Data for Metabolme analysis of OPC-163493 on the Liver of ZDF rats (part-II) (Study ST001136)

(Analysis AN001863)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3
Adenine 1.0176 0.9327 1.0497
Adenosine 1.4223 0.8270 0.7507
Alanine 1.0048 1.0018 0.9934
Arginine 1.0271 0.9422 1.0306
Argininosuccinic acid 0.9028 1.0251 1.0721
Asparagine 1.0853 0.9358 0.9789
Aspartic acid 0.8957 1.0663 1.0380
Beta-Alanine 1.0455 0.9278 1.0267
Betaine 0.7404 0.9801 1.2795
Betaine aldehyde 0.9037 1.0715 1.0248
Carnitine 0.7979 1.1062 1.0959
Choline 0.9094 1.0328 1.0578
cis-3-hydroxyproline 1.2717 0.8389 0.8894
Citrulline 1.0311 0.9179 1.0509
Creatine 1.0377 0.9440 1.0183
Creatinine 0.9706 1.0321 0.9973
Cystathionine 1.1173 0.9170 0.9657
Cysteine 0.7088 1.3473 0.9438
Dimethylglycine 0.9788 0.8702 1.1510
Gamma-Aminobutyric acid 0.9953 1.0265 0.9782
Glutamic acid 1.0782 1.0432 0.8785
Glutamine 0.9441 1.0669 0.9890
Glutathione 1.0197 1.0513 0.9291
Glycine 0.9778 0.9921 1.0301
Guanine 1.0037 0.9074 1.0889
Guanosine 1.2937 0.8888 0.8175
Histidine 0.8867 1.0482 1.0652
Hypoxanthine 1.2035 0.9574 0.8391
Inosine 1.2673 0.9193 0.8134
Isoleucine 0.9373 0.9688 1.0940
Leucine 0.9528 0.9569 1.0903
Lysine 0.9579 0.9781 1.0640
Methionine 1.1191 0.8833 0.9975
Ornithine 1.2478 0.9332 0.8190
Oxidized glutathione 0.9962 0.8514 1.1525
Phenylalanine 1.0387 0.9402 1.0210
Putrescine 1.0015 0.9881 1.0121
S-Adenosylhomocysteine 0.9085 1.0288 1.0627
S-Adenosylmethionine 0.8794 1.0918 1.0288
Sarcosine 0.9535 0.9400 1.1065
Serine 1.0350 0.9777 0.9874
Spermidine 0.8653 1.0058 1.1289
Spermine 0.9570 1.0766 0.9664
Threonine 0.9776 0.9879 1.0345
Tryptophan 1.0378 0.9777 0.9845
Tyrosine 1.0862 0.9664 0.9474
Urea 0.8984 1.0253 1.0762
Valine 0.8985 0.9897 1.1118
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Factors:

F1Genotype:11-week-old ZDF rat | Treatment:- | Duration (weeks):-
F2Genotype:17-week-old ZDF rat | Treatment:6 | Duration (weeks):6
F3Genotype:17-week-old ZDF rat | Treatment:- | Duration (weeks):6
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