Data for Metabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part I (Study ST001235)

(Analysis AN002053)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6
1-methylhistamine 0.9985 1.0037 0.9985 0.9963 1.0002 1.0034
2-deoxycytidine 0.9331 1.0369 0.9955 0.9858 1.0156 1.0566
3-hydroxyanthranilic acid 0.9925 0.9946 0.9935 1.0015 1.0023 1.0187
3-nitro-L-tyrosine 0.9985 1.0022 0.9915 1.0100 0.9919 1.0072
5-aminolevulinic acid 0.9989 0.9962 0.9996 0.9992 1.0010 1.0056
5-HIAA 0.9934 0.9952 1.0103 1.0016 0.9985 1.0022
5-methylthioadenosine 1.0102 0.9883 0.9935 1.0090 1.0117 0.9845
adenine 0.9972 0.9967 0.9983 1.0048 1.0126 0.9915
adenosine 0.9955 1.0219 0.9942 1.0001 0.9871 1.0033
ADMA 0.9990 0.9970 1.0021 1.0010 1.0004 1.0005
alanine 0.9986 0.9987 0.9986 1.0026 0.9982 1.0038
alpha-glycerophosphocholine 0.9976 1.0065 0.9981 1.0052 0.9954 0.9983
aminoisobutyric acid 0.9964 0.9881 1.0117 0.9988 1.0025 1.0027
anserine 1.0426 1.0172 0.9454 0.9755 0.9909 1.0179
arginine 1.0001 1.0005 0.9983 0.9991 1.0015 1.0005
argininosuccinate 1.0121 0.9881 0.9975 0.9952 1.0096 0.9936
asparagine 0.9961 0.9982 0.9972 1.0067 0.9999 1.0036
aspartate 1.0055 0.9914 1.0018 1.0016 1.0097 0.9880
beta-alanine 1.0075 0.9972 0.9889 1.0053 1.0074 0.9921
betaine 0.9988 1.0007 0.9990 1.0019 0.9989 1.0012
butyrobetaine 0.9980 0.9952 1.0049 1.0003 1.0032 0.9986
C10:2 carnitine 1.0096 1.0070 1.0140 0.9758 1.0032 0.9859
C10 carnitine 1.0089 1.0031 1.0170 0.9834 1.0024 0.9806
C12:1 carnitine 1.0088 1.0037 1.0168 0.9841 1.0076 0.9745
C12 carnitine 1.0055 1.0012 1.0177 0.9859 1.0060 0.9802
C14:1 carnitine 1.0063 1.0042 1.0193 0.9838 1.0094 0.9732
C14:2 carnitine 1.0077 1.0061 1.0157 0.9865 1.0053 0.9747
C14 carnitine 1.0001 0.9977 1.0159 0.9926 1.0080 0.9842
C16 carnitine 0.9923 1.0027 1.0079 1.0022 1.0037 0.9930
C16-OH carnitine 0.9993 0.9997 1.0119 0.9946 1.0062 0.9875
C18:1 carnitine 0.9949 1.0008 1.0134 0.9940 1.0088 0.9886
C18:1-OH carnitine 1.0057 1.0100 1.0167 0.9807 1.0098 0.9736
C18:2 carnitine 0.9894 1.0067 1.0061 1.0039 1.0017 0.9951
C18 carnitine 0.9943 0.9918 1.0103 0.9996 1.0111 0.9939
C20:4 carnitine 0.9841 1.0046 1.0068 1.0111 1.0032 0.9949
C20 carnitine 0.9952 0.9966 1.0038 1.0006 1.0076 0.9976
C22:6 carnitine 0.9985 1.0044 1.0232 0.9958 1.0130 0.9633
C26 carnitine 0.9961 0.9982 0.9987 0.9991 1.0034 1.0060
C2 carnitine 1.0001 1.0005 1.0012 0.9984 1.0016 0.9980
C3 carnitine 0.9991 0.9921 0.9986 1.0031 1.0023 1.0052
C4 carnitine 0.9970 0.9943 0.9999 1.0046 1.0009 1.0044
C4-OH carnitine 1.0009 1.0043 1.0108 0.9905 1.0071 0.9851
C5:1 carnitine 0.9967 0.9929 1.0051 1.0005 1.0016 1.0039
C5 carnitine 1.0011 0.9867 1.0000 0.9999 1.0054 1.0065
C5-DC carnitine 1.0010 0.9991 1.0050 0.9939 1.0011 0.9992
C6 carnitine 1.0072 1.0032 1.0109 0.9851 1.0058 0.9843
C7 carnitine 1.0088 0.9918 1.0079 0.9956 1.0041 0.9883
C9 carnitine 1.0084 0.9977 1.0047 0.9940 0.9994 0.9926
cAMP 0.9757 1.0004 1.0262 0.9853 0.9829 1.0322
carnitine 0.9999 0.9988 0.9999 1.0003 1.0010 1.0002
choline 0.9996 0.9970 1.0000 1.0032 0.9999 1.0005
citrulline 1.0005 1.0009 0.9963 1.0006 0.9980 1.0038
cotinine 1.0028 1.0010 0.9799 1.0141 0.9969 1.0061
creatine 1.0016 0.9962 0.9985 0.9979 1.0042 1.0012
creatinine 1.0025 0.9972 1.0045 0.9931 1.0041 0.9974
cytosine 0.9967 0.9821 0.9863 1.0187 1.0024 1.0161
dimethylglycine 1.0000 0.9926 1.0049 0.9997 1.0011 1.0013
epinephrine 1.0044 1.0026 0.9992 0.9952 0.9971 1.0000
GABA 1.0023 0.9966 1.0013 0.9963 0.9949 1.0078
glutamate 1.0123 0.9827 1.0028 0.9999 1.0117 0.9862
glutamine 1.0017 1.0056 0.9922 1.0006 0.9953 1.0047
glycine 0.9999 1.0009 0.9996 0.9994 1.0011 0.9993
guanidinoacetic acid 0.9927 1.0081 0.9927 1.0016 0.9943 1.0136
guanine 1.0000 0.9985 1.0040 0.9994 0.9991 0.9987
histamine 0.9958 1.0038 0.9971 1.0016 0.9975 1.0058
histidine 1.0000 1.0017 0.9969 1.0005 0.9992 1.0021
homocysteine 0.9955 0.9959 0.9929 1.0108 0.9949 1.0121
hydroxyproline 0.9981 0.9920 1.0147 1.0261 0.9879 0.9805
hypoxanthine 1.0057 0.9964 0.9955 0.9994 0.9983 1.0033
isoleucine 1.0000 0.9960 0.9977 1.0052 0.9986 1.0027
Kyn/Trp (log10) NA NA NA NA NA NA
kynurenic acid 1.0015 0.9964 1.0071 0.9952 1.0028 0.9958
kynurenine 0.9864 0.9724 1.0223 1.0024 1.0265 0.9925
leucine 1.0003 0.9976 0.9966 1.0054 1.0002 1.0002
lysine 1.0009 0.9996 0.9981 1.0003 1.0015 0.9994
melatonin 1.0133 0.9982 0.9995 0.9779 1.0148 0.9918
methionine 0.9982 0.9962 0.9972 1.0046 0.9977 1.0069
methionine sulfoxide 1.0011 0.9812 1.0031 1.0071 1.0033 1.0036
mevalonic acid 1.0035 0.9928 1.0045 1.0110 0.9984 0.9882
N-carbamoyl-beta-alanine 0.9954 0.9816 1.0103 1.0040 1.0069 1.0024
niacinamide 0.9889 1.0049 0.9939 0.9935 1.0123 1.0107
NMMA 0.9987 0.9994 0.9983 1.0008 0.9992 1.0043
ornithine 0.9991 1.0058 0.9973 0.9993 0.9961 1.0029
phenylalanine 0.9988 0.9937 1.0022 1.0042 1.0048 0.9964
pipecolic acid 1.0007 1.0035 0.9985 0.9989 0.9949 1.0034
proline 0.9981 0.9994 0.9980 1.0026 0.9993 1.0033
putrescine 1.0155 0.9964 1.0131 0.9742 0.9942 1.0008
pyroglutamic acid 1.0007 1.0035 0.9985 0.9989 0.9949 1.0034
quinolinic acid 0.9612 0.9653 1.0108 1.0266 1.0034 1.0453
S-adenosylhomocysteine 0.9822 0.9924 0.9961 1.0056 1.0203 1.0097
sarcosine 0.9936 0.9856 1.0090 0.9960 1.0096 1.0072
SDMA 1.0004 0.9967 1.0048 0.9973 1.0013 0.9991
serine 0.9999 0.9986 0.9985 1.0023 1.0003 1.0006
serotonin 1.0044 1.0091 0.9918 0.9967 0.9935 1.0037
spermine 1.0001 0.9827 1.0065 1.0084 0.9965 1.0050
taurine 0.9978 1.0041 1.0030 0.9975 0.9986 0.9994
thiamine 0.9949 0.9906 0.9894 1.0170 0.9954 1.0153
threonine 1.0007 0.9987 0.9977 0.9979 0.9982 1.0067
thymidine 1.0141 0.9968 1.0106 1.0042 0.9668 1.0018
thyroxine 1.0007 0.9970 1.0084 1.0036 1.0031 0.9863
triiodothyronine 0.9938 0.9960 1.0098 1.0094 1.0049 0.9871
trimethylamine-N-oxide 0.9961 0.9956 1.0063 0.9953 1.0046 1.0029
tryptophan 1.0013 0.9949 0.9996 1.0040 0.9996 1.0001
tyrosine 0.9992 0.9961 0.9993 1.0025 1.0017 1.0017
uracil 1.0027 1.0036 0.9777 1.0051 1.0075 1.0044
valine 1.0001 0.9978 0.9962 1.0051 1.0006 1.0005
xanthosine 1.0269 0.9815 1.0058 0.9951 0.9959 0.9852
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Factors:

F1Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):-
F2Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1
F3Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):-
F4Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1
F5Time point:week 6 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):-
F6Time point:week 6 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1
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