Data for Aspirin Metabolomics in Colorectal Cancer Chemoprevention (part 1 - Colon) (Study ST001091)
(Analysis AN001777)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 |
|---|---|---|---|---|---|
| 3-Hydroxymethylglutaric acid | 0.9750 | 0.9313 | 1.1631 | 1.1861 | 0.9348 |
| 3-Phosphoglyceric acid | 0.9217 | 0.6304 | 2.2020 | 0.0562 | 0.6506 |
| 3-Sulfinoalanine | 0.9851 | 1.0117 | 1.2593 | 0.2694 | 0.9876 |
| 5-Hydroxymethyluracil | 1.0148 | 0.9504 | 1.0235 | 1.0484 | 1.0047 |
| 6-Phosphogluconic acid | 1.0319 | 1.0608 | 0.7083 | 0.2238 | 1.2390 |
| Acetylcysteine | 1.1306 | 1.0195 | 1.1754 | 0.3506 | 1.0806 |
| Adenine | 0.9739 | 0.9265 | 1.6285 | 0.7620 | 0.9298 |
| Adenosine | 1.1206 | 1.0304 | 0.9262 | 0.2712 | 0.9702 |
| Adenosine 35-diphosphate | 0.9219 | 0.8619 | 1.9631 | 0.2195 | 0.8895 |
| Adenosine diphosphate ribose | 0.7283 | 0.7678 | 2.0416 | NA | 0.7386 |
| ADP-glucose | 1.0055 | 0.8764 | 1.4246 | 0.1622 | 0.9349 |
| All-trans-retinoic acid | 1.1252 | 1.0352 | 0.2135 | 0.3005 | 1.1509 |
| Aminoadipic acid | 1.0758 | 0.8873 | 1.5554 | 0.2884 | 0.9624 |
| Aspartic acid | 1.1899 | 1.1181 | 0.3796 | 0.3116 | 1.0851 |
| Caffeic acid | 1.4541 | 1.2588 | 0.2460 | 0.2155 | 0.7220 |
| Citramalic acid | 1.0291 | 1.0580 | 1.0256 | 0.1977 | 1.0438 |
| Citrulline | 1.3052 | 1.0346 | 0.4268 | 0.2693 | 1.0191 |
| Creatinine | 1.0867 | 1.0359 | 0.8198 | 0.7808 | 1.0589 |
| Cytidine triphosphate | 0.9986 | 0.9035 | 1.5787 | 0.2934 | 0.8520 |
| Dethiobiotin | 1.0020 | 0.8317 | 1.0409 | 0.9551 | 1.1718 |
| Diaminopimelic acid | 1.3076 | 1.1435 | 0.4264 | 0.2982 | 1.0416 |
| DL-O-Phosphoserine | 1.3306 | 0.9145 | 0.5083 | 0.3575 | 0.9480 |
| Dopamine | 1.0123 | 1.0827 | 1.0320 | 0.8378 | 0.9609 |
| FAD | 1.1445 | 1.1121 | 0.4155 | 0.1096 | 1.0888 |
| Gamma-Linolenic acid | 1.2467 | 1.1368 | 0.1815 | 0.6276 | 1.1026 |
| Gluconic acid | 1.3107 | 0.9059 | 1.1371 | 0.2489 | 0.8460 |
| Glutamine | 1.1303 | 1.0798 | 0.7414 | 0.2545 | 1.1197 |
| Glyceric acid | 1.3007 | 1.2146 | 0.3075 | 0.2536 | 1.0953 |
| Glycocholic acid | 1.1814 | 1.3823 | 0.0278 | 0.1015 | 1.3318 |
| Guanine | 1.1303 | 1.0442 | 0.7899 | 0.2872 | 1.0502 |
| Guanosine diphosphate | 1.1162 | 1.0803 | 0.4810 | 0.3572 | 1.1478 |
| Guanosine diphosphate mannose | 0.5556 | 0.5832 | 1.5840 | 0.1121 | 0.7479 |
| Guanosine monophosphate | 1.1124 | 1.1442 | 0.3183 | 0.2544 | 1.1640 |
| Histidine | 1.1366 | 1.0746 | 0.5109 | 0.5290 | 1.0715 |
| Hydroxypyruvic acid | 1.0942 | 0.8839 | 1.4100 | 0.2610 | 1.0096 |
| Hypoxanthine | 1.1632 | 1.1691 | 0.7499 | 0.1519 | 1.1119 |
| Imidazoleacetic acid | 1.0035 | 0.8768 | 1.4133 | 1.0400 | 0.9153 |
| Indoleacetaldehyde | 0.9067 | 0.9625 | 0.9343 | 1.3532 | 0.9969 |
| Kynurenic acid | 0.9891 | 1.0423 | 1.5199 | 0.4490 | 1.1755 |
| Lysine | 1.1758 | 1.1428 | 0.3017 | 0.3427 | 1.0998 |
| Methionine | 1.1628 | 0.9980 | 0.2783 | 0.2198 | 1.0517 |
| Mevalonic acid | 1.2277 | 0.9971 | 0.6436 | 0.5452 | 1.0125 |
| Myristic acid | 1.3126 | 1.1914 | 0.2404 | 0.4395 | 1.0788 |
| N-Acetylasparagine | 1.0867 | 0.9975 | 1.3177 | 0.4797 | 1.0153 |
| N-Acetylglutamic acid | 1.3516 | 0.9086 | 0.8969 | 0.3320 | 0.9251 |
| N-Acetyl-L-aspartic acid | 0.9861 | 1.0297 | 1.4356 | 0.1666 | 1.0310 |
| N-Alpha-acetyllysine | 1.2542 | 1.0420 | 0.2267 | 0.2492 | 1.0413 |
| N-Formyl-L-methionine | 1.2409 | 1.0325 | 0.8174 | 0.3072 | 1.1508 |
| Oxalic acid | 1.0558 | 0.8334 | 2.4323 | 0.1756 | 0.8197 |
| Oxoadipic acid | 1.1067 | 0.9445 | 0.9671 | 0.9282 | 0.9997 |
| Oxoglutaric acid | 1.0478 | 1.0373 | 0.4525 | 1.4121 | 0.9673 |
| Palmitoleic acid | 1.2753 | 1.2040 | 0.1192 | 0.4199 | 1.0724 |
| Pantothenic acid | 1.1859 | 1.1660 | 0.4301 | 0.1376 | 1.1127 |
| Phenylalanine | 1.1744 | 1.0424 | 0.2672 | 0.3152 | 1.1427 |
| Phosphocreatine | 0.5135 | 0.5319 | 2.2042 | 0.4033 | 0.4762 |
| Pyrrole-2-carboxylic acid | 1.1170 | 1.1059 | 1.0730 | 0.2245 | 1.0944 |
| Pyruvic acid | 1.1611 | 1.0755 | 1.0857 | 0.2024 | 1.0464 |
| Quinic acid | 1.6378 | 1.3399 | 0.1944 | 0.2823 | 0.6557 |
| Serine | 1.2359 | 1.1262 | 0.3097 | 0.2117 | 1.1250 |
| Shikimic acid | 1.2561 | 1.0899 | 1.0571 | 0.3804 | 0.8145 |
| Stachyose | 1.1385 | 1.0180 | 0.3375 | 0.7074 | 1.0819 |
| trans-Aconitic acid | 1.1443 | 1.1698 | 0.3779 | 0.1872 | 1.1757 |
| trans-Cinnamic acid | 1.2415 | 1.0876 | 0.3120 | 0.3152 | 1.1372 |
| Tyrosine | 1.1512 | 1.0419 | 0.2809 | 0.3665 | 1.1208 |
| Uracil | 1.3267 | 1.1305 | 0.2764 | 0.2093 | 1.1346 |
| Ureidopropionic acid | 1.1537 | 1.0502 | 0.6630 | 0.1871 | 1.1001 |
| Uric acid | 0.7465 | 0.8126 | 1.0542 | 2.2710 | 0.7958 |
| Uridine | 1.1541 | 1.1521 | 0.4293 | 0.1655 | 1.0964 |
| Uridine diphosphate glucose | 1.0614 | 1.0732 | 0.5618 | 0.3979 | 1.1664 |
| Vanillylmandelic acid | 1.5370 | 0.8503 | 0.2782 | 1.4771 | 0.5406 |
| Xanthine | 1.2019 | 1.0845 | 0.2179 | 0.1757 | 1.1503 |
Factors:
| F1 | Aspirin Dosage:ASA 325 | Sample.Matrix:Colon Mucosal Tissue |
| F2 | Aspirin Dosage:ASA 81 | Sample.Matrix:Colon Mucosal Tissue |
| F3 | Aspirin Dosage:NA | Sample.Matrix:Colon Mucosal Tissue |
| F4 | Aspirin Dosage:NA | Sample.Matrix:Plasma |
| F5 | Aspirin Dosage:PLACEBO | Sample.Matrix:Colon Mucosal Tissue |
