Data for Plasmodium Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis (Study ST001149)

(Analysis AN001896)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5
2_3-Diphosphoglyceric acid 1.0892 1.1644 0.5961 0.7634 1.1563
2-dehydro-D-gluconate 1.1453 0.6699 1.0638 0.1930 1.3174
2-Hydroxy-2-methylbutanedioic acid 1.1399 0.7614 1.2982 0.2294 1.2273
2-oxo-4-methylthiobutanoate 0.9398 0.8456 1.0419 NA 1.1064
3-phosphoglycerate 1.0578 1.2797 0.5366 0.6198 1.2290
3-phospho-serine 1.1340 0.3585 1.4725 0.3678 1.1480
4-aminobutyrate 1.1701 0.6268 0.8562 1.1527 1.0263
4-phosphopantetheine 1.0236 NA NA 1.0353 0.9411
4-phosphopantothenate 1.0860 0.7820 0.8854 0.6063 1.2844
4-Pyridoxic acid 0.8438 1.0055 1.0456 1.8979 0.8055
5-phosphoribosyl-1-pyrophosphate 1.3940 0.9746 0.4331 0.5739 1.1480
6-phospho-D-gluconate 1.1005 1.0410 0.7094 0.7528 1.1563
acetyl-aspartate 1.2132 0.3933 0.3967 1.1438 1.2480
acetyl-CoA 0.7540 1.1138 1.0280 0.4343 1.4374
Acetyllysine 1.4103 0.8316 0.7315 0.0668 1.3089
aconitate 0.9950 1.4611 0.7074 0.3746 1.1568
ADP-D-glucose 1.0835 1.3465 0.5708 0.6644 1.1326
a-ketoglutarate 1.0279 0.9952 0.9361 0.3296 1.3440
alanine/sarcosine 1.1415 1.1506 0.8138 0.3955 1.1903
arginine 1.9024 1.2531 0.5149 0.4010 0.9285
asparagine 1.0556 1.2415 1.1486 0.7799 0.9695
aspartate 1.1466 0.8782 0.9043 0.7308 1.2313
carnitine 0.9405 0.3823 1.5969 NA 1.0600
CDP 0.9015 1.0833 0.8343 0.6773 1.2929
CDP-choline 0.9248 1.1770 1.1586 0.7699 0.9697
CDP-ethanolamine 1.0920 1.0085 0.8752 0.2895 1.3290
citrate/isocitrate 1.0035 1.3277 0.9797 0.0284 1.3289
CMP 0.8527 1.0687 0.9837 0.6836 1.2670
coenzyme A 1.2595 0.7132 0.5169 0.9595 1.1659
CTP 0.8663 1.1879 0.9275 0.5720 1.2788
cyclic-AMP 1.0245 1.4277 0.8620 0.2084 1.2285
cytidine 1.1971 0.4682 1.5409 0.4808 1.0744
dAMP 1.0841 1.4577 0.6346 0.5507 1.1014
dATP 1.0956 1.0767 0.7883 0.8352 1.0622
dCDP 1.0626 0.7223 0.8842 0.8430 1.2178
dCMP 1.0149 1.0110 0.9403 0.5161 1.2527
dCTP 1.0627 0.9410 1.1416 0.4103 1.1961
deoxyinosine 0.9124 1.7407 0.2125 NA 1.0964
deoxyribose-phosphate 0.9554 1.5007 0.8538 NA 0.8599
dGDP/ADP 1.0297 1.6919 0.2589 0.7941 1.1003
D-gluconate 1.1750 0.6585 1.2559 0.3831 1.1908
dGMP/AMP 1.1694 1.1121 0.7476 0.5632 1.1333
dGTP/ATP 1.0960 1.0188 0.8596 0.6366 1.1545
dihydroorotate 2.0866 1.0698 0.7629 0.6921 0.2415
dihydroxy-acetone-phosphate 0.9330 1.7111 1.2701 0.3782 0.9397
DLH 1.3956 0.9919 0.2891 0.2680 1.3628
DL-Pipecolic Acid 1.7283 1.0129 0.2637 0.4427 1.1907
DLS 1.5070 1.2765 0.5812 0.4065 1.1576
D-sedoheptulose-1/7-phosphate 1.1360 0.7905 1.1568 0.5526 1.1254
dTDP 0.8214 1.4272 0.7189 0.3752 1.4031
dTMP 0.8578 1.4933 0.6715 0.3936 1.3511
dTTP 0.8332 1.2068 0.8754 0.3848 1.4194
dUMP 0.4426 1.4665 1.0402 NA 1.2111
dUTP 1.0095 1.3672 1.1126 0.3020 1.0643
FAD 1.1165 1.0558 1.0339 0.4300 1.1334
FMN 1.0195 1.2161 0.8582 0.5551 1.1674
folate 1.1821 0.5594 0.6450 1.0503 1.1654
fructose-1-6-bisphosphate 1.2397 0.6162 0.9958 0.9485 1.0000
fructose-6-phosphate 0.9963 1.0111 1.4985 1.0433 0.7270
fumarate 1.1689 1.5346 0.7956 0.2141 1.0730
GDP 1.0994 1.1050 0.6520 0.8732 1.0938
glucono-lactone 0.9810 0.9604 1.0434 0.9859 1.0293
glucose-1/6-phosphate 1.1711 0.6699 1.2019 NA 0.9215
glutamate 1.1077 0.8056 0.7473 1.0447 1.0711
glutamine 0.9881 1.1302 1.1604 0.9034 0.9632
glutathione disulfide 1.1472 1.1125 0.9016 0.3030 1.2065
glycerate 0.9473 1.3997 1.1657 0.0253 1.1832
GMP 1.0359 1.1247 0.6214 0.8400 1.1741
GTP 1.0812 0.9406 0.8420 0.9576 1.0555
guanine 1.1366 1.0304 1.1526 0.3929 1.0868
guanosine 1.1998 0.7084 0.7200 1.1557 1.0248
histidine 1.3064 1.0045 0.7421 0.6686 1.1518
HVDD 2.0134 0.9287 0.2781 0.2588 1.5210
hydroxyproline/Aminolevulinate 1.0330 NA NA 0.9349 1.0321
hypoxanthine 0.9568 0.9643 1.9779 0.0540 1.0397
IMP 1.1571 1.4498 0.1386 0.6339 1.2449
indole 0.9910 1.1467 0.8406 NA 1.0138
inosine 1.1679 0.5097 1.5623 0.3874 1.1164
isoleucine 0.9700 1.1475 0.9938 0.8936 1.0657
Isopentyl-PP 1.0395 0.9424 1.0194 0.9246 1.0740
lactate 1.1037 1.2043 0.9589 0.0872 1.2798
L-arginino-succinate 1.3176 NA NA 0.5552 1.1272
LD 1.2819 0.7144 0.4615 0.9950 1.1562
leucine 1.0726 1.0827 0.8626 0.7998 1.1550
lysine 1.8457 1.0480 0.2325 0.4474 1.0667
malate 1.2517 0.6380 1.6115 0.2646 1.0122
maleic acid 1.1509 NA NA 0.8277 1.0214
methionine 1.1013 0.9702 0.7736 0.9153 1.1115
myo-inositol 1.2638 0.5540 1.5305 0.1324 1.1498
Myristoyl/tetradecanoyl-CoA 0.9370 NA NA 1.0585 1.0044
N-acetyl-glucosamine-1/6-phosphate 1.4043 0.3549 1.4076 0.4150 0.9148
N-acetyl-glutamate 1.0326 1.3331 0.5725 0.4860 1.2743
N-acetyl-glutamine 0.9728 0.9064 1.2254 0.2190 1.3495
N-Acetyl-L-alanine 1.1927 0.5350 1.6241 0.2987 1.0944
N-acetyl-L-ornithine 1.3640 0.8978 0.6956 0.1071 1.3161
NAD+ 1.1659 0.6070 1.5617 0.2165 1.1554
NADH 0.8413 1.5020 1.4714 1.2173 0.5502
NADP+ 1.0816 0.9483 1.0352 0.6377 1.1146
NADPH 0.7520 1.1468 1.0450 1.1151 1.0738
N-carbamoyl-L-aspartate 1.7228 0.8285 0.6007 1.2704 0.4876
nicotinamide mononucleotide 0.9929 0.8294 0.9339 0.9244 1.2010
nicotinate 1.1301 0.5588 1.8886 0.1428 1.0856
Octulose 8/1P 1.1015 0.5539 1.5771 0.2361 1.2235
Octulose Bisphosphate 1.1880 0.7674 0.6313 1.0410 1.1078
ornithine 1.0980 0.5267 1.4872 NA 0.9115
orotate 0.8951 1.3952 0.6020 0.8281 1.1834
orotidine-5^-phosphate 1.1671 0.3978 0.3590 0.8590 1.5955
pantothenate 1.1017 0.5258 0.5418 1.1188 1.2457
PD 1.4340 0.8859 0.6752 0.3458 1.1487
PE 1.3424 1.2080 0.3597 0.2617 1.2714
PEE 1.3244 1.1458 0.2854 0.2072 1.3834
PEEK 1.5064 0.7026 0.5665 0.1216 1.3404
phenylalanine 1.1622 0.8895 0.7110 0.8171 1.2205
phenylpyruvate 1.0368 0.7692 1.4665 NA 0.8515
phosphoenolpyruvate 1.0358 1.2565 0.6230 0.5748 1.2400
p-hydroxybenzoate 0.9099 1.5796 0.2234 NA 1.1736
proline 1.0926 NA NA 0.8067 1.1007
PVNF 1.3892 0.4064 0.3756 0.3879 1.5582
pyridoxine 0.9028 1.1797 1.0248 0.8958 1.0992
Pyroglutamic acid 1.0684 1.2913 1.0546 0.0357 1.2465
Pyrophosphate 1.3276 0.3157 1.0376 NA 1.0503
pyruvate 0.8520 1.2997 1.0616 0.0526 1.4287
Ribose-5-phosphate 1.0461 NA NA 0.9752 0.9787
ribose-phosphate 1.1170 0.6666 1.2219 0.3739 1.1419
ribulose-5-phosphate 1.0350 1.1210 0.8703 0.7936 1.1757
S-adenosyl-L-homocysteine 1.0805 1.0190 0.7615 1.0590 1.0065
SD 1.3559 0.4301 0.5048 0.6757 1.3685
SDL 1.4289 NA NA 0.5327 1.0384
Sedoheptulose bisphosphate 1.1212 0.8279 0.8410 0.9262 1.0913
serine 1.0754 1.2262 1.1226 0.7854 0.9648
SID 1.4332 NA NA 0.5514 1.0154
S-methyl-5^-thioadenosine 0.8723 0.5672 1.2962 0.6061 1.2903
sn-glycerol-3-phosphate 1.3078 0.2748 2.1008 0.3020 0.8791
succinate/Methylmalonic acid 0.9686 1.5530 0.7560 0.2923 1.2281
succinyl-CoA/methylmalonyl-CoA 1.0509 NA NA 0.8755 1.0736
taurine 1.0822 1.0774 1.0144 0.9337 0.8923
thiamine 0.8486 1.3991 1.5224 0.7889 0.9018
Thiamine pyrophosphate 1.0219 0.9149 0.9791 0.9584 1.0726
threonine/homoserine 1.1521 1.1580 0.9882 0.7608 1.0139
thymidine 0.9231 0.0049 1.9064 NA 1.1084
thymine 0.9453 0.5110 1.5245 NA 1.0278
trehalose-6-Phosphate 1.1920 NA NA 1.0266 0.7814
tryptophan 0.9662 1.0929 1.1551 0.8402 1.0696
tyrosine 1.0684 0.9559 0.8679 0.9060 1.1137
UDP 0.8213 1.2939 0.7312 0.4921 1.4052
UDP-D-glucose 1.0565 1.1177 0.8490 0.6268 1.1514
UDP-D-glucuronate 1.0042 1.4278 0.7179 0.3683 1.2392
UDP-N-acetyl-glucosamine 1.0000 1.3581 0.7981 0.3898 1.2270
UMP 0.9453 0.4333 1.3973 0.4509 1.4094
uridine 0.8656 1.3276 0.6548 NA 1.1208
UTP 0.8428 1.0158 1.0849 0.4080 1.3897
valine 1.1278 1.0144 0.8411 0.7882 1.1562
VD 1.3753 1.1177 0.6044 0.3169 1.1365
xanthine 0.8305 0.5539 1.2982 NA 1.2152
xanthosine 1.1129 0.9170 1.6179 0.1086 1.0748
xanthosine-5-phosphate 0.9742 0.8393 1.1300 0.3297 1.3742
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Factors:

F1Drug treatment:Atovaquone, 2.5 hours
F2Drug treatment:MMV009108, 2.5 hours
F3Drug treatment:MMV019662, 2.5 hours
F4Drug treatment:MMV028038, 2.5 hours
F5Drug treatment:Untreated, 2.5 hours
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