Data for FASN effect on HCT116 metabolism probed by 13C6-glucose tracer (part II) (Study ST001046)

(Analysis AN001710)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
a-glycerol-3P_#1-0 NA NA NA NA
a-glycerol-3P_#1-13C0 1.0074 0.9793 0.5833 1.1433
a-glycerol-3P_#1-13C1 1.9728 1.0345 0.9298 0.0628
a-glycerol-3P_#1-13C2 1.2953 0.8052 0.6372 1.6251
a-glycerol-3P_#1-13C3 0.9361 1.1666 0.9318 1.0169
a-glycerol-3P_#1-ALL 0.9973 1.1093 0.8534 1.0622
a-glycerol-3P_#2-13C0 0.8721 0.9125 0.7939 1.2092
a-glycerol-3P_#2-13C1 1.3465 1.0785 0.7662 1.0214
a-glycerol-3P_#2-13C2 0.4744 1.1178 0.6741 1.5298
a-glycerol-3P_#2-13C3 1.3581 1.3242 0.9578 0.8007
a-glycerol-3P_#2-ALL 1.0267 1.0308 0.8341 1.0914
a-ketoglutarate-13C0 1.1840 0.8919 0.8485 1.0757
a-ketoglutarate-13C1 1.2230 0.4966 0.8768 1.1756
a-ketoglutarate-13C2 1.5932 1.0012 0.9957 0.8047
a-ketoglutarate-13C3 0.7691 1.0576 1.0479 1.0627
a-ketoglutarate-13C4 0.7440 0.7483 1.2013 1.0526
a-ketoglutarate-13C5 1.2558 NA 0.9696 0.7746
a-ketoglutarate-ALL 1.2594 0.8832 0.9421 0.9911
Ala-13C0 0.9098 0.9530 0.4841 1.3897
Ala-13C1 1.4640 0.0867 0.5501 1.4497
Ala-13C2 0.8970 1.1203 0.7914 1.1333
Ala-13C3 1.3440 1.5851 0.8333 0.8014
Ala-ALL 1.1397 1.2466 0.6717 1.0901
Arg-13C0 1.8406 1.1341 0.5215 0.9941
Arg-13C1 1.3470 0.9554 0.9929 0.9039
Arg-13C2 0.5060 0.4902 1.7020 0.5997
Arg-13C3 2.3408 1.2386 0.5442 0.7774
Arg-13C4 1.0000 NA NA NA
Arg-13C5 NA NA NA NA
Arg-13C6 1.0000 NA NA NA
Arg-ALL 1.7526 1.0788 0.6847 0.9331
ascorbate-13C0 NA 0.7963 1.5803 0.8745
ascorbate-13C1 NA 0.9969 0.6488 1.3543
ascorbate-13C2 NA 1.1507 0.2997 1.1832
ascorbate-13C3 NA 1.4589 NA 0.8470
ascorbate-13C4 NA 1.1810 0.3218 1.1657
ascorbate-13C5 NA NA 0.5964 1.2018
ascorbate-13C6 NA 0.6526 NA 1.3474
ascorbate-ALL NA 1.1947 0.4740 1.1104
Asn-13C0 1.1723 1.1159 0.5950 1.1740
Asn-13C1 1.3476 NA 0.3750 1.4512
Asn-13C2 1.6699 1.2531 0.7486 0.8599
Asn-13C3 1.0483 1.7119 1.2531 0.5779
Asn-13C4 0.2699 NA 1.3270 1.0381
Asn-ALL 1.2559 1.0790 0.6629 1.1131
Asp-13C0 0.9616 1.0320 0.5323 1.3139
Asp-13C1 1.0320 1.2275 0.7189 1.1009
Asp-13C2 1.1102 1.5084 0.7481 0.9617
Asp-13C3 1.1215 1.2035 0.7037 1.1338
Asp-13C4 1.8287 0.8147 0.3513 1.2180
Asp-ALL 1.0297 1.1394 0.5955 1.2133
bOHbutyrate-13C0 1.2201 1.3115 0.5053 1.1526
bOHbutyrate-13C1 0.9562 1.6144 0.3569 1.0242
bOHbutyrate-13C2 1.3740 1.0658 NA 0.7801
bOHbutyrate-13C3 NA NA NA NA
bOHbutyrate-13C4 NA NA NA NA
bOHbutyrate-ALL 1.2302 1.3577 0.4782 1.1519
citrate-13C0 0.8605 0.6164 0.6070 1.4364
citrate-13C1 1.0573 0.9999 0.7402 1.1541
citrate-13C2 1.3721 1.0579 1.0668 0.8122
citrate-13C3 1.6943 1.2526 0.9043 0.7481
citrate-13C4 1.2797 1.0539 0.9730 0.9068
citrate-13C5 1.6863 0.9277 0.9171 0.7759
citrate-13C6 NA 1.5447 1.2540 0.4737
citrate-ALL 1.1784 0.8986 0.8436 1.0786
Cys-13C0 NA NA NA NA
Cys-13C1 NA NA NA NA
Cys-13C2 NA NA NA NA
Cys-13C3 NA NA NA NA
Cys-ALL NA NA NA NA
fumarate-13C0 1.0937 1.0202 0.7920 1.1007
fumarate-13C1 0.8037 1.1019 0.8347 1.1416
fumarate-13C2 1.2494 1.2511 0.9500 0.8665
fumarate-13C3 1.4033 1.3584 0.9002 0.8126
fumarate-13C4 1.1555 1.4025 1.0754 0.7637
fumarate-ALL 1.1122 1.0906 0.8315 1.0448
GAB-13C0 1.2849 0.7747 0.7512 1.1460
GAB-13C1 0.5984 1.1255 0.6753 1.3085
GAB-13C2 1.6326 0.6676 1.2964 0.7023
GAB-13C3 0.9273 0.9875 0.0843 1.3336
GAB-13C4 NA 1.0642 NA 0.9358
GAB-ALL 1.2548 0.8028 0.7557 1.1437
Gln-13C0 1.2412 1.1284 0.5960 1.1461
Gln-13C1 0.8665 0.9191 0.6994 1.2719
Gln-13C2 2.9124 1.3217 0.2986 0.1687
Gln-13C3 0.2875 NA 1.6573 1.0276
Gln-13C4 NA 1.3743 0.5208 1.0349
Gln-13C5 1.0872 0.8351 0.7475 1.5827
Gln-ALL 1.2377 1.1230 0.6011 1.1457
Glu-13C0 1.0439 1.0488 0.5764 1.2515
Glu-13C1 0.9066 1.0598 0.8223 1.1297
Glu-13C2 1.3318 1.3344 0.7983 0.9124
Glu-13C3 1.3828 1.2438 0.5567 1.1300
Glu-13C4 1.0344 1.4579 0.7937 0.9601
Glu-13C5 1.7206 0.9265 0.5357 1.0938
Glu-ALL 1.1304 1.1480 0.6507 1.1401
Gly-13C0 1.1049 1.1304 0.7005 1.1212
Gly-13C1 1.2677 0.9855 0.8636 1.0065
Gly-13C2 1.1540 0.8224 0.9995 1.0082
Gly-ALL 1.1136 1.1094 0.7218 1.1111
His-13C0 1.4196 NA 0.8483 0.8661
His-13C1 NA NA NA 1.0000
His-13C2 1.3062 NA 1.0501 0.6437
His-13C3 NA NA 1.3249 0.6751
His-13C4 NA NA 1.0000 NA
His-13C5 NA NA NA 1.0000
His-13C6 NA NA NA 1.0000
His-ALL 0.7091 NA 0.9768 1.1571
Ile-13C0 1.2790 1.0801 0.6811 1.0929
Ile-13C1 1.7750 0.8452 0.8255 0.9096
Ile-13C2 1.3970 2.1691 0.3872 0.5233
Ile-13C3 2.0009 0.3083 0.7513 0.9798
Ile-13C4 NA 0.7019 0.9163 1.2328
Ile-13C5 1.8454 NA 0.1546 NA
Ile-13C6 0.2993 0.6503 NA 2.0505
Ile-ALL 1.3229 1.0681 0.6880 1.0777
lactate-13C0 1.0606 1.2073 0.6944 1.1144
lactate-13C1 NA 2.0251 0.7019 0.8570
lactate-13C2 1.7846 1.1747 0.8271 0.7955
lactate-13C3 1.6180 1.4575 0.6845 0.8518
lactate-ALL 1.3020 1.3219 0.6978 0.9935
Leu-13C0 1.2416 1.1653 0.6279 1.1124
Leu-13C1 0.6688 1.1516 0.8981 1.1278
Leu-13C2 NA 0.5626 0.7894 1.2160
Leu-13C3 1.3860 1.3675 0.0476 1.0663
Leu-13C4 1.9947 1.2217 0.7293 0.7750
Leu-13C5 NA NA 1.0000 NA
Leu-13C6 NA NA NA 1.0000
Leu-ALL 1.2013 1.1705 0.6329 1.1208
Lys-13C0 1.1374 0.9115 0.7082 1.1782
Lys-13C1 NA 0.9617 0.6488 1.2469
Lys-13C2 0.9363 1.7320 0.8702 0.7956
Lys-13C3 1.7552 NA NA 0.2448
Lys-13C4 NA 0.9545 NA 1.0455
Lys-13C5 NA NA NA NA
Lys-13C6 NA NA NA NA
Lys-ALL 1.0751 1.0067 0.7088 1.1668
Malate-13C0 0.8953 1.1481 0.7541 1.1494
Malate-13C1 1.5515 1.1409 0.6273 1.0176
Malate-13C2 0.9774 1.2519 0.9073 0.9780
Malate-13C3 0.8312 1.4974 0.7153 1.1204
Malate-13C4 1.4553 0.8150 0.7724 1.0616
Malate-ALL 1.0082 1.2338 0.7984 1.0537
Met-13C0 1.3200 1.0388 0.5673 1.1689
Met-13C1 1.0851 0.8316 0.9511 1.0905
Met-13C2 0.7792 1.1725 0.6292 1.2633
Met-13C3 0.5580 2.7237 0.8540 0.4321
Met-13C4 0.9785 1.0162 0.7186 1.1893
Met-13C5 0.8091 0.6250 0.7521 1.3539
Met-ALL 1.2580 1.0554 0.6159 1.1516
OHPro-13C0 1.0575 1.0362 0.6719 1.1875
OHPro-13C1 1.1219 1.4110 1.1743 0.7643
OHPro-13C2 1.8041 2.1851 0.4059 0.5995
OHPro-13C3 2.0366 NA 0.4247 1.0380
OHPro-13C4 NA 1.1251 0.9374 NA
OHPro-13C5 NA NA 0.2257 1.7743
OHPro-ALL 1.1267 1.1004 0.6667 1.1465
Orn-13C0 NA 0.3248 1.8980 0.4396
Orn-13C1 NA NA NA 1.0000
Orn-13C2 NA NA 0.8024 1.1976
Orn-13C3 NA NA 1.5935 0.7033
Orn-13C4 NA NA 0.4555 1.2722
Orn-13C5 NA NA 1.0000 NA
Orn-ALL NA 0.2608 1.7549 0.6148
Phe-13C0 1.3296 1.1925 0.6040 1.0900
Phe-13C1 1.5119 0.9441 0.6628 1.0728
Phe-13C2 0.8198 NA 0.8075 1.2826
Phe-13C3 1.0082 1.0498 0.9279 1.0047
Phe-13C4 0.4485 NA 1.5515 NA
Phe-13C5 1.2281 1.2545 0.7224 1.0242
Phe-13C6 0.3011 2.0752 0.9869 0.8833
Phe-13C7 0.7204 0.6441 1.5646 1.0354
Phe-13C8 NA 0.5955 0.3442 1.5302
Phe-13C9 1.9076 1.0146 0.6517 0.4262
Phe-ALL 1.3214 1.1635 0.6304 1.0848
Pro-13C0 1.0325 1.0249 0.6742 1.1981
Pro-13C1 1.1196 0.9982 0.6533 1.1919
Pro-13C2 1.3036 1.0711 0.9263 0.9242
Pro-13C3 1.2889 1.5300 0.5930 0.9975
Pro-13C4 2.1739 1.0902 0.9715 0.5976
Pro-13C5 0.9454 0.6512 0.8675 1.2228
Pro-ALL 1.1348 1.0530 0.7277 1.1190
pyroGlu-13C0 1.1296 1.1014 0.6374 1.1647
pyroGlu-13C1 1.6576 0.8999 0.5316 1.1264
pyroGlu-13C2 1.3393 1.2385 0.3579 1.3533
pyroGlu-13C3 1.7145 1.7314 0.9810 0.5307
pyroGlu-13C4 1.5206 1.2150 0.2613 1.0010
pyroGlu-13C5 NA 0.6950 1.8661 0.8129
pyroGlu-ALL 1.2129 1.1342 0.6173 1.1394
Ser-13C0 1.1236 1.1862 0.6028 1.1615
Ser-13C1 1.2447 1.7519 0.5937 0.9386
Ser-13C2 1.8624 1.2527 0.6009 0.8944
Ser-13C3 1.1119 1.6319 0.8924 0.8238
Ser-ALL 1.1549 1.2453 0.6128 1.1248
Succinate-13C0 1.3930 1.2000 0.7924 0.9408
Succinate-13C1 1.5903 0.8745 0.7730 0.9964
Succinate-13C2 0.9588 1.2717 0.8122 1.0484
Succinate-13C3 0.9575 1.3669 1.5265 0.5409
Succinate-13C4 1.1700 1.2842 0.0780 1.4679
Succinate-ALL 1.3883 1.1993 0.7930 0.9421
t-aconitate-13C0 0.8587 0.6812 0.5477 1.4549
t-aconitate-13C1 1.7087 1.1506 1.1523 0.6121
t-aconitate-13C2 1.1713 1.2226 1.0911 0.8080
t-aconitate-13C3 1.5517 NA 0.5518 0.9482
t-aconitate-13C4 0.6695 1.0222 1.2678 0.8864
t-aconitate-13C5 0.7123 0.7989 1.3502 0.8942
t-aconitate-13C6 1.6519 1.3541 0.7028 0.6456
t-aconitate-ALL 1.1809 0.9416 0.9055 1.0222
Thr-13C0 1.1560 1.1542 0.6261 1.1458
Thr-13C1 1.8509 0.7969 0.3056 1.2470
Thr-13C2 NA 1.9799 0.1262 0.8939
Thr-13C3 0.1118 1.4349 1.0891 1.1376
Thr-13C4 1.0739 NA 0.1259 1.8002
Thr-ALL 1.1750 1.1524 0.6150 1.1476
Trp-13C0 1.2626 1.0743 1.0304 0.8776
Trp-13C1 0.2351 1.7172 1.9587 0.5445
Trp-13C10 0.7540 0.2357 0.9371 1.3577
Trp-13C11 1.0618 NA 0.4894 1.2244
Trp-13C2 NA NA NA NA
Trp-13C3 NA NA NA NA
Trp-13C4 NA NA NA NA
Trp-13C5 NA NA NA NA
Trp-13C6 1.1137 NA NA 0.9432
Trp-13C7 0.9132 1.2360 NA 0.8507
Trp-13C8 1.5020 0.8010 1.0189 0.8927
Trp-13C9 0.1693 1.0536 0.9299 1.2824
Trp-ALL 1.2216 0.8705 0.9676 0.9801
Tyr-13C0 1.2776 1.1113 0.5966 1.1393
Tyr-13C1 1.5021 1.1821 0.5902 1.0451
Tyr-13C2 1.1520 NA 0.7953 1.0858
Tyr-13C3 NA NA 0.4496 1.3669
Tyr-13C4 1.8451 1.7011 0.0472 0.4067
Tyr-13C5 0.7720 NA 0.4964 1.7316
Tyr-13C6 NA 1.1227 0.2084 1.2229
Tyr-13C7 1.2049 NA 0.2814 1.1712
Tyr-13C8 1.0552 NA 0.9724 NA
Tyr-13C9 NA 1.3860 0.4056 1.2083
Tyr-ALL 1.2929 1.1075 0.5986 1.1341
Val-13C0 1.4246 1.0442 0.7051 1.0403
Val-13C1 1.1985 1.4953 0.4072 1.1639
Val-13C2 0.9689 0.4646 0.4673 1.8159
Val-13C3 2.0014 NA 0.3710 1.2567
Val-13C4 NA NA 0.3901 2.2197
Val-13C5 NA NA 1.0000 NA
Val-ALL 1.4080 1.0560 0.6841 1.0560
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Factors:

F1protocol.id:12CGlc_FASN_shRNA
F2protocol.id:12CGlc_NTC_shRNA
F3protocol.id:13CGlc_FASN_shRNA
F4protocol.id:13CGlc_NTC_shRNA
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