Data for P. falciparum infected erythrocytes (Study ST001188)

(Analysis AN001980)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10
1-3-Bisphosphoglycerate 0.7512 0.8818 1.1027 0.7845 1.0659 0.8503 1.0566 1.0681 0.9639 1.4421
1-Acyl-sn-glycero-3-phosphoglycerol 0.9430 0.8207 0.6690 1.2275 2.0389 0.9798 0.7425 0.6336 0.9077 0.9634
1D-myo-Inositol 3-phosphate 1.4729 0.4485 0.9000 1.7977 1.2745 1.4092 0.3301 0.6169 1.1852 0.5774
2-C-Methyl-D-erythritol 2,4-cyclodiphosphate 1.2978 0.2500 0.7063 2.4055 1.3988 1.9775 0.3982 0.6201 0.6890 0.3658
2-Hydroxycinnamic acid 0.9942 1.0001 0.9503 0.9759 1.0032 1.1873 1.0918 0.9518 0.9339 0.9261
3-Phosphoglyceric acid 0.9527 0.9137 1.1795 0.9133 1.1282 0.9665 0.9043 1.0563 0.8963 1.1003
4,5-Dihydroorotic acid 2.5387 0.3550 1.0982 1.6237 0.3804 2.1286 0.3525 0.5834 0.9809 0.2658
5-Aminolevulinic acid 0.9630 1.0045 0.9196 0.9861 1.0428 1.0200 1.0327 0.9565 1.0167 1.0473
6-Phosphogluconic acid 1.0841 0.9678 0.8882 1.1244 1.0612 1.0863 0.9726 0.9712 0.9961 0.8545
Acetyl-CoA 1.0416 0.9488 0.9315 1.1558 1.3970 1.1433 0.9577 0.8247 0.9089 0.7038
Acetylphosphate 0.6821 1.3751 1.2655 0.7275 0.9293 0.6341 1.2775 1.3440 0.7009 1.0176
Adenosine diphosphate ribose 1.1228 0.9754 0.8144 1.0627 1.3512 1.4015 0.8578 0.8596 0.8495 0.7428
Adenosine monophosphate 1.0948 1.6526 0.7183 0.6454 0.8024 1.1497 1.4536 0.8639 0.6517 0.9634
Adenosine triphosphate 0.9544 0.9566 1.0370 0.9155 1.1572 1.0457 0.9964 0.9317 0.9286 1.0809
ADP 1.0137 1.2804 0.9071 0.7619 0.9634 1.0959 1.2453 0.9747 0.7815 0.9779
Alanyl-theronine 1.3950 0.5501 1.7261 1.9987 0.6711 1.2593 0.3480 1.1799 0.3102 0.1133
Alpha-D-Glucose 1.0259 1.0169 0.8292 0.9843 0.9718 1.1254 1.1452 0.9825 1.0397 0.8769
CDP 0.9762 0.3354 0.6481 0.9087 1.8004 0.9511 0.3484 0.6108 0.9110 2.4628
CDP-Ethanolamine 1.3363 0.2383 0.8394 1.2728 1.4642 1.5093 0.2456 0.7208 1.0934 1.3559
cis-Aconitic acid 1.0603 0.8055 0.9343 1.5861 0.9384 1.0843 0.8058 0.8005 1.2356 0.7580
Citric acid 1.1999 1.4329 1.0367 0.6899 0.6407 1.2818 1.5196 0.9727 0.6644 0.6190
Citrulline 1.1189 1.3728 0.9187 0.7586 0.8711 1.0895 1.3911 0.9000 0.8494 0.7441
CMP-2-aminoethylphosphonate 1.0517 0.9055 0.8332 0.9581 1.0464 1.1385 1.0780 0.8387 0.8389 1.3137
Coenzyme A 1.1096 0.7520 0.8648 1.1648 1.3384 1.2405 0.7704 0.7127 0.9155 1.1551
Cyclic ADP-ribose 1.0009 0.7158 0.9314 1.2588 1.5005 1.1057 0.6259 0.7594 1.0677 1.0380
Cyclic AMP 1.1130 0.6250 1.0257 1.0576 1.5214 1.1197 0.6288 0.7005 1.0596 1.0242
Cytidine monophosphate 0.5960 0.1285 0.3178 0.7555 1.7082 0.5320 0.1855 0.2796 0.9685 4.3558
Cytidine triphosphate 1.1435 0.3770 1.1633 1.1878 1.7479 1.0827 0.3419 0.7655 0.9560 1.2775
D-4^-Phosphopantothenate 0.6797 0.6768 1.2012 1.6638 1.8553 0.7509 0.4930 0.5490 1.0383 1.1419
dCTP 1.2096 0.4195 0.6455 1.6909 1.3158 1.1592 0.4494 0.4787 1.0278 1.6053
Deoxyadenosine triphosphate 1.1357 0.7453 0.9215 1.1595 1.1045 1.1491 0.7713 0.7731 1.0737 1.1892
Deoxyribose 5-phosphate 1.3765 0.6668 1.2659 2.3498 0.8396 1.3720 0.4079 0.8078 0.5480 0.0614
D-Fructose 0.9676 1.3885 1.0463 0.7699 0.6099 0.9826 1.5238 1.0585 0.8976 0.7548
D-Galactose 6-phosphate 1.1410 0.7877 0.8836 1.3289 1.3376 1.1464 0.7990 0.7938 1.0869 0.6917
D-Glyceraldehyde 3-phosphate 1.5792 0.8651 0.8661 1.1589 1.0008 1.5630 0.9196 0.7570 0.7659 0.6365
Dihydroxyacetone phosphate 0.6212 1.6872 1.3481 0.3060 0.5868 0.6972 1.6933 1.4571 0.4088 1.1572
D-Ribose 1.2478 1.1281 0.8262 0.8510 0.7580 1.3131 1.2229 0.9722 0.9426 0.7810
D-Ribose 5-phosphate 0.6641 1.2942 1.1943 0.8388 1.0133 0.7030 1.3674 1.1303 0.7671 0.9787
D-Sedoheptulose 7-phosphate 1.5641 0.8559 0.7326 0.9351 0.9739 1.6674 0.8997 0.8137 0.8038 0.8610
dTDP 1.0881 1.6100 0.5345 0.7487 1.0867 0.9205 1.3931 0.9846 0.6335 1.1605
FAD 0.9670 0.7843 0.9514 1.1594 1.6562 1.0807 0.7996 0.8198 0.8911 0.8903
Farnesyl pyrophosphate 1.0694 0.1945 0.1788 1.8046 1.8589 1.3393 0.1630 0.1514 NA 0.1334
Flavin Mononucleotide 0.9559 0.8036 1.1225 0.9252 1.1990 0.9667 0.8290 1.0353 0.9783 1.1894
Fructose 1,6-bisphosphate 0.7885 1.2298 1.1029 0.6801 0.9840 0.9579 1.2225 1.0748 0.6834 1.2593
Fructose-1-phosphate 0.9209 1.2984 1.0122 0.8473 0.8655 1.0027 1.3498 1.0071 0.8726 0.8165
Fructose 6-phosphate 1.3016 0.8550 0.8707 1.1102 1.1385 1.4034 1.0148 0.8069 0.9498 0.6130
Fumaric acid 2.2609 0.4533 1.2189 1.2988 0.2908 2.4360 0.3560 0.7141 0.9141 0.3021
Gamma-Aminobutyric acid 0.8957 1.0404 1.0785 0.9338 0.9181 1.0572 1.1523 0.9994 0.9262 1.0021
gamma-Glutamylcysteine 1.0600 NA 1.0766 1.1838 0.8458 0.7280 NA NA 1.0520 1.0161
Geranylgeranyl-PP 1.9067 0.4357 0.8145 2.2915 2.1806 1.6150 0.2495 0.2390 0.2107 0.2053
GEYG 0.9988 0.8633 0.8290 1.1874 1.2605 1.2435 1.0855 0.7969 0.8950 0.8481
GGEAL 1.4444 0.2689 1.4614 2.3959 1.0973 1.5647 0.1829 0.6731 0.3241 0.1174
Gluconic acid 0.7179 1.2541 1.1983 0.8912 0.8260 0.8764 1.3022 1.0375 0.9628 0.9105
Glucose 6-phosphate 1.0764 0.8081 0.8961 1.2890 1.2778 1.1180 0.8582 0.8237 1.0947 0.7679
Glu-Lys-Gln 1.1852 0.3052 0.5853 1.8229 2.3803 1.1101 0.2164 0.3521 0.9419 1.0873
Glutamyl-D-alanine 1.5567 0.4085 0.3994 1.6677 1.8925 1.8120 0.5011 0.3285 0.7209 0.7980
Glutamylglutamic acid 1.0990 0.5854 0.8283 1.6709 2.0423 1.0262 0.4430 0.7237 0.9857 0.5904
Glutamylglycine 1.3465 0.9361 0.5726 1.2834 1.6746 1.4020 0.8324 0.5494 0.8024 0.6363
Glutathione 0.9224 1.0623 1.1082 1.0068 0.9584 0.9642 0.9749 1.0067 0.9197 1.0760
Glycerol 3-phosphate 0.5571 1.4966 1.3533 0.7332 0.6693 0.6616 1.5907 1.4006 0.8295 0.6605
Gly-Pro-Glu 1.7977 0.3467 1.8507 1.8884 1.0623 1.7824 0.2062 0.7595 0.3375 0.1436
Guanosine diphosphate 0.9668 0.9045 0.9451 1.0648 1.6632 0.9647 0.7464 0.8239 0.8057 1.1014
Guanosine diphosphate mannose 0.9104 0.8812 0.8603 1.0221 1.6771 0.9252 0.8264 0.7821 0.9269 1.1545
Guanosine monophosphate 1.0376 1.0651 0.5803 1.1956 1.4039 0.9124 0.8348 0.8765 1.0275 1.0141
Guanosine triphosphate 0.9254 0.7013 0.9829 1.0961 1.9821 0.9421 0.6633 0.7484 0.8267 1.1152
HLD 1.6341 0.2385 2.0844 2.3212 0.9918 1.7490 0.1734 0.7535 0.2560 0.0724
HVDD 1.9453 0.2988 2.1966 1.6350 0.6110 2.2198 0.1531 0.9378 0.3018 0.0743
HVDPENF 1.3329 0.3572 1.1965 2.2760 1.1070 1.4980 0.3707 0.6252 0.4399 0.2577
IDP 0.6133 1.0360 0.9301 0.8267 1.3339 0.8503 1.0986 0.9506 0.8317 1.4613
Inosine 1.0054 0.8150 0.9767 1.1691 1.0759 1.1845 0.9503 0.8848 1.0232 0.9336
Inosinic acid 0.9683 1.2557 0.7550 1.2617 0.7999 1.0906 1.2078 0.6941 1.1265 0.8197
L-Alanine 0.8952 1.1104 1.0580 0.8991 1.0052 0.9648 1.1682 1.0641 0.8841 0.9418
L-Arginine 0.9051 0.9029 0.9583 1.0260 1.3098 0.9319 0.9727 0.9296 0.8982 1.1428
L-Aspartic acid 0.8969 1.2190 0.9618 0.9532 1.0377 0.9256 1.2357 1.0098 0.9136 0.8227
LD 1.2679 0.9056 1.0126 1.0400 0.8829 1.4171 0.9282 0.9439 0.9194 0.7598
L-Galactose 1.0718 1.0768 0.8857 0.9584 0.8690 1.1283 1.2525 0.9704 0.9267 0.8702
L-gamma-glutamyl-L-leucine 1.3297 0.8120 1.0331 1.0918 0.7032 1.4264 0.8504 0.9935 1.0650 0.7825
L-Glutamic acid 0.8974 1.0902 0.9962 0.9386 0.9862 0.9758 1.1612 1.0226 0.9077 1.0095
L-Glutamine 0.9345 0.8407 0.9607 1.0938 1.0050 0.9743 0.9759 0.9410 1.1197 1.1398
L-Isoleucine 0.9186 0.9701 0.9585 0.9430 0.9895 1.0350 1.1470 0.9471 1.0249 1.0564
L-Lactic acid 1.4491 0.3133 0.3285 1.6266 2.2133 1.6873 0.4088 0.2575 1.0145 0.7528
L-Leucine 1.0931 0.8800 0.9169 1.1081 1.0634 1.2047 1.0092 0.8541 0.9911 0.9033
L-Lysine 0.9564 0.7471 0.8962 1.2126 2.4926 0.9414 0.8661 0.6113 0.4888 0.7646
L-Malic acid 1.1122 0.8635 0.8793 1.2746 1.2297 1.1149 0.9202 0.7688 0.8984 0.9502
L-Methionine 0.9221 1.0456 0.9326 0.9631 0.9664 0.9828 1.2203 0.9585 1.0207 0.9698
L-Methionine S-oxide 0.7473 0.9072 0.8555 1.1792 1.2772 0.9213 0.7798 0.9273 1.2519 1.1004
L-Phenylalanine 1.1845 0.8733 0.9221 1.1356 1.1013 1.2397 0.9373 0.8285 0.9439 0.8723
L-Proline 1.1222 0.9147 0.8548 1.1560 1.1381 1.1674 0.9833 0.8326 0.9894 0.8575
L-Threonine 1.0175 1.0079 0.8349 1.1738 1.1065 1.1269 0.9725 0.8631 1.0449 0.8498
L-Tyrosine 1.0192 0.9870 0.9196 1.0327 1.0171 1.0928 1.0913 0.9259 0.9856 0.9322
L-Valine 1.2415 0.8299 0.8707 1.2162 1.1543 1.2792 0.9031 0.8097 0.9508 0.7881
LysoPE(0:0/18:3(6Z,9Z,12Z)) 0.8134 0.9287 0.9426 1.4107 1.5511 0.9338 0.9202 0.9708 0.6784 0.7927
LysoPE(0:0/20:4(5Z,8Z,11Z,14Z)) 0.9231 0.8965 0.7003 1.4907 1.6144 0.9226 0.8291 0.7781 0.7631 1.0317
LysoPG(18:0/0:0) 1.0525 0.7307 1.6435 1.0541 1.3724 1.2614 0.5967 1.2072 0.6940 0.4940
Mannitol 1.0232 1.1682 0.9053 0.9781 0.8666 1.2472 1.1763 1.0138 0.9862 0.6546
Methyl glutathione 1.0409 1.1498 0.9067 1.1008 1.0854 1.0103 1.0357 0.9549 0.9270 0.7839
Methyl-thioinosine 1.6592 0.4001 1.0330 1.8410 0.5752 2.0896 0.3278 0.6991 1.2390 0.3340
myo-Inositol 0.9525 0.9414 0.9144 0.9841 1.1187 1.0125 1.0324 0.9128 1.0124 1.1055
N-Acetyl-aspartyl-glutamate 1.4261 0.4242 0.7098 1.7263 1.6580 1.2152 0.3407 0.5362 0.9389 1.0636
N-Acetylglutamic acid 0.9621 0.7401 1.0370 0.9323 2.0034 1.2350 0.9179 0.7666 0.6292 0.8023
N-Acetyl-L-aspartic acid 0.8649 1.3163 0.9705 0.8765 1.0116 0.9509 1.3325 0.9896 0.8219 0.8415
NAD 1.0164 0.8584 0.8507 1.4492 1.4014 0.9588 0.5786 0.8158 1.0979 0.9535
NADP 1.2121 0.6304 1.0176 1.1084 1.0603 1.1677 0.7315 0.8300 0.9626 1.3237
Nicotinic acid mononucleotide 0.8232 0.5433 0.7437 1.1131 1.8140 0.8516 0.6660 0.7485 1.0635 1.5685
O-Acetylserine 1.2665 0.4263 1.2290 1.5405 1.7857 1.5141 0.3007 0.6232 0.7413 0.6848
O-Phosphoethanolamine 0.8492 0.2092 0.2399 1.0055 2.5354 1.0200 0.2911 0.2743 0.9056 2.5708
Ornithine 1.0326 0.9977 0.8527 0.8161 1.1233 1.2086 1.1756 0.8210 0.8570 1.1259
Orotic acid 2.0513 0.3138 0.9850 1.7977 0.7898 2.2958 0.1714 0.4852 0.9621 0.2387
Orotidine 1.1210 1.1456 0.7775 1.0901 0.8797 0.8411 1.2068 0.9662 1.0782 0.8648
Oxidized glutathione 0.9435 0.9493 1.0433 0.9078 1.1093 1.1253 1.2862 0.8534 0.7243 1.0699
Oxoglutaric acid 1.1635 0.6353 0.7852 1.4249 1.5074 1.1160 0.4922 0.5933 1.3463 0.9432
Pantetheine 4-phosphate 1.0797 0.4117 0.7556 1.9408 1.0646 0.9707 0.4672 0.6760 1.2847 1.3274
Pantothenic acid 0.8308 0.9651 0.9656 0.9245 0.7892 0.9189 1.2507 1.0729 1.0573 1.1934
PAVH 0.9959 0.2388 1.1622 2.8420 2.0918 1.1783 0.2353 0.5807 0.4772 0.2352
PD 1.9677 0.4792 1.1496 2.1214 0.8715 1.8319 0.2821 0.7906 0.5930 0.1296
PE 1.4921 0.5162 1.6088 2.1186 0.7767 1.5191 0.3997 0.8651 0.5728 0.3109
PEE 1.7684 0.2672 1.5127 2.2551 1.2909 1.8850 0.2150 0.6926 0.2626 0.0911
PEEK 1.4174 0.2089 1.3252 1.7480 1.6129 1.5203 0.1069 0.6739 0.3727 0.4822
PENF 1.0343 0.1849 0.9873 1.8277 1.6637 1.1998 0.1756 0.5275 0.2983 0.1943
PHFD 1.3828 0.2320 0.4235 1.8164 1.9544 1.2152 0.2061 0.3282 1.1056 0.9911
Phosphoenolpyruvic acid 0.8311 0.8690 1.0856 0.7592 1.0345 0.8563 1.0511 1.0448 0.9635 1.4608
Phosphorylcholine 0.8241 0.2602 0.6360 1.0162 1.2761 0.5587 0.3005 0.5259 1.5609 2.9325
Pipecolic acid 2.0335 0.2849 0.8737 2.1636 1.5662 1.9898 0.1859 0.4090 0.4972 0.2072
PNALS 1.0819 0.3421 1.1189 2.6474 1.9602 1.2492 0.2208 0.5708 0.3160 0.1771
PPVQ 1.2982 0.7154 1.4426 1.9916 0.9393 1.4373 0.4285 0.7290 0.2546 0.0491
PPVQAA 0.9974 0.7474 1.0183 0.8667 1.1088 1.2376 1.0332 0.8911 0.9866 1.1411
Prolyl-Serine 1.2004 0.6856 0.9155 1.9378 1.7592 0.9982 0.3798 0.7785 0.8742 0.4834
PVNF 1.7512 0.3527 1.6930 2.4491 0.9430 1.7275 0.2133 0.6897 0.3477 0.0740
PVQ 1.2925 0.4258 0.8787 2.7258 1.6346 1.3244 0.3306 0.8178 0.4094 0.1174
PVQA 1.6066 0.2615 1.5856 2.1470 1.0941 1.8528 0.1683 0.7360 0.4869 0.2885
PWTQ 1.3686 0.3123 1.5242 2.2449 1.3958 1.5328 0.2995 0.7642 0.2238 0.1217
Pyridoxine 0.3480 1.2288 1.0257 0.9931 1.1015 0.4312 1.3906 1.1910 1.0806 1.0767
Pyroglutamic acid 0.9130 1.0468 1.0521 0.9405 0.9441 1.0086 1.1445 1.0327 0.9147 1.0001
Riboflavin 0.9182 1.1231 0.8428 1.0251 1.0022 1.0882 1.1611 1.0734 0.9988 0.7503
S-Adenosylhomocysteine 1.5244 0.1970 0.3640 2.1098 2.1170 0.9446 0.1716 0.3131 1.2995 0.9404
Sarcosine 1.0071 1.0870 0.8988 0.9557 0.9479 1.1288 1.2681 0.8935 0.9739 0.8431
S-Lactoylglutathione 1.2252 0.7095 0.6304 1.7447 1.6330 1.2472 0.6761 0.6166 0.8669 0.6618
Sorbitol 0.9865 1.0103 0.9566 1.0853 1.0171 1.0794 1.0821 0.9603 0.9264 0.8984
Succinic acid semialdehyde 1.1995 0.5856 0.7927 1.4009 1.4377 1.1513 0.4925 0.6366 1.3069 1.0123
succinyl-GLUTATHIONE 0.9917 0.9984 0.9836 1.0112 1.1289 1.0117 1.0023 0.9170 0.9312 1.0226
Threonic acid 1.0911 1.1524 0.7954 0.9567 1.0473 0.9628 1.3113 0.9720 0.9958 0.6985
Thymidine 5^-triphosphate 1.3119 0.0703 0.5296 1.8012 1.2520 1.1778 0.0795 0.2887 1.3198 1.9667
TNVK 1.6394 0.3603 1.5572 2.1439 0.7851 1.5200 0.2049 0.8239 0.4504 0.1389
TPDAVM 1.1221 0.3133 0.7993 2.3467 1.8065 1.0264 0.2595 0.4196 0.2378 0.0918
TSKY 1.5894 0.4089 0.8668 1.8367 1.6420 1.4436 0.3044 0.6104 0.7981 0.5998
UDP-N-acetyl-D-galactosamine 1.0534 0.8144 0.7837 1.1695 1.3153 1.0629 0.8467 0.7654 0.9857 1.1920
Ureidosuccinic acid 2.4358 0.3974 1.2547 1.5514 0.2935 2.1320 0.3523 0.7092 0.8590 0.3284
Uridine 5^-diphosphate 1.4266 0.3455 0.8311 1.4396 1.5315 1.3602 0.3039 0.6685 0.9969 1.1648
Uridine 5^-monophosphate 1.0831 0.2201 0.3877 1.4625 2.1320 0.8412 0.2181 0.3764 1.1062 2.0963
Uridine diphosphategalactose 1.0655 0.9508 0.9656 1.0624 1.1324 1.0727 0.9306 0.8711 0.9478 1.0126
VD 1.3979 0.6891 1.3040 1.9466 1.0300 1.2707 0.5028 0.8903 0.5894 0.4528
VDEVG 1.2376 0.2087 0.8503 2.2837 2.2287 1.2860 0.1659 0.4922 0.2427 0.1054
VDPVNF 1.4094 0.3896 1.1161 2.6845 1.2003 1.5100 0.3062 0.6405 0.3488 0.1488
VHLT 0.9908 0.5804 0.5457 1.3652 1.8973 1.0448 0.7203 0.4728 0.8136 1.4293
VHLTP 1.2258 0.6388 0.8525 1.7718 1.6198 1.2994 0.4892 0.5454 0.7244 0.8749
VLSPA 1.9916 0.3348 0.7853 2.0006 0.7605 1.8198 0.2834 0.4523 0.9820 0.7670
VLSPAD 1.4992 0.1842 0.7454 1.8996 1.6459 1.6168 0.1080 0.3624 0.6500 0.3363
VS 0.7909 0.2786 1.0429 2.7151 2.3158 0.6902 0.2004 0.4537 0.5350 0.7222
Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1Treatment:Control | Time (hr):30
F2Treatment:Control | Time (hr):58
F3Treatment:Control | Time (hr):68
F4Treatment:Control | Time (hr):78
F5Treatment:Control | Time (hr):88
F6Treatment:Indolmycin | Time (hr):30
F7Treatment:Indolmycin | Time (hr):58
F8Treatment:Indolmycin | Time (hr):68
F9Treatment:Indolmycin | Time (hr):78
F10Treatment:Indolmycin | Time (hr):88
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