA 0.3111 NA 0.2852 1.0111 NA 2.7481 NA NA NA NA NA 0.3500 0.1556 NA NA NA NA NA
2-Hydroxyglutarate M+7 0.0950 0.9102 0.7361 1.3653 2.9859 3.6508 1.8560 8.2058 1.2110 0.2869 0.2760 0.3285 0.1840 0.4558 0.1425 0.0636 0.0297 0.0490 0.0376 0.0801
Alanine M0 0.9842 1.0063 0.9867 1.0044 1.0079 0.9126 0.9927 0.9355 0.9956 1.0057 1.0087 1.0048 1.0071 1.0064 1.0069 0.9986 1.0105 0.9990 1.0093 1.0107
Alanine M+1 0.7845 0.5495 NA 0.7945 0.6025 3.2639 2.2576 2.1252 1.7941 1.0195 0.0794 1.2016 NA 0.7172 0.7216 NA 0.1721 NA 0.4131 0.2304
Alanine M+2 2.2105 0.2623 2.2223 0.3242 0.1032 7.2445 0.6897 5.7502 0.6543 0.1636 0.6654 0.1690 1.3234 0.1896 0.1385 2.1221 0.1238 2.0743 0.1513 0.0442
Alanine M+3 NA NA NA NA NA NA NA NA NA 0.5818 0.8145 NA 0.7758 NA NA 1.2606 1.1636 0.8727 1.7455 0.5818
Aspartate M0 1.0263 0.8270 1.0021 0.8084 1.0634 1.0226 0.6959 1.0132 0.7640 1.0767 1.0700 1.0455 1.0663 1.0273 1.0790 1.0643 0.9068 1.0609 0.9214 1.0276
Aspartate M+1 1.1588 1.9690 1.4511 2.3877 0.8512 1.1110 2.7655 1.2152 2.2954 0.3846 0.5743 0.3012 0.2205 0.5888 0.1661 0.8666 1.0699 1.6562 0.1214 1.3127
Aspartate M+2 1.1258 2.0677 1.7079 2.4130 0.1416 1.1324 3.3986 1.3428 2.7649 0.0298 0.1619 0.5072 0.6416 0.6146 0.0615 NA 0.6921 NA 1.0527 0.0218
Aspartate M+3 0.1197 0.7392 0.1802 0.7244 NA 0.2801 1.1822 0.3307 0.9564 NA 0.2999 0.3093 0.3521 0.2851 0.0685 0.2332 3.5457 0.2546 3.9753 1.1669
Aspartate M+4 0.0069 2.5174 0.0072 2.5298 NA NA 3.6978 0.0020 3.0744 0.0039 0.0562 0.9305 0.0363 1.5382 NA 0.1065 2.1450 0.0289 1.0464 0.3084
Aspartate M+5 NA NA 0.0895 NA 0.0575 0.0383 NA NA NA NA 0.0767 0.2045 0.3195 0.0895 0.1406 0.9330 8.6779 0.5048 3.1056 2.1854
Citrate M0 0.9460 0.8209 0.9019 0.8081 1.0456 0.9399 0.7011 0.9231 0.7505 1.0614 1.0488 1.0475 1.0343 1.0391 1.0520 1.0533 1.0232 1.0403 1.0082 1.0565
Citrate M+1 1.4028 1.9778 1.8738 2.4998 0.2467 1.5048 2.8648 1.7393 2.4427 NA 0.4808 0.3775 0.7593 0.4425 0.5261 0.0966 0.3670 0.3793 0.8640 0.2447
Citrate M+2 2.3514 1.5114 3.1617 1.7490 0.0057 2.4051 2.2863 2.6752 1.9606 0.0575 0.1885 0.0172 0.4985 0.3094 0.1523 0.4818 0.3146 0.5613 0.3612 0.0747
Citrate M+3 0.3302 2.1196 0.6852 2.1729 0.1420 0.5503 4.1469 0.7243 3.6143 0.0533 0.2592 0.1385 NA 0.8628 NA 0.1562 0.8968 0.5130 1.2654 0.1731
Citrate M+4 0.0689 4.8744 0.1433 4.6319 NA 0.0648 6.4808 0.0992 5.4544 0.0124 0.1045 0.4198 0.1358 0.9953 0.1684 0.0248 1.0315 0.0528 1.1258 0.0816
Citrate M+5 NA NA 0.2190 0.8032 NA 0.1565 5.2049 0.1669 5.9037 NA 0.4224 0.3651 0.6337 0.4850 0.0939 0.1669 0.8623 0.3825 1.9140 0.1878
Citrate M+6 0.4209 1.6369 NA 1.7772 0.4209 0.1403 1.9175 0.1403 1.8240 NA NA 1.1224 1.3750 1.2277 1.4031 0.6236 0.9354 0.2806 0.5145 0.4209
Citrate M+7 NA 3.0048 0.0819 1.2838 8.6318 NA 0.3278 0.0819 NA 0.0819 1.1655 0.4566 0.2224 0.9600 0.1912 0.1229 0.3278 0.4302 0.3414 0.3824
Fumarate M0 1.0275 0.8473 1.0230 0.8274 1.0664 1.0210 0.8034 1.0231 0.8125 1.0443 1.0503 1.0255 1.0619 1.0172 0.9492 1.0483 0.9804 1.0528 0.9953 0.9552
Fumarate M+1 0.9966 1.1747 0.9327 1.5579 NA 0.6672 1.9831 0.6252 1.6924 0.5075 0.6201 NA NA NA 0.7179 NA NA NA NA 0.1891
Fumarate M+2 0.8158 2.1356 0.9582 2.4923 0.0816 1.1358 2.7626 1.1486 2.6443 0.2735 0.6019 0.2507 0.3575 0.7247 1.0222 0.7774 0.9241 0.6079 0.7108 1.4165
Fumarate M+3 0.2040 2.0096 0.4457 2.1116 0.1020 0.8801 2.4251 0.7026 2.4024 0.0453 0.4382 0.7819 0.3003 0.5553 1.4052 0.1926 1.1156 NA 1.1320 1.3825
Fumarate M+4 0.0105 3.1953 0.0197 3.2645 0.0219 0.0052 3.4141 0.0079 3.4115 0.1785 0.0673 0.8216 0.1410 0.8729 1.7399 0.1120 1.4058 0.0621 1.1552 1.6629
Fumarate M+5 NA NA NA NA NA NA NA NA NA NA NA NA 1.0000 NA NA NA NA NA NA NA
Glutamate M0 0.9924 0.7994 0.9827 0.7864 1.0765 1.0101 0.6384 1.0001 0.7019 1.0683 1.0630 1.0399 1.0603 1.0178 1.0804 1.0585 0.9499 1.0573 0.9633 1.0766
Glutamate M+1 2.5074 1.4297 2.1315 1.8035 0.2912 1.5318 2.5357 1.7057 2.3075 0.8061 0.5338 0.5562 0.7004 0.5215 NA 0.3496 1.2467 0.4882 0.7535 NA
Glutamate M+2 2.6562 0.9236 3.4051 1.1504 0.0402 2.5197 1.5741 2.8871 1.2970 NA 0.4082 0.2058 0.7649 0.6164 0.0181 0.7243 0.7107 0.6271 0.9195 0.1175
Glutamate M+3 NA 2.9714 0.0977 3.3862 0.0179 0.0598 5.7275 0.0758 4.7902 0.0299 0.2273 0.6800 0.0574 0.6993 0.0814 0.3605 1.4239 0.3433 1.2863 0.1924
Glutamate M+4 0.1399 2.1401 0.4196 2.0561 NA 0.1399 4.2242 0.2658 3.3150 0.1678 0.1206 0.5770 0.1678 0.9511 0.2937 0.4756 3.0842 0.2098 1.7134 NA
Glutamate M+5 0.0015 2.4648 0.0019 2.4046 0.0015 NA 3.4832 NA 3.0067 NA 0.0034 0.4839 0.0020 0.8229 0.0102 NA 1.5263 NA 1.6196 0.0422
Glutamate M+6 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA
Glutamine M0 1.1355 0.7593 1.1451 0.7591 1.1246 1.0906 0.6256 1.1133 0.7097 1.1373 1.1390 0.8584 1.1427 0.8703 1.1362 1.1461 0.7932 1.1462 0.8495 1.1457
Glutamine M+1 0.6124 0.8597 NA 0.7240 1.7406 2.5520 1.0860 1.2670 1.1463 0.8024 1.1222 0.8339 0.5430 0.4299 0.1538 NA NA NA 1.0226 NA
Glutamine M+2 0.7797 0.2648 0.4855 0.4070 0.2991 3.3640 0.8631 2.5500 0.9955 0.2550 1.3240 1.3469 0.7282 1.5355 1.2210 0.4708 0.4781 0.6988 0.5296 0.5590
Glutamine M+3 NA 0.3329 0.2070 0.4953 NA NA 4.6522 NA 5.1962 NA 0.5602 0.0731 0.8386 0.4384 2.5088 0.3349 0.8860 0.1110 1.0771 0.3451
Glutamine M+4 0.0193 1.2564 NA 1.2467 0.0097 NA 1.7911 0.0097 1.3595 0.0193 0.0459 1.1280 0.0097 1.2274 0.0387 0.0145 2.0778 0.0338 1.6429 0.0097
Glutamine M+5 0.0013 2.0684 0.0007 2.0704 0.0022 0.0013 2.6365 0.0009 2.1594 0.0007 0.0016 1.4986 0.0026 1.4664 0.0024 0.0026 1.9135 0.0020 1.5777 0.0077
Glutamine M+6 NA NA NA NA NA NA NA NA NA NA 0.6882 NA NA 1.5484 1.6774 0.3871 0.5161 1.2043 1.0323 0.5161
Glutamine M+7 NA 0.5411 NA NA NA NA 0.7665 NA 0.4058 NA 0.1353 1.3076 0.1353 NA 0.1353 NA 1.3527 0.1353 2.2770 NA
Ketoglutarate M0 1.0193 0.8149 0.9822 0.8002 1.0539 1.0062 0.6722 0.9873 0.7236 1.0696 1.0437 1.0327 1.0297 1.0123 1.0712 1.0771 0.9688 1.0744 0.9661 1.0570
Ketoglutarate M+1 0.8445 1.7441 1.3085 1.7745 0.5706 1.0499 2.4383 1.2210 2.2500 0.3671 1.4512 0.9180 1.9469 0.7895 0.6390 0.1277 0.7557 0.1940 0.6657 0.5923
Ketoglutarate M+2 2.5647 0.9105 3.8924 1.2252 0.0215 2.8937 1.9021 3.2917 1.5899 0.0215 0.5833 0.3706 1.2383 0.5118 0.1537 0.4476 0.3688 0.6066 0.3692 0.0268
Ketoglutarate M+3 0.3567 2.8517 0.6118 3.2722 0.1196 0.0837 5.3926 0.1016 4.5476 0.0438 0.1534 0.4290 0.1650 0.7772 0.1714 0.0737 2.6395 0.0864 1.5624 1.0187
Ketoglutarate M+4 0.3830 1.1370 1.0771 1.3285 0.2872 0.7061 2.9681 1.1729 2.4056 0.2513 1.4641 0.2513 2.1184 0.6104 0.3770 0.2912 1.1541 0.2832 1.6803 0.1526
Ketoglutarate M+5 0.0149 3.0756 0.0383 3.2295 NA 0.0142 4.5021 0.0206 3.9916 0.0191 0.0883 1.3492 0.0089 1.1773 0.0064 0.0048 1.2020 0.0047 1.5030 0.0199
Ketoglutarate M+6 NA NA NA NA 0.0610 5.6361 NA 8.3220 NA 1.2819 2.2585 0.0712 0.4171 0.1221 0.1465 0.1424 0.8037 0.1424 0.8953 0.5290
Lactate M0 1.0146 1.0207 1.0130 1.0200 1.0246 0.8440 1.0177 0.8545 1.0179 1.0252 1.0158 0.9965 1.0215 1.0019 0.9997 0.9838 1.0171 0.9829 1.0182 1.0176
Lactate M+1 1.8865 0.3613 1.9267 0.1846 0.2087 0.6422 0.3091 0.6315 0.4897 NA 1.7661 1.8776 0.4790 1.5012 1.6858 0.9179 0.4585 0.8046 0.6535 0.5957
Lactate M+2 1.2254 0.1142 1.4331 0.0519 NA 3.1223 0.4050 3.3438 0.7062 NA 0.7944 1.0662 0.5296 0.9000 0.9415 1.1515 0.4362 1.1723 0.5815 0.4403
Lactate M+3 0.0702 0.1189 0.0869 0.1203 0.0080 6.1852 0.1657 5.7388 0.1858 0.0254 0.0465 0.0160 0.1029 0.0347 NA 2.8868 0.1176 3.1554 0.0842 NA
Lactate M+4 NA 0.7500 NA 1.8333 1.3333 NA NA NA NA 0.5000 1.2000 NA 0.6667 NA NA NA 0.5000 NA 0.5000 0.5000
Malate M0 0.9998 0.8032 0.9796 0.7899 1.0464 0.9932 0.6557 0.9839 0.7177 1.0410 1.0499 1.0336 1.0474 1.0142 1.0460 1.0482 1.0224 1.0483 1.0091 1.0391
Malate M+1 1.1792 2.1281 1.3071 2.6327 0.2837 1.2233 4.0980 1.4048 3.3584 0.4558 0.1233 0.1395 0.0777 0.5628 NA NA 0.3323 NA 0.3847 0.4489
Malate M+2 1.0839 2.0104 1.7007 2.3069 0.0357 1.1462 3.5337 1.2891 2.9726 0.0675 0.0337 0.1687 0.1562 0.5261 NA 0.0556 0.4394 0.1575 0.7517 NA
Malate M+3 0.6898 3.2333 1.0321 3.1491 NA 1.4113 5.4135 1.7483 4.4498 NA 0.1066 0.6863 0.2343 0.9676 0.4423 0.1521 0.5547 0.1246 0.8610 0.1659
Malate M+4 NA 4.8865 0.0072 4.8298 NA NA 7.0552 NA 6.0342 NA 0.0272 0.4263 0.0481 0.8363 0.0427 0.0491 0.5745 0.0257 0.8198 0.0784
Malate M+5 0.7058 NA 0.4191 NA 0.5294 0.4411 NA 0.7940 NA 1.5660 0.1456 0.8205 0.2316 1.4778 1.9686 0.7610 0.9705 0.4852 2.3727 1.7976
Succinate M0 1.0559 0.8268 1.0372 0.8023 1.0774 1.0255 0.6915 1.0051 0.7449 1.0731 1.0820 0.9541 1.0733 0.9376 0.9347 1.0829 1.0181 1.0840 0.9973 1.0513
Succinate M+1 0.4337 0.9410 0.4351 1.3424 0.4673 0.6278 1.3088 0.9928 1.2388 0.4575 0.1679 2.3661 0.3258 2.3635 2.3381 0.2784 0.7511 0.2128 0.8882 0.6695
Succinate M+2 1.2029 2.8459 2.1055 3.2245 0.0653 2.2920 4.9943 2.2827 4.0805 0.1324 0.3985 0.6394 0.3425 0.8085 0.9166 0.1581 0.5582 0.2891 0.7634 0.2415
Succinate M+3 0.0735 2.8912 0.0735 2.9525 NA 0.0735 3.3568 0.4655 3.3323 0.1470 0.5605 0.6395 1.3185 0.9923 1.2006 0.3267 0.8126 0.2573 1.0617 0.4962
Succinate M+4 0.0494 4.7600 0.0688 4.6353 0.0247 NA 6.8665 0.0064 5.9438 0.1192 0.1955 0.4272 0.3771 0.7906 0.7283 0.0820 0.9672 0.0698 1.2239 0.3346
Succinate M+5 NA NA NA NA NA 0.8095 NA 1.3878 NA NA NA 2.0816 NA 0.9541 NA 0.3469 NA 0.3469 NA NA
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Factors:

F1Sample type:Cells | Grouping:IV 12h GLC
F2Sample type:Cells | Grouping:IV 12h GLN
F3Sample type:Cells | Grouping:IV 24h GLC
F4Sample type:Cells | Grouping:IV 24h GLN
F5Sample type:Cells | Grouping:IV Basal
F6Sample type:Cells | Grouping:XVII 12h GLC
F7Sample type:Cells | Grouping:XVII 12h GLN
F8Sample type:Cells | Grouping:XVII 24h GLC
F9Sample type:Cells | Grouping:XVII 24h GLN
F10Sample type:Cells | Grouping:XVII Basal
F11Sample type:Media | Grouping:IV 12h GLC
F12Sample type:Media | Grouping:IV 12h GLN
F13Sample type:Media | Grouping:IV 24h GLC
F14Sample type:Media | Grouping:IV 24h GLN
F15Sample type:Media | Grouping:IV Basal
F16Sample type:Media | Grouping:XVII 12h GLC
F17Sample type:Media | Grouping:XVII 12h GLN
F18Sample type:Media | Grouping:XVII 24h GLC
F19Sample type:Media | Grouping:XVII 24h GLN
F20Sample type:Media | Grouping:XVII Basal
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