Data for Metabolite changes in human plasma before and after YF17D vaccination in symptomatic and asymptomatic subjects (Study ST001176)
(Analysis AN001952)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 2-Hydroxybutyric acid | 0.8166 | 1.0915 | 1.0728 | 1.0060 |
| 2-Oxoglutaric acid | 0.8532 | 1.1009 | 1.0459 | 1.1009 |
| 2-Oxoisovaleric acid | 0.9031 | 1.0591 | 1.0468 | 0.9940 |
| 2-Phosphoglyceric acid | NA | NA | NA | NA |
| 3-Hydroxybutyric acid | 0.6711 | 1.2707 | 1.0425 | 1.0074 |
| 3-Phosphoglyceric acid | NA | NA | NA | NA |
| 6-Phosphogluconic acid | NA | NA | NA | NA |
| Acetyl CoA_divalent | NA | NA | NA | NA |
| Adenine | NA | NA | NA | NA |
| Adenosine | NA | NA | NA | NA |
| ADP | NA | NA | NA | NA |
| Ala | 1.1458 | 1.0908 | 0.8592 | 0.9380 |
| AMP | NA | NA | NA | NA |
| Anthranilic acid | NA | NA | NA | NA |
| Arg | 0.9987 | 1.1137 | 0.8634 | 1.0402 |
| Asn | 1.0036 | 1.0394 | 0.9370 | 1.0261 |
| Asp | 0.6928 | 1.5006 | 0.5961 | 1.2381 |
| ATP | NA | NA | NA | NA |
| Betaine | 0.9278 | 0.9467 | 1.0804 | 1.0271 |
| Betaine aldehyde_+H2O | NA | NA | NA | NA |
| cAMP | NA | NA | NA | NA |
| Carnosine | NA | NA | NA | NA |
| CDP | NA | NA | NA | NA |
| cGMP | NA | NA | NA | NA |
| Choline | 0.9133 | 1.1265 | 1.0177 | 0.9481 |
| cis-Aconitic acid | 1.2204 | 0.9531 | 0.9429 | 0.8853 |
| Citric acid | 1.1876 | 0.9649 | 0.9439 | 0.9254 |
| Citrulline | 1.0345 | 1.0402 | 1.0049 | 0.9310 |
| CMP | NA | NA | NA | NA |
| CoA_divalent | NA | NA | NA | NA |
| Creatine | 1.1766 | 1.2094 | 0.8469 | 0.8223 |
| Creatinine | 1.0430 | 1.0218 | 0.9779 | 0.9666 |
| CTP | NA | NA | NA | NA |
| Cys | 0.6723 | 1.3644 | 1.1271 | 0.9492 |
| Cytidine | NA | NA | NA | NA |
| Cytosine | NA | NA | NA | NA |
| dATP | NA | NA | NA | NA |
| dCTP | NA | NA | NA | NA |
| Dihydroxyacetone phosphate | NA | NA | NA | NA |
| dTDP | NA | NA | NA | NA |
| dTMP | NA | NA | NA | NA |
| dTTP | NA | NA | NA | NA |
| Erythrose 4-phosphate | NA | NA | NA | NA |
| Fructose 1,6-diphosphate | NA | NA | NA | NA |
| Fructose 6-phosphate | NA | NA | NA | NA |
| Fumaric acid | NA | NA | NA | NA |
| GABA | NA | NA | NA | NA |
| GDP | NA | NA | NA | NA |
| Gln | 1.0185 | 0.9912 | 0.9948 | 0.9969 |
| Glu | 0.9983 | 1.2516 | 0.8459 | 0.9399 |
| Gluconic acid | 1.1007 | 0.9657 | 1.0033 | 0.9349 |
| Glucose 1-phosphate | NA | NA | NA | NA |
| Glucose 6-phosphate | NA | NA | NA | NA |
| Glutathione (GSH) | NA | NA | NA | NA |
| Glutathione (GSSG)_divalent | NA | NA | NA | NA |
| Gly | 1.0703 | 1.1115 | 0.9079 | 0.9363 |
| Glyceraldehyde 3-phosphate | NA | NA | NA | NA |
| Glycerol 3-phosphate | NA | NA | NA | NA |
| Glycolic acid | NA | NA | NA | NA |
| Glyoxylic acid | 1.3804 | NA | 0.6444 | 0.5948 |
| GMP | NA | NA | NA | NA |
| GTP | NA | NA | NA | NA |
| Guanine | NA | NA | NA | NA |
| Guanosine | NA | NA | NA | 1.0000 |
| His | 0.9912 | 1.0159 | 0.9999 | 0.9941 |
| Homoserine | NA | NA | NA | NA |
| Hydroxyproline | 1.0106 | 0.8718 | 1.0092 | 1.0916 |
| Hypoxanthine | 1.3505 | 1.5303 | 0.5538 | 0.6912 |
| Ile | 0.9979 | 1.0799 | 0.8983 | 1.0350 |
| IMP | NA | NA | NA | NA |
| Inosine | 0.1513 | NA | NA | 1.8487 |
| Isocitric acid | 1.2416 | 1.0327 | 0.9089 | 0.8951 |
| Lactic acid | 1.2519 | 1.1540 | 0.7930 | 0.8591 |
| Leu | 0.9720 | 1.1094 | 0.9372 | 0.9930 |
| Lys | 0.9292 | 1.0855 | 0.9513 | 1.0361 |
| Malic acid | 1.1317 | 1.2967 | 0.8176 | 0.8576 |
| Malonyl CoA_divalent | NA | NA | NA | NA |
| Met | 0.8075 | 1.2348 | 0.9470 | 1.0167 |
| NAD+ | NA | NA | NA | NA |
| NADP+ | NA | NA | NA | NA |
| N,N-Dimethylglycine | 0.9790 | 0.9942 | 1.0115 | 1.0115 |
| Ornithine | 1.0672 | 1.0639 | 0.9148 | 0.9729 |
| Phe | 0.9481 | 1.0525 | 0.9756 | 1.0238 |
| Phosphoenolpyruvic acid | NA | NA | NA | NA |
| Pro | 1.0259 | 0.9216 | 0.9877 | 1.0573 |
| PRPP | NA | NA | NA | NA |
| Putrescine | NA | NA | NA | NA |
| Pyruvic acid | 0.7654 | 1.0522 | 1.1578 | 0.9801 |
| Ribose 5-phosphate | NA | NA | NA | NA |
| Ribulose 5-phosphate | NA | NA | NA | NA |
| S-Adenosylmethionine | NA | NA | NA | NA |
| Sarcosine | 1.2123 | 1.0455 | 0.9610 | 0.8180 |
| Sedoheptulose 7-phosphate | NA | NA | NA | NA |
| Ser | 0.8904 | 1.0089 | 1.0171 | 1.0692 |
| Spermidine | NA | NA | NA | NA |
| Spermine | NA | NA | NA | NA |
| Succinic acid | 1.0115 | 1.2874 | 0.9598 | 0.8707 |
| Thr | 0.9491 | 1.0781 | 0.9241 | 1.0526 |
| Thymidine | NA | NA | NA | NA |
| Thymine | NA | NA | NA | NA |
| Trp | 0.9375 | 1.0358 | 0.9946 | 1.0283 |
| Tyr | 1.0329 | 1.0329 | 0.9161 | 1.0274 |
| Tyramine | 0.7759 | 1.3966 | 0.9163 | 0.9655 |
| UDP | NA | NA | NA | NA |
| UMP | NA | NA | NA | NA |
| Uracil | NA | NA | NA | NA |
| Uridine | 0.9797 | 1.1254 | 1.0361 | 0.8738 |
| UTP | NA | NA | NA | NA |
| Val | 0.9568 | 1.0651 | 0.9608 | 1.0204 |
| β-Ala | 1.5303 | 0.9296 | 0.7478 | 0.8581 |
Factors:
| F1 | Outcome:Asymptomatic | Day post-vaccination:day 0 |
| F2 | Outcome:Asymptomatic | Day post-vaccination:day 1 |
| F3 | Outcome:Symptomatic | Day post-vaccination:day 0 |
| F4 | Outcome:Symptomatic | Day post-vaccination:day 1 |
