Data for FASN effect on HCT116 metabolism probed by 13C6-glucose tracer (Study ST001045)

(Analysis AN001709)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
a-glycerol-3P_#1-13C0 1.3152 1.8860 0.7317 0.8678
a-glycerol-3P_#1-13C1 1.5181 0.4722 0.9360 1.0369
a-glycerol-3P_#1-13C2 0.1809 0.9822 1.4413 0.8376
a-glycerol-3P_#1-13C3 0.0008 0.0390 1.3606 1.2928
a-glycerol-3P_#1-ALL 0.7597 1.0830 1.0082 1.0443
a-glycerol-3P_#2-13C0 1.4256 1.7357 0.8108 0.8021
a-glycerol-3P_#2-13C1 NA 0.1082 1.4538 0.8435
a-glycerol-3P_#2-13C2 NA 0.2660 1.2085 1.0543
a-glycerol-3P_#2-13C3 NA NA 1.1358 0.8642
a-glycerol-3P_#2-ALL 0.6552 0.8257 1.2148 0.9582
a-ketoglutarate-13C0 1.1714 1.1166 1.0860 0.8181
a-ketoglutarate-13C1 0.6011 1.3466 0.8480 1.1695
a-ketoglutarate-13C2 0.1277 NA 1.2717 1.0191
a-ketoglutarate-13C3 NA 0.0916 1.3523 0.9504
a-ketoglutarate-13C4 0.0413 0.1073 1.3734 1.2437
a-ketoglutarate-13C5 0.0696 0.3256 1.2728 1.2621
a-ketoglutarate-ALL 0.7757 0.7718 1.1939 0.9569
Ala-13C0 1.5384 1.6035 0.9241 0.6952
Ala-13C1 0.3889 1.7417 1.3024 0.6541
Ala-13C2 0.3236 0.3211 1.3309 1.1208
Ala-13C3 NA NA 1.0451 0.9549
Ala-ALL 0.8159 0.8865 1.1472 0.9520
Arg-13C0 0.6246 0.6064 1.3182 0.9382
Arg-13C1 0.9278 0.5812 1.0489 1.1147
Arg-13C2 0.3141 0.4261 1.0624 1.3784
Arg-13C3 1.0665 1.1616 0.3004 1.1572
Arg-13C4 NA 1.5293 1.0896 0.6457
Arg-13C5 NA 1.0000 NA NA
Arg-13C6 NA NA NA 1.0000
Arg-ALL 0.6573 0.6278 1.2544 0.9839
ascorbate-13C0 0.6843 1.0750 NA 1.1204
ascorbate-13C1 NA 1.2752 NA 0.8624
ascorbate-13C2 1.0354 0.9713 NA 0.9967
ascorbate-13C3 0.9454 0.6335 NA 1.2106
ascorbate-13C4 1.0243 0.6734 NA 1.1511
ascorbate-13C5 NA NA NA NA
ascorbate-13C6 NA NA NA 1.0000
ascorbate-ALL 0.9305 0.9382 NA 1.0657
Asn-13C0 1.1069 1.2022 0.9932 0.9038
Asn-13C1 0.1950 0.5534 1.2703 1.1469
Asn-13C2 NA 0.0224 1.1614 1.1645
Asn-13C3 0.0462 NA 1.2380 1.0799
Asn-13C4 0.1281 0.0502 1.4038 1.2034
Asn-ALL 0.7748 0.8566 1.1060 1.0169
Asp-13C0 1.1637 1.4496 0.9670 0.8286
Asp-13C1 0.7024 0.6355 1.1044 1.1163
Asp-13C2 0.0016 0.0268 1.3996 1.2576
Asp-13C3 0.0548 0.0652 1.3244 1.3023
Asp-13C4 NA 0.0450 0.9907 1.3277
Asp-ALL 0.8072 0.9952 1.0815 0.9843
bOHbutyrate-13C0 0.8344 0.7505 1.1197 1.0187
bOHbutyrate-13C1 NA 0.4266 1.1742 1.0254
bOHbutyrate-13C2 0.4634 NA 1.4489 0.6388
bOHbutyrate-13C3 NA NA 1.0000 NA
bOHbutyrate-13C4 NA NA 1.0000 NA
bOHbutyrate-ALL 0.7534 0.6988 1.2073 0.9753
citrate-13C0 2.4585 2.4155 0.6104 0.4316
citrate-13C1 1.2671 0.6429 1.3086 0.7214
citrate-13C2 0.0287 0.0439 1.5971 1.0453
citrate-13C3 0.0580 0.0154 1.4109 1.2313
citrate-13C4 0.0123 NA 1.3515 0.9777
citrate-13C5 0.0171 NA 1.2539 1.0737
citrate-13C6 NA 0.0033 1.3203 1.0119
citrate-ALL 0.9169 0.8713 1.2104 0.8602
Cys-13C0 NA NA NA NA
Cys-13C1 NA NA NA NA
Cys-13C2 NA NA NA NA
Cys-13C3 NA NA NA NA
Cys-ALL NA NA NA NA
fumarate-13C0 1.1409 1.1577 1.0372 0.8632
fumarate-13C1 0.5190 0.6883 1.1853 1.0789
fumarate-13C2 0.0178 0.0989 1.3708 1.2569
fumarate-13C3 0.0423 0.1634 1.4075 1.1906
fumarate-13C4 NA NA 1.0456 0.9544
fumarate-ALL 0.7698 0.8176 1.1494 0.9881
GAB-13C0 0.9526 0.7881 1.2829 0.8035
GAB-13C1 1.0893 0.3206 1.3800 0.8166
GAB-13C2 1.0990 0.0015 1.5611 0.6081
GAB-13C3 0.4810 2.5072 0.8217 0.7895
GAB-13C4 NA NA 1.0000 NA
GAB-ALL 0.9666 0.7460 1.3044 0.7913
Gln-13C0 0.8222 0.8314 1.2112 0.9043
Gln-13C1 0.5783 0.8402 1.3121 0.8818
Gln-13C2 1.1150 0.2448 1.2958 0.9176
Gln-13C3 NA NA 0.7730 1.2270
Gln-13C4 NA 0.3763 1.0229 1.1849
Gln-13C5 0.0269 0.5878 0.9060 1.7397
Gln-ALL 0.8083 0.8206 1.2173 0.9064
Glu-13C0 1.1989 1.3946 1.0166 0.7855
Glu-13C1 0.7414 1.0724 1.2095 0.8525
Glu-13C2 0.0629 0.0507 1.4328 1.1960
Glu-13C3 0.0357 NA 1.2461 1.0753
Glu-13C4 NA 0.0130 1.1829 1.1461
Glu-13C5 NA 0.0543 1.1541 1.1611
Glu-ALL 0.7968 0.9363 1.1547 0.9343
Gly-13C0 0.8515 0.8733 1.1828 0.9089
Gly-13C1 1.8622 1.0286 1.0756 0.6275
Gly-13C2 NA 0.7257 0.5617 1.5298
Gly-ALL 0.8770 0.8780 1.1746 0.9071
His-13C0 NA NA NA NA
His-13C1 NA NA NA NA
His-13C2 NA NA NA NA
His-13C3 NA NA NA NA
His-13C4 NA NA NA NA
His-13C5 NA NA NA NA
His-13C6 NA NA NA NA
His-ALL NA NA NA NA
Ile-13C0 0.7833 0.7673 1.2457 0.9040
Ile-13C1 1.2638 0.9069 0.8887 1.0544
Ile-13C2 0.2723 0.1754 1.2976 1.4786
Ile-13C3 0.4475 2.5978 0.0395 0.9718
Ile-13C4 1.6111 NA 1.3290 0.0599
Ile-13C5 NA 0.6403 0.8744 1.2036
Ile-13C6 NA NA NA 1.0000
Ile-ALL 0.8091 0.7818 1.2156 0.9207
lactate-13C0 1.1867 1.8818 0.9313 0.7125
lactate-13C1 0.7177 1.0506 1.1919 0.8853
lactate-13C2 0.1972 NA 1.2441 1.0235
lactate-13C3 0.0213 0.0399 1.3512 1.2951
lactate-ALL 0.5834 0.9097 1.1571 1.0119
Leu-13C0 0.7934 0.8150 1.1912 0.9394
Leu-13C1 0.3732 0.5548 1.4796 0.8777
Leu-13C2 0.0284 NA 1.3239 NA
Leu-13C3 0.9505 NA 0.5550 1.4615
Leu-13C4 NA 0.6336 1.3997 0.7836
Leu-13C5 NA NA 1.4803 0.0393
Leu-13C6 0.4514 NA 2.0167 0.5319
Leu-ALL 0.7515 0.7713 1.2258 0.9333
Lys-13C0 0.5554 0.7087 1.2402 1.0051
Lys-13C1 0.1994 1.2058 1.3027 0.9947
Lys-13C2 0.7342 0.6781 1.5877 NA
Lys-13C3 NA NA 1.6264 0.3736
Lys-13C4 NA 0.7586 1.2414 NA
Lys-13C5 NA NA 1.0000 NA
Lys-13C6 NA NA NA 1.0000
Lys-ALL 0.5388 0.8089 1.2400 0.9774
Malate-13C0 1.1545 1.5906 0.8669 0.8848
Malate-13C1 0.1698 0.6574 1.3363 1.0546
Malate-13C2 0.0914 0.0131 1.2427 1.3891
Malate-13C3 NA 0.0479 1.1146 1.2027
Malate-13C4 NA 0.0342 0.8506 1.4714
Malate-ALL 0.7235 1.0168 1.0153 1.0712
Met-13C0 0.7963 0.7057 1.3308 0.8352
Met-13C1 0.7657 1.1611 1.5971 0.4273
Met-13C2 0.8949 0.7478 1.2905 0.8286
Met-13C3 0.8700 2.7548 0.1956 1.3942
Met-13C4 0.7917 0.7610 1.2156 0.9335
Met-13C5 NA NA 0.6860 1.1570
Met-ALL 0.7958 0.7624 1.3047 0.8425
OHPro-13C0 0.8328 0.7628 1.2947 0.8401
OHPro-13C1 0.8821 1.0510 0.9492 1.0731
OHPro-13C2 NA 1.1598 0.5907 1.0832
OHPro-13C3 0.9520 NA 0.8060 1.3149
OHPro-13C4 0.7567 0.0099 1.8034 0.8755
OHPro-13C5 NA 2.7207 0.4807 0.3179
OHPro-ALL 0.8276 0.7987 1.2573 0.8672
Orn-13C0 1.1637 1.4245 1.0490 0.7549
Orn-13C1 NA 0.3083 1.1914 1.0392
Orn-13C2 0.1062 0.0907 1.3641 1.2369
Orn-13C3 0.4036 NA 1.2621 0.9050
Orn-13C4 NA 0.0341 0.8736 1.4484
Orn-13C5 0.0400 0.0771 1.3542 1.2734
Orn-ALL 0.7641 0.9034 1.1767 0.9342
Phe-13C0 0.7756 0.7699 1.2461 0.9054
Phe-13C1 0.8801 0.7258 1.2749 0.8565
Phe-13C2 0.0134 0.8812 0.9092 1.4290
Phe-13C3 NA NA NA 1.0000
Phe-13C4 NA 0.4726 NA 1.1758
Phe-13C5 0.6021 0.9988 1.5918 0.5413
Phe-13C6 0.9768 1.4484 1.0728 0.8097
Phe-13C7 1.0689 0.3792 0.5412 1.7347
Phe-13C8 0.4712 0.6959 1.6220 0.6557
Phe-13C9 0.7582 1.0338 NA 1.2080
Phe-ALL 0.7682 0.7952 1.2455 0.9000
Pro-13C0 1.0506 1.0786 1.1236 0.8333
Pro-13C1 0.8342 0.2671 1.2736 1.0260
Pro-13C2 NA NA 1.2096 0.7904
Pro-13C3 0.0335 0.1404 1.3786 1.2301
Pro-13C4 0.0541 0.3299 1.1643 1.3743
Pro-13C5 0.1671 NA 1.2423 1.0353
Pro-ALL 0.7623 0.7698 1.2229 0.9330
pyroGlu-13C0 0.9067 1.1215 1.1162 0.8744
pyroGlu-13C1 0.6005 0.8233 1.1528 1.0393
pyroGlu-13C2 NA NA 0.9748 1.0252
pyroGlu-13C3 NA NA 1.1160 0.8840
pyroGlu-13C4 0.0402 0.0326 0.8741 1.7684
pyroGlu-13C5 0.1257 0.0731 1.2972 1.3032
pyroGlu-ALL 0.7429 0.9216 1.1492 0.9627
Ser-13C0 0.9162 0.8813 1.2462 0.8213
Ser-13C1 0.4474 1.1052 1.4864 0.6628
Ser-13C2 0.4184 NA 0.7107 1.3867
Ser-13C3 NA NA 1.2790 0.7210
Ser-ALL 0.8744 0.8783 1.2607 0.8218
Succinate-13C0 0.6656 0.7875 1.3115 0.8708
Succinate-13C1 0.6667 1.2180 1.1194 0.9191
Succinate-13C2 0.3239 0.2388 1.5255 0.9536
Succinate-13C3 0.5309 1.0794 0.8446 1.2853
Succinate-13C4 0.1924 0.1332 1.3209 1.2373
Succinate-ALL 0.6281 0.7879 1.2929 0.9018
t-aconitate-13C0 1.9515 2.0705 0.7985 0.5275
t-aconitate-13C1 1.4028 NA 0.4340 1.2430
t-aconitate-13C2 0.2783 0.1213 1.7176 0.8158
t-aconitate-13C3 NA NA 1.2480 0.7520
t-aconitate-13C4 NA NA 1.1767 0.8233
t-aconitate-13C5 NA NA 1.1756 0.8244
t-aconitate-13C6 NA NA 1.1946 0.8054
t-aconitate-ALL 0.7801 0.7013 1.3247 0.8482
Thr-13C0 0.8467 0.8048 1.2683 0.8478
Thr-13C1 0.4592 0.6134 1.3980 0.9111
Thr-13C2 0.4120 0.8567 1.2126 1.0468
Thr-13C3 0.7735 NA 1.6239 0.6026
Thr-13C4 NA NA 1.3760 0.2480
Thr-ALL 0.8290 0.7960 1.2757 0.8493
Trp-13C0 0.8044 0.3163 1.5246 0.7686
Trp-13C1 NA 0.2506 1.3497 0.9001
Trp-13C10 0.6600 NA 1.2589 0.5634
Trp-13C11 NA NA 1.2203 0.7797
Trp-13C2 0.4220 NA NA 1.1927
Trp-13C3 NA NA NA NA
Trp-13C4 NA NA NA 1.0000
Trp-13C5 1.0821 NA 0.9179 NA
Trp-13C6 NA NA 1.0653 0.9347
Trp-13C7 NA NA NA 1.0000
Trp-13C8 1.2811 0.8861 0.8816 1.0627
Trp-13C9 0.8146 1.7811 1.0291 0.7724
Trp-ALL 0.9077 0.5239 1.2957 0.8937
Tyr-13C0 0.7779 0.7516 1.2507 0.9062
Tyr-13C1 0.6310 0.9074 1.2930 0.8609
Tyr-13C2 0.4518 0.9091 1.0886 1.1244
Tyr-13C3 0.5921 0.3308 1.9288 0.2195
Tyr-13C4 1.0736 NA NA 0.9264
Tyr-13C5 0.6714 NA 1.1476 1.0333
Tyr-13C6 0.1212 NA 2.5346 0.3441
Tyr-13C7 1.0653 1.4288 NA 0.7530
Tyr-13C8 1.0643 NA 0.9357 NA
Tyr-13C9 NA 1.8070 0.7463 0.9540
Tyr-ALL 0.7625 0.7733 1.2531 0.9016
Val-13C0 0.7123 0.7873 1.2528 0.9140
Val-13C1 0.9126 0.7804 1.2546 0.9326
Val-13C2 0.4793 0.8610 1.3807 0.9661
Val-13C3 NA 1.0006 1.1414 0.8581
Val-13C4 NA 1.2121 1.4532 0.6674
Val-13C5 1.4154 NA 0.5846 NA
Val-ALL 0.7281 0.7993 1.2344 0.9231
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Factors:

F1protocol.id:12CGlc_FASN_shRNA
F2protocol.id:12CGlc_NTC_shRNA
F3protocol.id:13CGlc_FASN_shRNA
F4protocol.id:13CGlc_NTC_shRNA
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