Data for Different dose exposure of OPC-163493 on HepG2 cells (part-I) (Study ST001135)
(Analysis AN001860)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| Adenine | 1.0476 | 1.0450 | 0.7939 | 1.1135 |
| Adenosine | 0.9682 | 0.9757 | 1.0258 | 1.0303 |
| Alanine | 1.3808 | 1.1505 | 0.4910 | 0.9777 |
| Arginine | 0.9283 | 0.9350 | 1.1069 | 1.0299 |
| Argininosuccinic acid | 1.1266 | 1.0612 | 0.7156 | 1.0967 |
| Asparagine | 1.0894 | 1.0051 | 0.9425 | 0.9630 |
| Aspartic acid | 1.2713 | 1.1287 | 0.5827 | 1.0173 |
| Beta-Alanine | 1.0358 | 0.9663 | 0.9567 | 1.0412 |
| Betaine | 0.9294 | 0.9743 | 1.0349 | 1.0615 |
| Betaine aldehyde | 0.8762 | 0.6758 | NA | 1.7722 |
| Carnitine | 1.0329 | 1.0379 | 0.9391 | 0.9902 |
| Carnosine | 1.0315 | 0.9391 | 1.0182 | 1.0113 |
| Choline | 0.9993 | 0.9488 | 1.0695 | 0.9825 |
| cis-3-hydroxyproline | 0.9830 | 0.9649 | 1.0213 | 1.0308 |
| Citrulline | 0.9599 | 0.9343 | 1.0261 | 1.0797 |
| Creatine | 0.8592 | 0.8854 | 1.2051 | 1.0502 |
| Creatinine | 0.8706 | 0.9751 | 1.0569 | 1.0974 |
| Cystathionine | 0.9781 | 0.9954 | 0.9922 | 1.0343 |
| Cysteine | 0.9867 | 0.6846 | 1.1790 | 1.1498 |
| Gamma-Aminobutyric acid | 0.9616 | 0.9876 | 1.0650 | 0.9858 |
| Glutamic acid | 0.9986 | 0.9582 | 1.0232 | 1.0200 |
| Glutamine | 1.0354 | 1.0014 | 0.9164 | 1.0468 |
| Glutathione | 1.0183 | 0.8580 | 1.1292 | 0.9945 |
| Glycine | 0.9882 | 0.9777 | 0.9953 | 1.0387 |
| Guanosine | 0.9729 | NA | 1.0271 | NA |
| Histidine | 0.9526 | 0.9693 | 1.0520 | 1.0261 |
| Homocysteine | NA | NA | 1.0000 | NA |
| Homoserine | 0.9487 | 1.0167 | 0.9093 | 1.1599 |
| Inosine | NA | NA | NA | 1.0000 |
| Isoleucine | 0.9668 | 0.9625 | 1.0221 | 1.0486 |
| Leucine | 0.9789 | 0.9624 | 1.0321 | 1.0267 |
| Lysine | 0.9494 | 0.9700 | 1.0954 | 0.9852 |
| Methionine | 0.9761 | 0.9528 | 1.0558 | 1.0154 |
| Ornithine | 1.2204 | 1.1903 | 0.6188 | 0.9705 |
| Oxidized glutathione | 1.0522 | 1.1770 | 0.6877 | 1.0831 |
| Phenylalanine | 0.9849 | 0.9648 | 1.0262 | 1.0241 |
| Proline | 1.2363 | 1.1087 | 0.6176 | 1.0375 |
| Putrescine | 1.1528 | 1.0267 | 0.8052 | 0.9178 |
| S-Adenosylhomocysteine | 1.0358 | 1.0086 | 1.1386 | 0.8170 |
| S-Adenosylmethionine | 0.9689 | 0.9796 | 0.9825 | 1.0690 |
| Sarcosine | 1.3232 | 0.7057 | 1.1391 | 0.8465 |
| Serine | 1.0803 | 1.0072 | 0.8682 | 1.0444 |
| Spermidine | 1.0334 | 1.0402 | 0.8085 | 1.1179 |
| Spermine | 1.1257 | 1.2027 | 0.5663 | 1.1052 |
| Threonine | 1.0298 | 0.9945 | 0.9228 | 1.0528 |
| Tryptophan | 0.9640 | 0.9500 | 1.0484 | 1.0375 |
| Tyrosine | 0.9774 | 0.9640 | 1.0405 | 1.0180 |
| Valine | 0.9368 | 0.9406 | 1.0771 | 1.0454 |
Factors:
| F1 | Treatment:- |
| F2 | Treatment:1 |
| F3 | Treatment:10 |
| F4 | Treatment:3 |
